Gene GL50803_5999 (G.lamblia)

GL50803_5999

Species: G.lamblia
Alias: GK207, GL50803_5999
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_5999.AA Protein None 523 None Fasta, JSON
GL50803_5999.kin_dom Protein Kinase Domain None 268 None Fasta, JSON

Protein domain

Protein domains of GL50803_5999.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_5999.AA S_TKc 25-292 21 1.7e-24 88.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-292
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVSVCIKEIDVHFCTDAKIGLLKKELEELAKLSAPNLIAINHYEYNPDIRAFYIETPRCES---TLLSKLSDHRRAG
|| .. .| |.||.|  .. |..|  | ||.|.           ...|.. | |   ||.. .  . ..     .|. .  |.    .|.. . ...| |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TS--FTEGEVWKVLYDICRGLLYLHSKVRTTELPSPNAARKRAPFNGYIHGDLKLENVGFCDGNAVLLDYGMNSFIDQLRDQQTILSTSAFLAPEAALGK
.   |.| ......| ||..| |.||                   .| || ||| ||. ... .  . | |.  ..       |.  |  ..|||     
LRFPFPE-HARFYMYQICCALEYCHS-------------------HGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---

DFNP-KGDTWALGIIALALLRGRP--EKVSVDNHLLAHLSFSGEKDFTDRLRSFIEQCLNINAPVRISSADALL---------FI
 ... | | |..|.|   .| |.|  .    . ... ..        .. ...||..||. .   |..  .||          ..
GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_5999.AA Pkinase 25-292 20 1.3e-23 84.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-292
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVSVCIKEIDVHFCTDAKIGLLKK--ELEELAKLSAPNLIAINHYEYNPDIRAFYIETPRCESTLLSKLSDH----R
|. .. .| |.||.|  ...| .|  |..|.|...   . |   . .  |.. ...|. || . . .. ..   .  |. .. || .|   .. .    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

RAGTSF--TEGEVWKVLYDICRGLLYLHSKVRTTELPSPNAARKRAPFNGYIHGDLKLENVGFC-DGNA----VLLDYGMNSF--IDQLRDQQTILSTSA
.....|  .| |. ...| |.||| |.||.                   | || |||.||. .  .|.      . | |   .  .   .  .|.  |. 
WRHGCFYFSEWECKFYMYQILRGLEYCHSM-------------------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

FLAPEAAL-GKDFNPKGDTWALGIIALALLRG----RPE--------KVSVDNHLLAHLSFSGEKDFT-------------------DRLRSFIEQCLNI
..|||  . |..  || | |..|.|   .| |    . .        .. ... . . |.|. ... .                   . ...||. ||. 
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

NAPVRISSADALLF--I
.   |.. ...|    .
DPKKRPTAEQILQHPWF
Kinase GL50803_5999.AA CMGC 25-146 16 1.2e-11 33.66 In-house 1-201 (513) Show / Hide 
Range on Protein: 25-146
Range on HMM: 1-201/513
Sequence Identity: 16% (33 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVS--------------VCIKEIDVHFCTD-------AKIGLLK---KELEELAKLS-----------------APN
|| |...| ||.|.|  .. || .                | || |   |  .       .| |. .    |.. | .|.                  .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LIAINHYEYNPD---------------IRAFYIETPRCESTLLSKLSDHRR-----AGTSFTEGE------------VWKVL------YDICRGLL--YL
.. .  . | ..                . .|. .  .. .|.  . ....      .  ..| .            . . .      | |.|||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSK
||.
HSH
Kinase GL50803_5999.AA Ciliate-E2 165-289 18 2.8e-11 34.98 In-house 179-360 (365) Show / Hide 
Range on Protein: 165-289
Range on HMM: 179-360/365
Sequence Identity: 18% (34 aa)

NG-YIHGDLKLENVGFCDGNAVLLDYGMNSFIDQLRDQQT--------------------------------ILSTSAFLAPEAALGKD---------FN
..  || |.|.||. |      . | |.  ..|. ....|                                |. |  ..|||   ||.          .
KNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

PKGDTWALGIIALALLRGRPEKVSVDNHLLAHLSFSGE----------------KDFTDRLRSFIEQ----CLNINAPVRIS-SADAL
 | | |.||.|   .| |.|     ....   ..|. .                |. ..    .| .    .|. .   ||.   ..|
YKCDIWSLGVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase GL50803_5999.AA STE 25-146 17 8.6e-11 34.46 In-house 1-171 (359) Show / Hide 
Range on Protein: 25-146
Range on HMM: 1-171/359
Sequence Identity: 17% (30 aa)

YEQIQYLGTGTFGTVSTAIRKR---------------DGVSVCIKEIDVHFCT---------------DAKIGLLKKELEELAKLS--APNLIAINHYEY
.| |. .| |.|||| .|...                 |. . ||....  |.               . ..  ..||.. . |..   || .    ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

N----PDIR-AFYIETPRCESTLLSKLSDHR-RAGTSFT----------EGEVWKVLYDICRG-LLYLHSK
.     . .   .|    ..   |... .|.   | ...          | .. .....|..| | ||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH
Kinase GL50803_5999.AA CAMK 30-146 17 8.1e-10 27.07 In-house 1-198 (425) Show / Hide 
Range on Protein: 30-146
Range on HMM: 1-198/425
Sequence Identity: 17% (35 aa)

YLGTGTFGTVSTAIRKRDG------------VSVCIKEIDVHFCT--------------------------DAKIGLLKKELEELAKLS-------APNL
 ||.|.||.|  .|.|...            . | || ||    .                          . .   ...|.| . ||.        ||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IAINHYEYNPDIRA-----------------FYIET---PRCEST-----LLSKLSDHRRAG-----------TSFTEGEVWKVLYDICRGLLYLHSK
| . ..  .|.  .                 .|. .     |.       |.... .|.. |             ||| |. ..   || .. |.||.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH
Kinase GL50803_5999.AA CDK7 25-56 43 1e-09 21.58 In-house 1-32 (288) Show / Hide 
Range on Protein: 25-56
Range on HMM: 1-32/288
Sequence Identity: 43% (14 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVSVCIKEI
|| |. .| |.|.||. |  .  |  | ||.|
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase GL50803_5999.AA NEK 25-83 29 1.4e-09 30.31 In-house 1-65 (286) Show / Hide 
Range on Protein: 25-83
Range on HMM: 1-65/286
Sequence Identity: 29% (19 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVS-----VCIKEIDVHFCTDAKIGLLK-KELEELAKLSAPN
|| |. .| | ||.|  . ||.||       ...|.|..  ... .   .  .|   |..|  ||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPN
Kinase GL50803_5999.AA TKL 31-242 16 6e-09 28.36 In-house 1-287 (364) Show / Hide 
Range on Protein: 31-242
Range on HMM: 1-287/364
Sequence Identity: 16% (52 aa)

LGTGTFGTVSTAIRKR--------DGVSVCIKEIDVHFCTDAKI-------------------------GLLKKELEELAKLSAPNLIAINHYEYNPDIR
.| |.||.|  .. .         .|  | .| . .| .    .                           ...|.  . .|. ||.. .  |  .|. .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

A-----------FYIETPRC-ESTLLSKLSDHRRAGTSFTEGEVWKVLYDICRGLLYLHSKVR--TTELPSPNAARKRAPFNG--YIHGDLKLENVGFCD
            ..| .  |   .||. |                .  .||.||. ||||.     |                   || ||| .|. . |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT---------------KPPIIHRDLKSKNI-LVD

GN----------------AVLLDYGMNSFIDQLRD--------------------QQTILSTSAFLAPEAALGK----------------DFNPKGDTWA
 |                . . |.|   |..|  .                      |.  | ...|||.  |.                ....| | ..
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

LGIIALALLRGRP
 ||.   .| ...
FGIVLWEILTRCR
Kinase GL50803_5999.AA NAK 121-190 29 1.3e-08 24.76 In-house 113-171 (299) Show / Hide 
Range on Protein: 121-190
Range on HMM: 113-171/299
Sequence Identity: 29% (22 aa)

GTSFTEGEVWKVLYDICRGLLYLHS-KVRTTELPSPNAARKRAPFNGYIHGDLKLENVGFC----DGNAVLLDYG
|| ||| |... ..|.|.|. ..|. ..                  ..|| |.| ||. ..    ||| .| | |
GTCFTEDEILQIFCDVCEGVQAMHQCQP----------------PKPIIHRDIKIENILLSESHHDGNYKLCDFG
Kinase GL50803_5999.AA TyrKc 25-292 16 2.3e-08 -87.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-292
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVSVCIKEIDVHFCTDAKIGLLKKELEELAKL--SAPNLIAINHYEYNP-----DIRAFYIETPRCES-TLLSKLSD
 . .. || | ||.|  .. |   . | .| .  .      .  . .|.. . ||  . ||....  .   .      |   .| .  ..   |.. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HRRAGTSFTEGEVWKVLYDICRGLLYLHSKVRTTELPSPNAARKRAPFNGYIHGDLKLENVGFCDGN-AVLLDYGMNSFIDQL-----RDQQTILST--S
||.    ..  .  .  ..|..|  |||||                   ..|| ||   |.   ... .   | |.  .|.       ...    ..  .
HRPK---LCMKDLLSFCWQIACGMEYLHSK-------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

AF-------LAPEAALGKDFNPKGDTWALGIIA--LALLRGRPEKVS----VDNHLLAHLSFSG-----EKD--------FTDRLRSFIEQCLNINAPVR
.        .|||.   . |..| | |. |.    .  . . |        ..|  . ..  .|      ..         .| . . ..|| . ..  |
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

ISSADALLFI
 . ..   ..
PTFSEIHECF
Kinase GL50803_5999.AA MAPK 25-54 36 6.2e-07 19.76 In-house 1-36 (328) Show / Hide 
Range on Protein: 25-54
Range on HMM: 1-36/328
Sequence Identity: 36% (13 aa)

YEQIQYLGTGTFGTVSTAIRKR------DGVSVCIK
|. ....| | .|.|  || ||      .|  | ||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK
Kinase GL50803_5999.AA Ciliate-E2-Unclassified 168-242 22 6.7e-07 20.0 In-house 166-268 (352) Show / Hide 
Range on Protein: 168-242
Range on HMM: 166-268/352
Sequence Identity: 22% (23 aa)

IHGDLKLENVGFCDG----NAVLLDYGMNSFIDQLRD----------------QQTILSTSAFL----APEAALGKDFNPK----GDTWALGIIALALLR
|| |.|.||. | ..    .  . |.|  ....| ..                ..|.  |  ..    |||   |.  . .     | |.||.|. ..| 
IHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

GRP
|..
GYY
Kinase GL50803_5999.AA NEK 109-146 24 2e-06 18.75 In-house 93-133 (286) Show / Hide 
Range on Protein: 109-146
Range on HMM: 93-133/286
Sequence Identity: 24% (10 aa)

TLLSK---LSDHRRAGTSFTEGEVWKVLYDICRGLLYLHSK
.|  |   .  .. .|. | | ..|.... .| .| |.|..
DLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDR
Kinase GL50803_5999.AA Ciliate-E2-Unclassified 25-146 18 0.000109 12.22 In-house 1-162 (352) Show / Hide 
Range on Protein: 25-146
Range on HMM: 1-162/352
Sequence Identity: 18% (30 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVSV-------CIKEIDVHFCTDAKIGLLKKELEELAK----------------LSAPNLIAINHYEYNPDIRAFYI
|. |. .|.| ||.|  ...| ..  .        |......     .  .. ...|.  |                |. |... .. ...  |   .||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ETPRCESTLLSKLSDHR--------------RAGTSFTEGEVW-----KVLYDICRGLLYLHSK
 .  ||   |..   .|              . .  ||| ..      . .. |. || |||.|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK
Kinase GL50803_5999.AA STE 202-292 15 0.000254 11.31 In-house 221-359 (359) Show / Hide 
Range on Protein: 202-292
Range on HMM: 221-359/359
Sequence Identity: 15% (21 aa)

QTILSTSAFLAPEAALG------KDFNPKGDTWALGIIALALLRGRPEKVSVDNH----LLA------------------HLSFSG--------------
.|.  |  . |||  ..      |. . | | | ||. .. .. |.|.     ..    . .                  . ..                
NTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSG

---EKDFTDRLRSFIEQCLNINAPVRISSADALL----FI
    . ... .. ||..||...   | .. . |     ||
TTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_5999.AA CAMK 165-242 20 0.001461 6.55 In-house 198-332 (425) Show / Hide 
Range on Protein: 165-242
Range on HMM: 198-332/425
Sequence Identity: 20% (27 aa)

NGYIHGDLKLENVGFCD------------------GNAVLLDYGMNSFIDQLRDQQ------------------------TILSTSAFLA-PEAALG---
.. .| |||.||. ..|                  .|  . | |.  ..|.  ..                         |   | .. | ||  .|   
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------KDF-NPKGDTWALGIIALALLRGRP
          |.  .|| | |..|.|  ..| |.|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP
Kinase GL50803_5999.AA Ciliate-E2 25-76 21 0.00247 7.28 In-house 1-63 (365) Show / Hide 
Range on Protein: 25-76
Range on HMM: 1-63/365
Sequence Identity: 21% (14 aa)

YEQIQYLGTGTFGTVSTAIRKRDGVSVCIKEIDVHF---------CT---DAKIGLLKKELEEL
|. |. .|.|.||.|  . .....  . || || .          ..    |.  . |...|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQI
Kinase GL50803_5999.AA MAPK 133-145 53 0.004588 6.18 In-house 121-135 (328) Show / Hide 
Range on Protein: 133-145
Range on HMM: 121-135/328
Sequence Identity: 53% (8 aa)

LYDICRG--LLYLHS
.|.|.||  | |.||
MYQILRGLKLKYIHS
Ank GL50803_5999.AA Ank 338-361 25 2.349572 5.54 Pfam 1-24 (33) Show / Hide 
Range on Protein: 338-361
Range on HMM: 1-24/33
Sequence Identity: 25% (6 aa)

CNHSALDLAIQKGNMEYIEILVKY
.  ..| ||...|..| .. |...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_5999.AA Ank 413-438 38 1.8e-05 24.01 Pfam 1-25 (33) Show / Hide 
Range on Protein: 413-438
Range on HMM: 1-25/33
Sequence Identity: 38% (10 aa)

HGMTALMIAASMGHAECVRKLIREAG
.|.|.|..|...||.|.|. |.  .|
DGFTPLHLACRCGHTEVVKMLLQ-HG
Ank GL50803_5999.AA Ank 443-463 42 5.8e-05 22.15 Pfam 1-21 (33) Show / Hide 
Range on Protein: 443-463
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

KGWTALMYAVRENHVECVSLL
 |.|.|..|.| .|.|.|..|
DGFTPLHLACRCGHTEVVKML