Gene GL50803_14648 (G.lamblia)
GL50803_14648
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_14648.AA | Protein | None | 454 | None | Fasta, JSON |
| GL50803_14648.kin_dom | Protein Kinase Domain | None | 253 | None | Fasta, JSON |
Protein domains of GL50803_14648.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_14648.AA | NEK2 | 179-264 | 33 | 6.5e-18 | 56.8 | In-house | 234-319 (319) | Show / Hide |
Range on Protein: 179-264 Range on HMM: 234-319/319 Sequence Identity: 33% (29 aa) EVISGTSFSPASDVWSIGCIVYELCTLTPLFTARSVNDMLQDLQEISRLEFIPG-YSADLFLLLTQMLAVDEAARISASDALRHPRI |...| . .. ||.||.||..||.|.| | |.|.. .. . . || || .| . . |..|| | | |.||.| EQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQ-GHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | GL50803_14648.AA | Pkinase | 179-264 | 21 | 2.2e-16 | 58.98 | Pfam | 181-293 (293) | Show / Hide |
Range on Protein: 179-264 Range on HMM: 181-293/293 Sequence Identity: 21% (25 aa) EVIS-GTSFSPASDVWSIGCIVYELCTLTPLFTAR----SVNDMLQDLQEISRLEFIPGYS-----------------------ADLFLLLTQMLAVDEA ||| |. .|..|.||.|||.||... |.| . . .|..| ...| . .. .. .. ... .|..| . EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK ARISASDALRHPRI |..| ..| || . KRPTAEQILQHPWF |
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| Kinase | GL50803_14648.AA | Ciliate-E2 | 172-264 | 19 | 5.9e-16 | 51.24 | In-house | 250-365 (365) | Show / Hide |
Range on Protein: 172-264 Range on HMM: 250-365/365 Sequence Identity: 19% (25 aa) TTPYKSLEVISGTS---------FSPASDVWSIGCIVYELCTLTPLFTARSVNDMLQDLQEISRLEFIPG--------------------YSADLFLLLT | .|.. |...| . . ..|.||.|.| ||... | | .|.| .. | . |. TPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIK Q----MLAVDEAARIS-ASDALRHPRI . || .|. ||. ....| || . KFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_14648.AA | NEK | 190-264 | 35 | 1e-15 | 52.18 | In-house | 205-286 (286) | Show / Hide |
Range on Protein: 190-264 Range on HMM: 205-286/286 Sequence Identity: 35% (29 aa) SDVWSIGCIVYELCTL--TPLFTAR--SVNDMLQDLQEISRLEFIP-G--YSADLFLLLTQMLAVDEAARISASDALRHPRI ||.||.||..||.||| . | | . . .. . || || || |..||| .| | |... | .| | SDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| S_TKc | GL50803_14648.AA | S_TKc | 29-264 | 19 | 2.7e-13 | 18.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-264 Range on HMM: 1-231/231 Sequence Identity: 19% (53 aa) YKSDRL-------KVSLVLSVP----------KTGPSAEETLKEDIRFIDRLKHPHISRITAAVKDKSDYYEVCLSTHIEG--QTLRDLIDCKAADS--A |. |. || .. . | |... |. . .||.| .. . | ...| | ...| .|.|.|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVM--EYCDGDLGDLFDYIKKRGRHGLRF VIAEDKVWAILAQLLDAAAACQRLYRSHLNIAPSNIYISDLYYVKLG-----RPLLTSERKETTTWSSDTTP-YKSLEVISGTSFSP-ASDVWSIGCIVY .. | .. ...|...| . | .. | . |.|| ... .|.. | | . || | . ||. .... ..|.||.|||.| PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY ELCTLTPLFTARSVNDMLQDLQEISRLEFIPGYSADLFLLLTQMLAVDEAARISASDALR-------HPRI |... |.| .. |.. . | .. .. ..| .| . |..| .||. || . EMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_14648.AA | AGC | 179-264 | 18 | 3.2e-12 | 26.39 | In-house | 277-395 (395) | Show / Hide |
Range on Protein: 179-264 Range on HMM: 277-395/395 Sequence Identity: 18% (23 aa) EVISGTSFSPASDVWS--IGCIVYELCTLTPLFTARSVN----------DMLQDLQE-----ISRLEFI----------PGYSADLFLLLTQMLAVDEAA |.. ..| | || ||. ||. | | |.. ... .| | .. ...| . | .. |....| .| . EIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEK RIS----------ASDALRHPRI |. |.. .|| RLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | GL50803_14648.AA | NEK1 | 190-264 | 34 | 5.1e-12 | 38.15 | In-house | 202-276 (276) | Show / Hide |
Range on Protein: 190-264 Range on HMM: 202-276/276 Sequence Identity: 34% (26 aa) SDVWSIGCIVYELCTLTPLFTARSVNDMLQDLQEISRLEFIPGYSADLFLLLTQMLAVDEAARISASDALRHPRI ||.|| ||. ||||||. | |.. . . . | || .| |..||. .. | |. . | | | SDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_14648.AA | Ciliate-E2-Unclassified | 179-264 | 18 | 7.4e-12 | 37.44 | In-house | 236-352 (352) | Show / Hide |
Range on Protein: 179-264 Range on HMM: 236-352/352 Sequence Identity: 18% (22 aa) EVISGTSFS----PASDVWSIGCIVYELCTLTPLFTARSVND----------------MLQDLQE----ISRLEF------IPGYSADLFL-LLTQMLAV ||. | . ..|.|| |.| ||... .. | ... .. ..|. .. .. .. .. .|. || .|| . EVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKK DEAARISASDALRHPRI . ||.....| || . NPNKRITFEQILNHPWF |
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| Kinase | GL50803_14648.AA | CMGC | 175-219 | 22 | 4.7e-09 | 24.94 | In-house | 291-364 (513) | Show / Hide |
Range on Protein: 175-219 Range on HMM: 291-364/513 Sequence Identity: 22% (17 aa) YKSLEVISGTS----------FSPASDVWSIGCIVYELCT--------LTPLFTARSV-----------NDMLQ |.. |.. | . .... |.||.||| .|. | . ||| .| |.|. YRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLF |
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| Kinase | GL50803_14648.AA | CLK | 172-202 | 54 | 1.3e-08 | 21.14 | In-house | 210-240 (350) | Show / Hide |
Range on Protein: 172-202 Range on HMM: 210-240/350 Sequence Identity: 54% (17 aa) TTPYKSLEVISGTSFSPASDVWSIGCIVYEL | .| ||| | .| .|||||||| .|| TRHYRAPEVILGLGWSQPCDVWSIGCILFEL |
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| TyrKc | GL50803_14648.AA | TyrKc | 34-264 | 14 | 1e-07 | -97.8 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 34-264
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)
LKVSLVLS-------------------VPKTGPSAEETLKEDIRFIDRL--KHPHISRITAAVKDK-----SDYYEVCLSTHIEGQTLRDLI-DCKAADS
.. .| . | . .| . . .| .| .||.| |. ... .. .. . . .. |.| . ...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--
AVIAEDKVWAILAQLLDAAAACQRLYRSHL---NIAPSNIYISDLYYVKLG-----RPLLTS----ERKETTTW----SSDT-TPYK--SLEVISGTSFS
.. | ...|. .. | . .. .| |. ... . || . | . |.|.. . ...| |.. ..|.| |.
-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT
PASDVWSIGCIVYELCTLTPLFTA------RSVNDMLQDLQEISRLEFIPG--------YSADLFLLLTQMLAVDEAARISASDALRHPRI
..||||| | .|..|. | ........ |.. | ..... . .| . | . | . |. | ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | GL50803_14648.AA | DYRK | 179-224 | 43 | 1.4e-07 | 24.69 | In-house | 174-219 (320) | Show / Hide |
Range on Protein: 179-224 Range on HMM: 174-219/320 Sequence Identity: 43% (20 aa) EVISGTSFSPASDVWSIGCIVYELCTLTPLFTARSVNDMLQDLQEI ||| |. .. | |.|| |||..|| | ||| . .|.|. .|. EVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEV |
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| Kinase | GL50803_14648.AA | CDC2 | 191-213 | 50 | 8.2e-07 | 16.4 | In-house | 188-213 (301) | Show / Hide |
Range on Protein: 191-213 Range on HMM: 188-213/301 Sequence Identity: 50% (13 aa) DVWSIGCIVYEL---CTLTPLFTARS |.|||||| .|. .| ||| . | DMWSIGCIFAEMFMDVTKKPLFHGDS |
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| Kinase | GL50803_14648.AA | CDC2 | 240-264 | 56 | 1e-06 | 16.11 | In-house | 277-301 (301) | Show / Hide |
Range on Protein: 240-264 Range on HMM: 277-301/301 Sequence Identity: 56% (14 aa) LLTQMLAVDEAARISASDALRHPRI || |||. | . |||| .||.|| . LLMQMLQYDPQKRISAKEALQHPYF |
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| Kinase | GL50803_14648.AA | CMGC | 240-264 | 48 | 5e-06 | 14.88 | In-house | 489-513 (513) | Show / Hide |
Range on Protein: 240-264 Range on HMM: 489-513/513 Sequence Identity: 48% (12 aa) LLTQMLAVDEAARISASDALRHPRI || .|| | . ||.|..||.|| . LLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | GL50803_14648.AA | DYRK | 240-264 | 36 | 1.5e-05 | 16.99 | In-house | 296-320 (320) | Show / Hide |
Range on Protein: 240-264 Range on HMM: 296-320/320 Sequence Identity: 36% (9 aa) LLTQMLAVDEAARISASDALRHPRI .....| | . ||..|.||.|| . FIKKCLQWDPHKRITPSQALQHPWF |
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| Kinase | GL50803_14648.AA | CLK | 237-264 | 46 | 2.1e-05 | 11.41 | In-house | 323-350 (350) | Show / Hide |
Range on Protein: 237-264 Range on HMM: 323-350/350 Sequence Identity: 46% (13 aa) LFLLLTQMLAVDEAARISASDALRHPRI || |. .|| .| ..||...||| || LFDLIRKMLEYDPSKRITCKDALQHPFF |
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