Gene GL50803_137730 (G.lamblia)

GL50803_137730

Species: G.lamblia
Alias: GL50803_137730, GK047
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: IKS

Sequence

Name Sequence Type Origin Length Description Download
GL50803_137730.AA Protein None 715 None Fasta, JSON
GL50803_137730.kin_dom Protein Kinase Domain None 382 None Fasta, JSON

Protein domain

Protein domains of GL50803_137730.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_137730.AA IKS 131-276 29 1.7e-29 88.59 In-house 1-186 (360) Show / Hide 
Range on Protein: 131-276
Range on HMM: 1-186/360
Sequence Identity: 29% (54 aa)

FRQLGCIGSGSFGTVYRVRHQLNAVELGVYAIKIISVGASRPWLLKALSEVTVLEKLR--HQNIVQYHHCWAERYRTALNA----------TEETLHLFI
|. .  ||.| || ||..||  | |.|||.|.| | .|   ||. . . ||  || |   | ||. | | | |    .              ..   ..|
FKIDIKIGNGAFGSVYKCRHTINNVDLGVFAVKKIPIGNNMPWFFRCIREVKALETLTHKHRNIINYNHVWLEMDQPVDFVRSIDGSQSDSQPKVPCIYI

LLNYCKGGSLLN-LRRSVFNR---------------------------QMTEEEVLFLLFQAASGLAHLHAIGFLSRDVKLGNMLL
|  || .| |   . | .|||                            . |...  ..   . |.  || ||   ||.|  | |.
LMQYCNNGNLQDCMARKRFNRFSDTESPEERKKKFRTRKKNHGKSGEVGIPENQIWSFFRDICHGIHYLHHIGIIHRDIKPPNCLI
Pkinase GL50803_137730.AA Pkinase 131-439 17 3.6e-27 97.15 Pfam 1-207 (293) Show / Hide 
Range on Protein: 131-439
Range on HMM: 1-207/293
Sequence Identity: 17% (58 aa)

FRQLGCIGSGSFGTVYRVRHQLNAVELGVYAIKIISVGASRPWLLKAL---SEVTVLEKLRHQNIVQYHHCWAERYRTALNATEETLHLFILLNYCKGG-
.. ...|||||||.||. .|. .     ..|.|||..   ..| ....   ||. .. .|.| |||...... .             |. . . || || 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----------KDHIYMVMEYCEGGL

---SLL----NLRRSVFNRQM--TEEEVLFLLFQAASGLAHLHAIGFLSRDVKLGNMLLD--GDVPDDDPKGYISCIYNDPADFPDALTTKQRQELRYKQ
   .|            .. .  .|.|. | . | ..||...|. |.. ||.|. | |.|  |....                                 
YVMDLFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---------------------------------

RQFHTDESLREHCRQLQYIRRVGVEGLRVRIADFGQVGD-------GASAGTELYLAPELYCAISGTLQATEHASNDASGGDSMNGEDSPDLDRNFIIRD
                           .|.|.|||              .||  |.|||.       ..                               
---------------------------CVKICDFGLAKQFDYNNSMTTFCGTPWYMAPEV-------IR-------------------------------

KSFPEFVPTKPKSTQATDIYSLGISFLVLLF
        . .. ... |..|.|. .  .|.
--------GGQYYGPKVDMWSCGCILYEMLC
Kinase GL50803_137730.AA AGC 131-289 21 1.5e-23 56.35 In-house 1-194 (395) Show / Hide 
Range on Protein: 131-289
Range on HMM: 1-194/395
Sequence Identity: 21% (46 aa)

FRQLGCIGSGSFGTVYRVRHQLNA---VELGVYAIKIISVGA---SRP--WLLKALSE------------VTVLEKLR----------HQNIVQYHHCWA
|. | .|| ||||.|| ||.  .        .||.|...       .    . ....|              .|||..          |..||.      
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVK------

ERYRTALNATEET-LH--LFILLNYCK---------GG-SLLNLRRSV-FNRQMTEEEVLFLLFQ-------AASGLAHLHA-IGFLSRD-VKLGNMLLD
      |  . ..  |  |.... |..         ||  |.   . .  .. ..||.. | . .        ...| .||   |.  || .|. |.|||
-----ILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLD

GDVPDDDPKGYI
 |       |.|
ED-------GHI
Kinase GL50803_137730.AA S_TKc 131-511 16 1.4e-22 82.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 131-511
Range on HMM: 1-231/231
Sequence Identity: 16% (66 aa)

FRQLGCIGSGSFGTVYRVRHQLNAVELGVYAIKIISVGASRPWLLKALSEVTVLEKLRHQNIVQYHHCWAERYRTALNATEETLHLFILLNYCKG--GSL
.. |  ||.|.||.||..||        ..|||||.         ....|. .|.| .| |||... .. .             ||.. . || |  |.|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------------DHLYMVMEYCDGDLGDL

LNLRRSVFN----RQMTEEEVLFLLFQAASGLAHLHAIGFLSRDVKLGNMLLDGDVPDDDPKGYI-------SCIYNDPADFPDALTTKQRQELRYKQRQ
. . ..       ....| .. |.. | ...|...|  |.. ||.|  | |||           |       ....                        
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL------------------------

FHTDESLREHCRQLQYIRRVGVEGLRVRIADFGQVGDGASAGTELYLAPELYCAISGTLQATEHASNDASGGDSMNGEDSPDLDRNFIIRDKSFPEFVPT
                                         ||  |.|||.                                                 
-------------------------------------TTFCGTPWYMAPEVL------------------------------------------------

KPKSTQATDIYSLGISFLVLLFNYEEFAAATTDFGTGVAYDDYINSYKHQQDLLESISKLRSIYSAELCDLFAIMCSPDPSVRPSASAVAS--------F
 . .. . |..|.|. .  .|  |  |                     ..| ... |       | |..|.   ..  ||. ||.|  .           
-GYGKCKCDWWSCGCILYEMLCGYPPFP--------------------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

CF
 |
WF
Kinase GL50803_137730.AA CAMK 136-279 18 1.9e-20 61.93 In-house 1-215 (425) Show / Hide 
Range on Protein: 136-279
Range on HMM: 1-215/425
Sequence Identity: 18% (41 aa)

CIGSGSFGTVYRVRHQLNA-VEL--------GVYAIKIISVGA---------------------------SRPWLLKALSEVTVLEK-------LRHQNI
 .|.||||.|....| ..   |           .|||||.                              .  .. . ..|. .. |       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYHHCWAERYRTALNA----TEE------TLHLFILL---NYCKGGSLLN--LRRSVFNRQ---------------MTEEEVLFLLFQAASGLAHLHAI
.. .. .  .  .. |.    | .      . |... .    || || |.   . . | ...               .||.|. ..  | .|.....|  
IKLYEVYEDPHYFK-NTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GFLSRDVKLGNMLLDGD
.   || |. | ||| .
NIVHRDLKPENILLDDN
Kinase GL50803_137730.AA STE 131-432 15 1.9e-19 65.4 In-house 1-256 (359) Show / Hide 
Range on Protein: 131-432
Range on HMM: 1-256/359
Sequence Identity: 15% (56 aa)

FRQLGCIGSGSFGTVYRVRHQL---NAVELG----------VYAIKIISVGASR----------------PWLLKALSEVTVLEKLR--HQNIVQYHHCW
.. ...||.|.|||||. ..     .  . |          ..|||....  ..                  . . | |. .. |..  |.|||.|. | 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

AERYRTALNATEETLHLFILLNYCKGGSLLNLRRSVFNRQMT------------EEEVLFLLFQAASG-LAHLHAIGFLSRDVKLGNMLLDGDVPDDDPK
    .     ...  .|.| . |. ||||  . .... ....            |... . ..|   | |..||  .   ||.| .| ||          
FKEGHN----HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------

GYISCIYNDPADFPDALTTKQRQELRYKQRQFHTDESLREHCRQLQYIRRVGVEGLRVRIADFGQVGDGAS------------------------AGTEL
                                                         | ..|||  |  ..                        .||  
---------------------------------------------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-

YLAPELYCA-ISGTLQATEHASNDASGGDSMNGEDSPDLDRNFIIRDKSFPEFVPTKPKSTQATDIYSLGI
. |||      .|                                           ... .   ||.|||.
WMAPEVIQQNGQG-R-----------------------------------------DKGYDTKCDIWSLGC
Kinase GL50803_137730.AA TKL 137-279 21 1.1e-18 63.93 In-house 1-176 (364) Show / Hide 
Range on Protein: 137-279
Range on HMM: 1-176/364
Sequence Identity: 21% (39 aa)

IGSGSFGTVYRVRHQLNAVELG------VYAIKIISVGASRP-------------------------WLLKALSEVT-VLEKLRHQNIVQYHH-CWAERY
||||.||.||. ... . .  .      . |.|....  .                           |. . . |.. .. .|||.||||.   | ....
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

R-TALNATEETLHLFILLNYCKGGSLLNLRRSVFNRQMTEEEVLFLLFQAASGLAHLHAIG--------FLSRDVKLGNMLLDGD
.   ..   .. .|.|   ||.|||||..           .  . .  ..|.|...||. .         . || |  | |.| .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN
Kinase GL50803_137730.AA STE20 131-279 25 1.5e-17 60.95 In-house 1-153 (288) Show / Hide 
Range on Protein: 131-279
Range on HMM: 1-153/288
Sequence Identity: 25% (40 aa)

FRQLGCIGSGSFGTVYRVRH-QLNAVELGVYAIKIISVGASR---PWLLKALSEVTVLEKLRHQNIVQYHHCWAERYRTALNATEETLHLFILLNYCKGG
.  | .||.||.|.||...| . . ..   .|||....       . .   . |. .. ...|.|||.|. .                .|.|.  || ||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTC-------DDELWIVMEYCGGG

SLLNLRRSVFNRQ-------MTEEEVLFLLFQAASGLAHLHAIGFLSRDVKLGNMLLDGD
||. . . .....       |.||.. . . ..  ||..||. .   ||.| .| ||. |
SLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTED
Kinase GL50803_137730.AA WEE 131-260 28 3.1e-16 51.03 In-house 1-128 (297) Show / Hide 
Range on Protein: 131-260
Range on HMM: 1-128/297
Sequence Identity: 28% (41 aa)

FRQLGCIGSGSFGTVYRVRHQLNAVELGVYAIKII-SVGASRPWLLKALSEVTVLEKLR-------HQNIVQYHHCWAERYRTALNATEETLHLFILLNY
| ..  ||.||||.|| .|. ..     .|||| . .  .       || ||  ...|        | .||.|.  |           ||. |..|   |
FQEVQKIGEGSFGEVYKCRCRIDGC---IYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAW-----------EEDDHMYIQMEY

CKGGS--LLNLRRSVFN--RQMTEEEVLFLLFQAASGLAHLH
| |||  |...  .. |  . ..|...  .| . . ||.|.|
CNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIH
Kinase GL50803_137730.AA CMGC 131-279 15 6.2e-16 47.96 In-house 1-220 (513) Show / Hide 
Range on Protein: 131-279
Range on HMM: 1-220/513
Sequence Identity: 15% (35 aa)

FRQLGCIGSGSFGTVYRVRHQLN-----------AVELGVYAIKIISVGASRPWLLK-----------ALSEVTVLEKLR-----------------HQN
.  .. ||.|..|.||. |....                ..|||.|.     ..  |           || |.  |..|.                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQYHHCWAERY-RTALNATEET-----LHLFILLNYCKGGSLLNLRRSVF-------NRQMTEEE------------VLFLL------FQAASGLA--H
||. . .   .  .. .. . ..      ||..   |. . .|... ..         .. ..| .            . ...      .|   ||.  .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHAIG--FLSRDVKLGNMLLDGD
.|  .  .. || |  | |.. .
CHSHWGNIIHRDLKPENILINHN
Kinase GL50803_137730.AA NEK 131-260 29 5.2e-15 49.64 In-house 1-131 (286) Show / Hide 
Range on Protein: 131-260
Range on HMM: 1-131/286
Sequence Identity: 29% (41 aa)

FRQLGCIGSGSFGTVYRVRHQLNAVELG--VYAIKIISVG-ASRPWLLKAL-SEVTVLEKLRHQNIVQYHHCWAERYRTALNATEETLHLFILLNYCK-G
.. .  ||.||||.||.||.. .  .|.   |..| |..|  |.    .|. .|| .|..|.|.||| |. .. |         |.  .|.|   ||  |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE---------EQNNCLCIVMEYCEGG

GSLLNLRRSVFNR-----QMTEEEVLFLLFQAASGLAHLH
| | .. .|  ..      . ||...  ..| ...| ..|
GDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMH
Kinase GL50803_137730.AA HRI 131-201 43 1.8e-14 46.68 In-house 1-69 (613) Show / Hide 
Range on Protein: 131-201
Range on HMM: 1-69/613
Sequence Identity: 43% (31 aa)

FRQLGCIGSGSFGTVYRVRHQLNAVELGVYAIKIISV-GASRPWLLKALSEVTVLEKLRHQNIVQYHHCWAE
| |.  || | .| ||.||| |       |||| | . .. .  . | . || ||  | | ||| ||  | |
FEQKEIIGKGGYGRVYKVRHKLDKQ---HYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase GL50803_137730.AA TyrKc 131-346 13 4.9e-07 -108.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 131-346
Range on HMM: 1-280/280
Sequence Identity: 13% (39 aa)

FRQLGCIGSGSFGTVYRVRHQLNAVELGVYAIKIISVGASRPWLLKALSEVTVLEKL--RHQNIVQYHHCWAERYRTALNATEETLHLFILLNYCKGGSL
 . .  .|.| ||.||. .           |.| .  .|    .   ..|  .. ||  .|.|||. . .  .  |       .   |.|.. |...|.|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDL

LNLRRSVFNRQMTEEEVLFLLFQAASGLAHLHAIGFLSRDVKLGNMLLDGDV-------------PDDDPK----GYIS------CI-------------
..  |.  ..  . .. |   .|.|.| ..||  ..  ||    | |.. .               ||| .     |..      .              
KDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

-------------------------YNDPAD-----FPDALTTKQRQELRYKQRQFH--------TDESLRE---HCRQLQYIRRVGVEGLRVRI
                            . .      ...   .. .. ..  .  .          . . .    | . .   |   . .. ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_137730.AA Pkinase_Tyr 178-264 19 0.000297 15.03 Pfam 51-132 (270) Show / Hide 
Range on Protein: 178-264
Range on HMM: 51-132/270
Sequence Identity: 19% (18 aa)

LSEVTVLEKL-RHQNIVQYHHCWAERYRTALNATEETLH--LFILLNYCKGGSLLNLRRSV--FNRQMTEEEVLFLLFQAASGLAHLHAIGF
..|. .. .| .|.|||... .            ..  .  ..| . |...|.||.  |.    ... | .. |   .| |.|...|.....
MREAKIMKQLGHHPNIVRLYGVCT----------DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC
Kinase GL50803_137730.AA WEE 480-505 42 0.001302 8.07 In-house 265-290 (297) Show / Hide 
Range on Protein: 480-505
Range on HMM: 265-290/297
Sequence Identity: 42% (11 aa)

IYSAELCDLFAIMCSPDPSVRPSASA
|.|.|| .| . |  |||. ||....
IISQELKQLIKWMMHPDPEQRPTCQQ
Kinase GL50803_137730.AA Pkinase_Tyr 131-147 35 0.285024 4.93 Pfam 1-17 (270) Show / Hide 
Range on Protein: 131-147
Range on HMM: 1-17/270
Sequence Identity: 35% (6 aa)

FRQLGCIGSGSFGTVYR
 . .  .|.|.||.||.
ITFGKKLGEGAFGEVYK
Kinase GL50803_137730.AA TKL 340-432 12 0.30496 0.24 In-house 175-277 (364) Show / Hide 
Range on Protein: 340-432
Range on HMM: 175-277/364
Sequence Identity: 12% (18 aa)

EGLR--------------VRIADFG---------QVGDGA------------------SAGTELYLAPEL---------YCAISGTLQATEHASNDASGG
| ..              . |.|||         .  |..                    ||  ..|||.         .. |                 
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI-----------------

DSMNGEDSPDLDRNFIIRDKSFPEFVPTKPKSTQATDIYSLGI
                       | .  . . ....|.|| ||
----------------------DE-FCKGFEYSEKCDVYSFGI