Gene 82759.m00088 (T.vaginalis)

82759.m00088

Species: T.vaginalis
Alias: 82759.m00088, TvagK0649
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
82759.m00088.AA Protein None 449 None Fasta, JSON
82759.m00088.kin_dom Protein Kinase Domain None 279 None Fasta, JSON

Protein domain

Protein domains of 82759.m00088.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82759.m00088.AA DYRK 149-427 38 5.8e-112 378.27 In-house 1-320 (320) Show / Hide 
Range on Protein: 149-427
Range on HMM: 1-320/320
Sequence Identity: 38% (125 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKIEASSLAKVNKI---DTNNIVRAYDFFVFRNHPCITYELLGSSLR------GQRVI-
|||| ..|.| ||.||||.|||.. .||.||| . . .. |..|| . | . |.    |. ..|..||.|..||| ||. |||  .|.      ....  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

-TPSIKPICYQIFSALASLKKC-GIIHCDIKPDNLLFIQ--DTTKVKLIDFGTSCISGRQIFTYIQSRFYRAPEVILGCGYGHEIDVWSAALVCIELITG
    ......||. .|  |.|.  |||||.||.| .  |  .   .|.|||| ||  ...|.||||||||||||||||| |. .||.||   .  || ||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

KPLFPGSNEVDMLRLFIEFMKYPPIELLRKS--SRVLNFFDD------------KY--------------RPLFHVKPGTKNILDFVGSIDPQFYDLLTH
.|||||.||.|.|....|.. .|| ....|.  .|. .|||.            ..              |      ||..|. ..    | || |... 
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKK

CLRWLPSERFTPEQALAHPYF
|| | |..| ||.||| || |
CLQWDPHKRITPSQALQHPWF
Kinase 82759.m00088.AA DYRK2 149-427 38 4e-93 303.2 In-house 1-318 (318) Show / Hide 
Range on Protein: 149-427
Range on HMM: 1-318/318
Sequence Identity: 38% (124 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKIEASSLAKVNKID---TNNIVRAYDFFVFRNHPCITYELLGSSL----RGQRV--IT
|||| |.|.| || ||||.|||.| .||.|.|   .  ..|  .|   | .  ..|   | |.|.  |.|.|||| ||| |||. .|    ..     ..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

PS-IKPICYQIFSALASLKKCGIIHCDIKPDNLLFIQDT-TKVKLIDFGTSCISGR-QIFTYIQSRFYRAPEVILGCGYGHEIDVWSAALVCIELITGKP
.. . . ...|  .|  |.|  ||||| || | |  | .   .|.|||| ||   . .|.||||||||||||||||. || .|| ||   .  || ||.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGSNEVDMLRLFIEFMKYPPIELLRKS-----SRVLNFFDD-------------KYRPLFHVK--------PGTKNILDFVG-SIDPQFYDLLTHCLR
||||.||.| . ...|..  || ... ..     .|  .||..             .  . .|.|        ||.|.. ...  . |. | | .. |. 
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WLPSERFTPEQALAHPYF
| |||| ||.||| ||..
WDPSERMTPSQALKHPWI
Kinase 82759.m00088.AA CMGC 149-427 19 7.3e-90 295.4 In-house 1-513 (513) Show / Hide 
Range on Protein: 149-427
Range on HMM: 1-513/513
Sequence Identity: 19% (99 aa)

YEILLVLGSGAFGKVVKCFD--------------HKNKVLVAVKIIISTQQMAEQSK-------------IEASSLAKVNK--------------IDTNN
|||. ..|.|..|.|.||.|              |... .||.|.| . . . || |              | . | ..||               . ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRAYDFFVFRN-----------------HPCITYELLGSSLRGQRVITPS-------------------------IKPIC------YQIFSALA--SLK
||. ||.|...|                 | ..  |... .| .    ..                          || .       |||. .|.   . 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KCG--IIHCDIKPDNLLFIQDTTK-------------------VKLIDFGTSCISGRQ------------------------IFTYIQSRFYRAPEVILG
. .  |||.|.|| |.|. ....                    .|..||| ... .                          . .|...|.|||||..||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

CG----------YGHEIDVWSAALVCIELITG--------KPLFPGSNE-----------VDMLRLFIEFMKYPPIELLRKS---------SR----VLN
..          |. .||.||.. .  |..||        ||||||..|           .|.| . .. .  |. ....|.         ..    ...
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIK

------------------FFDDKYRPLFHV-----KPGTKNILDFVGS-----------------------------------IDPQFYDLLTHCLRWLP
                  ......|  ..      ..  |.. ...                                     .|||. |||  .|.. |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SERFTPEQALAHPYF
..| |.||||.||||
DKRITAEQALQHPYF
Kinase 82759.m00088.AA S_TKc 149-427 26 5.7e-71 243.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 149-427
Range on HMM: 1-231/231
Sequence Identity: 26% (80 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKIEASSLAKVNKIDTNNIVRAYDFFVFRNHPCITYELLGS---SLRGQRVITPS----
|||| ..|.|||||| || ..| . .||.|||       |. . | . | |    .  |||. ||.|.  .| ..  |...    .|.   .  ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

------IKPICYQIFSALASLKKCGIIHCDIKPDNLLFIQDTTKVKLIDFGTSCISGRQIFTYIQSRFYRAPEVILGCGYGH-EIDVWSAALVCIELITG
      .. ..|||..||. . . ||||.|.||.|.|. .    .|..||| ...      |.. ...|.||||.   |||. ..|.||   . .|...|
FPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

KPLFPGSNEVDMLRLFIEFMKYPPIELLRKSSRVLNFFDDKYRPLFHVKPGTKNILDFVGSIDPQFYDLLTHCLRWLPSERFTPEQALA-------HPYF
.|.||  ..  |...                                               .|.. |.. .||.. |..| |  .||.       ||.|
YPPFP--QMQMMFKKIG---------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 82759.m00088.AA HIPK 149-379 37 1e-56 176.94 In-house 1-248 (329) Show / Hide 
Range on Protein: 149-379
Range on HMM: 1-248/329
Sequence Identity: 37% (92 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKIEASSLAKVNKIDTN--NIVRAYDFFVFRNHPCITYELLGSSL---RGQRVITP---
||.| .|| | ||.||||  .  . .||.||.      | | .|| | |... . . .  ..||||..|  .|| |. .|.|   |     |    |   
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

-SIKPICYQIFSALASLKKCGIIHCDIKPDNLLFIQDTT---KVKLIDFGTSCISGRQIF-TYIQSRFYRAPEVILGCGYGHEIDVWSAALVCIELITGK
  |.||  |.  ||. ||. |.|| |.||.|.. .  |    .|| ||||   .  . .  ||.|||.|||||.|||  .  ..|.||   |  ||. | 
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLFPGSNEVDMLRLFIEFMKYPPIELLRKSSRVLNFF----DDKYRPL
||.||..| |  | ....   |   || . ..   ||    . |.||.
PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPW
Kinase 82759.m00088.AA DYRK1 149-373 38 1.5e-55 190.87 In-house 1-238 (321) Show / Hide 
Range on Protein: 149-373
Range on HMM: 1-238/321
Sequence Identity: 38% (92 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKIEASSLAKVNKIDTNN---IVRAYDFFVFRNHPCITYELLGSSL-------RGQRVI
|||   .| |.||.||| .||... .||.|||   .   .| .||   |  .|| |...   ||.    |.|||| |. .|||   |         . | 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

TPSIKPICYQIFSALASLK--KCGIIHCDIKPDNLLFIQDT-TKVKLIDFGTSCISGRQIFTYIQSRFYRAPEVILGCGYGHEIDVWSAALVCIELITGK
   .. .  |.  ||  .      |||||.||.|.| .     ..|.|||| || .|. |. ||||||||.|||.||  |  .||.||   . .|. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGSNEVDMLRLFIEFMKYPPIELLRKSSRVLNFFD
||| |||||| .   .| .  || ... .. .   .|.
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase 82759.m00088.AA Pkinase 149-427 27 1.4e-54 192.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 149-427
Range on HMM: 1-293/293
Sequence Identity: 27% (86 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKI-----EASSLAKVNKIDTNNIVRAYDFFVFRNHPCITYELL-GS----SLR-----
|.|. ..|||.||.| || ....  .||||||    .  .. ..     |.. ....|     |||| ||.|  ..|...  |.. |     .|      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--GQRV--ITPSIKPICYQIFSALASLKKCGIIHCDIKPDNLLFIQDTTK---VKLIDFGTSC---ISGRQIFTYIQ-SRFYRAPEVIL-GCGYGHEIDV
  . ..      .| ..|||...|. . ..||||.|.||.|.|. .. .    ||..||| ..   .   . .| .  ...|.|||||. | .||...|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSAALVCIELITGKPLFPGS----NEVDMLRLFIEFMKYPPIELLRKSSRVLNFFDDKYRPLFHVKPGTKNILDFVGSIDPQFYDLLTHCLRWLPSERFT
||. ....|...|.|.|||.    | .|.. .. . |. |. .   ..... .|| ... .        .    |   ... . |... ||.. |..| |
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

PEQALAHPYF
.||.| ||.|
AEQILQHPWF
Kinase 82759.m00088.AA GSK 242-427 34 9e-44 131.19 In-house 118-328 (328) Show / Hide 
Range on Protein: 242-427
Range on HMM: 118-328/328
Sequence Identity: 34% (72 aa)

IKPICYQIFSALASLKKCGIIHCDIKPDNLLFIQDTTKVKLIDFGTSC--IS--GRQIFTYIQSRFYRAPEVILGC-GYGHEIDVWSAALVCIELITGKP
|| . ||.| .|| | . || | ||||.|.|  .|| ..|. ||| .   ..  .    .|| ||.||||| |.||  |.. |||||.  |  |...|.|
IKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQP

LFPGSNEVDMLRLFIEFMKYPPIELLRKSSRVLNFFDDK------YRP--------------LFHVKPGTKNILDFVGSIDPQFYDLLTHCLRWLPSERF
|||| ..||.|.. |. . .|. | ...     ..|...      . |              ..| |  | ...  ....... .||.. ||.  |..|.
LFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQDWIDLISKCLVYDPKKRL

TPEQALAHPYF
.| .|.|||.|
SPLEACAHPFF
Kinase 82759.m00088.AA PRP4 247-373 45 6.9e-41 142.16 In-house 113-240 (320) Show / Hide 
Range on Protein: 247-373
Range on HMM: 113-240/320
Sequence Identity: 45% (58 aa)

YQIFSALASLKKCGIIHCDIKPDNLLFIQDTTKVKLIDFGT-SCISGRQIFTYIQSRFYRAPEVILGCGYGHEIDVWSAALVCIELITGKPLFPGSNEVD
.|.| ||  ||||.|.| ||||||.|   ...  |..|||. | |.   |  | .||||||||.|.|  |   ||.||..    || ||| .|||.   .
QQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNH

MLRLFIEFMKYPPIELLRKSSRVLNFFD
||.|| .     |  ..||.  . |.||
MLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase 82759.m00088.AA YAK 248-364 38 2.9e-30 99.72 In-house 114-231 (347) Show / Hide 
Range on Protein: 248-364
Range on HMM: 114-231/347
Sequence Identity: 38% (45 aa)

QIFSALASLKKCGIIHCDIKPDNLLFIQ-DTTKVKLIDFGTSCISGRQIFTYIQSRFYRAPEVILGCGYGHEIDVWSAALVCIELITGKPLFPGSNEVDM
||  ..  |.   ||||| || | .  . .   .|.|||| ||   . . ||||.|.||.||.|..  |   || ||   .  ||  | |.|||  | . 
QILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQ

LRLFIEFMKYPPIELLRK
.   |.   ||| ... .
IKRIIDMLGYPPSWMIDQ
Kinase 82759.m00088.AA RCK 241-345 39 4.5e-29 89.15 In-house 106-221 (298) Show / Hide 
Range on Protein: 241-345
Range on HMM: 106-221/298
Sequence Identity: 39% (46 aa)

SIKPICYQIFSALASLKKCGIIHCDIKPDNLLFI--------QDTTKVKLIDFGTS-CISGRQIFT-YIQSRFYRAPEVILGC-GYGHEIDVWSAALVCI
||| | |||. .|| . | |. | |.|| |..          ||.  .|..||| . .|  .. .| |. .| |||||..| |  |   .|.|.   . .
SIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMY

ELITGKPLFPGSNEVD
|| . .||||||.|.|
ELYMLRPLFPGSSEID
Kinase 82759.m00088.AA CLK 149-232 40 1.1e-26 76.37 In-house 1-93 (350) Show / Hide 
Range on Protein: 149-232
Range on HMM: 1-93/350
Sequence Identity: 40% (38 aa)

YEILLVLGSGAFGKVVKCFDHKN-KVLVAVKIIISTQQMAEQSKIEAS-SLAKVNKI-DTNNIVR-----AYDFFVF-RNHPCITYELLGSSL
|||. .||.|.|||||.| |||| | .||.||| .  .  |....| .  . |.|.. | ||. .      .| | .  .| ||  ||.| |.
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSI
Kinase 82759.m00088.AA YAK 149-232 39 1.4e-20 66.24 In-house 1-91 (347) Show / Hide 
Range on Protein: 149-232
Range on HMM: 1-91/347
Sequence Identity: 39% (36 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKIEASSLAKVNK----IDTN---NIVRAYDFFVFRNHPCITYELLGSSL
| .| .|| | || ||||     . |.|||.| . |    |.| |.  |   |.     . |    |.| |||||..|| |. .|.|  .|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNL
Kinase 82759.m00088.AA CLK 278-349 37 1.8e-13 36.06 In-house 184-258 (350) Show / Hide 
Range on Protein: 278-349
Range on HMM: 184-258/350
Sequence Identity: 37% (28 aa)

TKVKLIDFGTSC---ISGRQIFTYIQSRFYRAPEVILGCGYGHEIDVWSAALVCIELITGKPLFPGSNEVDMLRL
| ...||||             | ...| |||||||||.|.    |||| . . .|| ||  ||.. .... | .
THICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAM
Kinase 82759.m00088.AA RCK 402-427 50 1.1e-10 29.88 In-house 273-298 (298) Show / Hide 
Range on Protein: 402-427
Range on HMM: 273-298/298
Sequence Identity: 50% (13 aa)

DLLTHCLRWLPSERFTPEQALAHPYF
.|.. .|.| |..| |..||| ||||
ELMEKMLQWDPQKRITAQQALQHPYF
Kinase 82759.m00088.AA PRP4 149-233 30 1.1e-09 31.74 In-house 1-91 (320) Show / Hide 
Range on Protein: 149-233
Range on HMM: 1-91/320
Sequence Identity: 30% (28 aa)

YEILLVLGSGAFGKVVKCFDHKNKV-LVAVKIIISTQQMAEQSKIEASSLAKVNKI--DTNN---IVRAYDFFVFRNHPCITYELLGSSLR
|..    |.| |. |..| |  .    ||.||| .   |      |   | | |    | |    .|| .. | .|.| |. .| .  .||
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLR
Kinase 82759.m00088.AA CLK 399-427 44 4.4e-08 19.56 In-house 322-350 (350) Show / Hide 
Range on Protein: 399-427
Range on HMM: 322-350/350
Sequence Identity: 44% (13 aa)

QFYDLLTHCLRWLPSERFTPEQALAHPYF
|. ||.  .|   || | |  .|| ||.|
QLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 82759.m00088.AA TyrKc 149-427 19 7e-08 -95.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 149-427
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVKIIISTQQMAEQSKIEASSLAK----VNKI--DTNNIVRAYDFFVFR-------NHPCITYEL-----LGS
 . . .||.||||.|.|.      . |||| . .              . .      |.  .  |||| |   .           ..|  |.     | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

SLRGQR--VITPSIKPICYQIFSALASLKKCGIIHCDIKPDNLLFIQDTTKVKLIDFGTSCISGRQ-IF-----TYI-----QSR-----FYRAPEVILG
 ||  |  . ..    .|.|| .  . | . ..|| |.   | | . .   ||  ||| |   .          .|      ...        |||.|  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

CGYGHEIDVWSAALVCIELIT-GKPLFPG-----SNEVDMLRLFIEFMKYPPIEL----LRKSSRVLNFFDDKYRPLFHVKPGTKNILDFVGSIDPQFYD
. . .. ||||   .. |. | |..  ||      .  .....  . .  |. .                                   |     .  |.
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------F-VCCPDEMYQ

LLTHCLRWLPSERFTPEQALAHPYF
. . | .  |..| | ..   | .|
IMKQCWHEDPEDRPTFSEI--HECF
Kinase 82759.m00088.AA PRP4 399-427 48 4e-07 22.2 In-house 292-320 (320) Show / Hide 
Range on Protein: 399-427
Range on HMM: 292-320/320
Sequence Identity: 48% (14 aa)

QFYDLLTHCLRWLPSERFTPEQALAHPYF
|| |||  ||   |. | |...|| ||..
QFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase 82759.m00088.AA RCK 149-178 36 7.1e-07 17.53 In-house 1-30 (298) Show / Hide 
Range on Protein: 149-178
Range on HMM: 1-30/298
Sequence Identity: 36% (11 aa)

YEILLVLGSGAFGKVVKCFDHKNKVLVAVK
| |.  || |..| |.|  . ... .|| |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIK
Kinase 82759.m00088.AA CLK 242-273 34 1e-05 12.41 In-house 116-147 (350) Show / Hide 
Range on Protein: 242-273
Range on HMM: 116-147/350
Sequence Identity: 34% (11 aa)

IKPICYQIFSALASLKKCGIIHCDIKPDNLLF
|. . ||. .|. .| . ...| | || | .|
IRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase 82759.m00088.AA GSK 149-178 31 3.1e-05 11.31 In-house 1-38 (328) Show / Hide 
Range on Protein: 149-178
Range on HMM: 1-38/328
Sequence Identity: 31% (12 aa)

YEILLVLGSGAFGKVVKCFDH----KNKVL----VAVK
||.  | |.|.||.|..  .      .|      ||.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK
Kinase 82759.m00088.AA Pkinase_Tyr 149-188 26 5.5e-05 17.52 Pfam 1-49 (270) Show / Hide 
Range on Protein: 149-188
Range on HMM: 1-49/270
Sequence Identity: 26% (13 aa)

YEILLVLGSGAFGKVVKCFDH----KNKVLVAVKII--ISTQQ---MAE
 ... .||.||||.|.|.  .    ..|. ||||..   ....   ...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCRED
Kinase 82759.m00088.AA YAK 400-427 39 5.8e-05 12.37 In-house 320-347 (347) Show / Hide 
Range on Protein: 400-427
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FYDLLTHCLRWLPSERFTPEQALAHPYF
| |...  |   | || .| ||  ||. 
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 82759.m00088.AA DYRK1 399-427 41 8.7e-05 12.19 In-house 293-321 (321) Show / Hide 
Range on Protein: 399-427
Range on HMM: 293-321/321
Sequence Identity: 41% (12 aa)

QFYDLLTHCLRWLPSERFTPEQALAHPYF
.| ||. . |.. | .| || .|| |..|
KFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 82759.m00088.AA HIPK 399-427 34 0.002924 5.57 In-house 301-329 (329) Show / Hide 
Range on Protein: 399-427
Range on HMM: 301-329/329
Sequence Identity: 34% (10 aa)

QFYDLLTHCLRWLPSERFTPEQALAHPYF
.| ..|   . | . .| || .|| ||. 
EFVHVLKKMCTWDAHKRITPCEALNHPFV