Gene 92757.m00246 (T.vaginalis)

92757.m00246

Species: T.vaginalis
Alias: 92757.m00246, TvagK0605
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CRK7-like

Sequence

Name Sequence Type Origin Length Description Download
92757.m00246.AA Protein None 373 None Fasta, JSON
92757.m00246.kin_dom Protein Kinase Domain None 317 None Fasta, JSON

Protein domain

Protein domains of 92757.m00246.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92757.m00246.AA CDK 10-326 29 2e-99 318.78 In-house 1-284 (284) Show / Hide 
Range on Protein: 10-326
Range on HMM: 1-284/284
Sequence Identity: 29% (107 aa)

YTLIAGISSGTCGDVLKAHRKKTG-----EIVAVKRIKILNQ----A-VGFPPNSLQEISILRSLNHPNIARLIEVCTES-----------HHVYLVFSY
|  .. |  ||.| | ||  |.||     .||| |.|.. |.    .  |||  .. |||.|. | |||| .|..||. .           . .|.|| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

YEYDMYGLLYNHNLNLTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNN-----LQITDFGLATTNT---------NCSTNGVITIWYRPPE
 ..| ....           ..|| .||| |.  ||...|.||||||.|.|.|.  .     | |.|||||             .. |. |.| |||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ILLGKQGYG--KEIDIWSAGCIIYEMIT---HEVLFRSNLDQEADQLKAIFDIAGLP-DQQWPEWKKLPNAELFARKIVSEGKILLESTVDDEQHREFVI
.||| . |.   .||.||.|||..||.|    . ||  . .   |||. ||.| | | ...||...|||.                              
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE--IDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------------

DPEIVNRYSNRDLKNYIERRIKAKGEEYKAAIPLILSMLQFNPKVRLTADKCLENDFL
                                 |. .||...|| |..|. .|. ...
--------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 92757.m00246.AA CMGC 10-326 22 1.3e-93 307.92 In-house 1-513 (513) Show / Hide 
Range on Protein: 10-326
Range on HMM: 1-513/513
Sequence Identity: 22% (120 aa)

YTLIAGISSGTCGDVLK--------------AHRKKTGEIVAVKRIK---ILNQAV------GFPPNSLQEISILRSLN-----------------HPNI
|. |  | .|| | | |              || ..|.||||.|.||     .||       |||  .| ||.||. ||                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

ARLIEVCTESH-----------------HVYLVFSYYEYDMYGLLYNHN--------LNLTIDQ------------VRCYS------RQLLLGVK--ACH
 .|..... ..                 |.|||| | ..| |....|..        ..|.  .            .....      .|.| |.|   ||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DKN--ILHRDLKPANLLVNRGNNL--------------------QITDFGLAT-TNTN-----------------------CSTNGVITIWYRPPEILLG
 ..  |.||||||.|.|.|  . |                     | |||||. ....                         |. | | |||.||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

K---------QGYGKEIDIWSAGCIIYEMIT--------HEVLFRSNLDQ---------EADQLKAIFDIAGLP----------------DQQWPEWKKL
          ..|...||.||.|||..||.|        .. ||  . ..         . |||. ||.. | |                ...||...||
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PNAEL----------------FARKIVSEGKILLESTVDDEQHREFVIDP----------------EIVNRYSNRDLKNYIERRIKAKGEEYKAAIPLIL
|. ..                |||. .. .. . .    . .  .  ...                | .... .    |    .. ..  . . || |. 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSH-K--F-N----HQFKRKCCDPQAIDLLK

SMLQFNPKVRLTADKCLENDFL
 |||..|. |.||. .|. ...
KMLQYDPDKRITAEQALQHPYF
Kinase 92757.m00246.AA S_TKc 10-326 25 1.2e-86 295.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-326
Range on HMM: 1-231/231
Sequence Identity: 25% (84 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQAVGFPPNSLQEISILRSLNHPNIARLIEVCTESHHVYLVFSYYEY---DMYGLLYNHNLN---
|...  | .|. | | |.. ||||.|||.|.||          . ..||.||.. .|||| .|..|. . .|.|.|. | .    |.. .. ... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLATTNTNCSTNGVITIWYRPPEILLGKQGYGK-EIDIWSAGCIIYEMIT
  ..  ..|.| .|...... ||...|.||||||.|.|...  .. |.|||||.      |  . | ||..||.|    |||| ..|.|| |||.|||..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC

HEVLFRSNLDQEADQLKAIFDIAGLPDQQWPEWKKLPNAELFARKIVSEGKILLESTVDDEQHREFVIDPEIVNRYSNRDLKNYIERRIKAKGEEYKAAI
 . .|.        |....|.. |                                                                        . |.
GYPPFP--------QMQMMFKKIG-----------------------------------------------------------------------SPEAK

PLILSMLQFNPKVRLTADKCLE-------NDFL
 .|  .||..|. |.|| ..|.         ..
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92757.m00246.AA CDC2 10-237 39 1.3e-75 231.73 In-house 1-240 (301) Show / Hide 
Range on Protein: 10-237
Range on HMM: 1-240/301
Sequence Identity: 39% (96 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQAVG--FPPNSLQEISILRSLN-HPNIARLIEVCTESHHVYLVFSYYEYDMYGLLY---NHNLN
|. |  |  || | | |.  ..|..|||.|.|.. ..  |  .|  .. |||.|  |. |||| .| .|  . . .|.|| |...|   ..      | .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLA---TTNTNCSTNG--VITIWYRPPEILLGKQGYGKEIDIWSAGCIIYEM
.. . |. |  |.| ||  || . |.|||||| |.|...  |..| |||||   ... .  | .  |.| |||.||||||.. |  ..|.|| |||..||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ITHEVLFRSNLDQEADQLKAIFDIAGLPD-QQWPEWKKLP
   .| . ||    | | |||  || | | |. | ||. ..||
FMDVTKKPLFHG--DSEIDQLFKIFRILGTPNEQTWPGVTQLP
Kinase 92757.m00246.AA Pkinase 10-326 28 2.8e-73 254.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-326
Range on HMM: 1-293/293
Sequence Identity: 28% (95 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQAVGFPPNSLQ--EISILRSLNHPNIARLIEVCTESHHVYLVFSYYEY-----DMYGLLY-NHN
|...  | ||. | | |.|.|.||.|||||.||  ..  ... . .   ||.|...|||||| ||....... |.|.|. | |      | . ..    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

LNL--TIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNL----QITDFGLA----TTNTNCSTNGVITIWYRPPEILLGKQGYGKEIDIWSA
 ..  . .....| .|.| |.. ||...|.||||||.|.|... ...     |.|||||    . |    |  . |.||..||...| |.||...|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIIYEMITHEVLFRSNL---DQEADQLKAIFDIAG-LPDQQWPEWKKLPNAELFARKIVSEGKILLESTVDDEQHREFVIDPEIVNRYSNRDLKNYIER
|||.|||.. . .|. .    |  .||.. |. | |  .. .||.|   .. . | .   .                                     . 
GCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------------------------------F-

RIKAKGEEYKAAIPLILSMLQFNPKVRLTADKCLENDFL
. .   .  .... .| ..|...|| |.||. .|. ...
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 92757.m00246.AA CRK7 10-237 37 7.3e-71 241.73 In-house 1-284 (343) Show / Hide 
Range on Protein: 10-237
Range on HMM: 1-284/343
Sequence Identity: 37% (107 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQ---AVGFPPNSLQEISILRSLNHPNIARLIEVCTE--------SHH--VYLVFSYYEYDMYGL
| .|. | .|| | | ||  |.|||.|| |...  |      |||  .  || |||.|||.|| .| |. |.        .|   .|.|| |   |. ||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LYNHNLN-LTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLATTNTNCS-----TNGVITIWYRPPEILLGKQGY--------
| .  .     .|..|. .|||.|.  ||.||.||||.| .|.|.|   .. |.|||||      .     || ||| |||||| ||| . |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------GKEIDIWSAGCIIYEMITHEVLFRSNLDQEADQLKAIFDIAGLPD-QQWPEWKKLP
                              |.|||.|| |||  |  | . .|. |  .| .||  |. | | |  . |||  |||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGN--NEMAQLEKIYKICGSPNPNNWPEVMKLP
Kinase 92757.m00246.AA CDK5 10-238 39 1.8e-69 218.52 In-house 1-232 (287) Show / Hide 
Range on Protein: 10-238
Range on HMM: 1-232/287
Sequence Identity: 39% (93 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQAVGFPPNSLQEISILRSLNHPNIARLIEVCTESHHVYLVFSYYEYDMYGLLYNHNLNLTIDQV
|  .  |  || | | ||  |.|.|||| ||... .   | |   . ||..|. | |.|| ||. |        ||| .   |.   . . | ..  . .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLATTN---TNCSTNGVITIWYRPPEILLGKQGYGKEIDIWSAGCIIYEMI-THEVLF
. .  ||| |.  ||....||||||| |||.|.  .|   |||||       .| .  |.| ||||| .|.| . |   ||.||.|||. ||. .   ||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

RSNLDQEADQLKAIFDIAGLP-DQQWPEWKKLPN
  |  .. |||| ||.| | |   .||   |||.
PGN--DVEDQLKRIFKIMGTPCEDKWPSITKLPD
Kinase 92757.m00246.AA CDK-DD1 10-238 39 2.4e-69 213.09 In-house 1-232 (379) Show / Hide 
Range on Protein: 10-238
Range on HMM: 1-232/379
Sequence Identity: 39% (93 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQAVGFPPNSLQEISILRSLNH-PNIARLIEVCTES-HHVY-LVFSYYEYDMYGLLYNHNLNLTI
|  |  . .|. | | || .| | ..|| |..| .||  | |     |.. |  | | .||  ||.  .     .| .|| | |.|  ... ||.  ...
YQIISKCGQGIYGSVFKAIHKITHCMVALKNFKDWNQEDGEP---KVECKYLMQLRHCKNIVHLIDHFYNFKNSKYVMVFEYFEHDLWKFMSNHQCYMSL

DQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLATTNTN-----CSTNGVITIWYRPPEILLGKQGYGKEIDIWSAGCIIYEMITH
 .. |. .||| |.. ||   | ||| ||||||.|    | |||||..|  |.      | . |.. |||||| |.|   || |||.|| |||. |||| 
PCIKCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFTTYYTKRSEKHFSHQ-VVSLWYRPPELLMGSCQYGPEIDMWSVGCILMEMITN

EVLFRSNLDQEADQLKAIFDIAGLP-DQQWPEWKKLPN
  .|    .|   || .|.   | | .  ||   .|..
FYMFAGSNEQQ--QLELICKLCGCPTEKNWPGVSQLQG
Kinase 92757.m00246.AA PITSLRE 10-242 39 3.5e-57 196.28 In-house 1-243 (295) Show / Hide 
Range on Protein: 10-242
Range on HMM: 1-243/295
Sequence Identity: 39% (96 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKIL--NQAVGFPPNSLQEIS-ILRSLNHPNIARLIEVC--TESHHVYLVFSYYEYDMYGLLYNHN---
.  .  |  || | | .|  |.|.|||| ||.|.       |||  || ||. ||. |.||||  . |.   .    .|.|. | | |. .|. |..   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

LNLTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLA---TTNTNCSTNGVITIWYRPPEILLGKQGYGKEIDIWSAGCIIYEM
   .. .. |   |||.||.  ||. |.||||| .||| .   .| | |||||     .    | .|.| ||| ||.||| . |   .|.|| |||  |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ITHEVLFRSNLDQEADQLKAIFDIAGLPD-QQWPEWKKLPNAELF
|| ..||  .   | ||.. ||   | |  . || |..||.. ..
ITMKPLFQGK--SEIDQINCIFKEMGTPTEKIWPGWTELPHWKMM
Kinase 92757.m00246.AA Ciliate-E2 10-326 17 7.6e-53 179.72 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-326
Range on HMM: 1-365/365
Sequence Identity: 17% (79 aa)

YTLIAGISSGTCGDVLKAHRKKTGE-----------------------IVAVKRI-----KILNQAVGFPPNSLQEIS----------ILRSLNHPNIAR
| .|  | .|. |.| |. ..|...                       |.|.|..     ....|      . ..||           ||..|||||| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEI----HIMREINCFYKKINEKNILEQLNHPNIIK

LIEVCT--ESHHVYLVFSYYEY-DMYGLLYNHNLN----------LTIDQVRCYSRQLLL---------------GVKACHDKN-ILHRDLKPANLLVNR
..|.      ...|||. |... |.. ...|....          .|. ... ...|.|                ... .| || |.|||.|| |.|.  
MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

GNNLQITDFGLATTNTNCSTNGVI----------------------------------TIWYRPPEILLGKQ--------GYGKEIDIWSAGCIIYEMIT
   . |.||||.. ..... |. .                                  |  | .|||| ||.        ||....||||.|.|.|||..
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

HEVLFRSNLDQEADQLKAIFDIAGLPDQQWPEWKKLPNAELFARKIVSEGKILLESTVDDEQHREFVIDPEIVNRYSNRDLKNYIERRIK----------
 .  |                                                                           ... ..  |.          
GKPPF---------------------------------------------------------------------------QQQIKQCKIDFPCPEWQKDT

--------AKGEEYKAAIPLILS----MLQFNPKVRLT-ADKCLENDFL
         . .  . .. ||      ||| .|. |.| ....|.. ..
QCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 92757.m00246.AA CDK4 10-231 35 9e-52 175.81 In-house 1-234 (290) Show / Hide 
Range on Protein: 10-231
Range on HMM: 1-234/290
Sequence Identity: 35% (85 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQAV--GFPPNSLQEISILRSL---NHPNIARLIEVCTESHHVY------LVFSYYEYDMYGLLY
| ..| | .|  | | .|   .|| .|| |...| ..    | |   . |||..| |   .|||| .|..||. .  .       .||   . |   .| 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

NHNL-NLTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLATT--NTNCSTNGVITIWYRPPEILLGKQGYGKEIDIWSAGCII
.     .   ...  ..||| ||   |   | |||||| |.||..   . ..||||| .  ..   |  |.|.||| ||.||  . |   .|.||.|||.
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCIF

YEMITHEVLFRSNLDQEADQLKAIFDIAGLP-DQQWP
 ||     ||. .   |.|||  |||. |||  ..||
AEMYCRRPLFCGQ--SEKDQLHKIFDVMGLPPEDDWP
Kinase 92757.m00246.AA CDK9 10-200 38 1.4e-49 169.15 In-house 1-221 (340) Show / Hide 
Range on Protein: 10-200
Range on HMM: 1-221/340
Sequence Identity: 38% (84 aa)

YTLIAGISSGTCG-----------DVLKAHRKKTGEIVAVKRIKILNQAVGFPPNSLQEISILRSLNHPNIARLIEVC-------TESHH---VYLVFSY
|  .| |  || |            | ||  ||.. .|| |..   |   |||   | || .|  | |.|.  |||.|       . .     .|||| .
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFDF

YEYDMYGLLYNHNLNLTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLA-------TTNTNC--STNGVITIWYRPPEILLGK
 | |. ||| | |  ..   ..   ..|. |    |   |||||.| || |. .   |   |||||           |    || |.| |||||| ||| 
CEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGD

QGYGKEIDIWSAGCIIYEMIT
  ||  ||.| ||||  || |
RNYGPPIDMWGAGCIMAEMWT
Kinase 92757.m00246.AA Pkinase_Tyr 10-154 31 4.6e-15 51.63 Pfam 1-158 (270) Show / Hide 
Range on Protein: 10-154
Range on HMM: 1-158/270
Sequence Identity: 31% (51 aa)

YTLIAGISSGTCGDVLKAHRK----KTGEIVAVKRIKILNQAVGFPPNS------LQEISILRSL-NHPNIARLIEVCT-ESHH--VYLVFSYYEY-DMY
 |..  . .|  |.| |.. |    .|.  |||| .|      |  .        ..|..|...| .|||| ||. ||| .. .  .|.|. | .. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

GLLYNH---NLNLTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLA
  | .|   . .||. .  ....|   |    ..||. ||||   | ||...|   |.|||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 92757.m00246.AA TyrKc 10-246 20 4e-12 -26.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-246
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YTLIAGISSGTCGDVLKAHRKKTGEIVAVKRIKILNQAVGFPPNSLQEISILRSL--NHPNIARLIEVCTES-------HHVYLVFSYYEY-DMYGLLYN
 ||.  . .|  | | |.. |   . |||| .|       |    ..|..|...|  .|||| ||. |||..       . ...|. | .. |    | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HNLNLTIDQVRCYSRQLLLGVKACHDKNILHRDLKPANLLVNRGNNLQITDFGLATTNTNC----------------STNGVITIWYRPPEILLGKQG-Y
|  .|. ..   .. |   |    |.||. ||||   | ||....   |.||||.   ..                 ...... |   .|| .  . | .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

GKEIDIWSAGCIIYEMITHEVLFRSNL---DQEADQLKAIFDIAGLPDQQWP-----------------------EWKKLPNAELFARKI
  . |.|| |  ..|. |      ..    . ..... .  .  . ..|                          . .. |. .   ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 92757.m00246.AA CDK4 297-326 30 1.6e-07 21.67 In-house 261-290 (290) Show / Hide 
Range on Protein: 297-326
Range on HMM: 261-290/290
Sequence Identity: 30% (9 aa)

KAAIPLILSMLQFNPKVRLTADKCLENDFL
| .. |.. || .|.. |..| .||. ...
KQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 92757.m00246.AA CDC2 275-326 25 5e-06 14.08 In-house 248-301 (301) Show / Hide 
Range on Protein: 275-326
Range on HMM: 248-301/301
Sequence Identity: 25% (14 aa)

RYSNRDLKNYIERRIKAKGE--EYKAAIPLILSMLQFNPKVRLTADKCLENDFL
|.   ||........| | .    . .| |. .||| .|  |..|.. |.. ..
RWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 92757.m00246.AA CRK7 297-326 40 9.7e-05 12.04 In-house 314-343 (343) Show / Hide 
Range on Protein: 297-326
Range on HMM: 314-343/343
Sequence Identity: 40% (12 aa)

KAAIPLILSMLQFNPKVRLTADKCLENDFL
|..  |   ||  .|| | ||  ||. |..
KECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 92757.m00246.AA CDK5 302-326 36 0.000927 7.22 In-house 263-287 (287) Show / Hide 
Range on Protein: 302-326
Range on HMM: 263-287/287
Sequence Identity: 36% (9 aa)

LILSMLQFNPKVRLTADKCLENDFL
|   |||.||. |..|.. |.  . 
LLQKMLQCNPNQRISAKAALHHPYF
Kinase 92757.m00246.AA PITSLRE 306-326 42 0.001302 9.27 In-house 275-295 (295) Show / Hide 
Range on Protein: 306-326
Range on HMM: 275-295/295
Sequence Identity: 42% (9 aa)

MLQFNPKVRLTADKCLENDFL
|| .||| |.||.. |  .. 
MLTYNPKNRITASDALKHPWF
Kinase 92757.m00246.AA CDK-DD1 300-326 29 0.002416 5.5 In-house 353-379 (379) Show / Hide 
Range on Protein: 300-326
Range on HMM: 353-379/379
Sequence Identity: 29% (8 aa)

IPLILSMLQFNPKVRLTADKCLENDFL
. ||. ||  .|| |...   |.  . 
LDLIERMLTLCPKKRINTKEALQHPWF
Kinase 92757.m00246.AA CDK9 299-326 35 0.004297 6.21 In-house 313-340 (340) Show / Hide 
Range on Protein: 299-326
Range on HMM: 313-340/340
Sequence Identity: 35% (10 aa)

AIPLILSMLQFNPKVRLTADKCLENDFL
|. ||  .|   || |...|. |. |. 
ACHLIDKLLNIDPKKRMDSDEALDHDWF