Gene 93234.m00173 (T.vaginalis)

93234.m00173

Species: T.vaginalis
Alias: TvagK0666, 93234.m00173
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
93234.m00173.AA Protein None 455 None Fasta, JSON
93234.m00173.kin_dom Protein Kinase Domain None 300 None Fasta, JSON

Protein domain

Protein domains of 93234.m00173.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93234.m00173.AA DYRK 137-436 44 3.3e-134 452.18 In-house 1-320 (320) Show / Hide 
Range on Protein: 137-436
Range on HMM: 1-320/320
Sequence Identity: 44% (144 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRLNKA---EIRHVVRAYDFFIFRSHICVTFEILSKNLYEIIEQNNFKSL-
||||.  | | |||||.|.||| .  ||||.| | . .| |. || .||..||..   .  |.|..||.|..| | |..|| || |||| . .|.|. . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PIKLIRLYCLQILSALDQCHRL-NVVHCDLKPENVLLVNG-SNSTVKLIDFGSSCFKDHQIYEYIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELFLG
...|.| .. ||| .|.  |.. | .||||||||..|..  ..||.|.|||||||| ...|| |||||||||||||||.||. . |.||.     |||.|
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

LPLFPGENEADILSMMIALLGPPPKQLVQEG--KRKEEFFDEEDNFRTDLCEKERK-PFSTDLKAM-------------IKEK--NPTISDGELDLVIDF
 |||||||| | | ... .||.||| ....|  .||..|||.   |. . |... |  ..||   .              . .  .|..   . .. .||
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDF

IMKCITWDQKVRATAAQALQHPWI
|.|| .|| . | |..|||||||.
IKKCLQWDPHKRITPSQALQHPWF
Kinase 93234.m00173.AA DYRK2 137-436 44 2.4e-118 386.58 In-house 1-318 (318) Show / Hide 
Range on Protein: 137-436
Range on HMM: 1-318/318
Sequence Identity: 44% (143 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRL---NKAEIRHVVRAYDFFIFRSHICVTFEILSKNLYEIIEQNNFKSLP
||||.  | | |||||.|||||.|  ||||.| |    |.|  .| .||...   .| .   .|.  |.|.|| |.|.||| || |||| | .|.|. . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

IKLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLVNGSNSTVKLIDFGSSCFKDH-QIYEYIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELFLGLP
 .|.|  . .|| .|.  |. |..||||||||.||     |..|.|||||||| .  .|| |||||||||||||||..|| . | |||   . ||. | |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGENEADILSMMIALLGPPPKQLVQEG-----KRKEEFFD----------------EEDNFRTDLCEKERKPFSTDLKAMIKEKNPTISDGELDLVID
|||||||.| . .|. .|| |||....       .|.. ||.                |    ..    | | | |...|...|.       .| .. ||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKG-------CEDENFID

FIMKCITWDQKVRATAAQALQHPWI
||..| .|| . | |..|||.||||
FIKRCFEWDPSERMTPSQALKHPWI
Kinase 93234.m00173.AA CMGC 137-436 20 4.2e-104 343.07 In-house 1-513 (513) Show / Hide 
Range on Protein: 137-436
Range on HMM: 1-513/513
Sequence Identity: 20% (107 aa)

YEILSLFGAGAFGQVVRCYD--------------HKLKCQVAIKVIVNTEQMHEQGR-------------IEAQILSRLNKAE--------------IRH
|||..  | |..|.|..|.|              |. . .|||| | | . ..||..              | .|| .|||..                .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVRAYDFFIFRS-----------------HICVTFEILSKNLYEIIEQNN--------------------------FKSLPIKLIRLYCLQILSALD--Q
.|. ||.| ..                  |..  || . ..||..|..|.                           |...| .|| |. ||| .|.   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

CHRLN--VVHCDLKPENVLLVNG------------------SNSTVKLIDFGSSCFKDHQ------------------------IYEYIQSRFYRAPEVI
||. .  ..|.||||||.|. .                   .| ..|..|||.... ..                         ...|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGIP----------YGPPMDVWSFTILAIELFLG--------LPLFPGENE-----------ADILSMMIALLGPPPKQLVQEGK-------RKEEFFDE
|| .          |..|.|.||.     |...|         |||||..|            | | ... .||.|. .. | ||       ..||... 
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

EDN-----------------FRTDLCEKERKP---FSTDLKAMIKEKNPTISD-------------------------------GELDLVIDFIMKCITW
 ..                 . ..   . ...   | .  .  .|.. | ...                                . .. ||...|. ..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DQKVRATAAQALQHPWI
| . | ||.||||||..
DPDKRITAEQALQHPYF
Kinase 93234.m00173.AA S_TKc 137-436 27 9.9e-83 282.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 137-436
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRLNKAEIRHVVRAYDFFIFRSHICVTFEILSK---NLYEIIEQNNF----
|||| . | ||||.| .|...| . .||||.|       |. | | |||..       ..|. ||.|   .|... .| ..    .|...|....     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KSLPIKLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLVNGSNSTVKLIDFGSSCFKDHQIYEYIQSRFYRAPEVILGIPYGP-PMDVWSFTILAIELF
. .|   .| |. ||..||. ||.....|.||||||.|| .    ..|..|||....     . .. ...|.||||.   .||. . |.||. .. .|..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

LGLPLFPGENEADILSMMIALLGPPPKQLVQEGKRKEEFFDEEDNFRTDLCEKERKPFSTDLKAMIKEKNPTISDGELDLVIDFIMKCITWDQKVRATAA
 | |.||       . ||. ..|                                                       . ..|||.|| ..| . | || 
CGYPPFP------QMQMMFKKIG------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

QALQ-------HPWI
.|||       |||.
EALQDEWDIKCHPWF
Kinase 93234.m00173.AA YAK 137-368 40 1.5e-78 266.41 In-house 1-239 (347) Show / Hide 
Range on Protein: 137-368
Range on HMM: 1-239/347
Sequence Identity: 40% (97 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRLNKAE----IR---HVVRAYDFFIFRSHICVTFEILSKNLYEIIEQNNF
| .|   | | ||||| |     .  .|.||| |      |.. |.|||  ||. .         |..| ||||... | |. ||.|| |||| . ||.|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KSLPIKLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLVNGSNSTVKLIDFGSSCFKDHQIYEYIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELFL
. . . ||| .  ||| ..      ...||||||||..| .     .|.|||||||     .| |||.|.||.||.|....|    | ||      ||||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GLPLFPGENEADILSMMIALLGPPPKQLVQEGKRKEEFF
|||.|||  | . ..  |  || ||  ..  |. |  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase 93234.m00173.AA DYRK1 137-384 41 5.8e-77 262.0 In-house 1-254 (321) Show / Hide 
Range on Protein: 137-384
Range on HMM: 1-254/321
Sequence Identity: 41% (105 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRLNKAEIRH---VVRAYDFFIFRSHICVTFEILSKNLYEIIEQNNFKSLP
||| || | |.|||||. |||. ...||||.| |     .| .|| ..|  .||..  .   .|.    |.|| |.|. ||.|| |||...   .|.   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

IKLIRLYCLQILSALD--QCHRLNVVHCDLKPENVLLVNGSNSTVKLIDFGSSCFKDHQIYEYIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELFLGL
. |.| .  |.. ||       |...||||||||.||.|   | .|.|||||||  .. ||.||||||||.|||.|||.|   .|.||   . .|.  | 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGENEADILSMMIALLGPPPKQLVQEGKRKEEFFDE-EDNFRTDLCEKERK
||| | || | .. ..  || |||...... . . .|.  .||  . . ....|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKK
Kinase 93234.m00173.AA HIPK 137-373 41 8.2e-73 228.51 In-house 1-242 (329) Show / Hide 
Range on Protein: 137-373
Range on HMM: 1-242/329
Sequence Identity: 41% (100 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRLNK--AEIRHVVRAYDFFIFRSHICVTFEILSKNLYEIIEQNNFKSLPI
||.| . | | |||||.|  .  .  ||||.. |      ||.|| .||..| .  |.  |.||||..|  ..|.|  ||.|  |||.   ||.|  ||.
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

KLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLVNGSNS--TVKLIDFGSSCFKDHQIYE-YIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELFLGL
| ||   .|.| || .   | ..| ||||||..||  .     || |||||     . . . |.|||.|||||.|||.|.   .|.||      ||||| 
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLFPGENEADILSMMIALLGPPPKQLVQEGKRKEEFFDEEDN
||.|| .| |    ..   . | ..|.... .|. |||.. .
PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQ
Kinase 93234.m00173.AA Pkinase 137-436 29 1.5e-61 215.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 137-436
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRI-----EAQILSRLNKAEIRHVVRAYDFFIFRSHICVTFEILSK-----NLYEIIE-
|.|..  |.|.||.| .|....  ..||.|.|   .. ... ..     |.||. |||     ..|| ||.|  ..||.. .| . .      |...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--QNNFKSLPIKLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLV-NGSN-STVKLIDFGSSCF---KDHQIYEYIQSRFYRAPEVIL-GIPYGPPMDV
  ...|  .. . .. |..|||..|. ||. ...|.||||||.|.. || . ..||..|||....   ...  . .  ...|.|||||. | .|||. |.
WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFTILAIELFLGLPLFPGE----NEADILSMMIALLGPPPKQLVQEGKRKEEFFDEEDNFRTDLCEKERKPFSTDLKAMIKEKNPTISDGELDLVIDFI
||. .. .|...| |.|||.    | .| . |.   .|||..   ..  ..  ||   .   .                   . . |  .   .  .|||
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------------F-HWTF-HNWSEECKDFI

MKCITWDQKVRATAAQALQHPWI
 .|...| | | ||.|.|||||.
KWCLCKDPKKRPTAEQILQHPWF
Kinase 93234.m00173.AA PRP4 137-374 37 1.3e-56 194.45 In-house 1-245 (320) Show / Hide 
Range on Protein: 137-374
Range on HMM: 1-245/320
Sequence Identity: 37% (92 aa)

YEILSLFGAGAFGQVVRCY-DHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRLNKA-----EIRHVVRAYDFFIFRSHICVTFEILSKNLYEIIEQN-NF
|.. .  |.| |. |.||    . . .||||.| | | ||  |  |  || .|| |     .  |.|| .. | .| |.|  || .| || |.. .    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

KSLPIKLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLVNGSNSTVKLIDFGS-SCFKDHQIYEYIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELF
. | .| .| |  |.. ||    ..| .| |.|| | .||| |..| |..|||| |  ..  |  | .||||||||.|.|.||    |.||  .   ||.
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDN-ILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

LGLPLFPGENEADILSMMIALLGPPPKQLVQEGKRKEEFFDEEDNF
 |  .|||    . | ..  . |  |. ... |. |...||.  ||
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNF
Kinase 93234.m00173.AA DyrkP 137-371 36 9.7e-48 154.92 In-house 1-242 (323) Show / Hide 
Range on Protein: 137-371
Range on HMM: 1-242/323
Sequence Identity: 36% (89 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRLN---KAEIRHVVRAYDFFIFRSHICVTFEILSKNLYEIIEQN--NFKS
| |.   |. || . . | | .    . .|.| |     .|   | ..|  .|     . . |.| ||.|  . |. .  |.|  ||||    |  | . 
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

LPIKLIRLYCL--QILSALDQCHRLNVVHCDLKPENVLLVNGSNSTVKLIDFGSSCFKDHQIYEYIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELFL
    . ||  .  ||| |||  | | ..||||||||.|.   .   ||.||||||||    .  |.||| |||||||.|  |   .|.||   .  ||. 
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GLPLFPGENEADILSMMIALLGPPPKQLVQEGKRKEEFFDEE
|  ||  .|   .|  .| ..|| |  ..|||.  . || ..
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRK
Kinase 93234.m00173.AA CLK 137-275 30 4.2e-43 126.61 In-house 1-159 (350) Show / Hide 
Range on Protein: 137-275
Range on HMM: 1-159/350
Sequence Identity: 30% (49 aa)

YEILSLFGAGAFGQVVRCYDHKL-KCQVAIKVIVNTEQMHEQGRIEAQ-ILSRLNKA----EIRH--VVRAYDFFIF-RSHICVTFEILSKNLYEIIEQN
|||..  | |.|| ||.| |||  | .||.|.| | |.  |. ..| . |.  .|..     ..   ... .| | .   |||  ||.. ...|. .  |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FKSLPIKLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLVNG-----SNST
|      ....||  ||    |...|.   | .  .| |||||| ..|.      ....
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTF
Kinase 93234.m00173.AA CAMK 142-319 18 8.3e-42 132.02 In-house 1-319 (425) Show / Hide 
Range on Protein: 142-319
Range on HMM: 1-319/425
Sequence Identity: 18% (60 aa)

LFGAGAFGQVVRCYDHKLK------------CQVAIKVIVNT-----------------------------EQMHEQGRIEAQILSRLNKAE----IRHV
  | |.||.| .|.. . .             .||||.|  .                             ... .. | | .|...|.. .     ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRAYDFFI------------FRSH--------ICVTF---EILSKN-----LYEIIEQNNF-------------KSLPIKLIRLYCLQILSALDQCHRLN
.. |...             . |.        ..  .   |  |       |.. | ..               . .. .  | |  ||.||.. || .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVHCDLKPENVLLV-NGSNS--------------TVKLIDFGSSCFKDH--------------------------QIYEYIQSRFYRA-PEVILG-----
.||.||||||.||. |...|              ..|.|||| ....|.                            ...  .  | | |||..|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------IPYGPPMDVWS
          .|||. |.||
MQNATDEEKPYYGPKCDMWS
Kinase 93234.m00173.AA CLK 276-436 30 3.9e-27 77.79 In-house 186-350 (350) Show / Hide 
Range on Protein: 276-436
Range on HMM: 186-350/350
Sequence Identity: 30% (51 aa)

VKLIDFGSSC---FKDHQIYEYIQSRFYRAPEVILGIPYGPPMDVWSFTILAIELFLGLPLFPGENEADILSMMIALLG-PPPKQLVQEG---KRKEEFF
...|||||     | .   .. ...| ||||||||| ..  | ||||.    .|| .|  ||.. .. . | ||  ..| | |.   |     | |...|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

-DEEDNFRTDLCEKERKPFSTDLKAMIKEKNPTISDGELDLVIDFIMKCITWDQKVRATAAQALQHPWI
 .   ...     ..|. ..   | . . .  .. | | .  .| | |.   |   | |...|||||. 
YHNRLDWDW-HNSDGRYVME-NCKPLKQYM--DCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 93234.m00173.AA CAMK 385-436 17 5.1e-10 27.74 In-house 333-425 (425) Show / Hide 
Range on Protein: 385-436
Range on HMM: 333-425/425
Sequence Identity: 17% (16 aa)

PFSTD-----------------LKAMIKEKNPTISDGELDL------------------------VIDFIMKCITWDQKVRATAAQALQHPWI
||  |                 |. .|.. . .  . ...                         ..|.| |. . | . |.|..|.|.|||.
PFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 93234.m00173.AA TyrKc 137-436 18 3.3e-09 -73.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 137-436
Range on HMM: 1-280/280
Sequence Identity: 18% (62 aa)

YEILSLFGAGAFGQVVRCYDHKLKCQVAIKVIVNTEQMHEQGRIEAQILSRL-NKAEIRHVVRAYDFFIFR-------SHICVTFEILSK-NLYEIIEQN
 . .   | ||||.|...       |||.|.. .    .|  . ||.|...|  . .  ..|| |   .           ... .|  .. .| . .  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP--NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NFKSLPIKLIRLYCLQILSALDQCHRLNVVHCDLKPENVLLVNGSNSTVKLIDFGSSCFKDHQ-IY----EYI------QSR-----FYRAPEVILGIPY
  | |. |    .|.|| .  .  |. |..| ||   |.|. ..   |||  ||| | . ..        .|.      ...        |||.|    .
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GPPMDVWSFTILAIELF-LGLPLFPG-----ENEADILSMMIALLGPPPKQL----VQEGKRKEEFFDEEDNFRTDLCEKERKPFSTDLKAMIKEKNPTI
 .  ||||| ..  |.| .| .  ||      . ....    .   .|. .                                                 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------------

SDGELDLVIDFIMKCITWDQKVRATAAQALQHPWI
. .  | . . . .|   | . | | ..   |  .
FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 93234.m00173.AA DyrkP 408-436 48 1.2e-07 20.49 In-house 295-323 (323) Show / Hide 
Range on Protein: 408-436
Range on HMM: 295-323/323
Sequence Identity: 48% (14 aa)

LVIDFIMKCITWDQKVRATAAQALQHPWI
. |||. .|.  |   | ||  ||||||.
MFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 93234.m00173.AA PRP4 411-436 46 0.000374 11.2 In-house 295-320 (320) Show / Hide 
Range on Protein: 411-436
Range on HMM: 295-320/320
Sequence Identity: 46% (12 aa)

DFIMKCITWDQKVRATAAQALQHPWI
|.. ||.  | | | |  .||.|| |
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase 93234.m00173.AA HIPK 410-436 37 0.00186 6.2 In-house 303-329 (329) Show / Hide 
Range on Protein: 410-436
Range on HMM: 303-329/329
Sequence Identity: 37% (10 aa)

IDFIMKCITWDQKVRATAAQALQHPWI
..   | .|||.. | | ..||.||..
VHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 93234.m00173.AA YAK 407-436 40 0.001985 7.07 In-house 318-347 (347) Show / Hide 
Range on Protein: 407-436
Range on HMM: 318-347/347
Sequence Identity: 40% (12 aa)

DLVIDFIMKCITWDQKVRATAAQALQHPWI
|. ||||      . . | .. || ||| |
DCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 93234.m00173.AA DYRK1 411-436 38 0.01101 4.68 In-house 296-321 (321) Show / Hide 
Range on Protein: 411-436
Range on HMM: 296-321/321
Sequence Identity: 38% (10 aa)

DFIMKCITWDQKVRATAAQALQHPWI
| | . . .| | | |  .||||...
DLIKRMLQYDPKQRITPYYALQHSFF