Gene 94583.m00019 (T.vaginalis)

94583.m00019

Species: T.vaginalis
Alias: TvagK0670, 94583.m00019
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
94583.m00019.AA Protein None 395 None Fasta, JSON
94583.m00019.kin_dom Protein Kinase Domain None 290 None Fasta, JSON

Protein domain

Protein domains of 94583.m00019.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94583.m00019.AA CMGC 105-394 17 1.4e-80 264.29 In-house 1-513 (513) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-513/513
Sequence Identity: 17% (93 aa)

YQQLQFLGRGSFGTVIKCYD--------------HKLKMNVAIKVLTESDDDNF------------LINREINFLKILNKEEEKSN-----------SSN
|. .. .|.|..|.| ||.|              |. .  |||| . .  ...              ..||| .|| |||.... |             |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHNN

ILELIDTFRQHG-----------------FTFIVTKYFEENLYEYITNQSFS-------------------------QNLSLHDIKRIAKSVAQALY--T
|. |.| |. ..                   ..|. | . .||.|| |..|                          ..... .|. ... . ..|    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

CHQCG--IIHSDLKPENVVLNGN---------------------EVRLIDFGCASFTGET------------------------VYQTVQSLYYRAPEVI
||. .  ||| ||||||. .| |                     .....||| | ....                          .. |....|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FQ----------KGFGSSIDVWSFGCLLFEMVTG--------QPLFL-----------VRNEGELISQIKRILGDPSYEMIQQSNKM------RRYWF-R
.           ......||.||.|| ..||.||        .|||             ... . . .| ..|| |. .|||....        . |. .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

KQLIRDTT-----------------------------GSLKRSFIGSYVRNSN----------------------------------KEIIDLISSCLTW
..| .  .                                ....   . ...|                                  .. |||.. .|..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPKERPSMREILDSPFF
||..|..  ..|. |.|
DPDKRITAEQALQHPYF
Kinase 94583.m00019.AA DYRK 105-394 30 4.1e-80 272.48 In-house 1-320 (320) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-320/320
Sequence Identity: 30% (98 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIKVLTESDDDNFLINREINFLKILNKEEEKSNSSNILELIDTFRQHGFTFIVTKYFEENLYEYITNQSFSQN
|. |...|.|||| |.||.||| .  ||||..    .    . .||. |. ||..  . ...... . | |  .....||.  .. ||||.. | .|   
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

LSLHDIKRIAKSVAQALYTCHQC-GIIHSDLKPENVVLNG----NEVRLIDFGCASFTGETVYQTVQSLYYRAPEVIFQKGFGSSIDVWSFGCLLFEMVT
.||  ....|... ..|   |..  ||| ||||||..|.     ... .|||| ..| ....|. .|| .||||||| .  .. .||.||.|| | |..|
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GQPLFLVRNEGELISQIKRILGDPSYEMIQQS-NKMRRYWFRK---QLIRDTTGSLK----------------------RSFIGSYVRNSNKEIIDLISS
| |||   || ...  |  .|| |. .||...  . ... | .   . ... |.. |                      |. .... .   .. .|.|  
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKK

CLTWDPKERPSMREILDSPFF
||.|||..|..  . |. |.|
CLQWDPHKRITPSQALQHPWF
Kinase 94583.m00019.AA S_TKc 105-394 26 1.6e-76 261.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIKVLTESDDDNFLINREINFLKILNKEEEKSNSSNILELIDTFRQHGFTFIVTKYFEE---NLYEYITNQSF
|. |. .|.|.||.| ||...| .  ||||..         | |||. ||         .  ||  |.|.|.  .. ..|. | .    .|..|| ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

SQN---LSLHDIKRIAKSVAQALYTCHQCGIIHSDLKPENVVLNGNEVRLIDFGCASFTGETVYQTVQSLYYRAPEVIFQKGFGS-SIDVWSFGCLLFEM
  .   ..  ....... ...||  ||. |||| ||||||. |.  .. ..||| | .     .  . ...|.||||.   |.|  ..|.||.||.|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

VTGQPLFLVRNEGELISQIKRILGDPSYEMIQQSNKMRRYWFRKQLIRDTTGSLKRSFIGSYVRNSNKEIIDLISSCLTWDPKERPSMREILD-------
..|.|.|      ..   .|.|.                                            .| .|.|. ||..||..||.  |.|        
LCGYPPFP-----QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

SPFF
 |.|
HPWF
Kinase 94583.m00019.AA Pkinase 105-394 28 8.3e-70 243.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-293/293
Sequence Identity: 28% (90 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIKVLTESDDDNFLINR-----EINFLKILNKEEEKSNSSNILELIDTFRQHGFTFIVTKYFEE-----NLYE
|. .. .|.||||.| ||....    ||.|..  ....     .     ||  .| ||       . ||..|.|.|. ..   .|. | |       |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

YIT---NQSFSQNLSLHDIKRIAKSVAQALYTCHQCGIIHSDLKPENVVLN-GNEV----RLIDFGCA----SFTGETVYQTVQSLYYRAPEVIF-QKGF
||.   . .|.  .| ...|.... ....|. ||..|||| ||||||. ..  ...    ...|||.|       ..  .  . ...|.|||||  ... 
YISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

GSSIDVWSFGCLLFEMVTGQPLFLVR----NEGELISQIKRILGDPSYEMIQQS-NKMRRYWFRKQLIRDTTGSLKRSFIGSYVRNSNKEIIDLISSCLT
|...|.||.||.|.||..|.|.|  .    |  . .  |.||.| |  . .... ...... ||    .         |  . . | ..| .|.|..||.
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------F-HWTFHNWSEECKDFIKWCLC

WDPKERPSMREILDSPFF
.|||.||. ..|| .|.|
KDPKKRPTAEQILQHPWF
Kinase 94583.m00019.AA DYRK2 105-394 32 8.9e-69 222.69 In-house 1-318 (318) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-318/318
Sequence Identity: 32% (105 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIKVLTESDDDNFLINREINFLKILNKEEEKSNSSNILELIDTFRQHGFTFIVTKYFEENLYEYITNQSFSQN
|  | ..|.|||| |.||||||.|  ||||..         . .||. |. . ..  | |..|.  . | |   ....|..  .  |||||| . .| | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHI-RRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHF-QG

LSLHDIKRIAKSVAQALYTCHQCGIIHSDLKPENVVL---NGNEVRLIDFGCASFTGE-TVYQTVQSLYYRAPEVIFQKGFGSSIDVWSFGCLLFEMVTG
.||  . | |.|. |.|   |.  ||| ||||||..|   | . . .||||   |  .  .|  .||..||||||| .  .| .|| ||||| . |..||
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

QPLFLVRNEGELISQIKRILGDPSYEMIQQS----NKMRRYWFR------------------KQLIRDTTGSLKR---SFIGSYVR-NSNKEIIDLISSC
.|||   ||.. .  .  .|| |. ......     . |.| |                   . ..  ..|. .    . ..|...    .  || |. |
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LTWDPKERPSMREILDSPFF
..|||.|| . ...|. |..
FEWDPSERMTPSQALKHPWI
Kinase 94583.m00019.AA Ciliate-E2 105-394 18 1.1e-47 161.81 In-house 1-365 (365) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-365/365
Sequence Identity: 18% (76 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIK---------------------VLTESDDDNFLINREINFLKILN------KEEE---KSNSSNILELIDT
|  .. .|.|.||.| || . | . ..|||                     . . . .. . |..||. .. .|      .| .   . |. ||......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FR--QHGFTFIVTKYFEE-NLYEYITNQSFSQ--------NLSLHDIKRIAKSVAQ---------------ALYTCHQCG-IIHSDLKPENVVLNGNEVR
|   .    ..|. |..  .|..|| |.. ..        ....  ||.| | ..|               ||  .|. . ||| |.||||...    . 
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

LIDFGCASFTG----------------------------------ETVYQTVQSLYYRAPEVIF---------QKGFGSSIDVWSFGCLLFEMVTGQPLF
.|||| . .                                    ....... ...| |||..          ||| . ..|.||.|..|.||..|.| |
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

LVRNEGELISQIKRILGDPSYEMIQQSNKMRRYWFRKQLIRDTTGSLKRSFIGSYVRNSNK--------------------EIIDLISS----CLTWDPK
                                              ..    . .  ....                    | .|||.     .|  ||.
----------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPE

ERPS-MREILDSPFF
.|.. . .||. |.|
KRITGWEQILNHPWF
Kinase 94583.m00019.AA Ciliate-E2-Unclassified 105-394 20 2.1e-46 158.97 In-house 1-352 (352) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-352/352
Sequence Identity: 20% (74 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNV-AIKVLTESDDDN-----FLINREINFLKILNKEE---------------EKSNSSNILELIDTFRQHGFTFI
|  .. .|.|.||.| ||.. | |  . |.| .  . ...     . . ...| .|..|. .                 ... .|. ....|..    .|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VTKYFEE-NLYEYITNQSF--------------SQNLSLHDIK-----RIAKSVAQAL-YTCHQCGIIHSDLKPENVVL-NGN---EVRLIDFGCAS---
|. |.|  .| .||.....              .. ..   .|     .... . |.| | .|. .||| |.||||... |..   ....|||| ..   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------FTGETVYQTV-QSLYYR----APEVIFQKGFGSS----IDVWSFGCLLFEMVTGQPLFLVRNEGE-LISQIKRILG-DPSYEMIQQ
              .. .  ..|. ....|     ||||. ... . |    .|.||.|..|.||..|.. |  .|. .  ..... | . .  |.....
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNA--YRKQLY

SNKMRR-YWFRKQLIRDTTGSLKRSFIGSYVRNSNKEIIDLIS----SCLTWDPKERPSMREILDSPFF
.|.. . . |.|.  .                ....| .|.|.    ..| ..|..|... .||  |.|
QNIKQKNIQFPKFPWQQ------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 94583.m00019.AA CAMK 110-394 17 3.9e-46 146.24 In-house 1-425 (425) Show / Hide 
Range on Protein: 110-394
Range on HMM: 1-425/425
Sequence Identity: 17% (79 aa)

FLGRGSFGTVIKCYDHKLK------------MNVAIKV-----LTE------------------------SDDDNFLINREINFLKILNKEEEKSNSSNI
 |||||||.| .|.. . .              ||||.     |..                        .. |   . |||. .| |.. ..| .  ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LELIDTFRQHGF-------------------TFIVT---KYFEEN-----LYEYITNQSF------------SQNLSLHDIKRIAKSVAQALYTCHQCGI
. |....  . .                    ..|.    | .       |..||. ..             .  .. .. .|. . ...|.  ||...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHSDLKPENVVLNGNE------------------VRLIDFGCASF--------------------------TGETVYQTVQSLYYRA-PEVIFQ------
.| ||||||. |. |.                  . .|||| | .                          .|.  .  . ...| | |||. .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGFGSSIDVWSFGCLLFEMVTGQPLFLVRNEGELISQIKRILGDPSYEMIQQSNKMRRYWFRKQLIRDTTGSLKR-------SFIGSYVRNS
        .. | ..|.|| |..|. |..| | |   .. | .. ...                         | ..   |..       .|. .|. ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DEW-------------------------IGMNDYELFEKIMKGKYDFPPPYFSPI

N--------------------KEIIDLISSCLTWDPKERPSMREILDSPFF
                     .| .|||...|. ||..|..  ..|. |..
SCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 94583.m00019.AA HIPK 105-343 33 4.7e-46 142.75 In-house 1-243 (329) Show / Hide 
Range on Protein: 105-343
Range on HMM: 1-243/329
Sequence Identity: 33% (82 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIKVLTESDDDNFLINREINFLKILNKEEEKSNSSNILELIDTFRQHGFTFIVTKYFEENLYEYITNQSFSQN
|  | ||||| || |.||  .  .  ||||.| .    .  .  |.  |. | .|.  ..  ...   . |...  |..|    | |||..  .  |.  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQEN--ADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMP-

LSLHDIKRIAKSVAQALYTCHQCGIIHSDLKPENVVLNGNE-----VRLIDFGCASFTGETVYQT-VQSLYYRAPEVIFQKGFGSSIDVWSFGCLLFEMV
| |. |. | . |. ||    . |.|| ||||||. |         |. |||| ||   ..| .| .|| ||||||.|    |  ..|.|| || . |  
LPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGQPLFLVRNEGELISQIKRILGDPSYEMIQQSNKMRRYW-FRKQL
 | ||.   .| ..|  |    . |   ....  |  |.. . ||.
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQS
Kinase 94583.m00019.AA DYRK1 105-342 34 1.9e-45 157.28 In-house 1-241 (321) Show / Hide 
Range on Protein: 105-342
Range on HMM: 1-241/321
Sequence Identity: 34% (84 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIKVLTESDDDNFLINREINFLKILNKEEEKSNSSNILELIDTFRQHGFTFIVTKYFEENLYEYITNQSFSQN
|.    .|.|||| |.| |||. .  ||||..            ||  | ..|| ..| .  .|..|   |       .|.     |||. . | .| . 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNK-HDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF-RG

LSLHDIKRIAKSVAQALY--TCHQCGIIHSDLKPENVVLNGN---EVRLIDFGCASFTGETVYQTVQSLYYRAPEVIFQKGFGSSIDVWSFGCLLFEMVT
 ||  ....|. ...||.  .     ||| ||||||..|       ...|||| .  .|. .|| .|| .||.|||. .  .  .||.|| ||.| || |
VSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHT

GQPLFLVRNEGELISQIKRILGDPSYEMIQQSNKMRRYWFRKQ
| |||   || . ...|  .|| |  .||.|. | ..|. ...
GEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDP
Kinase 94583.m00019.AA CDK 105-394 25 3.2e-40 126.28 In-house 1-284 (284) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-284/284
Sequence Identity: 25% (87 aa)

YQQLQFLGRGSFGTVIKCYDHK-----LKMNVAIKVL-TES-----DDDNFLI--NREINFLKILNKEEEKSNSSNILELIDTFRQH-----------GF
|..|. .|.|..|.| |. |..      .  ||.| . .|.     ... | |   |||. || |          ||  |.| . ..             
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--------HPNIVKLHDVCHTKNMDRNNKDKHENK

TFIVTKYFEENLYEYITNQSFSQNLSLHDIKRIAKSVAQALYTCHQCGIIHSDLKPENVVLNGNE------VRLIDFGCASFTGE--------TVYQ-TV
 ..|  | .  |..|.             || . .   ..|. ||. .|.| |||| |  .| |       . . ||| |   |          .|   |
LYMVFEYMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

QSLYYRAPEVIF-QKGFG--SSIDVWSFGCLLFEMVT---GQPLFLVRNEGELISQIKRILGDPSYEMIQQSNKMRRYWFRKQLIRDTTGSLKRSFIGSY
  | |||||. . .|  .   .||.||.|| . ||.|   ..|||  ..| . .  | ||.| |. ..     |.  |                      
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------

VRNSNKEIIDLISSCLTWDPKERPSMREILDSPFF
         ||....|. ||| | |  . |..|.|
---------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 94583.m00019.AA STE 105-302 22 1.1e-33 116.42 In-house 1-266 (359) Show / Hide 
Range on Protein: 105-302
Range on HMM: 1-266/359
Sequence Identity: 22% (64 aa)

YQQLQFLGRGSFGTVIKCYDH------KLKMN---------VAIKVLTESD------------------DDNFLINREINFLKILNKEEEKSNSSNILEL
.. ....|.|.|||| |...|      | . .         .|||..  ..                  ..   | .||...| .|.      . || . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH----M-HPNIVKY

IDTFRQHG-------FTFIVTKYFE-ENLYEYIT-NQSFSQNLS----------LHDIKRIAKSVAQA-LYTCHQCGIIHSDLKPENVVLNGNEVRLIDF
.... . |         .|.  | .   | . |  . .  ..|.           . |..|.... .. ||  |. .||| |.|| |. |    | |.||
YGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDF

GCAS-FTGE---------------------TVYQTVQSLYYRAPEVIFQ------KGFGSSIDVWSFGCLLFEMVTGQP
|... .| .                     |.  |     . ||||| |      || . . |.||.||.. ||.||.|
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP
Kinase 94583.m00019.AA TyrKc 105-394 20 3.8e-12 -26.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 105-394
Range on HMM: 1-280/280
Sequence Identity: 20% (68 aa)

YQQLQFLGRGSFGTVIKCYDHKLKMNVAIKVLTESDDDNFLINREINFLKIL--NKEEEKSNSSNILELIDTFRQH-------GFTFIVTKYFEE-NLYE
 . .. ||.| ||.| |.      ..||.|.| |.      . ||.. .. |  . .       ||. |.   .|.       .  .||. | .  .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YI-TNQSFSQNLSLHDIKRIAKSVAQALYTCHQCGIIHSDLKPENVVLNGNE-VRLIDFGCASFTGET-------VYQTV----QS-----LYYRAPEVI
|.  ..     |.. |   ..  .|.     |. ..|| ||   |. .. |  |.  ||| . . ..         | ..    ..     .   |||.|
YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

FQKGFGSSIDVWSFGCLLFEMVT-GQPLFLV-----RNEGELISQIKRILGDPSYEM---IQQSNKMRRYWFRKQLIRDTTGSLKRSFIGSYVRNSNKEI
. . | .  |||||| ...|. | ||.          .  |.| ..|.    |  .    .                          |         .|.
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F-----VCCPDEM

IDLISSCLTWDPKERPSMREILDSPFF
 .....|   ||..||...||    .|
YQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 94583.m00019.AA STE 365-394 37 1.8e-07 22.59 In-house 328-359 (359) Show / Hide 
Range on Protein: 365-394
Range on HMM: 328-359/359
Sequence Identity: 37% (12 aa)

KEIIDLISSCLTWDPKERPSMREILD--SPFF
.| .| |. ||. ||..||.  . |    ||.
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 94583.m00019.AA Pkinase_Tyr 272-299 50 1.5e-05 19.44 Pfam 182-209 (270) Show / Hide 
Range on Protein: 272-299
Range on HMM: 182-209/270
Sequence Identity: 50% (14 aa)

APEVIFQKGFGSSIDVWSFGCLLFEMVT
|||.|. . | .  |||||| |..|..|
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase 94583.m00019.AA Pkinase_Tyr 105-142 30 0.000345 14.81 Pfam 1-42 (270) Show / Hide 
Range on Protein: 105-142
Range on HMM: 1-42/270
Sequence Identity: 30% (13 aa)

YQQLQFLGRGSFGTVIKCYDH----KLKMNVAIKVLTESDDD
 . .. ||.|.||.| |.. .    . |. ||.|.| |. ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMH
Kinase 94583.m00019.AA DYRK1 369-394 42 0.005667 5.71 In-house 296-321 (321) Show / Hide 
Range on Protein: 369-394
Range on HMM: 296-321/321
Sequence Identity: 42% (11 aa)

DLISSCLTWDPKERPSMREILDSPFF
|||   | .|||.| .  ..|  .||
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase 94583.m00019.AA HIPK 365-394 30 0.011698 3.64 In-house 300-329 (329) Show / Hide 
Range on Protein: 365-394
Range on HMM: 300-329/329
Sequence Identity: 30% (9 aa)

KEIIDLISSCLTWDPKERPSMREILDSPFF
.| ...    .|||...| .  | |..|| 
REFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 94583.m00019.AA Pkinase_Tyr 365-394 36 0.048994 7.52 Pfam 243-270 (270) Show / Hide 
Range on Protein: 365-394
Range on HMM: 243-270/270
Sequence Identity: 36% (11 aa)

KEIIDLISSCLTWDPKERPSMREILDSPFF
.|| ||. .|  .||..||...||    ..
DEIYDLMKQCWHYDPEDRPTFSEI--HEQL