Gene smi35A (Fruit Fly)

smi35A

Species: Fruit Fly
Alias: SFO108, DYRK, BG:DS01523.3, Dyrk2, DYRK2, smi35A, smell impaired 35A, Dual specificity tyrosine phosph, Dual specificity tyrosine phosphorylation-regulated kinase, CG4551
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 35A1--2,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
smi35A.AA Protein Various 722 None Fasta, JSON
smi35A.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 297 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of smi35A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase smi35A.AA DYRK2 198-494 60 3.3e-221 726.66 In-house 1-318 (318) Show / Hide 
Range on Protein: 198-494
Range on HMM: 1-318/318
Sequence Identity: 60% (193 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFS
|||||||||||||||....||||..|||||.|||||||.|||..|..||...|..| |...|..|||||.|||.|.||||||.|.||||.||||...|||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

MSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDR-KIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFP
..|.|||..||..|||.|.|.||||||||||||||||.. |.||||||||||.... .|||||||||||.||||||..||.||||||.|||.||||||.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGENEVEQLACIMEVLGLPPKVLISVA-----RRRRLFFD--------------SRDAPRCITNTKGRKRSPGSKSLAHILH-CQDRYFIDFLQRCLE
|||||||..|.||.|||||.|||......     .||..||.              |...|....|..|..| |||||....|. |.|..||||..||.|
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WDPAERMTPDEAAHHEFL
|||.|||||..| .|...
WDPSERMTPSQALKHPWI
Kinase smi35A.AA DYRK 198-494 54 7.29999999999e-192 643.69 In-house 1-320 (320) Show / Hide 
Range on Protein: 198-494
Range on HMM: 1-320/320
Sequence Identity: 54% (176 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGF-
|||||.|||||||||... ||||| .||||||||.|||..||  |..||. |...| | .....||.|| |.|.||||.|||.| ||||..|.|. .|| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SMSLIRRFCNSIVKCLRLLYKE-NIIHCDLKPENILLKQR-GSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTG
|..|.|.|. .|..||..|.|. ||||||||||||.|||. . | ||||||||||.....|||||||||||.||||||..|..||||||||||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

FPLFPGENEVEQLACIMEVLGLPPKVLISVA--RRRRLFFDS------------RD-------APRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQR
 ||||||||..||||||||||.||| .|. .  ||.. |||.            ..        ....|.. | .|.||.... . ..|.|. |.||...
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKK

CLEWDPAERMTPDEAAHHEFL
||.|||..|.|| .| .| ..
CLQWDPHKRITPSQALQHPWF
Kinase smi35A.AA CMGC 198-494 21 2.8e-120 397.2 In-house 1-513 (513) Show / Hide 
Range on Protein: 198-494
Range on HMM: 1-513/513
Sequence Identity: 21% (112 aa)

YEILEVIGKGSFGQVIRALD--------------HKTNTHVAIKIIRNKKRFLNQAV-------------VELNILDELREKDADGS-----------HN
|||...||.|..|.| .. |              |.|| .||||.|.|.. . .||               |. || .|....               ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-VIHMLDYTYFRK-----------------HLCITFELMSLNLYELIKKNN--YNG------------------------FSMSLIRRFCNSIVKCLR--
 .....|. |...                 ||.. ||.|  .||..||.|.  |.|                        |.. .|| ..  | ..|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

LLYKEN--IIHCDLKPENILLKQRGSS------------------SIKVIDFGSSCYVDRK------------------------IYTYIQSRFYRSPEV
 . . .  |||.||||||||. ... .                   .|..|||......                          ...|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGLQ----------YGTAIDMWSLGCILAELYTG--------FPLFPGENE-----------VEQLACIMEVLGLPPKVLISVAR-------RRRLFFD
.|| .          |.|.|||||.|||.||.|||         |||||..|           ..||..|..||| |.  .|. ..       . . ...
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SRD-------------------------APRCITNTKGRKRSPGSKSLAHILH--------------------------------CQDRYFIDFLQRCLE
  .                          .. ..|...... .  |.|   ..                                |.|  .||.|...|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPAERMTPDEAAHHEFL
.||..|.|...|  |...
YDPDKRITAEQALQHPYF
Kinase smi35A.AA DYRK1 198-460 48 3.4e-106 359.11 In-house 1-269 (321) Show / Hide 
Range on Protein: 198-460
Range on HMM: 1-269/321
Sequence Identity: 48% (131 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFS
|||   |||||||||..| ||..  .||||||.||| |.||| .|. .|. . ..|..   ...|.     || |||. |||.| |||.|..  .. | |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

MSLIRRFCNSIVKCLRLLYKE--NIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGF
. |.|.| . ... |  .     .|||||||||||||     | ||.||||||| ....|| ||||||||||||.||..| .||||||||||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDS-RDAPRCITNTKGRKR---SPGSKSLAHIL
||| | |||.|.  |.||||.||| .|  | . . .|.   |    .  |. .|.   .|. . | .||
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEIL
Kinase smi35A.AA YAK 198-432 43 7.6e-98 331.36 In-house 1-239 (347) Show / Hide 
Range on Protein: 198-432
Range on HMM: 1-239/347
Sequence Identity: 43% (104 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREK-DADGSH---NVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNY
| .| . |.| ||||.      ||  .|.|.| |.  .. ||  |  ||  | .. | .. .    .. |.|.  .. |.|. ||. |.||||..| |..
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

NGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYT
 |||..||| .  .|   .  |   .|||||||||||.|..  .  ||.|||||||.  . .|||||.|.|||||.|..  | |.|||||||||.|||. 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFF
| |.|||  | .|.  | ..|| ||  .|   | .  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase smi35A.AA S_TKc 198-494 27 1.4e-87 298.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 198-494
Range on HMM: 1-231/231
Sequence Identity: 27% (85 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSL---NLYELIKKNNYN
||||..||||.||.| .. ..||. .||||||.      ...  |..|| .       .  |.....|. .  .||.. .|...    .|...|||....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGT-AIDMWSLGCILA
|    |.   .|...  |.. |  . . .|||.||||||||| .     ||..|||... .    .|.. ...|..|||.   .||. ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAA
|...| |.||      |.. .....|                                                .. ..||...||..||..|.|  || 
EMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

H-------HEFL
.       |...
QDEWDIKCHPWF
Kinase smi35A.AA HIPK 198-433 39 3.5e-72 226.5 In-house 1-238 (329) Show / Hide 
Range on Protein: 198-433
Range on HMM: 1-238/329
Sequence Identity: 39% (95 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFS
||.||..|.| ||||...  . ||  |||||..|   .  |  .|. ||  |....||   ... ....   ..| |. ||..  |||.  |.|..    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

MSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL--KQRGSSSIKVIDFGSSCYVDRKIY-TYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTG
.  ||     ... |  | .  .|| |||||||.|  ..|    .|||||||  .| . .  ||.|||.|| ||.|||| .  ..|||||||..|||. |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

FPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFD
 ||.|| .| .|   | .  .|| . |.. |..   |||
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFD
Kinase smi35A.AA Pkinase 198-494 26 1.1e-71 249.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 198-494
Range on HMM: 1-293/293
Sequence Identity: 26% (86 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVV-----ELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSL-----NLYEL
|.|...||.||||.| .. ...|.  ||.|||. ...  .. .      |. |. .|.      . |.. ..|. . ..|... .|..        |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSS--SIKVIDFGSSC---YVDRKIYTYIQSRFYRSPEVIL-GLQYGTA
|.   ....  ||.  .....  |.. |  .....|||.||||||||....|    ..|..|||...   | ..  .|.  ...|..||||. |  ||..
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCILAELYTGFPLFPGE----NEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRC
.||||.||||.|...| |.|||.    | ..|...| ...| |..  ..  .....||  |. . .             . .    | ... ..||. .|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKWC

LEWDPAERMTPDEAAHHEFL
|..||..| |.... .|...
LCKDPKKRPTAEQILQHPWF
Kinase smi35A.AA DyrkP 198-415 40 1.1e-56 184.89 In-house 1-222 (323) Show / Hide 
Range on Protein: 198-415
Range on HMM: 1-222/323
Sequence Identity: 40% (90 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNG--
| |.| .|   | . |  .| .||  . .||| | | .  |.. |. .|  .         ||... || | . || |  ||.  ||||  | |  |   
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

--FSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYT
  | .  . .    |.  |  .    .|||||||||||.| .    .|.|||||||..   .  |.||| || ||||.| .|   |||||||||||||.|
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GFPLFPGENEVEQLACIMEVLG
|  ||  .|    || .. ..|
GNVLFQNDNIQGLLARVIGIIG
Kinase smi35A.AA CDK 198-494 25 3e-55 175.12 In-house 1-284 (284) Show / Hide 
Range on Protein: 198-494
Range on HMM: 1-284/284
Sequence Identity: 25% (86 aa)

YEILEVIGKGSFGQVIRALDHKTN-----THVAIKIIR---N-----KKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFR-----------KHL
||.|| || |..|.| .| |..|.       ||.| ||   .     |  |   |. | ..| ||        .|..  .|  .             . |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSS---IKVIDFGSSCYV--------DRKIYT-YIQS
 . || |   |.....           |. .   . . |  . . .|.| |||| |||.  .|.     .|. ||| ..           .. ||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRSPEVIL-GLQYG--TAIDMWSLGCILAELYT---GFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKS
. ||.||. |   .|.  |.|||||.|||.||..|   . |||||..| .|| .| ...| |            ..                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

LAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFL
             |.|...|  ||. |.. ..| .|...
-------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase smi35A.AA PRP4 198-422 37 1.5e-54 187.58 In-house 1-229 (320) Show / Hide 
Range on Protein: 198-422
Range on HMM: 1-229/320
Sequence Identity: 37% (86 aa)

YEILEVIGKGSFGQVIRAL-DHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREK--DADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKN-NY
|..   .|.| |. |.|.    ..|  ||||||||.         || ||  | ..  | .    .. | .  ..|.|.|. || || || |..||    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

NGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYV-DRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELY
 |...  .| .   .   |..| | ||.| |.|| |||      . .| .||||   . .  |  | .|||||.||.|.| .|  .||||| || |.|||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGFPLFPGENEVEQLACIMEVLGLPPKVLI
||  .|||    . |  .|.. |  |. .|
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMI
Kinase smi35A.AA CLK 198-332 34 2.1e-45 133.64 In-house 1-147 (350) Show / Hide 
Range on Protein: 198-332
Range on HMM: 1-147/350
Sequence Identity: 34% (51 aa)

YEILEVIGKGSFGQVIRALDHKT-NTHVAIKIIRNKKRFLNQAVVELN-ILDELREK-DADGSHN--VIHMLDYTYF-RKHLCITFELMSLNLYELIKKN
|||. . | | || | .  |||  ...||.||||| ...  .| ||.| |.  . || |... .   ...|.|.  .   | || |||. |..|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------YNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL
|      | .. .. ||..   . . .. | .  ..| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase smi35A.AA CLK 337-494 36 8.1e-40 116.57 In-house 183-350 (350) Show / Hide 
Range on Protein: 337-494
Range on HMM: 183-350/350
Sequence Identity: 36% (61 aa)

SSSIKVIDFGSSC---YVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLP-PKVLISVAR----RR
.  |.||||||     . . . .| ...| || ||||||| . .  | || |||| |||||| ||.. ...| || . ...|.| |.  |   |     .
NTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQ

RLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQD---RYFIDFLQRCLEWDPAERMTPDEAAHHEFL
. | . |   .  .| .||.     | |   . |.|   | ..| ....|| ||. |.| ..| .|.| 
KYFYHNRLDWDW-HNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase smi35A.AA TyrKc 198-494 18 1.8e-12 -21.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 198-494
Range on HMM: 1-280/280
Sequence Identity: 18% (61 aa)

YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDEL--REKDADGSHNVIHMLDYTYFR-------KHLCITFELMSL-NLYEL
 . ....| | ||.| ..      . ||.| ... .  .     |..|. .|  . .      |.. .. .           . |.| .|.|.. .| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRK-------IYTYI----QSR-----FYRSPEVIL
..|.  . ..|.    ||  | .  . | . |.|| ||   |.|.. ..   .|. ||| | ... .        |       ...        .||.| 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GLQYGTAIDMWSLGCILAELYT-GFPLFPGE----NEVEQLACIMEVLGLPPKVLI----SVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHC
   . |. | || |  . |..| | .  ||.     . ...    .  . .|.       |                               .     .|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------F----VCC

QDRYFIDFLQRCLEWDPAERMTPDEAAHHEFL
 |  .    ..| . ||..| |  |   ||..
PDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase smi35A.AA PRP4 469-494 46 6.6e-07 21.41 In-house 295-320 (320) Show / Hide 
Range on Protein: 469-494
Range on HMM: 295-320/320
Sequence Identity: 46% (12 aa)

DFLQRCLEWDPAERMTPDEAAHHEFL
|.| .||  ||. | |. || .| |.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase smi35A.AA DYRK1 467-494 42 1e-06 19.08 In-house 294-321 (321) Show / Hide 
Range on Protein: 467-494
Range on HMM: 294-321/321
Sequence Identity: 42% (12 aa)

FIDFLQRCLEWDPAERMTPDEAAHHEFL
| | ..| |..||..|.|| .| .|.|.
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase smi35A.AA YAK 467-494 42 3e-06 16.94 In-house 320-347 (347) Show / Hide 
Range on Protein: 467-494
Range on HMM: 320-347/347
Sequence Identity: 42% (12 aa)

FIDFLQRCLEWDPAERMTPDEAAHHEFL
||||.   |. .| || .|  |  | |.
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase smi35A.AA HIPK 465-494 40 1.3e-05 13.14 In-house 300-329 (329) Show / Hide 
Range on Protein: 465-494
Range on HMM: 300-329/329
Sequence Identity: 40% (12 aa)

RYFIDFLQRCLEWDPAERMTPDEAAHHEFL
| |.. | . . ||. .|.|| || .|.| 
REFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase smi35A.AA DyrkP 460-494 40 2.4e-05 12.82 In-house 289-323 (323) Show / Hide 
Range on Protein: 460-494
Range on HMM: 289-323/323
Sequence Identity: 40% (14 aa)

LHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFL
|. .|  |||| ..||  |   | |  ||  | ..
LRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase smi35A.AA Pkinase_Tyr 198-232 23 3.7e-05 18.11 Pfam 1-39 (270) Show / Hide 
Range on Protein: 198-232
Range on HMM: 1-39/270
Sequence Identity: 23% (9 aa)

YEILEVIGKGSFGQVIRALDH----KTNTHVAIKIIRNK
 ......|.|.||.| ..  .    .|...||.|.....
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG