Gene GL50803_41186 (G.lamblia)

GL50803_41186

Species: G.lamblia
Alias: GL50803_41186, GK288
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_41186.AA Protein None 1037 None Fasta, JSON
GL50803_41186.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of GL50803_41186.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_41186.AA STE 266-346 18 3e-12 39.67 In-house 230-359 (359) Show / Hide 
Range on Protein: 266-346
Range on HMM: 230-359/359
Sequence Identity: 18% (24 aa)

APELFRG------ATKGPAADIWALGCLAFEVVAQRKPRFNSAKL-----------------------VKDPVLQN------------------IDCSPS
|||  ..         .  .||| |||.. | .  . | ..   .                        . | |..                    .||.
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LLEFITSCCRFSPHERPSLVELMK--SKII
. .||  |..  |..||.  .|.|   . |
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_41186.AA Pkinase 264-346 19 5.9e-10 36.29 Pfam 177-293 (293) Show / Hide 
Range on Protein: 264-346
Range on HMM: 177-293/293
Sequence Identity: 19% (23 aa)

YKAPELFR-GATKGPAADIWALGCLAFEVVAQRKPRFNS----AKLVKDPVLQNIDC------------------------------SPSLLEFITSCCR
| |||. | |   ||..|.|..||. .|..  | |  ..      . .. ....| .                              |.....||..|..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

FSPHERPSLVELMKSKII
. |..||.  ...... .
KDPKKRPTAEQILQHPWF
Kinase GL50803_41186.AA Ciliate-E2 254-346 13 1.1e-09 29.39 In-house 227-365 (365) Show / Hide 
Range on Protein: 254-346
Range on HMM: 227-365/365
Sequence Identity: 13% (19 aa)

DTHTPVS----------------NTVYKAPELFRGAT---------KGPAADIWALGCLAFEVVAQRKPRFNSAKLVKDPVLQ-----------------
||..  .                .  |.||| ..|            . ..|||.||.. .| .  . |     .  |.  ..                 
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKW

--NIDCSPSLLEFITS----CCRFSPHERPS-LVELMKSKII
  . ..|..   .|      .    | .|..   .... ...
KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_41186.AA Ciliate-E2-Unclassified 264-346 17 1.1e-09 29.82 In-house 228-352 (352) Show / Hide 
Range on Protein: 264-346
Range on HMM: 228-352/352
Sequence Identity: 17% (22 aa)

YK----APELFRGATKG----PAADIWALGCLAFEVVAQRKPRFNSAKLVKDP--------------VLQNI-----------------DCSPSLLEFIT
|.    |||...|   .     ..|||.||....| . .. | |.. .  ..               ..|||                 . ||.  .||.
YMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP-FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN

----SCCRFSPHERPSLVELMKSKII
    ..    | .|... ....  ..
DLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_41186.AA TKL 255-344 17 4e-08 25.35 In-house 230-364 (364) Show / Hide 
Range on Protein: 255-344
Range on HMM: 230-364/364
Sequence Identity: 17% (24 aa)

THTPVSNTVYKAPELFRGATKGPAA----------------DIWALGCLAFEVVAQRKPRFNSA--------------KLVK----DPVLQ---------
|.|.. .. . |||..||... . .                |... | . .|... ..| ..                ..|      | .          
TMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKM

--NIDCSPSLLEFITSCCRFSPHERPSLVELMKSK
  . || ||. . .. |.   |..|||  |..|  
CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc GL50803_41186.AA S_TKc 8-346 11 2e-07 -67.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-346
Range on HMM: 1-231/231
Sequence Identity: 11% (43 aa)

YTDISTLSSTPAVVFFKANRRADAAPVLIKLFRTQEDSDSSARIKTIVSFTELLTVTSVALGTISAIREVDSGLLIEYALPPHATIQALPEYLLSKRALT
|. . .. .    . .|.  . .   | ||  .                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

ARESGQKASVSRPSSKLSNRPSSTRNLEHSMSTPNISDFPGTETWCTTPRFSRRAYRSRSNKSQSKVTTATAAPEWKVIA-------ATIDRWQERIVWQ
                                                                      ..  | ..           .| .|.     
---------------------------------------------------------------------EHIRREIQILKKHHPNIVKLYDVFQD-DHLY

IVAQLVQG-LADFYKAPESLRAG-----LTPTIC-------------------------PEAIFVVHDSCAPLRPEIVI----LACILDTHTPVSNTVYK
.|  .. | | | ..  .. . .     ...  .                         || |.. .        .| |    ||..|  .| .    | 
MVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL--TTFCGTPWYM

APELFRGATKGP-AADIWALGCLAFEVVAQRKPRFNSAKLVKDPVLQNIDCSPSLLEFITSCCRFSPHERPSLVELMK-------SKII
|||..     |. ..|.|..||. .| .. ..| |       . ....|  ||....||  |... | .||.  |...          .
APEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP----QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_41186.AA AGC 264-290 44 3e-07 13.23 In-house 273-297 (395) Show / Hide 
Range on Protein: 264-290
Range on HMM: 273-297/395
Sequence Identity: 44% (13 aa)

YKAPELFRGATKGPAADIWA--LGCLAFE
| ||| .     |.|.|.|.  |||| .|
YMAPEIL----YGKACDWWSFGLGCLMYE
Kinase GL50803_41186.AA Iota 264-297 52 1e-06 17.81 In-house 166-199 (271) Show / Hide 
Range on Protein: 264-297
Range on HMM: 166-199/271
Sequence Identity: 52% (18 aa)

YKAPELFRGATKGPAADIWALGCLAFEVVAQRKP
| |||. ||   | . | |||| | ||..| | |
YIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSP
Kinase GL50803_41186.AA TAO 279-346 26 4e-06 15.85 In-house 179-254 (254) Show / Hide 
Range on Protein: 279-346
Range on HMM: 179-254/254
Sequence Identity: 26% (20 aa)

ADIWALGCLAFEVVAQRKPRFNSAKLV--------KDPVLQNIDCSPSLLEFITSCCRFSPHERPSLVELMKSKII
.|.|.||    |.   . | ||   .           |.||. . | .  .|. .| .  |.||||  |... . .
VDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQQNEWSDCFHQFVDKCLQKMPQERPSAEECLRHEFV
Kinase GL50803_41186.AA STE11 266-286 45 7e-06 17.53 In-house 203-226 (303) Show / Hide 
Range on Protein: 266-286
Range on HMM: 203-226/303
Sequence Identity: 45% (11 aa)

APELFRGAT---KGPAADIWALGC
|||  .. .   .| .||||.|||
APEVIKQEGRDGYGRKADIWSLGC
Kinase GL50803_41186.AA CMGC 264-297 23 1.1e-05 13.68 In-house 291-341 (513) Show / Hide 
Range on Protein: 264-297
Range on HMM: 291-341/513
Sequence Identity: 23% (12 aa)

YKAPELFRGATK----------GPAADIWALGCLAFEVVAQ-------RKP
|.|||.  |...          ... |.|..||  .| .         .||
YRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKP
Kinase GL50803_41186.AA STE11-Unclassified 316-346 25 0.000292 11.07 In-house 278-308 (308) Show / Hide 
Range on Protein: 316-346
Range on HMM: 278-308/308
Sequence Identity: 25% (8 aa)

SPSLLEFITSCCRFSPHERPSLVELMKSKII
|. . .|.  |... |..||.  .| . . |
SQECKDFLRKCFQIDPKKRPTANQLLQHPFI
Kinase GL50803_41186.AA CMGC 311-346 11 0.001367 6.64 In-house 478-513 (513) Show / Hide 
Range on Protein: 311-346
Range on HMM: 478-513/513
Sequence Identity: 11% (4 aa)

QNIDCSPSLLEFITSCCRFSPHERPSLVELMKSKII
.. .|.| .....  . .. |..|..  . ..   .
KRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_41186.AA STE11 316-346 25 0.003261 7.81 In-house 273-303 (303) Show / Hide 
Range on Protein: 316-346
Range on HMM: 273-303/303
Sequence Identity: 25% (8 aa)

SPSLLEFITSCCRFSPHERPSLVELMKSKII
|. . .|.  |. . |..||.  .| . . |
SEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GL50803_41186.AA STE11-Unclassified 266-287 40 0.005268 6.56 In-house 203-227 (308) Show / Hide 
Range on Protein: 266-287
Range on HMM: 203-227/308
Sequence Identity: 40% (10 aa)

APELFRG--AT-KGPAADIWALGCL
|||. ..   | .. ..|||.|||.
APEVIKNSTQTGHCRKSDIWSLGCT