Gene Cdk4 (Fruit Fly)

Cdk4

Species: Fruit Fly
Alias: l(2)k06503, Cdk4/6: Cyclin-dependent kinase, Protein kinase-like 53C, Cdk4/6: Cyclin-dependent kinase 4/6, DmCdk4, CDK4, CDK4/6, Cdk4/6, Cyclin-dependent kinase 4/6, l(2)05428, Cdk4, cdk4/6, cdk4, l(2)s4639, CG5072, Pk?7, 8-6, Pk53C, SFO027
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 53D3--4,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK4

Sequence

Name Sequence Type Origin Length Description Download
Cdk4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 287 Kinase domain by global Sugen HMM Fasta, JSON
Cdk4.AA Protein Various 317 None Fasta, JSON

Protein domain

Protein domains of Cdk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdk4.AA CDK4 26-312 58 1.8e-222 745.33 In-house 1-290 (290) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-290/290
Sequence Identity: 58% (170 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNEN--GVPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDG-QLLILLVFEHVEQDLSDLID
||....||||||||||||||..||..||||.|||...|.  |.||||.||||....|....|.|||||..||.....|. ...|..||||...||....|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

RLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNSTVDIWSAACIIF
..|..||.|.||......||.|||||||||||||||||||.||.|.||.|.||||||..|...|.||.||||||||||||||...||..||.||..||..
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIFA

EMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF
||..||.||.|.|||.||..||...|.|.|..||...|....|||||||...||||||.||..||||.|||.|..|.|.||..||.|.||
EMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase Cdk4.AA CDK 26-312 40 4.6e-147 473.66 In-house 1-284 (284) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-284/284
Sequence Identity: 40% (130 aa)

YQELNIIGEGAYGTVYRARDVITG-----NIVALKKVRISLN----E-NGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQ------LLILLV
|. |. ||||.||.||.||| .||     .||||||.|.  .    |  |.|....|||||||.|    |.|||||..||   ..| .        . .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL----HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

FEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGH-----LKIADFGLAKTYGS-------EMKLTSVVVTLWY
||....||. ..|           |. . . || |....||..|.||||||||.|....|.     |||||||||. .|.        ...|..||||||
FEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPEVLL-AQPYN--STVDIWSAACIIFEMFN---RRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLCKYADDLLNK
||||.|| .. |.   ..|.||. ||. |||.   |..||||.|| .||..||.. | |||..||   .  .                       |||||
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------DLLNK

MLSYDLHLRPSALACLEHDYF
|| || . | || ..|.|.||
MLCYDPKKRISAEQALQHPYF
Kinase Cdk4.AA CMGC 26-312 24 8.49999999999e-128 422.38 In-house 1-513 (513) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-513/513
Sequence Identity: 24% (128 aa)

YQELNIIGEGAYGTVYRARDVITG--------------NIVALKKVRISLNENG---------VPMSTLREISLLKQLNAS--------------NHANI
|. .. ||||.||.||..||  |.              .|||.||..   .|..         .|...||||..||.||                .| ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLYEVCQFLERDGQL------------LILLVFEHVEQDLSDLIDRLPKS-------GMSPPT------------IQRLS------RELLTGVD--FLH
||||..... . ||..             . ||||....|| ..|.. ..        ..|.              |. ..      . .|.|..  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SHR--IIHRDLKPQNLLVSSQ--------------------GHLKIADFGLAKTYGSE----------------------MKLTSVVVTLWYRAPEVLLA
||.  ||||||||.|.|....                    |.|||.|||||. |...                      . .|. |||.||||||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

QP----------YNSTVDIWSAACIIFEMFNR--------RALFPGTSE-----------KNQLDRIFELTGRPT---------------EQQWPQTISV
 .          |....|.||..||..||...        . |||| ||            .||..||.. | ||               |..||. |. 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

ALEH----------------------------FPQRHPKRPKDFCPH-----------------------------------LCKYADDLLNKMLSYDLH
   .                            ||...||  |...|                                    ... | |||.||| || .
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

LRPSALACLEHDYF
 |..|  .|.|.||
KRITAEQALQHPYF
Kinase Cdk4.AA CDC2 26-312 41 2e-117 362.57 In-house 1-301 (301) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-301/301
Sequence Identity: 41% (129 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENG--VPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLID-
|| .. |||| || ||...|. |. ||||||.|.  .. |  || ...||||.|| |.  .| ||||| .|           . .||| ...||  . | 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK--DHPNIVKLHDVIHQ------NKLYMVFEYLDMDLKKYMDM

RLPK-SGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LT--SVVVTLWYRAPEVLL-AQPYNSTVDIWSA
 .|| . |.| ... .   .| ||.|.|..||.||||||||.|....| .||||||||.. |  .. .|    ||||||||||.|| .. |. .||.|| 
SIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSI

ACIIFEM---FNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVA--LEHFPQRHPKRPKDFCPH---------LCKYADDLLNKMLSYDLHLRPSA
 ||. ||    ....||.| ||  || .||.  | |.|| ||   .     . ||. .|. ... ||          |.. . |||..|| ||   | ||
GCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISA

LACLEHDYF
 . |.| ||
KEALQHPYF
Kinase Cdk4.AA CDK5 26-312 41 5.9e-103 326.19 In-house 1-287 (287) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-287/287
Sequence Identity: 41% (123 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLP
|. .. |||| |||||.||.  |. |||||.||.  .  ||| . .|||.||| |    | ||| |. |   .  .  |   ||||.. |||   .| . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKEL---KHKNIVRLHDV---IHSEKKL--TLVFEFCDQDLKKYMDSCN

KSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKL-TSVVVTLWYRAPEVLL-AQPYNSTVDIWSAACIIFE
  .|....|. .   || |. | |.|.. ||||||||||.. .|.|| ||||||  .|   .  .. |||||||.| ||. .. |.  .|.||. ||. |
G-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

MF-NRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTIS-----VALEHFPQRHPKR-PKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF
|  . | ||||.....|| |||...| |.| .||         .  . .| ....   .  .|.| .   |||.||| .. . | || | |.| ||
MANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Cdk4.AA S_TKc 26-312 29 1.2e-96 328.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-231/231
Sequence Identity: 29% (90 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQ---DLSDLID
|. |..||.||.|.||..|.. || |||.|...          ...|||..||.    .| ||||||.|.|         . .|.|....   || |.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK----HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIK

RLPK----SGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAPEVLLAQPYNS-TVDIWSA
. ..    ..... ..... .... .....|||.||||||||.|.|...  |.||.|||||. .      |....|.||.|||||   .|.   .|.|| 
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

ACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLE-------HD
 ||..||. .. .||      |....|.. |                                  . | |...|.| .|   ||.|  .|.       | 
GCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

YF
.|
WF
Kinase Cdk4.AA Pkinase 26-312 31 4.2e-89 307.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLR--EISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDR
|. . .||.|..|.||..... || |||.|... . .. ..... .|  ||...| ||   | |||.||....    .. .   .|.|..| .|. ..| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED---KDHIY--MVMEYCEGGLY-VMDL

L------PKSGM--SPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHL----KIADFGLAKT--YGSEMKLTSVVVTLWYRAPEVLL-AQPY
        . ..  |. ....  ...| |....||..||||||||.|.|....||.    ||.||||||   | .   .|....|.||.||||.. .|.|
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

NSTVDIWSAACIIFEMFNRRALFPGT----SEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSAL
 . ||.||. ||..||...| .|||     .  .|. .|..  |.|.. .||...|. ...|... .. .. | . . . . |.....| .| . ||.| 
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

ACLEHDYF
 .|.|..|
QILQHPWF
Kinase Cdk4.AA PITSLRE 26-256 44 1.5e-83 283.86 In-house 1-232 (295) Show / Hide 
Range on Protein: 26-256
Range on HMM: 1-232/295
Sequence Identity: 44% (107 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRIS--LNENGVPMSTLREIS-LLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLID
.| || |.||.|| ||||.|  |. |||||.. .       | |   ||||. .|. |   .| |||.. |.      |    | .|.| || || .|..
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMAL---QHPNIVNVKEIVMGSNMD---KIYMVMEYVEHDLKSLME

RLP--KSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSE-MKLTSVVVTLWYRAPEVLLAQPYNST-VDIWSAA
     .   .|. |  |   || ||...|.. |.|||||  ||| | .| |||.|||||  |||  ...|..||||||||||.|| ..  || ||.||  
NMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVG

CIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP
||  |.   . ||.| || .|...|| . | |||. ||
CIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWP
Kinase Cdk4.AA PFTAIRE 26-312 39 2.7e-76 259.8 In-house 1-287 (287) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-287/287
Sequence Identity: 39% (119 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLP
|. |.  ||| | |||...  |.. .|||| .|.  .| |.|    || ||||.|    ||||| |  .    |     .  .||| |. ||.  .|. |
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEE-GTPFTAIREASLLKNL---KHANIVCLHDIIHTKE-----TLTFVFEYVHTDLCQYMDKHP

KSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLA-------KTYGSEMKLTSVVVTLWYRAPEVLL-AQPYNSTVDIWSA
  || |  ..     || |  . |  |. ||||||||||.|  | || ||||||       .|| .|      ||||||| | ||| .  | . .|.| .
-GGMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHE------VVTLWYRPPDVLLGSTEYSTHLDMWGV

ACIIFEMFNRRALFPGT-SEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHP---KRPKDFC---PHLC--KYADDLLNKMLSYDLHLRPSALACLE
 || .||.  ...|||     .||..||.. | |||. || ...   .  |.. .    .||  |   | .     | ||..||| .    | || . ..
GCIFVEMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWP-GVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQ

HDYF
|.||
HPYF
Kinase Cdk4.AA CDK10 26-312 40 9e-73 248.07 In-house 1-285 (285) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-285/285
Sequence Identity: 40% (119 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLP
.  || .|||.|| ||||||. .  ||||||||.     |.|.| |||| ||.|.    | |||.| ||    . |    | || .. ||||  |.| .|
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQC---RHENIVELHEVVVGQHLDS---IFLVMQYCEQDLASLLDNMP

KSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLLAQPYNST-VDIWSAACIIFE
 .  .   .. .   .| |. .||.. .||||||  |||.. .| .|.||||||. ||  .| .|  .|||||||||.||    . | .|.| . ||. |
-QPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGE

MFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP--QTISVALEHFPQRHP-KRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF
.   . |.||.||  |.| | .| | | |. ||    . .. ..  .. |    |   . | .    ||| .. |.   |  |  |||  ||
LLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase Cdk4.AA MAPK 26-312 33 1.1e-71 244.46 In-house 1-328 (328) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-328/328
Sequence Identity: 33% (113 aa)

YQELNIIGEGAYGTVYRARDVI------TGNIVALKKV-RISLNENGVPMSTLREISLLKQLNASNHANIVKLYEVCQFLE----RDGQ--LLILLVFEH
|| |  ||.||||.|  |.|.       .|..||.||. |   |.      |.||| ||. ..  .| ||.||... .  .    .. .    | .|.| 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-RTYREIKLLRHFH--HHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMEL

VEQDLSDLIDRLPKSGMSPPTIQRLSRELLTG--VDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSE---------------MKLTSVVVTL
 | ||  .| . .   .|   || .   .| |  . ..|| ..||||||| |.|| . . |||.||||| .  .|               | .|  |.| 
METDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPEVLLA---QPYNSTVDIWSAACIIFEMFN-RRALFPGTSEKNQLDRIFELTGRPTEQQWPQTI-SVALEHFPQR---HPKRPK-DF----CP---
||||||..|    . |. .||.||. ||  || . |. ||||..  .|. .|.|..| |.|. . .   | .  .. |.   .||.|| ..    .    
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

HLCKYADDLLNKMLSYDLHLRPSALACLEHDYF
. .  | ||| |||  | . | ..  .|.| ||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Cdk4.AA CRK7 26-312 32 1.1e-71 244.42 In-house 1-343 (343) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-343/343
Sequence Identity: 32% (114 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLN---ENGVPMSTLREISLLKQLNASNHANIVKLYEVCQF----LERDGQL-LILLVFEHVEQDL
|. ...|||| || || |..  || .|||||||       . | |    ||| .|.||   ||.|||.| |.       .|   .   . .||| .  ||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL---NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL

SDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGS---EMKLTSVVVTLWYRAPEVLL-AQPY-----
. | .       |.  .  . . || |.| .|   ..|||.|  |.|.  ||..||||||||  | |   . ..|  |.|||||.|| || .. |     
MGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------NSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKR--
                                 .  .|.||  ||  | |.....|.|  |  ||. |... | |. . ||  .   |  .    |||  
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVM--KLPWWNTMKPKRQY

----PKDFCP-----HLCKYADDLLNKMLSYDLHLRPSALACLEHDYF
     ..|        . | . ||| ||| .|   | .|  ||.||.|
NRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Cdk4.AA TyrKc 26-312 20 4.6e-15 20.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

YQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQL--NASNHANIVKLYEVCQF-LERDGQ---LLILLVFEHVEQDLSD
 . . ..||||.|.||...       || |... .       .  .||......|  .   | |||.|| ||    ..        ...|.|...    |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGH---HPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPH--GD

LIDRLPKSG--MSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSE--------MKLT----SVV--VTLWYRAPEVL
| |.| |..   ....    .     | ..|||...|||||   | ||..... ||.||||..  ...        .. .    .    . .   |||..
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LAQPYNSTVDIWSAACIIFEMFNRRALFPGTSEK--NQLDRIFELTGRPTEQQWPQT---ISVALEHFPQRHPKRPKDFCPH-LCKYADDLLNKMLSYDL
    ...  |.||    ..|.| . .  .   ..     ....|.  .      |.    .|                | ..   .  . .  .   .| 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------F-VCCPDEMYQ-IMKQCWHEDP

HLRPSALACLEHDYF
. ||.  ..  |..|
EDRPTFSEI--HECF
Kinase Cdk4.AA Pkinase_Tyr 26-181 29 2.8e-14 48.96 Pfam 1-160 (270) Show / Hide 
Range on Protein: 26-181
Range on HMM: 1-160/270
Sequence Identity: 29% (50 aa)

YQELNIIGEGAYGTVYRARDV----ITGNIVALKKVRISLNENGVPMST------LREISLLKQL-NASNHANIVKLYEVCQFLERDG-QLLILLVFEHV
 . .  .||||.|.||...       |.  || |...     .|   .       .||....||| .   | |||.|| ||   .... .  |..|.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGH---HPNIVRLYGVCT--DQGEPN-QIYIVMEYM

EQ-DLSDLIDRL--PKSGMSPPTIQRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKT
.  || |   .   .|   .....   ...   | ..|.|...|||||   | ||..... ||.|||||..
PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase Cdk4.AA PITSLRE 287-312 46 8e-06 17.36 In-house 270-295 (295) Show / Hide 
Range on Protein: 287-312
Range on HMM: 270-295/295
Sequence Identity: 46% (12 aa)

DLLNKMLSYDLHLRPSALACLEHDYF
||||.|| |.   | .| . | |..|
DLLNQMLTYNPKNRITASDALKHPWF