Gene GL50803_22850 (G.lamblia)

GL50803_22850

Species: G.lamblia
Alias: GK038, GL50803_22850
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
GL50803_22850.AA Protein None 360 None Fasta, JSON
GL50803_22850.kin_dom Protein Kinase Domain None 291 None Fasta, JSON

Protein domain

Protein domains of GL50803_22850.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_22850.AA ERK7 15-305 65 1.9e-193 648.93 In-house 1-292 (292) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-292/292
Sequence Identity: 65% (191 aa)

YEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTDAQRTFREIMFLQELD-HDNIIRLFNVLKAENDKDIYLVFEFLDSDLHQVIK-SNILEDI
|||..|.||||||.||||. ..| ..||||||| ||.|.|||||||||||||||.. |.||||| ||..|.||.||||||||...||| ||.  |||.||
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAALSEPSSATNPILTDYVATRWYRSPEILLGCTRYTKGVDMWAIGCILGE
||.||.|| ..|.||.||....||||||||.||.|||..|..||||||||| . |  .  ||.||.||||||||.|||||| .||||||||| |||||||
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY-DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

MLGGSPMFPGSSTMNQLDKIMEVTGRPTPEDIEATESPFASMMLDSLQPKTGKALSEIYPNAPADALDLLKKLLQFNPNKRLTAEQALEHPYL
|| | |||||.|||||..||.|....|| ||||| .| .|. ||.... .  | |....|... ||.||||.||.|||.|||||||||.||| 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase GL50803_22850.AA MAPK 15-305 42 1.1e-172 580.0 In-house 1-328 (328) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-328/328
Sequence Identity: 42% (141 aa)

YEIIHRVGKGAYGVVWKAVNRK------TNETVALKKIFQAFQNDTDAQRTFREIMFLQEL-DHDNIIRLFNVLKAE-----ND----KDIYLVFEFLDS
|.|. ..|.||||||..|. ..      ....||.|||...||| |...||.|||..|... .|.|||.|......|     |.    .|||.|.|. ..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQVIKSNI-LEDIHKRYIIYQCVKA--LKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAA-LSEPSSATNP------ILTDYVATRWYRSP
||||.|||.  |.|.|..|..||  ..  |||.||| ..||||||||.|.|..|  |..||||||||.   ... .  .|       .|.||||||||.|
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILLG--CTRYTKGVDMWAIGCILGEMLG-GSPMFPGSSTMNQLDKIMEVTGRPTPEDIEATE-SPFASMMLDSL---QPKTGKALSEIYPN----APAD
||.|.   ..|||.||||..|||..|||. . |.|||.....|. .||||.| |..|.|.  . |. |  .. ||   .....| .....||    |  .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLKKLLQFNPNKRLTAEQALEHPYL
|.|||.|.|.|.|.||.|.|.||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase GL50803_22850.AA ERK 15-305 43 7.50000000001e-142 477.55 In-house 1-307 (307) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-307/307
Sequence Identity: 43% (135 aa)

YEIIHRVGKGAYGVVWKAVNRK-----TNETVALKKIFQAFQNDTDAQRTFREIMFLQELD-HDNIIRLFNVLKAE---NDKDIYLVFEFLDSDLHQVIK
|.|| ..|.|||||| .|.. .     |...|| |||..|| .  .. || ||| .|  .. |.||| ||.... .   . .|||.|.|. ..||||.|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SN-ILEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLAR----SIAALSEPSSATNPILTDYVATRWYRSPEILLGCTRYTKG
|   |.| |  | .||   .|||.||| ..||||||||.|.|| |  | .||||||    |..  .|    .....|.||||||||.|||.|  . ||| 
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE---CNQNFMTEYVATRWYRAPEIMLSWQKYTKA

VDMWAIGCILGEMLGGSPMFPGSSTMNQLDKIMEVTGRP-TPEDIEATESPFASMMLDSLQP--KTGKALSEIYPNAP--ADALDLLKKLLQFNPNKRLT
.|.|..|||. ||||. |.||| ....|.. | ...| | . ||..  .|. |  .. .|.   ...| ...|.|||.   .|.|||.|.|.|.|.||.|
MDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRIT

AEQALEHPYL
.|..|||||.
VEECLEHPYF
Kinase GL50803_22850.AA CMGC 15-305 26 2.1e-141 467.95 In-house 1-513 (513) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-513/513
Sequence Identity: 26% (138 aa)

YEIIHRVGKGAYGVVWKAVN--------------RKTNETVALKKIFQAFQNDTDAQ----------RTFREIMFLQEL-----------------DHDN
|||| ..|.|.||||.|...              ..||| ||.|||...| ....|.          |..|||..|..|                 .| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIRLFNVLKAEN---------------DKDIYLVFEFLDSDLHQVIKSN----------ILEDIH------------KRYII------YQCVKALK--YL
|..|..... .|               ....|||||..| ||.|.||.|           |.. |            ..|..      ||  ..||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAE--ILHRDLKPSNLLLNSECHM--------------------KMADFGLARSIAALSEP---------------SSATNPILTDYVATRWYRSPEIL
||.   |.||||||.|.|.|..|                      | .||||||..   |..               .  .|  .|.||.|||||.||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEIL

LGC---------TRYTKGVDMWAIGCILGEMLGG--------SPMFP-----------GSSTMNQLDKIMEVTGRP----------------TPEDIEAT
||.         . ||...|||..|||..||. |         |.||           |.|. .||.||..| | |                . |... .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

E--------------------SPFASMMLDS---LQPKTGKALSEIYPN-----------------------------------APADALDLLKKLLQFN
.                    |.||   . |   .... .| .....|.                                   .. .|.|||||.||..
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PNKRLTAEQALEHPYL
|.||.||||||.|||.
PDKRITAEQALQHPYF
Kinase GL50803_22850.AA p38 15-305 39 1.5e-113 383.5 In-house 1-289 (289) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-289/289
Sequence Identity: 39% (118 aa)

YEIIHRVGKGAYGVVWKAVNRKTNET---VALKKIFQAFQNDTDAQRTFREIMFLQELDHDNIIRLFNVLKA-----ENDKDIYLVFEFLDSDLHQVIKS
|. .  ||.|||| | ||. |.|..    || ||..  ||   .| ||.||.  |. ..|.|.| | .|        .. .|.|.| .| ..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NILEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAALSEPSSATNPILTDYVATRWYRSPEILLGCTRYTKGVDMWAI
  | | | ....||  ..||| |||.| ||||||||. .| .| ..  ||||||          ..   .|.||||||||.|||.|   .||. ||.| .
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSV

GCILGEMLGGSPMFPGSSTMNQLDKIMEVTGRPTPEDIEATESPFASMMLDSLQPKTGKALSEIYPNAPADALDLLKKLLQFNPNKRLTAEQALEHPYL
|||. |.. | . |||.  ..|| .||.|.| |..| ..  .|  |   . |. . . . .......|   |.||| |.|.  | ||.|||.|..|||.
GCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase GL50803_22850.AA CDK 15-305 34 5.5e-110 353.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

YEIIHRVGKGAYGVVWKAVNRKTN-----ETVALKKIFQAFQ-----NDTDAQRTFREIMFLQELDHDNIIRLFNVLKAEN---------DKDIYLVFEF
||.. ..| |.|||| || ...|.     . ||||||    .      .   . . |||  |.|| |.||..|. |   .|         .. .|.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDSDLHQVIKSNILEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECH-----MKMADFGLARSIAALSEPSSATNPILTDYVATRWYRSPEI
.| || ....         . ...|  ..| |.||  |.||||||.|.|.|.  .      | |||||||     .. |   |  .|  | |.|||.||.
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPEL

LLGCTRYT--KGVDMWAIGCILGEMLG---GSPMFPGSSTMNQLDKIMEVTGRPTPEDIE-ATESPFASMMLDSLQPKTGKALSEIYPNAPADALDLLKK
|||...|.   ..|||..|||..||.    . |.|||.|  .||.|| .. | ||...    |. |                             ||| |
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNK

LLQFNPNKRLTAEQALEHPYL
.|...|.||..|||||.|||.
MLCYDPKKRISAEQALQHPYF
Kinase GL50803_22850.AA ERK5 15-305 44 4.4e-108 365.38 In-house 1-295 (295) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-295/295
Sequence Identity: 44% (131 aa)

YEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTDAQRTFREIMFLQELDHDNIIRLFNVLKAEND----KDIYLVFEFLDSDLHQVIKSNI-L
|.|| ..| ||||||  |..||. . ||.|||  ||   | |.|||||.  |.   ||||| . ..|. .      ||.| ||. ..|||||.| ||  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

EDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAALSEPSSATNPILTDYVATRWYRSPEILLGCTRYTKGVDMWAIGCI
   | || .|| .. |||.|||...|||||||||| |  | .|. |||.|| .. .|  .      .|.|||||||| ||...    ||. .|.|..|||
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFS--PDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCI

LGEMLGGSPMFPGSSTMNQLDKIMEVTGRPTPEDIEATESPFASMMLDS-LQPKTGKALSEIYPNAPADALDLLKKLLQFNPNKRLTAEQALEHPYL
.|||..   ||||   ..||. ||.| | | |  |.|. .      . . . ... | ....|| |   ||||| ..| | | .|.|. .|| ||.|
FGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase GL50803_22850.AA S_TKc 15-305 31 8.49999999999e-102 345.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-231/231
Sequence Identity: 31% (98 aa)

YEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTDAQRTFREIMFLQELDHDNIIRLFNVLKAENDKDIYLVFEFLDS---DLHQVIKSNI---
|||.  .||||.|.|.|....||.. ||.|.|          ... |||  |.. .|.||..|. |      ...|.|.|..|    ||...||..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAALSEPSSATNPILTDYVATRWYRSPEILLGCTRYTK-GVDM
    .   | |...|| ..||.|.||  |.||||||.|.||..  | | .|||||| .              | .. |.||..||.|     |.|  .|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----GYGKCKCDW

WAIGCILGEMLGGSPMFPGSSTMNQLDKIMEVTGRPTPEDIEATESPFASMMLDSLQPKTGKALSEIYPNAPADALDLLKKLLQFNPNKRLTAEQALE--
|..|||| ||| | | ||      |....... |                                     . .|.|...|.||..|.||.|| .||.  
WSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HPYL
     ||..
WDIKCHPWF
Kinase GL50803_22850.AA ERK1 15-305 44 1.4e-99 337.17 In-house 1-289 (289) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-289/289
Sequence Identity: 44% (131 aa)

YEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTDAQRTFREIMFLQELDHDNIIRLFNVLKA---ENDKDIYLVFEFLDSDLHQVIKSNILED
|  .. .|.||||.|  |. . ... ||.|||   |   |  ||| |||  |.   |.||| . ....|   |. .|.|.| . .. || ...|.  |  
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSN

IHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAALSEPSSATNPILTDYVATRWYRSPEILLGCTRYTKGVDMWAIGCILG
 |  | .|| .. |||.||| .|||||||||||||  | .|. ||||||    ...|       ||.|||||||| |||.|    ||| .|.|..|||| 
DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR----IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA

EMLGGSPMFPGSSTMNQLDKIMEVTGRPTPEDIEATESPFASMMLDSLQPKTGKALSEIYPNAPADALDLLKKLLQFNPNKRLTAEQALEHPYL
|||   |.|||   . || .|. | | |  .|..      |   | ||  |.  .. ...|.| . ||||| |.| |||.||.| |.|| ||||
EMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase GL50803_22850.AA Pkinase 15-305 30 1.1e-98 338.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

YEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTDAQRTFR--EIMFLQELDHDNIIRLFNVLKAENDKDIYLVFEFLDS-----DLHQVIK--
|.|. ..|.|..|.|.|.....|...||.|.|    ...   |. .|  ||  ...|.|.||.||. .     ...||.|.|...      ||. .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-SNIL--EDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHM----KMADFGLARSIAALSEPSSATNPILTDYVATRWYRSPEILLGCTRYT
 .. .  .. . . ..|| ...|.|.||  |.||||||.|.|.....|     | .|||||. .          |. .|... |.||..||...|.. |.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KGVDMWAIGCILGEMLGGSPMFPGS----STMNQLDKIMEVTGRPTPEDIEATESPFASMMLDSLQPKTGKALSEIYPNAPADALDLLKKLLQFNPNKRL
. ||||..|||| ||| | | |||.    . ..|. .| .. |.|...|.. . |.  .. .   . .  . ...  .|.. ...|..|..|...|.||.
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

TAEQALEHPYL
||||.|.||..
TAEQILQHPWF
Kinase GL50803_22850.AA CDC2 15-240 39 1.2e-80 247.48 In-house 1-229 (301) Show / Hide 
Range on Protein: 15-240
Range on HMM: 1-229/301
Sequence Identity: 39% (95 aa)

YEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTD--AQRTFREIMFLQELD-HDNIIRLFNVLKAENDKDIYLVFEFLDSDLHQVIK-SNI--
|. | ..|.| |||| |. ...||. ||||||    ... |   . . |||  |.||. |.||..|. |..    . .|.|||.|| || .  . |.   
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

--LEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAALSEPSSATNPILTD-YVATRWYRSPEILLGCTRYTKGVDMWA
  .. .  . ..|| .... ..|.  |.||||||.|.|....   | |||||||   | . |.   ....|.  | |.|||.||||||| ||. .||||.
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLAR---AFGIPI---RTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

IGCILGEM---LGGSPMFPGSSTMNQLDKIMEVTGRPT
||||. ||       |.|.| |   || || .. | |.
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPN
Kinase GL50803_22850.AA MAPK-Unclassified 15-162 44 4.6e-66 225.78 In-house 1-159 (575) Show / Hide 
Range on Protein: 15-162
Range on HMM: 1-159/575
Sequence Identity: 44% (70 aa)

YEIIHRVGKGAYGVVWKAVNRKT-NETVALKKIFQAFQNDTDAQRTFREIMFLQELDHDNIIRLFNVLKAENDKD-----IYLVFEFLDS---DLHQVIK
|| .  .| ||||.| .|.  |. |  || ||.  .|.| ||. |. |||  | .| | |||.. ... .. ..      ||.| ..  .   ||||.||
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SNI--LEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSI
||.  ....| .|..|| .. |||||||.|.||||||||||.|  |  ...|||..|||
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase GL50803_22850.AA MAPK-Unclassified 176-305 32 2.3e-45 157.05 In-house 405-575 (575) Show / Hide 
Range on Protein: 176-305
Range on HMM: 405-575/575
Sequence Identity: 32% (56 aa)

LTDYVATRWYRSPEILLGCTRYTKGVDMWAIGCILGEMLGG-----------SPMFPGSS--------------------TMNQLDKIMEVTGRPTPEDI
.| ||.||||| |||.|    |.. ||.|.||||..||.             .|.|||..                       |.  | .. |.|  ||.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

EATESPFASMMLDSLQPKTGKALS-EIYPNAP---------ADALDLLKKLLQFNPNKRLTAEQALEHPYL
   ... |   . |. .||    .  ....||          ...|...|.|||||.|| ||.||||||| 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase GL50803_22850.AA CDC2 263-305 36 3.9e-17 48.71 In-house 250-301 (301) Show / Hide 
Range on Protein: 263-305
Range on HMM: 250-301/301
Sequence Identity: 36% (19 aa)

TGKALSEIYPN---------APADALDLLKKLLQFNPNKRLTAEQALEHPYL
. . ||.| ||         .. ...|||...|| .|.||..|..||.|||.
KPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase GL50803_22850.AA TyrKc 15-305 18 7.8e-15 17.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-305
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

YEIIHRVGKGAYGVVWKAVNRKTNETVALKKIFQAFQNDTDAQRTFREIMFLQEL--DHDNIIRLFNVLKAE-----NDKDIYLVFEFLDS-DLHQVIKS
 . ..  | ||.|.|.|.. .   ..|| |..          .   ||.  . .|  .|.||.||. |   .      .. ...|.|. .  ||.. ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NI--LEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSIAAL---SEPSSATNPI----LTDY-VATRWYRSPEILLGCTR
.   |   .. .. .|  .   ||||  . ||||   | |.... ..| .||||.| |         |. .        ... .  ||. .|| .   ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWM-APECI--NYG

-YTKGVDMWAIGCILGEM--LGGSPM-------FPGSSTMNQLDKIMEVTGRPT----PEDIEATESPFASMMLDSLQPKTGKALSEIYPNAPADALDLL
 .|   | |. |  . |.  .|..|         . .  ...... .     |                                .   . .|..  .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------F---VCCPDEMYQIM

KKLLQFNPNKRLTAEQALEHPYL
|.  ...|..| | ..   | ..
KQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_22850.AA Pkinase_Tyr 15-162 27 1.2e-13 46.87 Pfam 1-161 (270) Show / Hide 
Range on Protein: 15-162
Range on HMM: 1-161/270
Sequence Identity: 27% (45 aa)

YEIIHRVGKGAYGVVWKAVNR----KTNETVALKKIFQAFQNDTD--AQRTFREIMFLQEL-DHDNIIRLFNVLKAENDK-DIYLVFEFLDS-DLHQVIK
 ....  |.||.|.|.|.. .    .|. .|| |..      . .   .  .||.  . .| .|.||.||  |   . .   ||.|.|.    ||.   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SN-----ILEDIHKRYIIYQCVKALKYLHSAEILHRDLKPSNLLLNSECHMKMADFGLARSI
..      |   ..  . .|  |.. ||.|  . ||||   | |.... ..| .|||||| |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI