Gene 92853.m00143 (T.vaginalis)

92853.m00143

Species: T.vaginalis
Alias: TvagK0665, 92853.m00143
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
92853.m00143.AA Protein None 414 None Fasta, JSON
92853.m00143.kin_dom Protein Kinase Domain None 296 None Fasta, JSON

Protein domain

Protein domains of 92853.m00143.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92853.m00143.AA DYRK 117-412 36 2.1e-102 346.51 In-house 1-320 (320) Show / Hide 
Range on Protein: 117-412
Range on HMM: 1-320/320
Sequence Identity: 36% (118 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHLQLN--GENHHILHYIDVFQFRSFFCIVMELLGQNLHSVLSDNGHKSL-
|. |...|.|||| |.|| ||||.. ||||.|.  |. |.|   |. ||..|  .   ...|..|. | |..| ..||| ||| .||. .|  |. . . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

ALPMIKTIAYQLGNAIQYMHES-NIIHCDIKPDNVLFSQV-RKTSLRVIDFGCSCWVGKTMYEYIQSRFYRAPEVILNLKYSTGIDVWSYGCVLFEIANG
 |  ....|.|. ... ..|.. ||||||.||.|..  |   |  . ||||| || .....| |||||||||||||| ..|.. ||.|| ||.| |.  |
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

RPLFMPDNEEELFHMMIEALGSPPDYLVAKA-------------GKYCDFLGPYKK-------IEPYQNKKTGKLYFPLALPFEKRITHMSESYIDVIKA
 |||  .|| ... ...| || ||  .. |.               .||     .|       ... ..|. |. . |   ... |..   . ..| || 
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKK

CLTWDHEKRPSMAEILKMPYF
||.|| .||.. .. |. | |
CLQWDPHKRITPSQALQHPWF
Kinase 92853.m00143.AA DYRK2 117-412 35 4.1e-96 313.08 In-house 1-318 (318) Show / Hide 
Range on Protein: 117-412
Range on HMM: 1-318/318
Sequence Identity: 35% (114 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHLQLN--GENHHILHYIDVFQFRSFFCIVMELLGQNLHSVLSDNGHKSLA
|  | ..|.||||.|.||.||||.| ||||.|   |. |.| . |. ||.|.  .   ... . |  | | || ..||. |||. || . .  |  . ..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LPMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLFSQVRKTSLRVIDFGCSCWVGK-TMYEYIQSRFYRAPEVILNLKYSTGIDVWSYGCVLFEIANGRP
|  .   |... ....  |. |||||| || |.|  |  . .. ||||| || .    .| |||||||||||||| .||.. || || ||.. |.  | |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFMPDNEEELFHMMIEALGSPPDYLVAKA----GKYCDFLGP--------------YKKIEPYQNKKTGKLYFPLALPFEKRIT-HMSESYIDVIKACLT
||  .|| . | .|.| || ||  .. ..     .. .   .               ..|..  .. .|| . | . .. . ..   .|..|| || |..
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WDHEKRPSMAEILKMPYF
|| ..| . ...|| |..
WDPSERMTPSQALKHPWI
Kinase 92853.m00143.AA CMGC 117-412 18 1.4e-95 314.54 In-house 1-513 (513) Show / Hide 
Range on Protein: 117-412
Range on HMM: 1-513/513
Sequence Identity: 18% (97 aa)

YQQLQILGQGSFGSVIKCLD--------------HKTHQTVAIKVIKDSKKTHKQMV-------------LELDILKHLQLNG------------ENHH-
|. .. .|.|..| | || |              |.| . |||| ||  .  . |.               |. |||||. |.            ..|. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ILHYIDVFQFRS-----------------FFCIVMELLGQNLHSVLSDNGH--------------------------KSLALPMIKTIAYQLGNAIQ--Y
|.. .|.|...                   ...|.|.....|. .. .| .                          |.. .  |. ..||. ...   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

MHESN--IIHCDIKPDNVLFSQ------------------VRKTSLRVIDFGCSCWVGKT------------------------MYEYIQSRFYRAPEVI
.|  .  |||.|.|| |.|...                  . .  |...||| ..|...                         ...|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNLK----------YSTGIDVWSYGCVLFEIANG--------RPLFMPDNE-----------EELFHMMIEALGSPPDYLVAKA---------GK-----
|. |          |.|.||.|| ||...|. .|        .||| ...|            .  ..... ||.|. ..  |.          .     
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

---------------------YCDFLGPYKKI---EPYQNKKTGKLYFPLALP----------FEKRIT-----------------HMSESYIDVIKACL
                     ...|   |...    | ...|. |  || . .          | ..                   ....  || .| .|
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML

TWDHEKRPSMAEILKMPYF
..|..||.. ...|..|||
QYDPDKRITAEQALQHPYF
Kinase 92853.m00143.AA S_TKc 117-412 25 3.1e-85 290.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 117-412
Range on HMM: 1-231/231
Sequence Identity: 25% (78 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHLQLNGENHHILHYIDVFQFRSFFCIVMELLGQ---NLHSVLSDNGH---
|. |...|.|.||.| || ..||.. ||||.||      ...  |..|||.        .| ...||||  .....|||....   .|.... ..|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KSLALPMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLFSQVRKTSLRVIDFGCSCWVGKTMYEYIQSRFYRAPEVILNLKYST-GIDVWSYGCVLFEI
 . .   ... ..||. .|..|.|. .|||.|.||.|.|...     . ..||| .. .    . .. ...|.||||.   .|..  .|.|| ||.|.| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ANGRPLFMPDNEEELFHMMIEALGSPPDYLVAKAGKYCDFLGPYKKIEPYQNKKTGKLYFPLALPFEKRITHMSESYIDVIKACLTWDHEKRPSMAEILK
. |.|.|   .....|...                                                      |.. .| |. ||..| ||||.  |.|.
LCGYPPFP--QMQMMFKKIG-----------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------MPYF
       .|.|
DEWDIKCHPWF
Kinase 92853.m00143.AA Pkinase 117-412 24 1.7e-70 245.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 117-412
Range on HMM: 1-293/293
Sequence Identity: 24% (80 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVL-----ELDILKHLQLNGENHHILHYIDVFQFRSFFCIVMELLGQNLHSVLSDN---
|. ....|.||||.| || ...| ..||.|.|| ... ... .      |. |.|.|.   .|  |. ..|.|. ..  ..|||...  |. |..     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPN--IVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYI

---GHKSL--ALPMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLFS--QVRKTSLRVIDFGCSC---WVGKTMYEYIQSRFYRAPEVIL-NLKYSTGID
    |...      .| ..||.  ...|.|. .|||.|.||.|.|..   . .......|||...   . .  |. .  ...|.|||||. . .|.. .|
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSYGCVLFEIANGRPLFMPD------NEEELFHMMIE-ALGSPPDYLVAKAGKYCDFLGPYKKIEPYQNKKTGKLYFPLALPFEKRITHMSESYIDVIK
.||.||.|.| ..|||.|  .      .. ... .  .  | .. ...  .   . ..  . .                    .... . .||. .|.||
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------F-HWTF-HNWSEECKDFIK

ACLTWDHEKRPSMAEILKMPYF
 ||..| .|||. ..||. |.|
WCLCKDPKKRPTAEQILQHPWF
Kinase 92853.m00143.AA DYRK1 117-344 38 6.2e-66 225.36 In-house 1-232 (321) Show / Hide 
Range on Protein: 117-344
Range on HMM: 1-232/321
Sequence Identity: 38% (90 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHLQLNGENH--HILHYIDVFQFRSFFCIVMELLGQNLHSVLSDNGHKSLA
|.    .|.|||| |.|  ||.... ||||.||  |    |  .|. .|  .  . ...  .|.|    | ||   |.|.|||  ||  .|     .  .
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LPMIKTIAYQLGNAIQYMH--ESNIIHCDIKPDNVLFSQVRKTSLRVIDFGCSCWVGKTMYEYIQSRFYRAPEVILNLKYSTGIDVWSYGCVLFEIANGR
| ... .| |.. |. .|   | .|||||.||.|.|    ..  ...|||| || .|. .|.||||||||.|||.|...|.. ||.|| ||.| |.  | 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFMPDNEEELFHMMIEALGSPPDYLVAKAGK
|||   || . .. ..| || ||.... .| |
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPK
Kinase 92853.m00143.AA HIPK 117-344 34 4.1e-55 171.77 In-house 1-232 (329) Show / Hide 
Range on Protein: 117-344
Range on HMM: 1-232/329
Sequence Identity: 34% (81 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHL-QLNGENHHILHYIDVFQFRSFFCIVMELLGQNLHSVLSDNGHKSLAL
|  | .||.| || |.||  . |.  ||||..|.     .|   |. ||. | |.| .. |..   ..|. .. .|.| |.| |||.  . .|    | |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

PMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLFSQVRKTSLR--VIDFGCSCWVGKTMYE-YIQSRFYRAPEVILNLKYSTGIDVWSYGCVLFEIANGR
 .|..|  |   |.  . |  .|| |.||.|..     .   |  |||||    | |.  . |.|||.|||||.|| |..   .|.|| |||. |   |.
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLFMPDNEEELFHMMIEALGSPPDYLVAKAGK
||.   .| ..   ...  . | ..|. .| |
PLYPGADEYDQIRYICQTQHLPHEHLLHAACK
Kinase 92853.m00143.AA YAK 117-315 38 3.9e-54 182.14 In-house 1-205 (347) Show / Hide 
Range on Protein: 117-315
Range on HMM: 1-205/347
Sequence Identity: 38% (78 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHL----QLNGEN--HHILHYIDVFQFRSFFCIVMELLGQNLHSVLSDNGH
|  | .|||| || |.||    |   .|.||||       |  .|  ||. |      |..|   |||  .| | ..  ||.| |.|  ||   |  |  
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KSLALPMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLFSQVRKTSLRVIDFGCSCWVGKTMYEYIQSRFYRAPEVILNLKYSTGIDVWSYGCVLFEIAN
. .   .|..   |   ..    ...||||| || |..  .. |  ...|||| ||   |..| |||.|.||.||.|.   |.| || || ||.. |   
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GRPLF
| |.|
GLPIF
Kinase 92853.m00143.AA CAMK 122-412 18 9.1e-49 154.86 In-house 1-425 (425) Show / Hide 
Range on Protein: 122-412
Range on HMM: 1-425/425
Sequence Identity: 18% (85 aa)

ILGQGSFGSVIKCLDHKTH------------QTVAIKV-------------------IKDSKKTH----------KQMVLELDILKHLQLNGE---NHHI
.||.|||| | .| . .|             | ||||.                   |..||. |          |..  |..|.|.|| .|.     .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LHYIDVFQ-----------------FRS---FFCIVM---ELLGQN-----LHSVLSDNGH-------------KSLALPMIKTIAYQLGNAIQYMHESN
.. ..|..                 | .   ....||   |.         | . . ..|.             . .     ...  |.  |..|.|. |
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHCDIKPDNVLFSQVRKTS---------------LRVIDFGCSCWV--------------------------GKTMYEYIQSRFYRA-PEVILN-----
|.|.|.||.|.|...  . |               . .|||| .. .                          |. |...  .  | | |||..      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LKYSTGIDVWSYGCVLFEIANGRPLFMPD-------------NEEELFHMMIEALGS-PPDYL--------------VAKAGKYCDFLGPY
           |.  .|.|| |..|.    |.| |  |             |..|||.. ...  . ||.|.              . .           
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE----------

KKIEPYQNKKTGKLYFPLALPFEKRITHMSESYIDVIKACLTWDHEKRPSMAEILKMPYF
                     | ..  . |.. .| |. .|. | |||.. ...|. | .
---------------------F-HH--FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 92853.m00143.AA DyrkP 117-339 34 1.8e-44 143.98 In-house 1-229 (323) Show / Hide 
Range on Protein: 117-339
Range on HMM: 1-229/323
Sequence Identity: 34% (79 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHLQLNG--ENHHILHYIDVFQFRSFFCIVMELLGQNLHSVLSDN----GH
|| .  ||   |   |.|.| .| | . .|.|   |    | . |. .|. .  ||  .   .|.| | |  .    |. ||| .||      |      
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

KSLALPMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLFSQVRKTSLRVIDFGCSCWVGKTMYEYIQSRFYRAPEVILNLKYSTGIDVWSYGCVLFEIAN
.   .  .. |  |.  |. |.|   .||||.||.|.|     |   ..|||| ||..   .  |.||| |||||||.  ||   ||.|| ||.| |.  
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GRPLFMPDNEEELFHMMIEALGSPPDYLV
|  ||  ||   |   .|  .|  |....
GNVLFQNDNIQGLLARVIGIIGPFPEWMM
Kinase 92853.m00143.AA Ciliate-E2-Unclassified 117-412 21 2.6e-44 151.59 In-house 1-352 (352) Show / Hide 
Range on Protein: 117-412
Range on HMM: 1-352/352
Sequence Identity: 21% (82 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMV-------LELDILKHLQ---------------LNGENHHILHYIDVFQFRSFFCIVM
|  ....|||.||.| || . |. |  |.| .|.... ... .       .|..... ..               ||  . .|......|| .  ..|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELL-GQNLHSVLSDNGH---------------KSLALPMIK-----TIAYQLGNAIQYMHESN-IIHCDIKPDNVLFSQVR-KTSLRVIDFGCS------
|.. |..|.  ......               | .    .|     ....|. ....|.|..| ||| ||||.|.||..   .  ...|||| |      
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------CWVGKTMYEYIQSRFYR----APEVILNLKYS----TGIDVWSYGCVLFEIANGRPLFMPDNEEELFHMMIEALGSPPDYLVAKAGKY
             |  . |.  ...  |     ||||. . .|.      .|.|| |..|.|.  |.. |   |.|. . . .. .    .         
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N--N---------

CDFLGPYKKIEPYQNKKTGKLYFPLALP--FEKRITHMSESYIDVIK----ACLTWDHEKRPSMAEILKMPYF
  .     . . |||.| ....|| . .  .     | |....| |.     .| .. .||... .||. |.|
--A----YRKQLYQNIKQKNIQFPKFPWQQIP---KHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 92853.m00143.AA CLK 117-249 28 3.9e-34 99.19 In-house 1-147 (350) Show / Hide 
Range on Protein: 117-249
Range on HMM: 1-147/350
Sequence Identity: 28% (42 aa)

YQQLQILGQGSFGSVIKCLDHKT-HQTVAIKVIKDSKKTHKQMVLELD-ILKHLQLN----GENH-HILHYIDVFQF-RSFFCIVMELLGQNLHSVLSDN
|  .  ||.| || | .| |||   . ||.|.|.  .|   .  .|.. |.|... .    . .  |... .| | .    .|||.||.| .. ... .|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G------HKSLALPMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLF
.       ... .  |. .|||| .|.. .|.  ..| | || | .|
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase 92853.m00143.AA TyrKc 117-412 19 4.2e-16 37.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 117-412
Range on HMM: 1-280/280
Sequence Identity: 19% (66 aa)

YQQLQILGQGSFGSVIKCLDHKTHQTVAIKVIKDSKKTHKQMVLELDILKHLQLNG-ENHHILHYIDVFQFR-------SFFCIVMELLGQ-NLHSVLSD
 . ...|| | || | |.      ..||.|..|...  .. .  |. |...|   | .. .|.  . |              .||||.    .|.. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NGHKSLALPMIKTIAYQLGNAIQYMHESNIIHCDIKPDNVLFSQVRKTSLRVIDFGCSCWVGKT-MY----EYI------QSR-----FYRAPEVILNLK
...| | ..    ...|  .  .| |. |.|| |.   |.| .  .    .. ||| |  ..   .     .|.      ...        |||.|   |
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSTGIDVWSYGCVLFEIA-NGRPLFMP-----DNEEELFHMMIEA--LGSPPD----YLVAKAGKYCDFLGPYKKIEPYQNKKTGKLYFPLALPFEKRIT
..|  ||||.| ...||  .| .          . .|...   .   .  ||.                                         |     
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------F----V

HMSESYIDVIKACLTWDHEKRPSMAEILKMPYF
....   ...| |   | |.||...||    .|
CCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 92853.m00143.AA CLK 250-334 39 1.2e-15 42.7 In-house 179-266 (350) Show / Hide 
Range on Protein: 250-334
Range on HMM: 179-266/350
Sequence Identity: 39% (35 aa)

SQVRKTSLRVIDFGCSC---WVGKTMYEYIQSRFYRAPEVILNLKYSTGIDVWSYGCVLFEIANGRPLFMPDNEEELFHMMIEALGSP
..|  |  .|||||            .. ...| |||||||| | .|.  |||| ||.|||   |  ||   .. |   || . .| |
WHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase 92853.m00143.AA Pkinase_Tyr 117-242 24 5.8e-10 34.37 Pfam 1-137 (270) Show / Hide 
Range on Protein: 117-242
Range on HMM: 1-137/270
Sequence Identity: 24% (34 aa)

YQQLQILGQGSFGSVIKCLDH----KTHQTVAIKVIKDSKKTHKQ-----MVLELDILKHLQLNGENHHILHYIDVFQ-FRSF--FCIVMELLGQ-NLHS
 . .. ||.|.||.| |.  .    .|...||.|..|. . .|.|     .  |. |.|.|   | ...|. .. |    .     .||||.    .|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQL---GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

VLSDN--GHKSLALPMIKTIAYQLGNAIQYMHESNIIHCDI
 | ..  . ..| ....  ...|  .. .| .. |.|| |.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 92853.m00143.AA Pkinase_Tyr 283-308 50 3e-06 21.95 Pfam 182-207 (270) Show / Hide 
Range on Protein: 283-308
Range on HMM: 182-207/270
Sequence Identity: 50% (13 aa)

APEVILNLKYSTGIDVWSYGCVLFEI
|||.| . |..|  ||||.| ...||
APECINYGKFTTKSDVWSFGVLMWEI
Kinase 92853.m00143.AA DyrkP 385-412 39 3.1e-05 12.46 In-house 296-323 (323) Show / Hide 
Range on Protein: 385-412
Range on HMM: 296-323/323
Sequence Identity: 39% (11 aa)

YIDVIKACLTWDHEKRPSMAEILKMPYF
.|| .. ||  |  .||.  | |. |.|
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 92853.m00143.AA CLK 383-412 30 3.3e-05 10.79 In-house 321-350 (350) Show / Hide 
Range on Protein: 383-412
Range on HMM: 321-350/350
Sequence Identity: 30% (9 aa)

ESYIDVIKACLTWDHEKRPSMAEILKMPYF
.. .| |. .|  |  ||.. ...|. |.|
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 92853.m00143.AA HIPK 384-412 34 0.000194 9.35 In-house 301-329 (329) Show / Hide 
Range on Protein: 384-412
Range on HMM: 301-329/329
Sequence Identity: 34% (10 aa)

SYIDVIKACLTWDHEKRPSMAEILKMPYF
....| |. .||| .|| . .| |. |. 
EFVHVLKKMCTWDAHKRITPCEALNHPFV