Gene Pitslre (Fruit Fly)

Pitslre

Species: Fruit Fly
Alias: Gta, Pitslre, Galactosyltransferase-associated, Galactosyltransferase-associated kinase-like, PITSLRE, Gat: Gat-like, CG4268, SFO197, Gat-like, group 3
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 77E6,

Classification

Group: CMGC
Family: CDK
Subfamily: PITSLRE

Sequence

Name Sequence Type Origin Length Description Download
Pitslre.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 294 Kinase domain by global Sugen HMM Fasta, JSON
Pitslre.AA Protein Various 952 None Fasta, JSON

Protein domain

Protein domains of Pitslre.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Pitslre.AA PITSLRE 558-851 71 1.1e-237 795.91 In-house 1-295 (295) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-295/295
Sequence Identity: 71% (215 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKME--KEKEGFPITSLREINTLLKG-QHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRK
|||||||.|||||||||||||||.|||||||||||  |||||||||||||||..|.. ||||||.|.|||.|||||||..||.|||||||||||.||.|.
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEF
|.|.|||.|||.|||||.|.|.|||||.||||||||||.|||||||..|||||||||||||.||..|||||||||||||....||||.|.||||||||||
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQ--EKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFF
..| |||.||||||..|.||||.|||.||||||.||||..|.| .    |..||...|||.|.  ...|..|..||...|||.||.|..|..||||..|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNN----FPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Pitslre.AA CDK 558-851 43 3.7e-171 552.01 In-house 1-284 (284) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-284/284
Sequence Identity: 43% (144 aa)

FQCLNRIEEGTYGVVYRAKDKRTN-----EIVALKRLKMEK-----EKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMD---------KIFIVMDY
...|..| ||||||||.|.||.|.     .|||||...||.     ||||||||..|||..| .  |||||.........|||         |...|..|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGI-----LKVGDFGLAREYGS------PIKKYTSLVVTLWYR
..||||..|.             .||...||||.....|.|||.|||||..|.|....|.     ||..||||||..|.      |...||. |||||||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELLLCSPVYS--TPIDVWSVGCIFAEFLQ---MLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSE
|||||| |  ||  ||||.|||||||||...     |||||.|||| | .||. .|||.|..||| |.||                              
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------------

MGLSLLQGLLTYDPKQRLSADAALKHGFF
    ||...|.||||.|.||..||.| .|
---DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Pitslre.AA CDC2 558-851 44 3.5e-138 427.55 In-house 1-301 (301) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-301/301
Sequence Identity: 44% (137 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEG--FPITSLREINTLLKGQ-HPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRK
.|....| ||||||||..||..||.|||||. . | | ||  .| |..||| .| . . |||||. .....     |...| .|...||| .|.  .  .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYT--SLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFA
... |  || .. |.|..|...| . |.||||| .|.|.. || .|..||||||  | ||..||    ||||||||||.|| .  ||||.|.||.|||||
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EF---LQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEK--------TSEMGLSLLQGLLTYDPKQRLS
|.    .  |||.|.||||.| .||. ||||||..||| |.||  ||       | ... ..|.|..  .        . . |..||. .| ||| .|.|
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNT------FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

ADAALKHGFF
|..||.| .|
AKEALQHPYF
Kinase Pitslre.AA CMGC 558-851 26 3.5e-137 453.81 In-house 1-513 (513) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-513/513
Sequence Identity: 26% (136 aa)

FQCLNRIEEGTYGVVYRAKDKRTN--------------EIVALKRLK---MEK------EKEGFPITSLREINTLLKGQ-----------------HPNI
......| ||||||||...|||||              ||||.|..|   .|       ||.||||..||||  | . .                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTVREIVVGSNMD---------------KIFIVMDYVEHDLKSLMETMKN-----RKQSFFPGE------------VKCLT------QQLLRAVA--HLH
|. ..|.. .|.|               ....|..|..|||. ... ...     |.. . . .            .|...      .|.||...  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNW--ILHRDLKTSNLLLSHK--------------------GILKVGDFGLAREYGSP---------------------IKKYTSLVVTLWYRAPELLLC
 .|  |.||||| .|.|..|.                    |.||..|||||| |...                      . ||. |||.||||||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SPVYS---------TPIDVWSVGCIFAEFLQM--------LPLFPGKSE-----------IDELNRIFKELGTPN---------------EKIWPGYTEL
.. |.         ||||.||||||||| ..          |||||.||           || |..||| ||||.               |..||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

P--------------------AVKNMLSQNSQFTEYPVSQLRKHFQE----------------------------------KTSEMGLSLLQGLLTYDPK
|                     ..| ...| .| ..|   ... |                                    . .. .. ||...|.|||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRLSADAALKHGFF
.|..|. ||.| .|
KRITAEQALQHPYF
Kinase Pitslre.AA CDK10 558-851 50 5.5e-124 418.21 In-house 1-285 (285) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-285/285
Sequence Identity: 50% (148 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSF
|  |||. |||||.||||.| |..||||||. .|.|||.| || .||||  |.. .|.||| ..|.|||  .| ||.||.| | || ||.. |    | |
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNM---PQPF

FPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQM
   .|||.. |.||..  ||||...||||| ||||.. || .|| |||||| || |.|  |  .|||||||||||| .    | ||.| |||| .| |  
TETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVH

LPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFF
 ||.|| |||  .. | . ||||.|.||||...||.|     ||    . |   |.. |.   |. |. ||. |. |.||.|  |. .|.  .|
KPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMV-----QNFTLKKQPYNNLKHKFH-WLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase Pitslre.AA CDK5 558-851 43 1.6e-119 379.43 In-house 1-287 (287) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-287/287
Sequence Identity: 43% (128 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSF
.. ...| |||||.||.|..| | ||||||| ... | || | | .|||  |   .|.|||    ..   .  |. .|  ..  |||  |. ..      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNG---EM

FPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFL-Q
 .  .| .  |||. .|  |.. .||||||  ||| . .|.|| .|||||| .| |.. |.. |||||||.|  |. | .|||.||.||.||||||    
DMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

MLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQ-LRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFF
  ||||| .. |.| |||| .|||.|  ||. |.||  |       |.  ||. | . .. ..  .| |. |||..| ..|.||.||.|||.| .|
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNH---QQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Pitslre.AA CDK7 558-851 38 1.9e-119 319.86 In-house 1-288 (288) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-288/288
Sequence Identity: 38% (115 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLK----MEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNR
.. .  | ||....||.| |. |..||| |. |     .  | |   | .|||  |   ||.|..  . |      . |  |.|. . ||    .  |  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLE---VVIKDK

KQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAE
.  . | ..|  . ..|. . ..| |||||||||  |||..  |.||..|||||| |||| . ||. ||| ||||||||     | | .|.|||||||||
SIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAE

FLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPV---SQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGF
 .   | .|| |.|| | |||. ||||.|. ||. ....          .|...|      ||. |   . .  | |..|..| .| .|...  .||. .
LMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY-------IKFKDFPGYSRTPLRHIFTAASDDL-LDLMCGMWTMNPCKRWTCTQCLKMPY

F
|
F
Kinase Pitslre.AA CRK7 558-851 35 1.2e-99 337.31 In-house 1-343 (343) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-343/343
Sequence Identity: 35% (124 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKE---KEGFPITSLREINTLLKGQHPNIVTVREIVVG------SNMDK--IFIVMDYVEHDLKSL
.. .. | ||||| || ||.|.|.|.||||...|. |   |||||||. |||  |   .|.|||. .|||.       .. .|  .. | .|. |||  |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

METMKNRK--QSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPI--KKYTSLVVTLWYRAPELLLCSPVY----
.|     |  . | ....||.  |||  .. .|.. .||||.| ||.|.  .|..|  |||||| | |    ..||  |.|||||.|||||    |    
LES----KEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQH

----------------------------------STPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQF
                                   . ||.||.|||..| .   |.|.|. |.. |  |.|  |.||   ||  ..||   |.. .  |.
ILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWW-NTMKPKRQY

TEYPVSQLRKHFQE-----KTSEMGLSLLQGLLTYDPKQRLSADAALKHGFF
.    . ||. | .       ..  | || ..|..||| | .|  .| |..|
N----RRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Pitslre.AA S_TKc 558-851 26 1e-93 318.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEH---DLKSLMETMKNRK
.. |. | .|..|.||....|.|..|||.|..|         .. .|||. | | .|||||.  .. .    |....||.|...   ||..... .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--QSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYST-PIDVWSVGCIF
  . | . .......|...|....|...|.||||| .|.||..   .|..||||||..       |....|.||.|||.|     |.. ..|.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

AEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALK----
.|.|   |.||      .....|| .|                                          |. ........|..||..|..|  ||.    
YEMLCGYPPFP------QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HGFF
   | .|
IKCHPWF
Kinase Pitslre.AA Pkinase 558-851 29 1.3e-87 302.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLR--EINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETM----K
.... .| .|..|.||....| |..|||.|..| ..||.....| .|  ||  ... .|||||. ....     |.| .||.|.|..|. .|. .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

NRKQSF--FPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGIL----KVGDFGLAREY-GSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDV
 |. .|   . |.|.   |.||.....|...|.||||| .|.|....| .    |..|||||. .   .   .|....|.||.|||... .. |....|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGCIFAEFLQMLPLFPGK----SEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRL
||.|||..|.|   |.|||.    . .|.. .|.. .|.|..  ||   . .  . .  . .        . .. |  ..|| ..... ..|..|||.|.
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

SADAALKHGFF
.|. .|.| .|
TAEQILQHPWF
Kinase Pitslre.AA CDK4 558-851 39 8.5e-84 284.7 In-house 1-290 (290) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-290/290
Sequence Identity: 39% (119 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKE--GFPITSLREINTLLK----GQHPNIVTVREIVVGSNMDK----IFIVMDYVEHDLKSLM
.||.. | || || |||| |  |  .||||. .   . |  | |.  .||| ....      |||||   ..   .  |     | .|.  .. ||. ..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREI-SVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

ETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSV
.  |  .    |  .| .. ||||.|  || . | |||||  |.|..  | .|  ||||||.|..   . |..|||||||||| || |. | ||.| |||
D--KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLLQSY-YNTPVDMWSV

GCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALK
||||||     |||.|.|| | | .||.  |.| |. ||    ||         . |  .   .. | |    .. |. |||  |.|... |.|| ..|.
GCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPW--------DHFPQRHPRPF-KDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQ

HGFF
|..|
HPYF
Kinase Pitslre.AA PFTAIRE 558-851 38 7.9e-78 264.87 In-house 1-287 (287) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-287/287
Sequence Identity: 38% (114 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKG-QHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQS
.. |..  ||.|  ||... . .. .||||  ....| || | |  ||   |||. .| |||.   |.         .|  ||. ||.  |.   .    
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREA-SLLKNLKHANIVCLHDIIHTKET--LTFVFEYVHTDLCQYMDKHPG---G

FFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQ
  |  |.    ||||  .  |   .||||||  |||.||.| ||  ||||||    | . | . ||||||| |  || |  ||| .|.| ||||| | ..
MHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMW

MLPLFPGK-SEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFT--EYPVSQLRKHFQEKT-SEMGLSLLQGLLTYDPKQRLSADAALKHGFF
  |.|||     | |..||| ||||.|  ||| ..||  |       .|.   |   .|.. .        . .|....| . |..|.||..|..| .|
GQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPH-----WFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase Pitslre.AA TyrKc 558-851 19 1e-12 -17.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 558-851
Range on HMM: 1-280/280
Sequence Identity: 19% (65 aa)

FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKG--QHPNIVTVREIVVGS-----NMDKIFIVMDYVEH-DLKSLMET
 . .  . || .|.||... |   . || | || .. .| |    .||.. . |   .|||||    ... .       . ..||| |..| |||.    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSP-----IKKYTS------LV--VTLWYRAPELLLCSP
 ...   . . .      |  .  ..||.. . |||| . | |...... |..||||.|. ..       |.| .          . .   ||| .    
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

VYSTPIDVWSVGCI------FAEFLQ--M----LPLFPGKSEIDELNRIFKELG----TPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKT
...|  |||| |        . .     |    .. .     ... .|  .                                            | . .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------FVCCP

SEMGLSLLQGLLTYDPKQRLSADAALKHGFF
.||   . .    .||..| .  .   | .|
DEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase Pitslre.AA Pkinase_Tyr 566-708 30 2.2e-11 39.21 Pfam 9-159 (270) Show / Hide 
Range on Protein: 566-708
Range on HMM: 9-159/270
Sequence Identity: 30% (48 aa)

EGTYGVVYRAKDK----RTNEIVALKRL---KMEKE--KEGFPITSLREINTLLKG-QHPNIVTVREIVV--GS-NMDKIFIVMDYVEH-DLKSLMETMK
|| .|.||... |     |.  || | |    |...  .| |    .||.... .  .|||||    ...  |  |  .|.||| |..| ||..   . .
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHR

NRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAR
. ||.. . .  .  .|  .. ..|... . |||| . | |...... |..||||||
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR