Gene 81704.m00034 (T.vaginalis)

81704.m00034

Species: T.vaginalis
Alias: TvagK0647, 81704.m00034
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
81704.m00034.AA Protein None 313 None Fasta, JSON
81704.m00034.kin_dom Protein Kinase Domain None 289 None Fasta, JSON

Protein domain

Protein domains of 81704.m00034.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81704.m00034.AA DYRK 23-311 32 3e-93 316.09 In-house 1-320 (320) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-320/320
Sequence Identity: 32% (106 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREVEFLKILSKHKNGSRHNNICEILDTFYFRGFIFIVTKYYEDNLYDKIKENNYSGF
|| .. .|.|||| |.|| ||||...||.| .    . |.|. .|.. |. |... .     ..  ..| ||.|.. .||.  .. |||. .|.|.  ||
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-DLEKVRYLGKEIAKALSFTHSA-GIVHSDIKPENILLHNH----KVYLIDFGCSCYDGEPLYETVQSLYYRAPEVVFSIKYNKSIDVWSFGCLLYELFT
  |. ||  .. | ..| | |.   |.| |.|||||.| ..     . .|||| ||. .. .|  .|| .||||||   ..|...||.||.|| |.||||
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GKPLFWSSTESDLISQIVNIVGEPPKEMVNSS--RKMKRYFYQ------------KKLSQTNND---EKKKTYLKNNLKNAS----------PEFIDLIS
|.|||  ..| |..  |. . | |||.|....  |. ...| .            .| ... .     ..|.  ...... .           .|.|.| 
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIK

QCICWNPTERVTMNDVLNHPFF
.|  |.|..|.| .. |.||.|
KCLQWDPHKRITPSQALQHPWF
Kinase 81704.m00034.AA CMGC 23-311 18 9.2e-90 295.07 In-house 1-513 (513) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-513/513
Sequence Identity: 18% (98 aa)

YEQVQLLGRGSFGSVIKCID--------------HKTKQYVAVKALA-DSADDHQQI------------VREVEFLKILS-KHKNGS----------RHN
|| .. .|.|..| | ||.|              |.|...||.| .  .  ...|.              ||...|| |. .|..             ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NICEILDTFYFRG-----------------FIFIVTKYYEDNLYDKIKENN--YSG-----FDLEK------------VRYLG------KEIAKALS--F
||  ..| ||...                  ...|. | . .||. ||.|.  | |     ..  .            ..|.       . | ..|   .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

THSAG--IVHSDIKPENILLHN---------------------HKVYLIDFGCSCYDGEP------------------------LYETVQSLYYRAPEVV
 ||..  |.| |.||||||. .                      .. ..||| ... ...                        ... |....|||||. 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FSIK----------YNKSIDVWSFGCLLYELFTG--------KPLFWSSTE-----------SDLISQIVNIVGEPPKEMVNSSR-------KMKRYFYQ
.. |          |...||.||.|| ..|..||        ||||  ..|            | . .|... | |. .| ....       . . ... 
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

KKLSQTNNDEK------------------------KKTYLKNNLKN---------------------------------------ASPEFIDLISQCICW
.||   |.. |                        .... ....||                                       ..|..|||.... ..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

NPTERVTMNDVLNHPFF
.|..| |  . |.||.|
DPDKRITAEQALQHPYF
Kinase 81704.m00034.AA DYRK2 23-311 35 2.4e-89 290.7 In-house 1-318 (318) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-318/318
Sequence Identity: 35% (112 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREVEFLKILSKHKNGSRHNNICEILDTFYFRGFIFIVTKYYEDNLYDKIKENNYSGF
|| .  .|.||||.|.|| ||||||.||.| .      |.|...|.. |. ....   . . |.  .|| ||||....|..  .  |||. ||.|.. ||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTM-NCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

DLEKVRYLGKEIAKALSFTHSAGIVHSDIKPENILLHNH---KVYLIDFGCSCYDGE-PLYETVQSLYYRAPEVVFSIKYNKSIDVWSFGCLLYELFTGK
 |. ||  .. | ..|.| |   |.| | |||||||  .    . .|||| ||.. . ..|  .||..||||||   .||...|| ||||| . ||.||.
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGY

PLFWSSTESDLISQIVNIVGEPPKEMVNSS-----RKMKRYFY--------------QKKLSQTNNDEKKKTY------LKNNLK-NASPEFIDLISQCI
|||  . | | .  .  . | |||.... .     .. | .|               .....   .  ..| .      .|. ||   .. ||| |..| 
PLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCF

CWNPTERVTMNDVLNHPFF
 | |.|| |  . |.||..
EWDPSERMTPSQALKHPWI
Kinase 81704.m00034.AA S_TKc 23-311 27 3e-86 293.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREVEFLKILSKHKNGSRHNNICEILDTFYFRGFIFIVTKYYED---NLYDKIKENNY
|| ....|.|.||.| ||...||...||.| .       ..| ||.. ||         .| ||. ..|.|.  .....|. | .    .|.| ||....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

----SGFDLEKVRYLGKEIAKALSFTHSAGIVHSDIKPENILLHNHKVYLIDFGCSCYDGEPLYETVQSLYYRAPEVVFSIKYNK-SIDVWSFGCLLYEL
    ..|.   .|.. ..|..|| . || ||.| |.||||||| .  . ..||| ..      .  . ...|.||||.   .|.| ..|.||.||.|||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FTGKPLFWSSTESDLISQIVNIVGEPPKEMVNSSRKMKRYFYQKKLSQTNNDEKKKTYLKNNLKNASPEFIDLISQCICWNPTERVTMNDVLN-------
..|.|.|.       . .. ...|                                          |||..|.|..| ...|..| |  ..|.       
LCGYPPFP------QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

HPFF
||.|
HPWF
Kinase 81704.m00034.AA Pkinase 23-311 26 1.3e-74 258.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-293/293
Sequence Identity: 26% (86 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQ---IVR--EVEFLKILSKHKNGSRHNNICEILDTFYFRGFIFIVTKYYED-----NLYD
|. .. .|.||||.| ||....| . |||| .  . .....    .|  |.. .| |.       | ||....|.|. .. | .|. | |       |.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

KIK---ENNYSGFDLEKVRYLGKEIAKALSFTHSAGIVHSDIKPENILLH-NHKV----YLIDFGCSC---YDGEPLYETVQSLYYRAPEVVF-SIKYNK
 |.   ..... |. . ..   ..|...| . || ||.| |.||||||.. |  .     ..|||...   | .. ..  . ...|.||||.  . .| .
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDVWSFGCLLYELFTGKPLFWSS----TESDLISQIVNIVGEPPKEMVNSS----RKMKRYFYQKKLSQTNNDEKKKTYLKNNLKNASPEFIDLISQCI
..|.||.||.|||...|.|.|...    .  | .  |..| | |...    .    . . ... . .           . .. . .|.|.|..|.|. |.
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----------F-HWTF-HNWSEECKDFIKWCL

CWNPTERVTMNDVLNHPFF
|..|..| |  ..|.||.|
CKDPKKRPTAEQILQHPWF
Kinase 81704.m00034.AA DYRK1 23-272 37 3.3e-60 206.34 In-house 1-257 (321) Show / Hide 
Range on Protein: 23-272
Range on HMM: 1-257/321
Sequence Identity: 37% (96 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREVEFLKILSKHKNGSRHNNICEILDTFYFRGFIFIVTKYYEDNLYDKIKENNYSGF
||   |.|.|||| |.|  ||....|||.| .       .|   |.  | .. || . ..  .| ..   | ||  . .|.     |||| ..  .. | 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKY-YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

DLEKVRYLGKEIAKALSF--THSAGIVHSDIKPENILLHNHK---VYLIDFGCSCYDGEPLYETVQSLYYRAPEVVFSIKYNKSIDVWSFGCLLYELFTG
 |  .| . . ...|| |  |    |.| |.||||||| | |   . .|||| ||  |. .|. .|| .||.|||.  |.|. .||.|| ||.| |. ||
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTG

KPLFWSSTESDLISQIVNIVGEPPKEMVNSSRKMKRYFYQ---KKLSQTNNDEKKKTY
 |||  | | | ...|| ..| |||.|.... | ..|| .   .  ..  . .|||.|
EPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHY
Kinase 81704.m00034.AA Ciliate-E2-Unclassified 23-311 21 3.7e-55 189.58 In-house 1-352 (352) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-352/352
Sequence Identity: 21% (82 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREV----EFLKILSKHKNGSRHN--------------NICEILDTFYF--RGFIFIV
|. .. .|.|.||.| ||.. |.||| | | . .. ...|......      .|.. ..|. . ..              ... . . ..|  .  |.||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TKYYE-----DNLYDKIK---------ENNYS--GFDLEKVR-----YLGKEIAKALSFTHSAG-IVHSDIKPENILLHNH----KVYLIDFGCSCYDGE
. | |     . . .. |         .|...   |. ....     .. ..| ..|.. |. . |.| ||||||||..|     .. .|||| | . ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

P------------------LYETVQSLYYR----APEVVFSIKYN----KSIDVWSFGCLLYELFTGKPLFWSSTESD---LISQIVNIVGEPPKEMVNS
.                  .. ......|     ||||  . .|.    ...|.||.|..|||. .|.. | . .. .   ||.|..|.           
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN-----------

SRKMKRYFYQKKLSQTNND-EKKKTYLKNNL----KNASPEFIDLIS----QCICWNPTERVTMNDVLNHPFF
       .   .. . .|  .|.  . | .     |. ||| .|.|.    ... .|| .| |....||||.|
-------A--YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 81704.m00034.AA Ciliate-E2 23-311 21 2.1e-54 185.13 In-house 1-365 (365) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-365/365
Sequence Identity: 21% (86 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSA--------DDHQQIVREVEF----LKILSKHKNGSR-------------------HNNICEILD
|. ....|.|.|||| || . |... .| |               . ..|.    .    ...... ..  |                   |.||... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

TFY--FRGFIFIVTKYYED-NLYDKIKEN----------NYSGFDLEKVRYLGKEIAK---------------ALSFTHSAG-IVHSDIKPENILLHNHK
.|.   .  |..|. |..  .|.| ||.|              |......|. |.|..               || . || . |.| ||||||||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

VYLIDFGCSCYDGEP-----------LYETVQ------------------------SLYYRAPEVVFSIK---------YNKSIDVWSFGCLLYELFTGK
. .|||| | .  ..           .|   .                        ...| |||.. . |         |....|.||.|..|||. .||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PLFWSSTESDLISQIVNIVGEPPKEMVNSSRKMKRYF---YQKKLSQTNNDEKKKTYLKNNLKNASPEFIDLISQ----CICWNPTERVT-MNDVLNHPF
| |                      . .   .  ...   .||. .| .. . .|   | . |. |.| .|||..    ... .| .| | ....||||.
PPF----------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKW--K-SWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPW

F
|
F
Kinase 81704.m00034.AA CAMK 28-311 19 1.6e-53 170.43 In-house 1-425 (425) Show / Hide 
Range on Protein: 28-311
Range on HMM: 1-425/425
Sequence Identity: 19% (89 aa)

LLGRGSFGSVIKCIDHKTK------------QYVAVKA-----LAD------------------------SADDHQQIVREVEFLKILSKHKNGSRHNNI
 ||||||| | .||. .|.            | ||.|      | |                        .. | ... ||.| .| |....|  .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CEILDTFYFRGF-------------------IFIVT---KYYEDN-----LYDKIKENNY-------------SGFDLEKVRYLGKEIAKALSFTHSAGI
. .....  . .                   ...|.    | .       |.|.|.|. .               |. . .|.. . |. |. . || .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHSDIKPENILL-HNH-----------------KVYLIDFGCSCY--------------------------DGEPLYETVQSLYYRA-PEVVFSIK----
|| |.||||||| .|.                 .. .|||| ...                          .|..... . ...| | |||. . .    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNKSIDVWSFGCLLYELFTGKPLFWSS-------------TESDLISQIVNIVGE-PPKEMVNSSRKMKRYFYQKKLSQTNNDEKKKTYL
          |....|.|| |..|| . .|.| |...             ....|  .| .   . ||... ..|.    |                   
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN---Y-------------------

KNNLKN---------ASPEFIDLISQCICWNPTERVTMNDVLNHPFF
..   .          |.| .|||... . .|..| |  ..||||..
GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 81704.m00034.AA HIPK 23-259 32 2.5e-51 159.63 In-house 1-241 (329) Show / Hide 
Range on Protein: 23-259
Range on HMM: 1-241/329
Sequence Identity: 32% (78 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREVEFLKILSKHKNGSRHNNICEILDTFYFRGFIFIVTKYYEDNLYDKIKENNYSGF
|| . .|||| || |.||  . |.  ||.| | . .    |.  ||. |. ||.    .   ..   .. |  .  ...|    | ||||  |.|...  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQEN--ADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

DLEKVRYLGKEIAKALSFTHSAGIVHSDIKPENILL-----HNHKVYLIDFGCSCYDGEPLYET-VQSLYYRAPEVVFSIKYNKSIDVWSFGCLLYELFT
 |  .| . . ...||    . |..| |.|||||.|       ..|  ||||   .  .   .| .|| ||||||..  .......|.|| || . ||| 
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

GKPLFWSSTESDLISQIVNIVGEPPKEMVNSSRKMKRYFYQKK
| ||.  . | |.|  |    . | . .... .| .|.| ..|
GWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDK
Kinase 81704.m00034.AA ULK 23-311 23 6.6e-49 168.79 In-house 1-329 (329) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-329/329
Sequence Identity: 23% (83 aa)

YEQVQLLGRGSFGSVIKCIDHKTK----QYVAVKALA---DSADDHQ--------QIVREVEFLKILS---KHKNGSRHNNICEILDTFYFRGF--IFIV
|.  . || |||| | | ...|||    ..||.| .     . . ..        .. .|.. .| |    .|||  .| ||.. .| |.   .  |.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKN--HHPNIVKLYDWFETSNHNNIYII

TKYYED-NLYDKIKENNYSGFDL--------EKVRYLGKEIAKALSFTHSAGIVHSDIKPENILLHNHKVY-------------LIDFGCSCYDGEP---
. | .. .| . ||.|.... |         ....   | |. .. . |. .|.| ||||.|||.||.. .             . ||| .    ..   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

---LYETV------QSLYYRAPEVVF----SIKYN-KSIDVWSFGCLLYELFTGKPLFWSSTESDLI-SQIVNIVGEPPKEMVNSSRKMKRYFYQKKLSQ
   .. .|       . .| ||...      ..|. .  |.||.||..||. .||| | ..  .|..  .| . .  ||.                    
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQ-----------------

TNNDEKKKTYLKNNLKN---------ASPEFIDLISQCICWNPTERVTMNDVLNHPFF
           |..  .          |||..|||..... ....| .  ...|||.|
---------QIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 81704.m00034.AA YAK 23-255 32 1.1e-47 159.93 In-house 1-239 (347) Show / Hide 
Range on Protein: 23-255
Range on HMM: 1-239/347
Sequence Identity: 32% (78 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREVEFLKILSKHKNGSRHN---NICEILDTFYFRGFIFIVTKYYEDNLYDKIKENNY
|     ||.| || |.||    |.  .||| .       ||   |.  |..| .       |    |  ..| | ..    .|    . |||. .| |..
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

SGFDLEKVRYLGKEIAKALSFTHSAGIVHSDIKPENILLHN---HKVYLIDFGCSCYDGEPLYETVQSLYYRAPEVVFSIKYNKSIDVWSFGCLLYELFT
 ||  . .|   | |  ..    .. |.| | |||||.| .     . .|||| ||.    .|  .|. .||.||..  . |  ||| || || . ||| 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GKPLFWSSTESDLISQIVNIVGEPPKEMVNSSRKMKRYF
| |.|    | . |. |. . | || .|..  |   .||
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase 81704.m00034.AA TyrKc 23-311 20 1.1e-12 -17.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-311
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YEQVQLLGRGSFGSVIKCIDHKTKQYVAVKALADSADDHQQIVREVEFLKIL-SKHKNGSRHNNICEILDTFYFR-------GFIFIVTKYYED-NLYDK
 .  . ||.| || | |..     . |||| | ..|  .. . || . .. |        .| ||  ..             . ..||. | .  .| | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG------HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKENNYSGFDLEKVRYLGKEIAKALSFTHSAGIVHSDIKPENILLHNHK-VYLIDFGCSCYDGEPLYET----VQSLYYR----------------APEV
....    . ...  .    ||.  .. || ...| |.   |.|... . |   ||| | .    .|.     . . |||                |||.
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD----IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

VFSIKYNKSIDVWSFGCLLYELFT-GKPLFWS-----STESDLISQIVNI-VGEPPKE---MVNSSRKMKRYFYQKKLSQTNNDEKKKTYLKNNLKNASP
 .  |..   |||||| ...|.|| |..  .       . ...| .. .    ..|..   |                                   ...
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------FVCCPD

EFIDLISQCICWNPTERVTMNDVLNHPFF
|  ....||   .| .| |....  | .|
EMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 81704.m00034.AA Pkinase_Tyr 23-79 32 7.6e-08 27.2 Pfam 1-65 (270) Show / Hide 
Range on Protein: 23-79
Range on HMM: 1-65/270
Sequence Identity: 32% (21 aa)

YEQVQLLGRGSFGSVIKCIDH----KTKQYVAVKALADSADDH----QQIVREVEFLKILSKHKN
 .  . ||.|.||.| |.. .    .||. |||| | ..|...    .   ||.. .| | .|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPN
Kinase 81704.m00034.AA DYRK1 284-311 39 6.5e-05 12.65 In-house 294-321 (321) Show / Hide 
Range on Protein: 284-311
Range on HMM: 294-321/321
Sequence Identity: 39% (11 aa)

FIDLISQCICWNPTERVTMNDVLNHPFF
| ||| . . ..| .|.|  ..| |.||
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 81704.m00034.AA HIPK 283-311 34 0.000216 9.2 In-house 301-329 (329) Show / Hide 
Range on Protein: 283-311
Range on HMM: 301-329/329
Sequence Identity: 34% (10 aa)

EFIDLISQCICWNPTERVTMNDVLNHPFF
||...  . . |.. .|.|  . ||||| 
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 81704.m00034.AA YAK 284-311 42 0.000241 10.23 In-house 320-347 (347) Show / Hide 
Range on Protein: 284-311
Range on HMM: 320-347/347
Sequence Identity: 42% (12 aa)

FIDLISQCICWNPTERVTMNDVLNHPFF
|||.| |    || ||..      ||| 
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 81704.m00034.AA Pkinase_Tyr 203-216 71 0.000259 15.23 Pfam 196-209 (270) Show / Hide 
Range on Protein: 203-216
Range on HMM: 196-209/270
Sequence Identity: 71% (10 aa)

DVWSFGCLLYELFT
|||||| |..|.||
DVWSFGVLMWEIFT
Kinase 81704.m00034.AA APH 144-174 22 0.000993 13.6 Pfam 170-205 (248) Show / Hide 
Range on Protein: 144-174
Range on HMM: 170-205/248
Sequence Identity: 22% (8 aa)

AGIVHSDIKPENILLH----NHKV-YLIDFGCSCYD
....| | .| |....    . .| ..||....|..
PCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDACWG