Gene GL50803_7653 (G.lamblia)

GL50803_7653

Species: G.lamblia
Alias: GK304, GL50803_7653
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_7653.AA Protein None 634 None Fasta, JSON
GL50803_7653.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of GL50803_7653.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_7653.AA S_TKc 11-298 18 2.6e-14 32.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-298
Range on HMM: 1-231/231
Sequence Identity: 18% (54 aa)

YRITEKISDGPYDTLYLGTNAKYKDLVVFRHIVLPEARRTRTELVHSQTTLVPALRHPHIIPQLQTEQAPNNDIITTTPYYEN--GSLQLLINVLKKDRK
|.| .||  | . . |.... | . .|    |     ...| |.   .       .||.|.  . . |   ...   . | ..  |.|  .|   .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

R--VSKSCFFSYTYQLLTALSYLHCPRKDETYQGPTGTTISIKRVVHGAIRPASVLIDNNGKKVILGNMTHCQEITNSTLTVKLAATGVNVYYSSPEQVK
|   .     .|.||.. || |.|                  ....|  . |. .|.|.    . ..    . ..             .  .| .|| . 
RFPFPE-HARFYMYQICCALEYCHS-----------------HGIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL-

GMPLSE-TTDIWSLGATLYEFFTLTPLTYLSQLESAGKLIMDSPDRKYPPNPDLSVITDKDVRFLLSVMLCMDPAERISAAELLT---LDAFTPYF
  . .    |.||.| .|||...  |. .  |..   |.|.                 ..... ... .|..||..|..| |.|.   . .  |.|
--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_7653.AA Ciliate-E2 198-294 17 3.9e-10 30.97 In-house 252-365 (365) Show / Hide 
Range on Protein: 198-294
Range on HMM: 252-365/365
Sequence Identity: 17% (24 aa)

YYSSPEQVKGMP---------LSETTDIWSLGATLYEFFTLTPLTYLSQLESAGKLIMDSPDRKYPPNPDLSVITDKDVRFL------------------
.| .|| ..| .          ..  |||||| .|||. .  |                           .  | .....|                   
GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSW

----------LSV----MLCMDPAERIS-AAELLTLDAF
          ..     ||. || .||. . ..|    |
KKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_7653.AA NEK2 198-231 50 1.5e-09 28.2 In-house 229-262 (319) Show / Hide 
Range on Protein: 198-231
Range on HMM: 229-262/319
Sequence Identity: 50% (17 aa)

YYSSPEQVKGMPLSETTDIWSLGATLYEFFTLTP
|| ||||..|.. .|  ||||.|  .||  .| |
YYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHP
Kinase GL50803_7653.AA Pkinase 198-294 17 1.8e-09 34.57 Pfam 176-293 (293) Show / Hide 
Range on Protein: 198-294
Range on HMM: 176-293/293
Sequence Identity: 17% (21 aa)

YYSSPEQVK-GMPLSETTDIWSLGATLYEFFTLTPLTYLS----QLESAGKLIMDSPDRKYPPNPDLSVITD-----------------KDVRFLLSVML
.| .|| .. | . .   |.||.| .|||...  |. . .       .  ..|    ..... . . .                     .. . ... .|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

CMDPAERISAAELLTLDAF
|.||..|..|...|  . |
CKDPKKRPTAEQILQHPWF
Kinase GL50803_7653.AA ULK 198-294 21 1.2e-08 26.92 In-house 212-324 (324) Show / Hide 
Range on Protein: 198-294
Range on HMM: 212-324/324
Sequence Identity: 21% (25 aa)

YYSSPEQVK----GMPLSET-TDIWSLGATLYEFFT-LTP---LTYLSQL----ESAGK------LIMDSPDRKYPPNPDLSVITDKDVRFLLSVMLCMD
.| .|. ..    ..| ..  .||||||  .||  .  .|     . .|     .   .      .| . | ....|.   ...  .... |.. ||. |
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP--KDPKISPECKDLIRRMLQYD

PAERISAAELLTLDAF
. .|||  |..    |
EKDRISWEEIFNHPWF
Kinase GL50803_7653.AA TKL 65-228 14 9.5e-08 23.99 In-house 82-284 (364) Show / Hide 
Range on Protein: 65-228
Range on HMM: 82-284/364
Sequence Identity: 14% (33 aa)

LRHPHIIPQLQTEQAPNND------------IITTTPYYENGS-LQLLINVLKKDRKRVSKSCFFSYTYQLLTALSYLHC--P---RKDETYQGPTGTTI
||||.|.. .   ..|...            .   . |...|| | .|.            . ...  ..   ...|||   |   .             
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-------------

SIKRVVHGAIRPASVLIDNNGK-------------KVILGNMTHCQEITNST----------------LTVKLAATGV-NVYYSSPEQVKGM--------
  . ..|  . .. .|.|.|..             .. .. .  ......|.                .. |   | . . .. .||  .|.        
-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVG

--------PLSETTDIWSLGATLYEFFT
        . || .|..| |  |.| .|
IDEFCKGFEYSEKCDVYSFGIVLWEILT
Kinase GL50803_7653.AA Trio 201-224 50 1.8e-07 14.55 In-house 168-191 (258) Show / Hide 
Range on Protein: 201-224
Range on HMM: 168-191/258
Sequence Identity: 50% (12 aa)

SPEQVKGMPLSETTDIWSLGATLY
.|| ..| | |..||||| |.. |
APEIIQGNPVSYGTDIWSIGVLTY
TyrKc GL50803_7653.AA TyrKc 11-294 16 7.5e-07 -111.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-294
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

YRITEKISDGPYDTLYLGTNAKYKDLVVFRHIVLPEARRTRTELVHSQTTLVPAL--RHPHIIPQL--QTEQAPN----NDIITTTPYYENGSLQLLINV
 .  .|.  | . . |.||      . |    . ..|     |  ..   .   |  .||.|.  .   |.|  |      .   . | ..|.|.   . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK---DY

LKKDRKRVSKSCFFSYTYQLLTALSYLHCPRKDETYQGPTGTTISIKRVVHGAIRPASVLIDNNGKKVILGNMTHCQEITNS--------TLTVKL--AA
|.| |.... . . |. .|     .|||                   ...|  .    .|...|.  |  .    . .|..         . ..|    .
LRKHRPKLCMKDLLSFCWQIACGMEYLHSK-----------------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

TG-VNVYYSSPEQVKGMPLSETTDIWSLGATLYEFFTLTPLTYLSQLE---SAGKLIMDSPDRKYPPNPDL-----SVITDKDVRFLLSVMLCMDPAERI
 . . .   .||  .    .. .|.|| | ...| ||.    |  . .   |.  .| .  .....| |.      .|.  ...  . .     ||..| 
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

SAAELLTLDAF
. .|.   . |
TFSEI--HECF
Kinase GL50803_7653.AA STE 201-294 13 9.2e-07 20.05 In-house 230-359 (359) Show / Hide 
Range on Protein: 201-294
Range on HMM: 230-359/359
Sequence Identity: 13% (18 aa)

SPEQVKGM------PLSETTDIWSLGATL-------YEFFTLTPLTYLSQLESAGKLIM----------DSPDRKYP------PNPDLSVITD-------
.|| ....      . ..  |||||| |.       .......|.  . .    ..  .          ..|  . .      ..    .          
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMIS----Y--GGSGTTYP

----KDVRFLLSVMLCMDPAERISAAELLT--LDAF
    .. .  ..  | .|| .| .| .||      .
HKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_7653.AA NEK 198-231 47 1e-06 20.09 In-house 189-224 (286) Show / Hide 
Range on Protein: 198-231
Range on HMM: 189-224/286
Sequence Identity: 47% (17 aa)

YYSSPEQVKGMPLSETTDIWSLGATLYEFFTL--TP
|| |||.... | ..  ||||||  |||  ||   .
YYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH
Kinase GL50803_7653.AA CMGC 239-294 17 3e-06 15.55 In-house 420-513 (513) Show / Hide 
Range on Protein: 239-294
Range on HMM: 420-513/513
Sequence Identity: 17% (16 aa)

ESAGKLIMDSPDRKYPPNPDLSVI--------------------------------------TDKDVRFLLSVMLCMDPAERISAAELLTLDAF
|.| . |   .. . .| .... .                                       |.. . ||. ||..||..||.|.. |  . |
EFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_7653.AA NEK1 198-230 51 3.5e-05 14.1 In-house 186-218 (276) Show / Hide 
Range on Protein: 198-230
Range on HMM: 186-218/276
Sequence Identity: 51% (17 aa)

YYSSPEQVKGMPLSETTDIWSLGATLYEFFTLT
|| |||     |    .||||||  |||  ||.
YYLSPEICQNKPYNNKSDIWSLGCVLYELCTLK
Kinase GL50803_7653.AA Ciliate-E2-Unclassified 149-228 25 4e-05 13.76 In-house 163-265 (352) Show / Hide 
Range on Protein: 149-228
Range on HMM: 163-265/352
Sequence Identity: 25% (26 aa)

KRVVHGAIRPASVLIDNNG-----KKVILGNMTHCQEITNSTLTVK-----------LAATGVNVYYS----SPEQVKGMPLSET----TDIWSLGATLY
. ..|  | |  .|.||||     |   .|.  . |.  |.. |             .  .  . .|     .||  .|   ...     ||||||  ||
NNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILY

EFFT
|. .
EMLF
Kinase GL50803_7653.AA NEK 265-294 33 0.00048 10.59 In-house 257-286 (286) Show / Hide 
Range on Protein: 265-294
Range on HMM: 257-286/286
Sequence Identity: 33% (10 aa)

KDVRFLLSVMLCMDPAERISAAELLTLDAF
.| . |.| ||. || .| |. ..| .   
QDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_7653.AA Ciliate-E2-Unclassified 270-294 36 0.006123 6.06 In-house 328-352 (352) Show / Hide 
Range on Protein: 270-294
Range on HMM: 328-352/352
Sequence Identity: 36% (9 aa)

LLSVMLCMDPAERISAAELLTLDAF
||. ||  .| .||.. ..|    |
LLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_7653.AA NEK1 265-294 23 0.006684 6.1 In-house 247-276 (276) Show / Hide 
Range on Protein: 265-294
Range on HMM: 247-276/276
Sequence Identity: 23% (7 aa)

KDVRFLLSVMLCMDPAERISAAELLTLDAF
.....|.|.|.  .|  | |.  .|.    
YELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_7653.AA CMGC 118-130 46 0.016948 2.98 In-house 185-199 (513) Show / Hide 
Range on Protein: 118-130
Range on HMM: 185-199/513
Sequence Identity: 46% (7 aa)

YTYQLLTALS--YLH
|.||.|..|   |.|
YMYQILRGLKLKYCH
Kinase GL50803_7653.AA CMGC 211-232 26 0.030204 2.14 In-house 313-342 (513) Show / Hide 
Range on Protein: 211-232
Range on HMM: 313-342/513
Sequence Identity: 26% (8 aa)

SETTDIWSLGATLYEFFT--------LTPL
... |.||.|  ..| .|        . ||
TTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase GL50803_7653.AA Pkinase 65-130 25 6.917197 0.68 Pfam 57-125 (293) Show / Hide 
Range on Protein: 65-130
Range on HMM: 57-125/293
Sequence Identity: 25% (18 aa)

LRHPHIIPQLQTEQAPNNDIITTTPYYENG----SLQLLINVLKKDRKRV--SKSCFFSYTYQLLTALSYLH
|.||.|.  . . .  ...|   ..| |.|    .|  .| .  ......  |     .| ||.| .| |.|
LNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCH
Ank GL50803_7653.AA Ank 505-530 34 0.000247 19.89 Pfam 1-26 (33) Show / Hide 
Range on Protein: 505-530
Range on HMM: 1-26/33
Sequence Identity: 34% (9 aa)

MGRTALMLAAEKNQTRTVEILINYEA
.|.|.|.||.....|. |. |... |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_7653.AA Ank 536-568 24 0.001157 17.47 Pfam 1-33 (33) Show / Hide 
Range on Protein: 536-568
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

HGNTALILATMNNSIESIKILCKKESNIENRAR
.|.|.| || .....| .| | ..  ..  . .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_7653.AA Ank 572-587 31 52.522331 0.67 Pfam 6-21 (33) Show / Hide 
Range on Protein: 572-587
Range on HMM: 6-21/33
Sequence Identity: 31% (5 aa)

LLIAAHKGNLEAIRLL
| .|...|..| ...|
LHLACRCGHTEVVKML