Gene GL50803_21116 (G.lamblia)

GL50803_21116

Species: G.lamblia
Alias: GK030, GL50803_21116
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CMGC-GL1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_21116.AA Protein None 604 None Fasta, JSON
GL50803_21116.kin_dom Protein Kinase Domain None 368 None Fasta, JSON

Protein domain

Protein domains of GL50803_21116.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_21116.AA CDK 110-185 28 1.8e-14 42.57 In-house 92-161 (284) Show / Hide 
Range on Protein: 110-185
Range on HMM: 92-161/284
Sequence Identity: 28% (23 aa)

SLILVFPFCPCDLHSFLHSGNLINYSWDRFLHLCFLLVRSVAILHSVGWSHRDIKPSNALVSGDGQ-----LLLCDFGMAR
.| .||.... || ....             .. . | | .. .|| .  |||.||.| |.. .|.     | . ||| ||
KLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR
S_TKc GL50803_21116.AA S_TKc 6-533 10 5.6e-14 28.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-533
Range on HMM: 1-231/231
Sequence Identity: 10% (57 aa)

YVISSNVKGSGSYGCVLEGHLKSDPAVKLAFKFLRVTDGHGLLPHTQTRDIMALVSLEKIMAERPDLGGGDIFVDFPIIPLLDIINGSDVQLLDPHPPID
| |   . |.|..|.|  .. |.    . | | ..                   .  |  . ..             |. |.|..               
YEILRKI-GKGAFGKVYKCRHKK-TGRIVAIKIIK-----------------EHIRREIQILKK---------HHPNIVKLYDVFQD-------------

YVPYSLILVFPFCPC---DLHSFLHSGNLIN----YSWDRFLHLCFLLVRSVAILHSVGWSHRDIKPSNALVSGDGQLLLCDFGMARCEIPFFGRFGHKG
    .| .|. .|.    ||...... .       ..  .  ...  ... .. .|| |  |||.||.| |..   .. .||||.||             
---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------

CYNHSTKRYLRNKMTDVGSINCKVPTIPQLELLNGNTAICGTVWWRAPEQCFGLNKHYSGFVGDSWSLGCSICDLIFDVPLFKTIHRDDLKATGEVLALI
                                    | .||| |..||| .     .|...  | ||.|| .  ..   |.|      ..... ...   
------------------------------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--

NYLNPLVNCTKYHAGFLDTSKHQMRAELFNVYKQTIRALNSDELIEKLFALRSKNDKLKCVDDEDTTSSPNKHLQDRDPSIRARSLSLTVAYEKHKSERI
                                                                                                    
----------------------------------------------------------------------------------------------------

KAVRQTLGPLVAERTPEGINSISESIRLARLVMRNMLLLSGKYWRRKIYYTTSSYSIRELLFFSLLIRFSSTTGLETLRTSSLQLGHYKDLLILLELNED
                                                                                                    
----------------------------------------------------------------------------------------------------

VVVEMRTLAALLEKMLNIDPDGRTLPTIVMN-------SPIF
     . .  ...|.|. ||. |     ...        | |
----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_21116.AA CMGC 109-189 19 1.6e-13 39.87 In-house 128-256 (513) Show / Hide 
Range on Protein: 109-189
Range on HMM: 128-256/513
Sequence Identity: 19% (25 aa)

YSLILVFPFCPCDLHSFLHSGN--------------------------LINYSWDRFLHLCFLLVRSVA--ILHSVG--WSHRDIKPSNALVSGD-----
..| ||| ....||. .... .                            ...       .. . |...   .|| .    |||.||.| |.. .     
NHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELIT

---------------GQLLLCDFGMARCEIP
               |.| .||||.|| . |
RMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase GL50803_21116.AA Pkinase 108-189 23 2.6e-12 44.6 Pfam 72-165 (293) Show / Hide 
Range on Protein: 108-189
Range on HMM: 72-165/293
Sequence Identity: 23% (23 aa)

PYSLILVFPFCPC-----DLHSFLH---SGNLINYSWDRFLHLCFLLVRSVAILHSVGWSHRDIKPSNALVSGDGQL----LLCDFGMARC--EIP
. .. .|...|..     ||.....   .|...  |..   . .  ..| .. .|| |  |||.||.| |.. .|..     .|||| |..  . .
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-N
Kinase GL50803_21116.AA CDK5 111-185 37 2.5e-11 31.58 In-house 73-146 (287) Show / Hide 
Range on Protein: 111-185
Range on HMM: 73-146/287
Sequence Identity: 37% (28 aa)

LILVFPFCPCDLHSFLHSGNLINYSWDRFLHLCFLLVRSVAILHSVGWSHRDIKPSNALVSGDGQLLLCDFGMAR
|.||| ||  ||  .. | |  . . .    . . | . .|. |.    ||| || | |..  |.| | |||.||
LTLVFEFCDQDLKKYMDSCNG-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLAR
Kinase GL50803_21116.AA LKB 153-184 53 2.5e-11 29.94 In-house 120-151 (265) Show / Hide 
Range on Protein: 153-184
Range on HMM: 120-151/265
Sequence Identity: 53% (17 aa)

LHSVGWSHRDIKPSNALVSGDGQLLLCDFGMA
||| . .|.||||.| |.. |. | .|||| |
LHSQRVVHKDIKPGNLLLTHDNTLKICDFGVA
Kinase GL50803_21116.AA JNK 153-191 58 2.8e-11 38.24 In-house 122-160 (309) Show / Hide 
Range on Protein: 153-191
Range on HMM: 122-160/309
Sequence Identity: 58% (23 aa)

LHSVGWSHRDIKPSNALVSGDGQLLLCDFGMARCEIPFF
|||.| .||| |||| .|  |. | .|||| || |.|.|
LHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTF
Kinase GL50803_21116.AA CDC2 104-185 23 1.9e-10 27.8 In-house 69-151 (301) Show / Hide 
Range on Protein: 104-185
Range on HMM: 69-151/301
Sequence Identity: 23% (20 aa)

IDYVPYSLILVFPFCPCDLHSFLHSGNLI--NYSWDRFLHLCFLLVRSVAILHSVGWSHRDIKPSNALVSGDGQLLLCDFGMAR
. .  ..| .|| .. .||  ..   .    . . .    . . ... |. .|. .  |||.||.| |.. .|.. . ||| ||
VIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLAR
Kinase GL50803_21116.AA CDK7 160-185 57 3.2e-10 22.96 In-house 125-150 (288) Show / Hide 
Range on Protein: 160-185
Range on HMM: 125-150/288
Sequence Identity: 57% (15 aa)

HRDIKPSNALVSGDGQLLLCDFGMAR
|||.|| | |.. .||| . ||| ||
HRDLKPNNLLMNENGQLKIADFGLAR
Kinase GL50803_21116.AA nmo 146-187 47 4.9e-10 26.42 In-house 111-152 (292) Show / Hide 
Range on Protein: 146-187
Range on HMM: 111-152/292
Sequence Identity: 47% (20 aa)

LVRSVAILHSVGWSHRDIKPSNALVSGDGQLLLCDFGMARCE
..| .  ||| .  |||||| | ||  .  | .||||.|| .
ILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVW
Kinase GL50803_21116.AA CDKL 160-185 62 6.1e-10 30.17 In-house 121-147 (286) Show / Hide 
Range on Protein: 160-185
Range on HMM: 121-147/286
Sequence Identity: 62% (17 aa)

HRDIKPSNALVS-GDGQLLLCDFGMAR
|||||| | |..  .||. ||||| ||
HRDIKPENILITPKNGQVKLCDFGFAR
Kinase GL50803_21116.AA ERK7 113-185 36 1.8e-09 28.23 In-house 78-148 (292) Show / Hide 
Range on Protein: 113-185
Range on HMM: 78-148/292
Sequence Identity: 36% (27 aa)

LVFPFCPCDLHSFLHSGNLINYSWDRFLHLCFLLVRSVAILHSVGWSHRDIKPSNALVSGDGQLLLCDFGMAR
||| |   |||     ||..     ..    . |.| .  .||    |||.|||| |.  .  . .||||.||
LVFEFMETDLHAVIRKGNILKDIHKQY--IMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLAR
Kinase GL50803_21116.AA CDKL 509-533 36 0.000121 11.8 In-house 262-286 (286) Show / Hide 
Range on Protein: 509-533
Range on HMM: 262-286/286
Sequence Identity: 36% (9 aa)

LLEKMLNIDPDGRTLPTIVMNSPIF
...|.| .||| |.  .  |..|.|
FMKKCLHMDPDERMTCEQLMHHPYF
Kinase GL50803_21116.AA ERK7 240-280 39 0.000243 10.4 In-house 169-207 (292) Show / Hide 
Range on Protein: 240-280
Range on HMM: 169-207/292
Sequence Identity: 39% (16 aa)

TVWWRAPEQCFGLNKHYSGFVGDSWSLGCSICDLIFDVPLF
| |.||||   |  ..|   | | ||.|| . ... . |.|
TRWYRAPEILLG-SHRYTKGV-DMWSIGCILGEMLRGKPMF
Kinase GL50803_21116.AA CDK7 240-280 46 0.000944 5.39 In-house 165-203 (288) Show / Hide 
Range on Protein: 240-280
Range on HMM: 165-203/288
Sequence Identity: 46% (19 aa)

TVWWRAPEQCFGLNKHYSGFVGDSWSLGCSICDLIFDVPLF
| | ||||  ||  .||   | | || || .  |.  || .
TRWYRAPELLFG-ARHYGTGV-DMWSVGCIFAELMLRVPYL
Kinase GL50803_21116.AA Pkinase 234-287 30 0.001978 13.21 Pfam 168-222 (293) Show / Hide 
Range on Protein: 234-287
Range on HMM: 168-222/293
Sequence Identity: 30% (18 aa)

NTAICGTVWWRAPEQCFGLN-KHYSGFVGDSWSLGCSICDLIFDVPLFKTI----HRDD
.| .||| |..|||    ..   | |   | ||.|| .  ...  |.|.      . .|
MTTFCGTPWYMAPEV---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HD
Kinase GL50803_21116.AA CDK5 240-280 40 0.003108 5.53 In-house 161-200 (287) Show / Hide 
Range on Protein: 240-280
Range on HMM: 161-200/287
Sequence Identity: 40% (17 aa)

TVWWRAPEQCFGLNKHYSGFVGDSWSLGCSICDLI-FDVPLF
| |.|.|   .|  ||||  . | || || .  ..    |||
TLWYRPPDVLMG-SKHYSTSI-DMWSCGCIFAEMANAGRPLF
Kinase GL50803_21116.AA nmo 240-274 42 0.005165 4.42 In-house 166-198 (292) Show / Hide 
Range on Protein: 240-274
Range on HMM: 166-198/292
Sequence Identity: 42% (15 aa)

TVWWRAPEQCFGLNKHYSGFVGDSWSLGCSICDLI
| ..||||   |  .||.. | | || ||   .|.
TQYYRAPEILMG-ARHYTSAV-DIWSVGCIFAELL
Kinase GL50803_21116.AA CMGC 509-533 44 0.007578 4.15 In-house 489-513 (513) Show / Hide 
Range on Protein: 509-533
Range on HMM: 489-513/513
Sequence Identity: 44% (11 aa)

LLEKMLNIDPDGRTLPTIVMNSPIF
||.||| .||| |  .   .. | |
LLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_21116.AA CDC2 240-280 43 0.018792 2.76 In-house 168-209 (301) Show / Hide 
Range on Protein: 240-280
Range on HMM: 168-209/301
Sequence Identity: 43% (19 aa)

TVWWRAPEQCFGLNKHYSGFVGDSWSLGCSICDL---IFDVPLF
| | ||||  .|  |.||  | | ||.|| .  .   .   |||
TLWYRAPEILLG-CKRYSTPV-DMWSIGCIFAEMFMDVTKKPLF
Kinase GL50803_21116.AA LKB 506-533 32 0.02204 2.95 In-house 238-265 (265) Show / Hide 
Range on Protein: 506-533
Range on HMM: 238-265/265
Sequence Identity: 32% (9 aa)

LAALLEKMLNIDPDGRTLPTIVMNSPIF
|. |...|| .|.. |     .|. | |
LQNLIKGMLQYDHNKRFSCHQIMHHPWF
Kinase GL50803_21116.AA CDK5 509-533 36 0.144311 0.17 In-house 263-287 (287) Show / Hide 
Range on Protein: 509-533
Range on HMM: 263-287/287
Sequence Identity: 36% (9 aa)

LLEKMLNIDPDGRTLPTIVMNSPIF
||.||| ..|. |      .. | |
LLQKMLQCNPNQRISAKAALHHPYF
Pkinase GL50803_21116.AA Pkinase 7-33 40 0.838889 3.92 Pfam 1-30 (293) Show / Hide 
Range on Protein: 7-33
Range on HMM: 1-30/293
Sequence Identity: 40% (12 aa)

VISSNVKGSGSYGCVLEGHLKSDP---AVK
     . ||||.||| ..| |...   |||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK