Gene cdc2 (Fruit Fly)

cdc2

Species: Fruit Fly
Alias: CDCDm, DmCdk1, cdc2Dm, CDK1/CDC2, CDC2, Cdc2 kinase, Cdk1, CG5363, l(2)31Eh, CDK1, Dm cdc2, group 4, Dmcdc2, cdc, DmCdc2, cdc2, SFO103, cdk1, Cdc2, Dcdc2
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 31E2,

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
cdc2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
cdc2.AA Protein Various 297 None Fasta, JSON

Protein domain

Protein domains of cdc2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase cdc2.AA CDC2 4-287 65 1.8e-230 716.39 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-301/301
Sequence Identity: 65% (198 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEG--VPSTAIREISLLKELK-HENIVCLEDVLMEENRIYLIFEFLSMDLKKYMD-SLPVDKH
..|||||||||||||||.... |.||||.||||||..|||  ||||||||||.||||| |.|||.|.||... |..|..||.|.|||||||| |.| .||
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYT--HEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEM
|...||.||.||| ... |||.||..||||||||.||||.| ||.|||||.| ||||.| ||  ||.|||||||||.|||. |||.|||.||||||||||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKN---------LDANGIDLIQKMLIYDPVHRISAKDILEHP
   .|.||||.|||||||||..|||| ||.|..|||||.|||||||||.| ...|.....|         || .||||...||.||| .|||||..|.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase cdc2.AA CDK 4-287 51 3.6e-183 591.06 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-284/284
Sequence Identity: 51% (166 aa)

FEKIEKIGEGTYGVVYKGRNRLTG-----QIVAMKKIRLES-----DDEGVPSTAIREISLLKELKHENIVCLEDVLMEE-----------NRIYLIFEF
.||.|||||||||||||.|...||     ||||.||||.|.     ..||.|.|||||||||||| |.|||.| || . .           |..|..||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGL-----IKVADFGLGRSFGI------PVRIYTHEIVTLWYRA
. .|||||||            ...|..|. ... .||.....||||||||.||.. |      .|.||||| | |||      |.| ||||.|||||||
MDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRA

PEVLLGSPRYS--CPVDIWSIGCIFAEMAT---RKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQK
||.|||| .||  .|.|.||.|||||||.|   |||||.|||||||||. |||. |||||.|||||.||||                        ||..|
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNK

MLIYDPVHRISAKDILEHPYF
|| ||| .||||.. |.||||
MLCYDPKKRISAEQALQHPYF
Kinase cdc2.AA CDK5 4-287 58 2e-177 565.66 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 58% (168 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESE
.||.|||||||||.|||.||. |. |||.|..||.|.||||||||||||.|||||||.||| | ||.  |... |.|||.  ||||||||. .   |. .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG--EMDMH

LVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMA-TRKP
...|..||    . ||| ..||||||||||||| | |  | ||||| | |||||| |.||.||||||.| ||.||  || ..|.||.|||||||| . .|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYK---NTFPCWSTNQ-LTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYF
|| | .. |||.| |.|. ||.|| ||..| |||||   . .| .  .| . .  ..||..| || ||||...| .|||||. |.||||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase cdc2.AA CMGC 4-287 27 7.2e-149 492.9 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

FEKIEKIGEGTYGVVYKGRNRLTG--------------QIVAMKKIRLESDDE----------GVPSTAIREISLLKELK-----------------HEN
.|.|.||||||||||||.|...|.              .|||.|||...  .|          |.|..|.|||..||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVCLEDVLMEEN-----------------RIYLIFEFLSMDLKKYMDSLP------VDKHMESEL------------VRSYL------YQITSAIL--FC
||.| |... .|                  .||.||.. .||..|... .        ....               .....      |||  ..   .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HRRR--VLHRDLKPQNLLIDKS--------------------GLIKVADFGLGRSFGIP---------------------VRIYTHEIVTLWYRAPEVLL
|...  ..||||||.|.||..                     | .|..|||| |.....                     .| |||..||.||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GSPRYS---------CPVDIWSIGCIFAEMATR--------KPLFQGDSE-----------IDQLFRMFRILKTPT---------------EDIWPGVTS
|...|.         .|.|.||.||||||| |.        ||||.|.||           |||||..|..| |||               |..||....
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPDYKN--------------T------------FPCWSTNQLTNQLKN-----------------------------------LDANGIDLIQKMLIYDP
||.|..              .            || |  . ..|. ..                                   .|  .|||..|||.|||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

VHRISAKDILEHPYF
  ||.|...|.||||
DKRITAEQALQHPYF
Kinase cdc2.AA PCTAIRE 4-287 47 8.3e-123 414.29 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-291/291
Sequence Identity: 47% (140 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESE
. |..| |||||  |||.| .||. .||.| ||||  .|| | |||||.||||.||| ||| | |..  .    |.||.. ||||.|||       |.. 
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDD--CGNIMNMH

LVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPL
 |. .|.|.     .||||..||||||||||||.  |  | ||||| |   .| ..| ||.|||||| |.||.||  || ..|.| .||||.||.| .||
NVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPL

FQGDS------EIDQLFRMFRILKTPTEDIWPGVTSLPDYKN-TFPCWSTNQLTNQLKNLD---ANGIDLIQKMLIYDPVHRISAKDILEHPYF
| |          |||   |||| ||.|  ||||.|......  ||..    | |    ||    ...||....| | .  |.|| . ..||||
FPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase cdc2.AA PITSLRE 4-287 43 4.6e-122 411.82 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-295/295
Sequence Identity: 43% (128 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLE--SDDEGVPSTAIREIS-LLKELKHENIVCLEDVLM--EENRIYLIFEFLSMDLKKYMDSLP--V
|... .|.||||||||......|. |||.|.. .|   . || | |..|||. .|..|.|.||| .  ..|    . ||...|..  |||  |.      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

DKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAE
..  ..| . . . |  ... . |   ..|||||  |||.  .|  |..||||.| .| |.. ||  .|||||||||.|||.. || |||.||.||||||
QPFKPGE-IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAE

MATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKN-T-FPCWSTNQLTNQLK---NLDANGIDLIQKMLIYDPVHRISAKDILEHPYF
. | ||||||.|||||. . |  . |||| ||||.|.||  |. . ||    |.| .  .    .  .| || ..|| |.|  ||.| | | ||.|
FITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase cdc2.AA PFTAIRE 4-287 48 2e-118 399.76 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 48% (141 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESE
.||.|| |||.|  ||||. ....|.||.| |||. ..||.| ||||| ||||.||| ||||| |.   .    ..||..  ||..|||. |    |. .
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHP--GGMHPN

LVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPL
 || .|.|      .||.||||||||||||||| . |  | ||||| |   .| . | ||.|||||| | |||||  ||  .|.| .|||| || . .|.
NVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPA

FQGD-SEIDQLFRMFRILKTPTEDIWPGVTSLPDYK-NTFP--CWSTNQLTNQLKNLD--ANGIDLIQKMLIYDPVHRISAKDILEHPYF
| |     ||| . |..| ||||| ||||..|| ||   |.    .  .| .|.  ..  ... ||..||| . |  |.||.. ..||||
FPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase cdc2.AA Pkinase 4-287 33 2.8e-107 367.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIR--EISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSL-----PV
.....|||.|..|.|||.... ||.|||.|.|.......... |..|  ||...|.|.|.||| | |. .....||...|.. ..|.  ||         
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

DKHM--ESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLI----KVADFGLGRSF-GIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWS
.. .  . . ...|.||| ... .||.....||||||.|.|||. | |    |..|||| . |   . . .|.  .|.||.||||..|.. |. .||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGCIFAEMATRKPLFQGD----SEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHP
.|||..||....|.|.|.    . .||.....||...|..  ||   | .... ... | .  ..   .|.. ...|.| ..| .||  |..|..||.||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase cdc2.AA S_TKc 4-287 31 9.20000000001e-106 358.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSM---DLKKYMDSLPVDKH-
.|...|||.|..|.|||.|.. ||.|||.|.|.          ...|||..||. .|.||| | ||  . ...|...|...    ||..|... .  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSC-PVDIWSIGCIFAE
  .    .|.|.||| .|. .||.....||||||.|.|.|.   ||..|||| | .       |. ..|.||.|||||     |.. ..|.||.|||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILE-------HPYF
|....|.|.      |...||....                                   .  ..|.|.|.| .|| .|..| ..|.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase cdc2.AA CDK4 4-287 42 1.1e-96 327.55 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-290/290
Sequence Identity: 42% (127 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDE--GVPSTAIREISLLKELK---HENIVCLEDV--LMEENR----IYLIFEFLSMDLKKYMD
....  |||| || ||. |   ||..|| |..|  . .|  |.|   |||||... |.   | ||| | ||   |.  |    | ..||    ||. |.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SLPVDK-HMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIG
 .|  .  |  . ..    |. ... | |  |. ||||||||.|.  .| .| ||||| | ..      |  .|||||||||||| |. |  |||.||.|
KCP--PPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMAL-TPVVVTLWYRAPEVLLQSY-YNTPVDMWSVG

CIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYF
||||||  |.||| | || ||| . | .  .|.|| ||   |||     ||  .  ..      ..  |.||.|||| |.. .|.||   |.||||
CIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase cdc2.AA CDK7 118-287 47 5.7e-94 250.61 In-house 117-288 (288) Show / Hide 
Range on Protein: 118-287
Range on HMM: 117-288/288
Sequence Identity: 47% (82 aa)

FCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMF
.|||  .||||||| |||... | .|.||||| |..| | ||||| .|| |||||| | |   |   ||.||.||||||   | | . |||.|||| | |
YCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIF

RILKTPTEDIWPGVTSLPDYKN--TFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYF
..| ||||  ||......||     ||  |   | .         .||...|.  .|. |... . |..|||
QTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase cdc2.AA CRK7 4-287 32 1.1e-93 317.61 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-343/343
Sequence Identity: 32% (113 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESD---DEGVPSTAIREISLLKELKHENIVCLEDVLME--------ENR--IYLIFEFLSMDLKKY
.|.|. ||||||| ||| .|  ||..|| ||.|.. .    || | |||||| .|..|.|.||| | ..  .        . .  .|..||    ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPV--RIYTHEIVTLWYRAPEVLLGSPRY-------
..|  . .|   . ..... |.   .  ||.. .||||.|  |.|.. .| .| ||||| | .      |.||  ..|||||.|| |||  ||       
LESKEM-HHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK

-------------------------------SCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDY-----KNTFPCWS
                                  .|.|| |||..| .|.||.|||  |..||   ..|  .|. . || |. || .     | ..   .
ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRL

TNQLTNQLK--NLDANGIDLIQKMLIYDPVHRISAKDILEHPYF
 ..   . |  ....   ||  ||| .||  |..|.. |.|..|
REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase cdc2.AA CDK7 4-87 44 1.3e-44 116.44 In-house 1-88 (288) Show / Hide 
Range on Protein: 4-87
Range on HMM: 1-88/288
Sequence Identity: 44% (39 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIR----LESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDL
.|||..||||....|||..   |||||| |||.     .  . |.  |||||| .|.|..|.|.. | |..|    |.|.|.|.  ||
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDL
Kinase cdc2.AA Pkinase_Tyr 4-149 27 1.2e-22 77.28 Pfam 1-157 (270) Show / Hide 
Range on Protein: 4-149
Range on HMM: 1-157/270
Sequence Identity: 27% (44 aa)

FEKIEKIGEGTYGVVYKGRNR----LTGQIVAMKKIRLESDDEGVPSTA------IREISLLKEL-KHENIVCLEDVLM-EENR--IYLIFEFLSM-DLK
 ....|.||| .|.||||. .     |.. || |...     ||  . .      .||....|.| .|.|||.|  | . ..    ||...|.    ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYMDSL-PVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGL
.|  .  . ...   .   .. .|| ..  . ....  ||||   | |..... .|..||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase cdc2.AA TyrKc 4-253 20 5.8e-15 19.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-253
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKEL--KHENIVCLEDVLMEE-------NRIYLIFEFLSM-DLKKYM-D
 ....|.||| .|.||||. .   . || |... ..         .||......|  .|.|||.|  | ...         .....|. .  |||.|  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVR--------IYT-----HEI--VTLWYRAPEVLLG
. |       .   |. .|| .   . |.... ||||   | |... . .|..|||| |   |            |.     ..   . .   |||..  
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

SPRYSCPVDIWSIGCIFAEMATR-KPLFQG-------DSEIDQLFRMFRILKTPTEDIWPGV----TSLPDYKNTFPCWST--------NQLTNQL
. ...   |.|| |    |. |. ..   |       ..|. .. .  . .. | .|  | .     .   |.    ||          ...  ..
G-KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF