Gene 90019.m00227 (T.vaginalis)

90019.m00227

Species: T.vaginalis
Alias: 90019.m00227, TvagK0663
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
90019.m00227.AA Protein None 352 None Fasta, JSON
90019.m00227.kin_dom Protein Kinase Domain None 310 None Fasta, JSON

Protein domain

Protein domains of 90019.m00227.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90019.m00227.AA CMGC 38-347 17 1e-69 228.0 In-house 1-513 (513) Show / Hide 
Range on Protein: 38-347
Range on HMM: 1-513/513
Sequence Identity: 17% (92 aa)

YMVQDIIGSGGFSEVYKVID--------------VETQQVYAIKIYK-HLPDHSQ---------IDRQAEREIMVLTEFN-TFNNGT----------ELN
| . . ||.| ...||| .|               ||....|||. |    .. |         . . | |||. | ..| . ..              |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

TIGTMIDWFEYKR-----------------HKVILMNFYPFSLLQLIQM--------RGLG-------------------FPISLVQQVAREISQAIK--
 | ...|.| .|                  |  . . . . .|.|.|..        |...                   |.| ...  .. | ...|  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

LLHRKN--YIHGDIKPENIVIDTNNQP--------------------KLIDFGSTLISGDP------------------------DFFYIQSRFYRAPEI
 .|...   || |.||||| |. |..                     |..|||.  . ...                           |...|.||||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILQLG----------CSQKIDIWSFGCLLAELYLG--------WPLFP-----------GTTTLQMLQMIEFTVGKFPKSIVDQVRQFD------TTYFD
.|  .           ...||.||.|| .||.|.|        .||||           |. .. .|..|  . |... .. .. .  .      .  . 
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFNFCKHEEEWP

DNGNINRYQFPSNLY-------TLEYLVMNYFCAENNDEHSIEIDRRRK----------------------------------------SIFLDLLRNLL
.  .  .|. .           .. . . ||.   |.      .. ...                                        . ..||| ..|
NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML

KIDPRQRYTIDQIIHHPFL
..|| .| |..|.  ||..
QYDPDKRITAEQALQHPYF
Kinase 90019.m00227.AA DYRK 38-347 31 1.1e-67 231.22 In-house 1-320 (320) Show / Hide 
Range on Protein: 38-347
Range on HMM: 1-320/320
Sequence Identity: 31% (105 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIKIYKHLPDHSQIDRQAEREIMVLTEFNTFNNGTELNTIGTMIDWFEYKRHKVILMNFYPFSLLQLIQMRGL
| . ..||.| |. | |. |  |..  |||| .  ..     ||| .||  |   |. ..  . . .  | | | .. |  |    .  .| ...  .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFH---RQAQIEIKILEYLNQQDPDDKYHCV-HMYDYFYHRNHLCIVFELLSMNLYEFLKNNHF

-GF-PISLVQQVAREISQAIKLLHRK-NYIHGDIKPENIVIDTN-NQP--KLIDFGSTLISGDPDFFYIQSRFYRAPEIILQLGCSQKIDIWSFGCLLAE
 || ...||...|. | ...|.||.. |.||.|.|||||..    |..  |.|||||    ..  . |||||||||||.||..  . .||.||.|| |||
QGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAE

LYLGWPLFPGTTTLQMLQMIEFTVGKFPKSIVDQVR-QFDTTYFDDNGNINRYQFPSNLYTLEY---LVMNYFCAENNDEHSIEIDRRR---------KS
|..||||||| .   .|..|  . |..|| ..|. | .. ...||.     .|..  .  . ..     |...| .... ... .  ||          .
LFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC----FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDH

IFLDLLRNLLKIDPRQRYTIDQIIHHPFL
 |.|... .|..||..| |  |  .||..
QFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 90019.m00227.AA S_TKc 38-347 22 7.7e-67 229.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-347
Range on HMM: 1-231/231
Sequence Identity: 22% (73 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIKIYKHLPDHSQIDRQAEREIMVLTEFNTFNNGTELNTIGTMIDWFEYKRHKVILMNFYPF---SLLQLIQM
| . ..||.|.|..|||.....|....|||| |         ....||| .| .            | ...|.|.   |  . | . .    .|...|. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RGLG-----FPISLVQQVAREISQAIKLLHRKNYIHGDIKPENIVIDTNNQPKLIDFGSTLISGDPDFFYIQSRFYRAPEIILQLGCSQ-KIDIWSFGCL
|| .     ||   .. ....| .|.. .|... || |.||||| .|.  . |..|||.  .       .. ...|.|||..   | .  |.|.||.||.
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LAELYLGWPLFPGTTTLQMLQMIEFTVGKFPKSIVDQVRQFDTTYFDDNGNINRYQFPSNLYTLEYLVMNYFCAENNDEHSIEIDRRRKSIFLDLLRNLL
|.|.. | |.||  .  .|...|                                                                  . ..|..|..|
LYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------SPEAKDFIRKCL

KIDPRQRYTIDQIIH-------HPFL
. ||..|.|. .. .       ||..
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 90019.m00227.AA DYRK2 38-241 38 7e-55 176.75 In-house 1-204 (318) Show / Hide 
Range on Protein: 38-241
Range on HMM: 1-204/318
Sequence Identity: 38% (82 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIKIY---KHLPDHSQIDRQAEREIMVLTEFNTFNNGTELNTIGTMIDWFEYKRHKVILMNFYPFSLLQLIQM
| .  .||.| |  | |. |  |.|  |||.    | .       .|| .|| .| .  . .     | .  | | | .  |  |    .  .|  .|  
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRF------HNQAYEEIRILHHIRRQDKDNTMNCV-HMLDYFYFRNHHCITFELLSMNLYEYIKK

RGL-GFPISLVQQVAREISQAIKLLHRKNYIHGDIKPENIVIDTNNQP--KLIDFGSTLISGD-PDFFYIQSRFYRAPEIILQLGCSQKIDIWSFGCLLA
.   ||  .||   |. | |....||. | ||.| |||||.    |.   |.|||||       ... |||||||||||.||..  .  ||.||||| .|
NHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMA

ELYLGWPLFPG
||| | |||||
ELYTGYPLFPG
Kinase 90019.m00227.AA Pkinase 38-347 24 2.1e-53 188.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-347
Range on HMM: 1-293/293
Sequence Identity: 24% (85 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIKIYKHLPDHSQIDRQAER--EIMVLTEFNTFNNGTELNTIGTMIDWFEYKRHKVILMNFYPF-----SLLQ
| .  .||||.|..||| ... |....|.|| |   ..|. |... |  || .. ..|  |       | ...||||.|.|  . | . .      .|  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-------IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

LIQ-MRGLGF--PISLVQQVAREISQAIKLLHRKNYIHGDIKPENIVIDTNNQP----KLIDFGS-----TLISGDPDFFYIQSRFYRAPEIIL-QLGCS
.|. .|. .|  .   .. ....| .... .|... || |.||||| || |...    |..|||.     .  .. .. |   ...|.|||.|. . . .
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIRGGQYYG

QKIDIWSFGCLLAELYLGWPLFPGT----TTLQMLQMIEFTVG---KFPKSIVDQVRQFDTTYFDDNGNINRYQFPSNLYTLEYLVMNYFCAENNDEHSI
.|.|.||.||.|.|...| |.|||     . . ..|||. . |   .|. .  . .. |  ... .                                  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------------------------

EIDRRRK----SIFLDLLRNLLKIDPRQRYTIDQIIHHPFL
 . ....    . ..|.....|. || .|.|..|| .||..
-F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 90019.m00227.AA YAK 38-347 29 2.8e-39 130.85 In-house 1-347 (347) Show / Hide 
Range on Protein: 38-347
Range on HMM: 1-347/347
Sequence Identity: 29% (105 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIKIYKHLPDHSQIDRQAEREIMVLTEFNTFNNGTELN---TIGTMIDWFEYKRHKVILMNFYPFSLLQLI-Q
|.| |. | | |  | |     |  . |.|. |  .   |   ||  || .|   |     .. |    |  |.| | .| |  .       .|  .. |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQ---QAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQ

MRGLGFPISLVQQVAREISQAIKLLHRKNYIHGDIKPENIVIDTNNQP--KLIDFGSTLISGDPDFFYIQSRFYRAPEIILQLGCSQKIDIWSFGCLLAE
 .  || ..|..|    |  ..  |  |. || | |||||     |.|  |.|||||          |||.|.||.||||.    .  || || || .||
NKFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

LYLGWPLFPGTTTLQMLQMIEFTVGKFPKSIVDQVRQFDTTYF--------DDNGNIN--------RYQFPS-------------------NLYTLEYLV
|.|| |.|||      .  |  . |..|  ..|| | | . ||        ||| | |         | | .                   .  .|  . 
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGR-FKNKYFHCHDGSNSDDNNNNNNNNNGKPYYYIFKTKQDYQIDEKIQLKESKTYFQYKCLNDIK

MNYFCAENNDEHSIEIDRRRKSIFLDLLRNLLKIDPRQRYTIDQIIHHPFL
 ..          .. ..|.  .|.|..  ||  .|| | .  |   |||.
NYMYFKQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 90019.m00227.AA Ciliate-E2 38-347 17 5.5e-36 121.01 In-house 1-365 (365) Show / Hide 
Range on Protein: 38-347
Range on HMM: 1-365/365
Sequence Identity: 17% (77 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIK-IYKHLPDHSQ----------------IDRQAEREIMVLTEFNTFNNGT-----------ELNT--IGTM
| .. .||.|.|. |||. . ..|. .||| |. ..   .|                . .| |   ... .... |              .||   |  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKM

IDWFE--YKRHKVILMNFYPF-SLLQLIQMRGL----------GFPISLVQQVAREISQ---------------AIKLLHRKN-YIHGDIKPENIVIDTN
...|.   . .  . | ..   .|...|. . .           | .  .... ..| |               |.. || ||  || |||||||..   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

NQPKLIDFGSTLISGDP-----------DFFYIQ------------------------SRFYRAPEIILQLG---------CSQKIDIWSFGCLLAELYL
  .|.||||   .  |.            . . .                        .  | ||||.   .          . |.||||.|..| |.  
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GWPLFPGTTTLQMLQMIEFTVGKFPKSIVDQVRQFDTTYFDDNGNINRYQFPSNLYTLEYLVMNYFCAENNDEHSIEIDRRRKSIFL-------------
| | |                                                                      ...    |  |              
GKPPF----------------------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQC

-------------DLLRN----LLKIDPRQRYT-IDQIIHHPFL
             ||...    .|. || .|.| ..||. ||..
KWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 90019.m00227.AA DYRK1 38-265 32 5.9e-32 109.21 In-house 1-229 (321) Show / Hide 
Range on Protein: 38-265
Range on HMM: 1-229/321
Sequence Identity: 32% (75 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIKIYKHLPDHSQIDRQAEREIMVLTEFNTFNNGTELNTIGTMIDWFEYKRHKVILMNFYPFSLLQLIQMRGL
| ..  || | |  | |  | ..|.  |||| |          ||  || .|   |   .  . . . ..   | .. |  . . .  . |  |..    
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIK---NKKPFYNQAQIEIRLLELMNKHDKEMKYYIV-HLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF

-GFPISLVQQVAREISQAIKLLHRK--NYIHGDIKPENIVIDTNN--QPKLIDFGSTLISGDPDFFYIQSRFYRAPEIILQLGCSQKIDIWSFGCLLAEL
 |  . |... |. . .|.  .     . || |.|||||..      . |.|||||   .|.  . ||||||||.||..|..  . .||.|| ||.| |.
RGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEM

YLGWPLFPGTTTL-QMLQMIEFTVGKFPKSIVDQ
  | ||| |.  . || ...|  .|  || ..||
HTGEPLFSGSNEVDQMNKIVEV-LGMPPKHMIDQ
Kinase 90019.m00227.AA PRP4 154-279 41 3.5e-31 109.93 In-house 118-244 (320) Show / Hide 
Range on Protein: 154-279
Range on HMM: 118-244/320
Sequence Identity: 41% (53 aa)

AIKLLHRKNYIHGDIKPENIVIDTNNQP-KLIDFGSTLISGDPDFF-YIQSRFYRAPEIILQLGCSQKIDIWSFGCLLAELYLGWPLFPGTTTLQMLQMI
| |.| . |..| |||| ||..  ...  |..|||| .   . .   | .||||||||||.       ||.|| || |.||| |  .||| |  .|| ..
ALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLF

EFTVGKFPKSIVDQVRQFDTTYFDDNGN
    ||.|. .. .  ||  ..|| | |
MDYKGKMPNKMI-RKGQFKDNHFDQNCN
Kinase 90019.m00227.AA GSK 153-251 42 8.9e-28 81.43 In-house 127-231 (328) Show / Hide 
Range on Protein: 153-251
Range on HMM: 127-231/328
Sequence Identity: 42% (45 aa)

QAIKLLHRKNYIHGDIKPENIVID-TNNQPKLIDFGS--TLIS--GDPDFFYIQSRFYRAPEIILQLGCSQ---KIDIWSFGCLLAELYLGWPLFPGTTT
.... || ..  | ||||.||..|  . . |. ||||   |..  . |  .|| ||.||||| |  .||..   .||.||.|| .||. .| ||||| ..
RGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELI--FGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSS

LQMLQMI
. .|  |
VDQLVEI
Kinase 90019.m00227.AA CLK 200-278 40 6.7e-24 67.91 In-house 208-289 (350) Show / Hide 
Range on Protein: 200-278
Range on HMM: 208-289/350
Sequence Identity: 40% (33 aa)

IQSRFYRAPEIILQLGCSQKIDIWSFGCLLAELYLGWPLFPGTTTLQMLQMIEFTVG-KFPKSIVDQVR--QFDTTYFDDNG
...| |||||.|| || ||. |.||.|| | |||.|  ||..   .. |.|.|   |  .|..     |  .  . || .|.
VSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNR
Kinase 90019.m00227.AA CLK 38-173 25 1.4e-20 57.78 In-house 1-145 (350) Show / Hide 
Range on Protein: 38-173
Range on HMM: 1-145/350
Sequence Identity: 25% (37 aa)

YMVQDIIGSGGFSEVYKVIDVET-QQVYAIKIYKHLPDHSQIDRQAEREIM-VLTEFNTF--NNGTELNTIGTMIDWFEY-KRHKVILMNFYPFSLLQLI
| . .  |.| |. |....| .   . .|.|| .    ...   .|  ||  ..   |.    |.. .  .. |.|||.| . |  |..  |  |.  ..
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIR---NVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFM

QMRG-------LGFPISLVQQVAREISQAIKLLHRKNYIHGDIKPENI
   .       ...||. ... |. . .|.| ||    .| | |||||
KSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENI
Kinase 90019.m00227.AA CAMK 128-229 20 2.5e-19 58.26 In-house 151-324 (425) Show / Hide 
Range on Protein: 128-229
Range on HMM: 151-324/425
Sequence Identity: 20% (36 aa)

LLQLIQMRGLG--------------FPISLVQQVAREISQAIKLLHRKNYIHGDIKPENIVIDTN-----------------NQPKLIDFGST--LISGD
|.. |. .| .              |. . .... | | .|.. .| .| .| |.||||| .|.|                 |. |.||||    ...|.
LFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE

PDFF------------------------YIQSRFYRA-PEIILQ--------------LGCSQKIDIWSFGCLL
 .|.                        .  .  | | ||....               ....|.|.|| |..|
NNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 90019.m00227.AA CAMK 322-347 46 4.4e-11 31.21 In-house 400-425 (425) Show / Hide 
Range on Protein: 322-347
Range on HMM: 400-425/425
Sequence Identity: 46% (12 aa)

DLLRNLLKIDPRQRYTIDQIIHHPFL
||.|..|. || .|.||.|.  ||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 90019.m00227.AA CAMK 43-89 18 1.7e-10 29.26 In-house 1-85 (425) Show / Hide 
Range on Protein: 43-89
Range on HMM: 1-85/425
Sequence Identity: 18% (16 aa)

IIGSGGFSEVYKVIDVETQ------------QVYAIKIYKH--LPDH------------------------SQIDRQAEREIMVL
..|.|.|..|...|. .|.            | .||||..   |.|.                         .  .. .||| ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIM
Kinase 90019.m00227.AA TyrKc 38-347 17 3.9e-09 -75.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-347
Range on HMM: 1-280/280
Sequence Identity: 17% (61 aa)

YMVQDIIGSGGFSEVYKVIDVETQQVYAIKIYKHLPDHSQIDRQAEREIMVLTEF--NTFNNGTELNTIGTMIDW---FEYKRHKVILMNFYPF-SLLQL
    ...|.| | |||| .    .|| |.|  |.        .   ||. .....  .  |    .. .|  ..    | |     |.| . |  .|.. 
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA-----REDFMREARIMCKLGGHHPN---IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IQMRGLGFPISLVQQVAREISQAIKLLHRKNYIHGDIKPENIVIDTNNQPKLIDFG-STLISGD------PDFFYI----QSR-----FYRAPEIILQLG
.. ..  .. .   . .  |..    ||.||.|| |.   |. .. |.. |  ||| |  |  |       |        ...        ||| |    
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

CSQKIDIWSFGCLLAELY-LGWPLFPG-----TTTLQMLQMIEFTVGKFPKSIVD----QVRQFDTTYFDDNGNINRYQFPSNLYTLEYLVMNYFCAENN
.. | |.|||| .. |.. .| .  ||      .  .... ..   |. ..   .                                             
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--QGYRMPQPPNDYPMS----------------------------------------

DEHSIEIDRRRKSIFLDLLRNLLKIDPRQRYTIDQIIHHPFL
   .    .  . ..  . .   . || .| |  .|  | ..
---F---VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 90019.m00227.AA CLK 319-347 37 1e-08 21.52 In-house 322-350 (350) Show / Hide 
Range on Protein: 319-347
Range on HMM: 322-350/350
Sequence Identity: 37% (11 aa)

IFLDLLRNLLKIDPRQRYTIDQIIHHPFL
.. ||.|..| .|| .| | ... .||| 
QLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 90019.m00227.AA GSK 38-67 31 8.1e-08 19.33 In-house 1-38 (328) Show / Hide 
Range on Protein: 38-67
Range on HMM: 1-38/328
Sequence Identity: 31% (12 aa)

YMVQDIIGSGGFSEVYKVIDV----ETQQV----YAIK
|   . ||.| |. ||. ..     ||...    .|||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK
Kinase 90019.m00227.AA GSK 321-347 33 8.6e-07 16.13 In-house 302-328 (328) Show / Hide 
Range on Protein: 321-347
Range on HMM: 302-328/328
Sequence Identity: 33% (9 aa)

LDLLRNLLKIDPRQRYTIDQIIHHPFL
.||.  .|..||..| . .... ||| 
IDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 90019.m00227.AA PRP4 320-347 42 1.5e-05 16.34 In-house 293-320 (320) Show / Hide 
Range on Protein: 320-347
Range on HMM: 293-320/320
Sequence Identity: 42% (12 aa)

FLDLLRNLLKIDPRQRYTIDQIIHHPFL
| ||| ..|  ||  | |. .  .|||.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase 90019.m00227.AA DYRK2 320-347 32 0.000104 10.87 In-house 291-318 (318) Show / Hide 
Range on Protein: 320-347
Range on HMM: 291-318/318
Sequence Identity: 32% (9 aa)

FLDLLRNLLKIDPRQRYTIDQIIHHPFL
|.| ..  .. || .| | .|. .||..
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 90019.m00227.AA DYRK1 320-347 39 0.000334 10.1 In-house 294-321 (321) Show / Hide 
Range on Protein: 320-347
Range on HMM: 294-321/321
Sequence Identity: 39% (11 aa)

FLDLLRNLLKIDPRQRYTIDQIIHHPFL
| ||.. .|. ||.|| |  ....|.|.
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 90019.m00227.AA PRP4 38-68 34 0.057225 3.1 In-house 1-32 (320) Show / Hide 
Range on Protein: 38-68
Range on HMM: 1-32/320
Sequence Identity: 34% (11 aa)

YMVQDIIGSGGFSEVYKVI-DVETQQVYAIKI
| |   .|.| || | .      ...  ||||
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKI