Gene Cdk9 (Fruit Fly)

Cdk9

Species: Fruit Fly
Alias: SFO063, PTefb, P-TEFb, CG5179, P-TEF, CDK9, small subunit, positive transcription elongation factor b, p43 PITALRE, positive transcription elongatio, cdk9, Cdk9, Positive transcription elongation factor b, Positive transcription elongatio
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 59A4,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK9

Sequence

Name Sequence Type Origin Length Description Download
Cdk9.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 298 Kinase domain by global Sugen HMM Fasta, JSON
Cdk9.AA Protein Various 404 None Fasta, JSON

Protein domain

Protein domains of Cdk9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdk9.AA CDK9 50-347 71 1.8e-261 874.89 In-house 1-340 (340) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-340/340
Sequence Identity: 71% (245 aa)

YEKVAKIGQGTFG-----------EVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRS--TFYLVFD
|||.|||||||||           ||||||.|| ||..||||||||.||||||||||||||..||||||||||||||||||||||.|.|..  |||||||
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKK-NKRMVAMKKVLMENEKEGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFD

FCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNR--YTNRVVTLWYRPPELLLG
||||||||||||||||||||.|||.||.|.|||||||.|||||||||||||||||.|||||||||||||||.|||...||  ||||||||||||||||||
FCEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLG

DRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSI------ELPKNQKRRVKERLRPYVK------------
|||||||.|||||||||||||||||||||||||.||..|||||||.||||||..|..||....      ||||.|||.||.|...|.|            
DRNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDRMKNYMKFDAPDSKTDPFG

----------DQTGCDLLDKLLTLDPKKRIDADTALNHDFF
          ||..|.|.||||..|||||.|.|.||.||.|
KNVKQHDSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF
Kinase Cdk9.AA CDK 50-347 44 8.10000000001e-169 544.4 In-house 1-284 (284) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-284/284
Sequence Identity: 44% (144 aa)

YEKVAKIGQGTFGEVFKAREKK-G---NKKFVAMKKVLMDN-----EKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRS----TFYLVFD
|||..|||.||.|.|.||| |. |   ....||.||. |.|     |||||||||.||| .|. | |.|.|.|...| ||....|. ..    ..|.||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

FCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGI-----LKLADFGLARAFSIP---KNESKNRYTNRVVTLWYRP
...|||.....          ||  |.|||.||.|.|||.|.|||.| .| ||.. |.     ||.|||||||||.||   . |  . ||..|||||||.
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRA

PELLLGDRNYG--PPVDMWGAGCIMAEMWT---RSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDL
||||||...|.  .|.|||..|||.|||.|   | |...|..|. ||  |...||. |.|.||||..| .|                           ||
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DL

LDKLLTLDPKKRIDADTALNHDFF
|.|.|..|||||| |. ||.|..|
LNKMLCYDPKKRISAEQALQHPYF
Kinase Cdk9.AA CRK7 50-347 42 6.00000000001e-140 471.22 In-house 1-343 (343) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-343/343
Sequence Identity: 42% (146 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNE---KEGFPITALREIRILQLLKHENVVNLIEICRTK--ATATNGYRSTFYLVFDFCEHDLAG
||... || ||.| | ||. |. ... || ||| ||||   |||||||| |||.||. |.|.|.||| ||   |  | . . .. .||.||.   |||.|
YEMIMQIGEGTYGQVYKAKNKH-TGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

LLSNMNVK-FSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNY-----
|| .  .. ||....|  | ||| |. |.| ...|||| | .|.|.   |..|.||||||| .   ..| .  |||||.||||||||||||. .|     
LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYN--SEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------GPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKR
                                 || .|||. |||..|  |. || ||| | .||  |...||| .|..|| | .| ... .   .. .|
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNR

RVKERLR----PYVKDQTGCDLLDKLLTLDPKKRIDADTALNHDFF
|. |       |   ..   |||||.|.||||||. |  .|.||.|
RLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Cdk9.AA CMGC 50-347 25 3.2e-137 453.94 In-house 1-513 (513) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YEKVAKIGQGTFGEVFKAREK-------------KGNKKFVAMKKVL---MDN------EKEGFPITALREIRILQLLK-----------------HENV
||.. |||.||.|.|.|.| |             . ....||.||.    ...      ||.||||.|||||.||. |.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNLIEICRTKATATNGYR---------STFYLVFDFCEHDLAGLLSNMN--------VKFSLGE------------IKKVM------QQLLNGLY--YIH
|.|..|...| ...|.|.           .||||....|||.... |..        ...|  .            ||. |      .|.|.||   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNK--ILHRDMKAANVLITKH--------------------GILKLADFGLARAFSIPKNESKNR-----------------YTNRVVTLWYRPPELLLG
|..  |.|||.| .|.||..                     |.||..||||||........ ..                  ||..|||.|||.||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

D---------RNYGPPVDMWGAGCIMAEMWTR--------SPIMQGNTE-----------QQQLTFISQLCGSFT---------------PDVWPGVEEL
.         ..|..|.|||..|||.|||.|.         |. .|..|           . ||  | ...|..|               .. ||.. .|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

ELY---------------KSIE----------LPKNQKRRVKERLRPYV---------------------------------KDQTGCDLLDKLLTLDPK
  |               .|.           .|. ...  |.   ..                                   |. . |||.|.|..||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRIDADTALNHDFF
||| |. ||.|..|
KRITAEQALQHPYF
Kinase Cdk9.AA CDC2 50-347 38 3.2e-114 352.55 In-house 1-301 (301) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-301/301
Sequence Identity: 38% (122 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEG--FPITALREIRILQLLK-HENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLL
|.|. ||| ||.|.|.|..... |.  ||.||.  ..| ||  .| ||.||| .|. || |.|.| | ..            .  |.||.....||  ..
YQKIEKIGEGTYGVVYKCKDMQTNQ-IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---------NKLYMVFEYLDMDLKKYM

SNMNV---KFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYT--NRVVTLWYRPPELLLGDRNYGPP
 . ..   ....  .|. | |.|.|. . |...|.||| |  | || | | .|.|||||||||.||...    ||    |||||||.||.|||.. |  |
DMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRT----YTTEHEVVTLWYRAPEILLGCKRYSTP

VDMWGAGCIMAEM---WTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRP-------YVKDQTGCDLLDKLLTLD
||||  |||.|||    |. |. .|  |  ||  | .  |. . . ||||..|  ||.   |. ..   .. .            |..| |||...| .|
VDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNT-FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYD

PKKRIDADTALNHDFF
| ||| |..||.| .|
PQKRISAKEALQHPYF
Kinase Cdk9.AA PITSLRE 50-347 42 9.69999999999e-114 384.17 In-house 1-295 (295) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-295/295
Sequence Identity: 42% (132 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMD--NEKEGFPITALREIR-ILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLL
.... .|. ||.|.|..|..|. .   ||.|.. |.   ||||||||.||||  ||  |.|.|.||. ||   .           |.|... ||||..|.
FQCLNRIHEGTYGVVYRAKDKRTD-EIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMD------KIYMVMEYVEHDLKSLM

SNMN---VKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVD
 ||.    .|..||||  |||||.|  . |.|.|.||| | .| |..  ||||..|||||| .  |       ||  ||||||| |||||| . | .|||
ENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP----IKPYTPCVVTLWYRAPELLLGCKKYSTPVD

MWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIE-LPKNQKRRVKERLR--PYVKDQTGCDLLDKLLTLDPKKRIDADT
||  |||.||. |  |..||. |  |.  | .. |  |   |||. || . | .. .|.      ..|     .. | || ||| ..||..||.|| |. 
MWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISD-TGFDLLNQMLTYNPKNRITASD

ALNHDFF
|| |..|
ALKHPWF
Kinase Cdk9.AA CDK5 50-347 42 5e-109 345.71 In-house 1-287 (287) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-287/287
Sequence Identity: 42% (129 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNM
|||. ||| ||.| |.|||.|.  . .||.|.| .|.| || | ||.||| .|. |||.|.| |. .  .    |        ||| ||  ||   . ..
YEKMEKIGEGTYGTVYKARNKE-THEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLT--------LVFEFCDQDLKKYMDSC

NVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGC
|.. ..  ||  | ||| || . |....||||.|  | || |.|.|||||||||||| || .     |.  |||||||||  |.| . |  ..||| .||
NGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC----YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGC

IMAEMW-TRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYK--SIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALNHDF
|.|||  .  |   || .. ||  | .. |. . | ||.. .|  ||    ..|. . . . . . |   |..| ||| |.| ..|..||.|. ||.| .
IFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPY

F
|
F
Kinase Cdk9.AA S_TKc 50-347 26 5.9e-95 322.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEH---DLAGLL
||.. |||.|.||.|.|.|.||  .. ||.|..          ....|||.||.  .|.|.|.|......         . .|.|...|..   ||  ..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYI

SNMNVK-----FSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGP-
 ... .     |.  .....|.|....| |.||..|.||| | .|.|...   .|..|||||| .           |  ..|.||..||.|     ||. 
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKC

PVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADT
..|.|  |||..|| .. |  .      |.  . ...|                                      .. ..|...|.|. ||.||. |  
KCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

ALN-------HDFF
||.       | .|
ALQDEWDIKCHPWF
Kinase Cdk9.AA Pkinase 50-347 31 4e-94 323.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALR--EIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEH-----DL
|... |||.|.||.|.|...|. .|  ||.|..  ..||.....|..|  ||.|.. |.|.|.| |......        ..  |.|...||.     ||
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDL

AGLLS-NMNVKF--SLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGIL----KLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGD
. ..|  .. .|  |  |.|..| |.| ||.|.||..|.|||.| .|.|| ..| .    |..|||||. |.   . ..  .| ...|.||..||...|.
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGG

RNYGPPVDMWGAGCIMAEMWTRSPIMQGN----TEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLD
. |||.||||..|||..|| .. |. .|     .   |.  | .  |  ..  ||   .  ... .   .       .... .  .....|.....|..|
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKD

PKKRIDADTALNHDFF
||||. |. .|.|..|
PKKRPTAEQILQHPWF
Kinase Cdk9.AA CDK10 50-347 39 2e-89 303.39 In-house 1-285 (285) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-285/285
Sequence Identity: 39% (119 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNM
.||. ..| ||.| |..||. .  .  ||.||| || ||.| || .|||| .|  ..|||.|.| |.   .           .|| ..|| ||| || ||
FEKLNRVGEGTYGIVYRARDMR-SDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLD------SIFLVMQYCEQDLASLLDNM

NVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGC
   |.  ..| .| |.| || |.|.| ..|||.| .|.|.| .| .|.|||||||....|        | ..|||||| |||||| |.    .||| .||
PQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKP----MTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGC

IMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALNHDFF
|..|.    |.| || | .|.  | .| |.    .|||  .| . .   | |     .|..    .  |.|  ||. |.  .||||  |. .|.  .|
ILGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFH--WLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase Cdk9.AA CDK-Unclassified 50-347 30 5.6e-86 282.83 In-house 1-324 (324) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-324/324
Sequence Identity: 30% (101 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKE----------GFPITALREIRILQLLKHENVVNLIEICRTKATAT-NGYRST----FYLV
|.   |.|.||||.|.||.    .|. ||.||.   |.|            ..||..||| .||...|.|.  ....         | | .     ||.|
YRMQCKYGEGTFGCVCKAIDFQTQKH-VAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMV

FDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHG-----ILKLADFGLARAFS--------IPKNESKNRYTNRV
 .    .. . | |     |  .|.. | |.| |. |.|.||| ||| | .|..||  .     .||.||||.|.               ..   |.  |
MEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQV

VTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGC
.| ||| ||||.|.. |.. ||.|..|||.||.  . || ||.||  |.  |... |. . | ||    . .| .|  .  ||..  .|   . |  .. 
STRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKC-KHASEN

DLLDKLLTLDPKKRIDADTALNHDFF
...  .. ..|..|  .  .| |  |
NCEFQMVMYQPYNRWKCMEILQHPWF
Kinase Cdk9.AA PFTAIRE 50-347 37 4.1e-83 282.42 In-house 1-287 (287) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-287/287
Sequence Identity: 37% (114 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNM
|||. | | |..  |.|.. .  |..|||.| . ...| || | || ||   |. ||| |.| |  |  || | |        .|| . . ||.  ..  
YEKLEKLGEGSYATVYKGISCI-NQQFVALKEIRLQQE-EGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLT--------FVFEYVHTDLCQYMDKH

NVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGC
.       ..  . ||| || |.|  ..||||.|  | ||.. | ||||||||||| |.|       | . |||||||||  |||  .|   .||||.||
PGGMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVP----SHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGC

IMAEMWTRSPIMQGN-TEQQQLTFISQLCGSFTPDVWPGVEELELYKSIELP--KNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRIDADTALNHDF
|. || .  |   |  . . ||  | .. |. |.| |||| .|  ||   ..    . .  .. .    .   . ||. |.| . |..|. |. |. |..
IFVEMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPY

F
|
F
Kinase Cdk9.AA Pkinase_Tyr 50-205 28 1e-20 70.76 Pfam 1-160 (270) Show / Hide 
Range on Protein: 50-205
Range on HMM: 1-160/270
Sequence Identity: 28% (49 aa)

YEKVAKIGQGTFGEVFKAREK---KGNKKFVAMKKV---LMDNE--KEGFPITALREIRILQLL-KHENVVNLIEICRTKATATNGYRST--FYLVFDFC
 ..  |.|.| ||||.|.. |   ...|  || |..    |. .  .| |    .||..|.  | .|.|.|.|. .|          .     |.|. ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCT-------DQGEPNQIYIVMEYM

EH-DLAGLLSNM---NVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARA
.| ||   | .    . .... .. .  .|  .|. | .|... |||  | |.|.|. .. | .||||||.
PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase Cdk9.AA TyrKc 50-347 21 9.6e-13 -16.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-347
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

YEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLL--KHENVVNLIEICRTKATATNGYRSTFYLVFDFCEH-DLAGLL
 ..  |.| | ||||.|.. |      || |..  |          .||.||.  |  .|.|.|.|. .|...      |    ..|. ...| ||   |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYL

SNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKN----ESKNRYT-----NRV--VTLWYRPPELLLGD
 .   |... .  . . |  .|  |.||... |||  | |.|... .. | .||||.|.  |       |||  |.     ..   . .   .|| .  .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NY

RNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFISQLCGSFTPDV----WPGVEELELYKSIELPKNQKRRVKERLRPYV----KDQTGCDLLDKL
. . .  | |  |  | |. |                   ....  |..     .  | .|. |. . ..  .        | .      .   ..  . 
GKFTTKSDVWSFGVCMWEIFT-------------------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-----P-MSFVCCPDEMYQIMKQC

LTLDPKKRIDADTALNHDFF
   ||..|    .   |..|
WHEDPEDRPTFSEI--HECF