Gene 96145.m00225 (T.vaginalis)
96145.m00225
Species: T.vaginalis
Alias: TvagK0512, 96145.m00225
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 96145.m00225.AA | Protein | None | 971 | None | Fasta, JSON |
| 96145.m00225.kin_dom | Protein Kinase Domain | None | 253 | None | Fasta, JSON |
Protein domains of 96145.m00225.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 96145.m00225.AA | CK1 | 16-271 | 28 | 1.5e-78 | 267.29 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-339/339 Sequence Identity: 28% (97 aa) YIVEKTIGRGAFG-RIVKVT----KNNNDG-----KEYALKIPKKGKE---RSLVTERKFLEKLQG--------------------SPYFPKIIDYREGY . |.| || |.|| | ||. |. ... .|||.|. .| . ..| | ....|||| .|........ |. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED EKNNYLAMELLGPSLGKVKD-VAPCHR-LSLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLVR-------GSRMY--------PIVLIDYGISR-RY ...||. |.||||.|..... ..| | .|..|.....| || ... | ||||||||||||.. | . ...||.|..| .| DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY LDA-----------ETGRPIPPRP---FVGFVG-TMKYASINAHEGRELGRRDDLYSWFVSLLVIMTDH--VPWKTNRNNKI-----MAQTKKITNIEKF .| .|....|||. .||.| | .|.|||.|.|.|.||||||.||| |. . . ||. . .. . . |. || RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK CLK------------LPKQLVKIYYIIMRMKFGDEPKYDLL .. .|... ||. .|. .|..|.|.|. . MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | 96145.m00225.AA | TTBKL | 16-275 | 26 | 1.8e-69 | 233.72 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-288/288 Sequence Identity: 26% (78 aa) YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKIPKKGKE---RSLVTERKFLEKLQ--GSPYFPKIIDYREGYEKNNYLAMELLGPSLGKVKDVAPCHR-L . ..| ||.|.|| . .| .. ....|.|..|. .| . . | . | ||| |||.|||.... . ... |...|.|.||.|.... |. . . WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGK-RKDYNFMVMTLCGPNLQDLRKMMPNKKRF SLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLVRGS---RMY--PIVLIDYGISRRYLDAETGRP----------IPPRP---FVGFVGTMKYASIN | .|. |.|| | ... | ||||||.|| |. . . . . . |||.|..|.|.. . ... .||. ..| ||..|.|.| SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN AHEGRELGRRDDLYSWFVSLLVIMTDHVPWKTNRNNKIMAQTKKITNIEKFCLK------LPKQLVKIYYIIMRMKFGDEPKYDLLIAFL .|...|.|| |||.||. .. . ||. . ......|| .. |... . .|... |.. . .... |.| |. ..... MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | 96145.m00225.AA | CK1-Unclassified | 16-204 | 38 | 1e-50 | 147.91 | In-house | 1-199 (244) | Show / Hide |
Range on Protein: 16-204 Range on HMM: 1-199/244 Sequence Identity: 38% (77 aa) YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKI-PKKGKERSLVTERKFLEKLQGSP-------YFPKIIDYREG-YEKNNYLAMELLGPSLGKVKDVAPC | |.. || |.|| | |.. ... .|.|.|. |. | . |. | |.. ||. ..||.. . . |.. |.|||||| . . | YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM--C H-RLSLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLV--RGSRMYPIVLIDYGISRRYLDA-ETGRPIPPRPFVGFVGTMKYASINAHEGRELGRRD ..|| | . |. | .|. .||||||||||||. .| . . . .||.|.| ||.|. .||. || | ...|| ||||||| | | .||| NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRD DL || DL |
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| Kinase | 96145.m00225.AA | Worm6 | 16-271 | 27 | 6e-50 | 172.26 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-279/279 Sequence Identity: 27% (78 aa) YIVEKTIGRGAFGRIVKVTKNNNDGK-EYALKIPK--KGKERS-LVTERKFLEKL--QGSPYFPKIIDYREGYEKN---NYLAMELLGPSLGKVKDVAPC . |.| || |.|| . ||.. . | ..|.| | .. .|. | | | .. .....|.||.|. | .| ||. |.|.|..|. . .| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDR--GKVDNRGFNYIVMTLVGKNLWDLRKNRPD HRLSLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLV-R-----GSRMYPIVLIDYGISR-RYLDAETGRPIPPR-PFVGFVGTMKYASINAHEGREL ..|..|.....|..|..|. |. ||||||.|| || . | . | ..|.|..| .... . . ..|| . .||.|| .||....| |.|. RKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQ GRRDDLYSWFVSLLVIMTDHVPWKTNRNNKIMA-QTKKITNIE-----KFCLK-LPK-QLVKIYYIIMRMKFGDEPKYDLL .|.||. ||| .. . ||. . . . . |.. . .. .. || ....| .| ... |.| |. . CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | 96145.m00225.AA | CK1 | 16-204 | 36 | 4.4e-49 | 167.11 | In-house | 1-199 (271) | Show / Hide |
Range on Protein: 16-204 Range on HMM: 1-199/271 Sequence Identity: 36% (74 aa) YIVEKTIGRGAFGRIVKVTKNNNDGKE--YALKI-PKKGKERSLVTERKFLEKLQG------SPYFPKIIDYREGYE-KNNYLAMELLGPSLGKVKDVAP | |.. || |.|| | ... ..|.| .| |. ..| | |. | |.. ||| ....|... . . . |.. |.|||||| . .. YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF-- CH-RLSLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLV-R-GSRMYPIVLIDYGISRRYLDAETGRPIPPRPFVGFVGTMKYASINAHEGRELGRRD |. ..|| | . .. |.. | .|. .||||||||||||. | | . . .||.|.. ||.|..|.. || | ...|| |||||.| |.| .||| CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD DL |. DM |
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| Kinase | 96145.m00225.AA | TTBK | 16-271 | 33 | 3.8e-45 | 156.29 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-257/257 Sequence Identity: 33% (88 aa) YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKIPK-KGKERSLVTERKFLEKLQGSPYFPKIIDY-REGYEKNNYLAMELLGPSLGKVKDVAPCHRLSLST | | || |.|| | . |. . |.|. . . . | | | |||| .. . | |. .| ||. |.|.| .| .| |||| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRN--DKFNYMVMQLQGKNLADLRRKQPRGCFSLST SIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLV--RGSRMYPIVLIDYGISRRYLDAETGRPIPPRPFVGFVGTMKYASINAHEGRELGRRDDLYSWFVSL .|.|. .| ||.. | .|| |||||| || . |.. . ..|.| |.|. | .| |||. || || ||||||| ||.||.||| | | | TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNA-CGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML LVIMTDHVPWKTNRNNKIMAQTKKITNIEKFCLKLPKQLVKIYYIIMRMKFGDEPKYDLL . || . ..|. . .|... | ....| | | |. VEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | 96145.m00225.AA | CK1-A | 16-271 | 34 | 1.8e-38 | 133.48 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-261/261 Sequence Identity: 34% (92 aa) YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKIPK-KGKERSLVTERKFLEKLQGSPYFPKIIDYREGYEKN-NYLAMELLGPSLGKVKDVAPCHR-LSLS | . . || |.|| | .. | ..|.| |.|. . | . |. | | . ||| . .|.. | | ||. | . |.|||||| . . |.| .. YRLVRKIGSGSFGDIY-LGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWY--GCEKDYNVMVMDLLGPSLEDLFNF--CKRRFTMK TSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLVRGSR-MYPIVLIDYGISRRYLDAETGRPIPPRPFVGFVGTMKYASINAHEGRELGRRDDLYSWFVSL | . . |. | |. .||||||||||||. | . |||.|....| |..| . || | .|| .||||||| | | ||||. | . TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM LVIMTDHVPW-------KTNRNNKIMAQTKKITNIEKFCLKLPKQLVKIYYIIMRMKFGDEPKYDLL . ..|| | . || . | | ||. | | .. . . ..| ..| | | MYFNRGKLPWQGMKAMTKKQKYEKISEK-KMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | 96145.m00225.AA | CK1-D | 16-271 | 36 | 3.9e-37 | 128.49 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-261/261 Sequence Identity: 36% (98 aa) YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKI-PKKGKERSLVTERKFLEKLQGSPYFPKIIDY-REGYEKNNYLAMELLGPSLGKVKDVAPCHR-LSLS | . . || |.|| | | | . . | |.|. . | | | | || .|| |.| . .|| | . |.|||||| . ||| || YRIGRKIGSGSFGDIYHGT-NIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEG--DYNVMVMDLLGPSLEDLFNY--CHRKFSLK TSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLVR-GSRMYPIVLIDYGISRRYLDAETGRPIPPRPFVGFVGTMKYASINAHEGRELGRRDDLYSWFVSL | . .. |.. | | ||||||||||||. | | . .||.|...|| ||.| . || | || .||||| | | | ||||| | | TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL LVIMTDHVPW-------KTNRNNKIMAQTKKITNIEKFCLKLPKQLVKIYYIIMRMKFGDEPKYDLL . .|| | .. ..|. . | |.|.. | .|.. .. ..|| | | | | MYFNRGSLPWQGLKAATKRQKYERICEK-KMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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| Kinase | 96145.m00225.AA | Dual | 59-275 | 27 | 6.8e-27 | 87.36 | In-house | 59-282 (282) | Show / Hide |
Range on Protein: 59-275 Range on HMM: 59-282/282 Sequence Identity: 27% (61 aa) ERKFLEKLQGSPYFPKIIDYREGYE-KNNYLAMELLGPSLGKVKDVAPCHRLSLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLV-RGSRMYPIVLI | . .|| | |. .|| . | .|. | . |||| . . || ..| |.| |||.|. | .|..||.||| || . | . . . EKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQ DYGISRRYLDAETGRPIPPRPFVGFVGTMKYASINAHEGRELGRRDDLYSWFVSLLVIM-TDH-VPWKTNRNNKIMAQTK---KITNIEKFCLKLPKQLV |..| | |.| |.. ..| | . |. ||.. .. || ||| .| . .| | ..|. .. ..| . | . .. .. . |..|. DFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLK KIYYIIMRMKFGDEPKYDLLIAFL .. . . . | || .. .| PLVSYVNGYQYDSTPDYDYFRNCL |
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| Kinase | 96145.m00225.AA | CK1-G | 16-204 | 39 | 1.2e-26 | 87.3 | In-house | 1-191 (266) | Show / Hide |
Range on Protein: 16-204 Range on HMM: 1-191/266 Sequence Identity: 39% (77 aa) YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKI-PKKGKERSLVTERKFLEKLQGSP-YFPKIIDYREGYE-KNNYLAMELLGPSLGKVKDVAPCHR-LSL | | | || | || . || . | |. | | . | | .| | | | |.. | | . | | . |.|||||| |. | | |. YRVGKKIGCGNFGEL-FEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQV--YYFGQCGKYNIMVMDLLGPSLEDLFDW--CDRKFSV STSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLV-RGSRMYP--IVLIDYGISRRYLDAETGRPIPPRPFVGFVGTMKYASINAHEGRELGRRDDL | . | | |.. ... |. | ||.||||||. | | . | .||.|. . | | ||.. || | || | ||| | ||| ||||. KTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM |
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| Kinase | 96145.m00225.AA | Pkinase | 16-184 | 23 | 2.1e-18 | 66.19 | Pfam | 1-174 (293) | Show / Hide |
Range on Protein: 16-184
Range on HMM: 1-174/293
Sequence Identity: 23% (44 aa)
YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKIPKKGKERSLVT-------ERKFLEKLQGSPYFPKIIDYREGYEKNNYLAMELLGPSLGKVKDVA----
| ....||.|.||. . .. ..||..|.|| || .|.| . | . . .| ..|. ...|. | ... |. ||... | | | .
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYIS
--PCHRL--SLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLVRGSRMYP---IVLIDYGISRRYLDAETGRPIPPRPFVGFVGT
.. | . ... ..|| . |. |.||||.||.|.|. ..... . ..| |... . . . . .|.||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGT
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| Kinase | 96145.m00225.AA | S_TKc | 16-957 | 6 | 2.7e-14 | 32.7 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 16-957
Range on HMM: 1-231/231
Sequence Identity: 6% (58 aa)
YIVEKTIGRGAFGRIVKVTKNNNDGKEYALKIPKKGKERSLVTERKFLEKLQGSPYFPKIIDYREGYEKNNYLAMELLGPSLGKVKDVAPCHR-------
| . ..||.||||. |..... .|...|.|| | ... |.. |.| . |. |..|. . .. |. ||... .|| ..|. ..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP
LSLSTSIRVGIEMLRSIRAFHKLGFIHRDIKPDNFLVRGSRMYPIVLIDYGISRRYLDAETGRPIPPRPFVGFVGTMKYASINAHEGRELGR-RDDLYSW
.. . .. .... . |..|.||||.||.| |. | ..| |..|.. |.|| | . |. . | .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC
FVSLLVIMTDHVPWKTNRNNKIMAQTKKITNIEKFCLKLPKQLVKIYYIIMRMKFGDEPKYDLLIAFLNEALKEVGGSWSEKYDWENFSKNRLNKISSVN
. | .. |. ... |||
GCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------------------------------------------
IVPPHDEPANIPTNLPSTNIEIPMSSPLPLLPRNTQSLGNNFSKSQFLFNLQQQAQEVTDDSEDSYSYTSSSACSTFSWSTSRRFYTGSHTSSISTESQY
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SSSSDDDSDSYYYSSSSSSSSYSSGSSSDSKPSKQAAAAKPPAPAPPAQKKNRPAAWHDSIECLKALPVTKKRRRHYKSDPSVMTKTNSKAPANEYKKHL
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VRSHDEIRSPSEVDNFDISAKNFGDPNWPKASPVTGDYGRRMSMVPRMLQSSPQFDLAAAKLKRPPPIPIKKTSFSPPTPVLRNEFPKINTLNSPTPPSP
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IITGGAPSDNSQCNELTDSNPKISLDTHPRAVEDHTSILYSHAPPTEPKPSPEAKPRRRSSIIGEENYIPMTEIAPVSSPKKEPLLKKVSFSFDNESPSK
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INEGEERIIDIEISDKIEKEMQSEDEDKSISSSLSSTVVNSSEQSTSNSSTTSEKGDEDKQKSQNKDDEDKQKSQNKDDEDKQKSQNKDDEDKQKSQNKD
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DEDKQKSQNKGDEDKQKSQNKDDEDKQKSQNKDDEDKQKSQNKDDEDKQKSQNKDDEDKNIVKGDKNKQINEEKKPEQTTKPKEEEKTEQKPIIADDNKI
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SQESKPEPPKQNNTDQKPQISSEKPS---------EEEKRVNSDETKKNEEVKKQKQAK
|. . ||| | ..|.. |. .
---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 96145.m00225.AA | CK1-G | 232-271 | 35 | 3e-06 | 17.11 | In-house | 225-266 (266) | Show / Hide |
Range on Protein: 232-271 Range on HMM: 225-266/266 Sequence Identity: 35% (15 aa) QTKKITNIEKFCLK--LPKQLVKIYYIIMRMKFGDEPKYDLL .||. |||| | .|.|. . .. |..| ..| || | DTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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| Kinase | 96145.m00225.AA | CK1 | 227-269 | 25 | 0.005551 | 6.34 | In-house | 229-271 (271) | Show / Hide |
Range on Protein: 227-269 Range on HMM: 229-271/271 Sequence Identity: 25% (11 aa) NKIMAQTKKITNIEKFCLK-LPKQLVKIYYIIMRMKFGDEPKYD .||| .| |..| | .|.... .. ...| ..|.|. EKIME-KKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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