Gene mnb (Fruit Fly)

mnb

Species: Fruit Fly
Alias: min, ME-IV, CG7826, Dyrk1, SFO144, mnb, Mnb, Minibrain
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 16E3--4,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK1

Sequence

Name Sequence Type Origin Length Description Download
mnb.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
mnb.AA Protein Various 843 None Fasta, JSON

Protein domain

Protein domains of mnb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase mnb.AA DYRK1 99-419 81 2.9e-238 797.83 In-house 1-321 (321) Show / Hide 
Range on Protein: 99-419
Range on HMM: 1-321/321
Sequence Identity: 81% (263 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVS
|||||||||||||||||||||.||..||||||||||||.||||||..|||.||..|.|.|||||.||||||.||||||||||||||||||||||.|||||
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGE
||||||||||.||||||.|||||.|||||||||||||||||||||||.|||||||||||||.||||||||||||||||.||.||||||||||||||||||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILR
|||||.||||||||||||||||||...||| |..|.|.|   .. |..|...  ..|| |. ||||.|||||||||||||..||||||.|||||||||.|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

MLDFDPKTRVTPYYALQHNFF
||..|||.|.||||||||.||
MLQYDPKQRITPYYALQHSFF
Kinase mnb.AA DYRK 99-419 53 1.1e-192 646.45 In-house 1-320 (320) Show / Hide 
Range on Protein: 99-419
Range on HMM: 1-320/320
Sequence Identity: 53% (174 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGV-
|||.. |||||||||||..||  . .||||||.|.|.|..|||||.|.|| .|..| ..||..|.....|..|||||.||||||.|||..|.|..|.|. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNP-KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHT
||||.||||||..|.|.||...| ||||||||||||.|..| ..|.||..||||||. .|||| ||||||||.|||.||..|. |||||||||||.|..|
SLNLVRKFAQQILTCLKFLHKNE-NIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQA--HKTRKFFDKIVADGSYVLKKNQNGRKY--KPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKF
|.|||.| ||.||...|.|||||||| ..|..   ...||||.      |  .... ....  . .. .|.| ... ....|.|||  .|.|   |...|
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC----FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQF

KDLILRMLDFDPKTRVTPYYALQHNFF
||.|...|..||. |.||..|||| .|
KDFIKKCLQWDPHKRITPSQALQHPWF
Kinase mnb.AA DYRK2 99-367 49 1.9e-131 429.85 In-house 1-283 (318) Show / Hide 
Range on Protein: 99-367
Range on HMM: 1-283/318
Sequence Identity: 49% (142 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVS
|||.. |||||||||||.|||  . |||||.| ||| |.|||..|.. |. . | |  | . .|...  |. |||.|..||||| |||..... .| | |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ-RIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTG
|.| |.||... ..| ||.  . ||||||||||||||  . || ||..||||||   | ||| ||||||||.||| ||..|. ||||||.|||..|. ||
LQLVRRFAHSILQCLRFLH--KNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

EPLFSGCNEVDQMNKIVEVLGMPPKYLLDQA-----HKTRKFFD--------KIVADGSYVLKK--NQNGRKYKPPGSRKLHDIL
 ||| | ||.||.  . |||||||| ..|..      ... ||.         ...|.| ...|  .... | .||||... ..|
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVL
Kinase mnb.AA CMGC 99-419 21 1.4e-116 384.88 In-house 1-513 (513) Show / Hide 
Range on Protein: 99-419
Range on HMM: 1-513/513
Sequence Identity: 21% (115 aa)

YEIDSLIGKGSFGQVVKAYD--------------HEEQCHVAIKIIKNKKPFLNQAQ-------------IEVKLLEMMN-RADAEN-----------KY
|||.. ||.|..|.|.|..|              || . .||||.|||.. . .||.              |.|.|...| . |. |           . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

YIVKLKRHFMWRN-----------------HLCLVFELLSYNLYDLLRNTN--------------------------FRGVSLNLTRKFAQQLCTALL--
.||||. .|. .|                 ||.||||.. ..||....|..                           .  .. . | ...|....|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLSTPELNIIHCDLKPENILLCNPKRS------------------AIKIVDFGSSCQLGQR------------------------IYHYIQSRFYRSPEV
..    .||||.||||||||... ...                   .|| |||........                        ..||...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLGIQ----------YDLAIDMWSLGCILVEMHTG--------EPLFSGCNE-----------VDQMNKIVEVLGMPPKYLLDQAH-------KTRKFFD
||| .          |. .|||||.|||. || ||        .||| | .|           .||..||..|||.|. ......        .......
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

KIV----------------------ADGSYVLKKNQNGRKYKPPGSRKLHD------------ILGVETGGPGGRRLDEPGHSVS---------------
.|                           |. ..|. ......| ...  .            ..  . .              .               
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IY-------------EEKFKSHKFNHQFKRK

-DYLKFKDLILRMLDFDPKTRVTPYYALQHNFF
 .  .. ||. .|| .||. | |.  |||| .|
CCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase mnb.AA YAK 99-335 43 7.3e-98 331.43 In-house 1-239 (347) Show / Hide 
Range on Protein: 99-335
Range on HMM: 1-239/347
Sequence Identity: 43% (104 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMN-RADAENKY---YIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNF
| .    |.| ||||||         .|.|.|||.  .. ||  |...|.. | . | .||     |...   | ..||.|||||.|| |||..| ...|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEM
.| | .| | .  |   ..  |   . .|||||||||||.||.| . .|||.|||||||  . .| |||.|.|||||..... |  .|||||||||..| 
CGFSFQLIRQWTKQILDGMCVLE--NKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL

HTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF
  | |.| |  | .|.  |...|| ||  ..||     |.|
FLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase mnb.AA S_TKc 99-419 27 2.9e-79 270.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 99-419
Range on HMM: 1-231/231
Sequence Identity: 27% (91 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSY---NLYDLLRNTNFR
|||  .||||.||.| |..... . .|||||||      .... |...|..       .  .||||. .|   .||..|.|...    .|.|.... . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----VSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDL-AIDMWSLGCI
|     .   .|....|.| || ..   ...|||.|||||||||..     ||| |||...||    .... ...|..||||   .|.  ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYCH--SHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYL
| || .|.|.|.      ||... ...|                                                                        
LYEMLCGYPPFP------QMQMMFKKIG----------------------------------------------------------------------SP

KFKDLILRMLDFDPKTRVTPYYALQ-------HNFF
 .||.| ..|..||. | |   |||       | .|
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase mnb.AA HIPK 99-337 41 1.6e-73 230.83 In-house 1-239 (329) Show / Hide 
Range on Protein: 99-337
Range on HMM: 1-239/329
Sequence Identity: 41% (101 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVS
||.  ..|.| ||||||.  .  .  |||||.||   .  | ||||..|. .   .|.. | .|.    |  .|| |||||.|  |||| ... .|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMH
|.  |   ||  |||. |   || .|| |||||||.|  |.|    .|..||||   . . .   |.|||.|| ||..||. .  ..|||||||.. | .
LKHIRPILQQVLTALMKLK--ELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK
 | ||. | .| ||   | .  . | ..|| .| |. .|||.
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDR
Kinase mnb.AA Pkinase 99-419 27 4.5e-61 214.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 99-419
Range on HMM: 1-293/293
Sequence Identity: 27% (95 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQI-----EVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSY-----NLYDL
|.| . ||.||||.| |.... ... ||.|||| ..   .. |.     |.... ..|    .|   ||.|.. |. ..|...|.|..        |.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPN---IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LR---NTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQL---GQRIYHYIQSRFYRSPEVLL-GIQ
..   ...|   | .  .... |.. .| ..     .|||.||||||||.   ..  |    || |||...|.   ..  ...  ...|..|||.. |  
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQY

YDLAIDMWSLGCILVEMHTGEPLFSGC----NEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGG
|. ..||||.|||| || .|.|.|.|.    | .||| .|....| |...  .. .  . ||     . .                              
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------

PGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF
   . . .  | .|. .  ||.| ..|..||| | |.  .||| .|
---F-HWTF-HNWSEEC--KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase mnb.AA PRP4 99-303 40 1.7e-59 204.01 In-house 1-207 (320) Show / Hide 
Range on Protein: 99-303
Range on HMM: 1-207/320
Sequence Identity: 40% (84 aa)

YEIDSLIGKGSFGQVVKAYDHEEQC-HVAIKIIKNKKPFLNQAQIEVKLLEMMNRA--DAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRN-TNF
|.. . .|.| |. |... |       |||||| |.         |.  |  .| |  | . |. .|...||| .|.|.||||| .| || ..|      
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLG-QRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVE
 | .|.  | .||||  ||  |    .||.| |.|| |||  |  .. .|..||||  .   . |  | .|||||.||...|..|| .||||| || | |
VGLHLKAVRSYAQQLFLALKHLK--KCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

MHTGEPLFSG
. ||  .|.|
LYTGKIMFPG
Kinase mnb.AA CLK 99-238 33 7e-48 141.22 In-house 1-150 (350) Show / Hide 
Range on Protein: 99-238
Range on HMM: 1-150/350
Sequence Identity: 33% (51 aa)

YEIDSLIGKGSFGQVVKAYDHEE-QCHVAIKIIKNKKPFLNQAQIEVK-LLEMMNRA-DAENKYY--IVKLKRHFMW-RNHLCLVFELLSYNLYDLLRNT
||| .  | | || ||.  ||.    .||.|||.| . .  .|..|..  ..  | . |..|||   ..|.   |    .| |.||||.  ..||... .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNP
|      ...  .. .|..| |||.|. ||   .. ..| |||||||.....
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH--DMKLTHTDLKPENICFVDS
Kinase mnb.AA GSK 99-322 34 5e-46 138.22 In-house 1-240 (328) Show / Hide 
Range on Protein: 99-322
Range on HMM: 1-240/328
Sequence Identity: 34% (85 aa)

YEIDSLIGKGSFGQVVKAYDH----EEQCH----VAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWR-NH--------LCLVFELL
||.. .|| |||| |..||.     |..      |||| .  .| .   .. |.. ..|. ..|  |   ||.|| .|    .         .|||.| .
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYK--CNRELQIMKMLGKLDHPN---IVRLKYFFYMHYEKKDENHVYCNCLVMEYM

SYNLYDLLR--NTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI----YHYIQSRFYRSPEVLLG
 ..||...|  ..| . ..... . .. |.. .| .|   ...| | |.||.|||. .|.    || ||||. ||  .       || ||.|| || ..|
PQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLH--SHGICHRDIKPQNILV-DPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFG

I-QYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPK
. .|. .||.||.||.. || .|.|||.| ..|||   |...|| |.|
CTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTK
Kinase mnb.AA CDK 160-419 25 6.6e-44 138.26 In-house 68-284 (284) Show / Hide 
Range on Protein: 160-419
Range on HMM: 68-284/284
Sequence Identity: 25% (75 aa)

YIVKLKRHFMWR-----------NHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPK---RSAIKI
.||||.  ..             | | .||| . . |. ...            . . .||  .| ..   . .|.| |||| |||. |     .  .||
NIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCH--SNWIMHRDLKPQNILINNNGEVKCGRLKI

VDFGSSCQLG--------QRIY-HYIQSRFYRSPEVLL-GIQYD--LAIDMWSLGCILVEMHT---GEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHK
 ||| ..  |        .| | | .  . ||.||.||   .|.   .|||||.|||..|| |   ..||| | .| ||. || ...| |         |
ADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTK

TRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF
   .                                                           ||. .|| .||| |..   |||| .|
LPDY-----------------------------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase mnb.AA CLK 243-320 34 1.6e-16 45.37 In-house 186-266 (350) Show / Hide 
Range on Protein: 243-320
Range on HMM: 186-266/350
Sequence Identity: 34% (28 aa)

IKIVDFGSSC---QLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMP
|...||||     .     .  ...| || ||| ||  .    | || ||||.|  ||. || . .... .  . ...|||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase mnb.AA TyrKc 99-419 16 4.3e-10 -59.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 99-419
Range on HMM: 1-280/280
Sequence Identity: 16% (58 aa)

YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKL-LEMMNRA--DAEN---KYYIVKLK--RHFMWRNHLCLVFELLSY-NLYDLL
 . .  .| | ||.|.|.        ||.| .|. .      . .    ...| .   . .|    | ..  .  . ||    |..|.|. .. .| | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYL

RNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-------IYHYI----QSR-----FYRSPEVL
|..  . ...    .|. | .    .|.  . |.|| ||   |.|. ...   .|| ||| |  ..          |       ...        .||..
RKHRPK-LCMKDLLSFCWQIACGMEYLH--SKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LGIQYDLAIDMWSLGCILVEMHT-GEPLFSGC----NEVDQMNKIVEVLGMPPKYLL----DQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLH
    .  . | || |  . |. | |..  .|      . ... . |.  ...|.                                              
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

DILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF
                    .|    .  .....  ..||. | |      | .|
--------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase mnb.AA GSK 394-419 50 2.7e-09 23.9 In-house 303-328 (328) Show / Hide 
Range on Protein: 394-419
Range on HMM: 303-328/328
Sequence Identity: 50% (13 aa)

DLILRMLDFDPKTRVTPYYALQHNFF
||| ..| .||| | .|. |..| ||
DLISKCLVYDPKKRLSPLEACAHPFF
Kinase mnb.AA CLK 394-419 57 2.7e-09 23.25 In-house 325-350 (350) Show / Hide 
Range on Protein: 394-419
Range on HMM: 325-350/350
Sequence Identity: 57% (15 aa)

DLILRMLDFDPKTRVTPYYALQHNFF
||| .|| .||  |.|   |||| ||
DLIRKMLEYDPSKRITCKDALQHPFF
Kinase mnb.AA CDK 99-131 36 2.8e-08 22.43 In-house 1-38 (284) Show / Hide 
Range on Protein: 99-131
Range on HMM: 1-38/284
Sequence Identity: 36% (14 aa)

YEIDSLIGKGSFGQVVKAYDHEEQ-----CHVAIKIIK
||.   || |..|.| || |.. .       ||.| |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR
Kinase mnb.AA PRP4 392-419 50 3.9e-08 25.96 In-house 293-320 (320) Show / Hide 
Range on Protein: 392-419
Range on HMM: 293-320/320
Sequence Identity: 50% (14 aa)

FKDLILRMLDFDPKTRVTPYYALQHNFF
||||. ..|  ||| |.|.  ||.| |.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase mnb.AA DYRK2 392-419 42 2e-06 16.44 In-house 291-318 (318) Show / Hide 
Range on Protein: 392-419
Range on HMM: 291-318/318
Sequence Identity: 42% (12 aa)

FKDLILRMLDFDPKTRVTPYYALQHNFF
| | |.| .. ||..| ||  ||.| ..
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase mnb.AA HIPK 386-419 32 8e-06 13.72 In-house 296-329 (329) Show / Hide 
Range on Protein: 386-419
Range on HMM: 296-329/329
Sequence Identity: 32% (11 aa)

VSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF
. |.  | ..  .|.  |.. |.||  ||.|.| 
KIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase mnb.AA Pkinase_Tyr 99-133 25 3.6e-05 18.15 Pfam 1-39 (270) Show / Hide 
Range on Protein: 99-133
Range on HMM: 1-39/270
Sequence Identity: 25% (10 aa)

YEIDSLIGKGSFGQVVKAYDH----EEQCHVAIKIIKNK
 ...  .|.|.||.|.|.. .    .....||.|..|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase mnb.AA YAK 392-419 39 0.000141 11.04 In-house 320-347 (347) Show / Hide 
Range on Protein: 392-419
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FKDLILRMLDFDPKTRVTPYYALQHNFF
| |.|  .|. .|. |..|  | || | 
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase mnb.AA Pkinase_Tyr 172-228 23 0.196104 5.48 Pfam 80-137 (270) Show / Hide 
Range on Protein: 172-228
Range on HMM: 80-137/270
Sequence Identity: 23% (14 aa)

NHLCLVFELLSY-NLYDLLRNT--NFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDL
|....|.|.  . .|.| ||.   . . ...    ....| . .. .|.  . |.|| ||
NQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE--SKNCIHRDL