Gene rl (Fruit Fly)

rl

Species: Fruit Fly
Alias: Sevenmaker, Mapk, CT39192, ERKA, DERK, Extracellular-signal-related kin, ErkA: Extracellular-regulated ki, DmMAPK, ERK, Erk1, SFO224, dpMAPK, mapk, l(2)41Ac, MAP kinase, dpERK, D-ERK, CG12559, ERKa, MAP-kinase, rl, CT34260, EY2-2, rll, DmERK-A, DmERKA, E(sina)7, Sem: Sevenmaker, DERK-A, Su(Raf)2B, ErkA: Extracellular-regulated kinase A, Erk, GroupII, Extracellular-regulated kinase A, l(2R)EMS45-39, SR2-1, MAPK, Extracellular-signal-related kinase A, sevenmaker, Enhancer of seven in absentia 7, ERK-A, EK2-1, Sem, Dsor2, Erk/Map kinase, rl/MAPK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: h41,

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
rl.AA Protein Various 376 None Fasta, JSON
rl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 289 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of rl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase rl.AA ERK1 38-326 90 1.7e-246 825.14 In-house 1-289 (289) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-289/289
Sequence Identity: 90% (261 aa)

YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSND
|..|.||||||||||.||.||...||||||||||||||||||||||||.|||||||||||.|.||.|.|.|.|||||||||||||||||||||||.||||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN
||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN

RPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYL
||||||||||||||||||||||||.|||.|||||||||||.|||.||.||||.|||.||. |||||.|||||||||||.||||||||||
RPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase rl.AA MAPK 38-326 56 7.89999999999e-203 680.12 In-house 1-328 (328) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-328/328
Sequence Identity: 56% (185 aa)

YIKLAYIGEGAYGMVVSADDTLTNQR------VAIKKIS-PFEHQTYCQRTLREITILTRF-KHENIIDIRDILRV------DSIDQMRDVYIVQCLMET
|  | .||.||||.|.||.|..|||.      ||||||| ||...|.|.||.||| .| .| .||||| ..||..       .|.....|.|||. ||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLKTQR-LSNDHICYFLYQILRG--LKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADP-EHDHTG----------FLTEYVATRWYRAP
||....|.|. ||.|||.||.||||||  |||||||||.||||||||.|.|. ||||||||||||..|| .|.|..          ..||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGVLGSPSRDDLECII-NEKARNYLESL---PFKPNVPWAKLFPN----ADAL
|||||  ...|||..|.||||||.||||. ..|.||||.|.||.|.|. |||.||.....||  .|.||||..||   | .| .||.|.|||    |. .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLGKMLTFNPHKRIPVEEALAHPYL
|.||| |||.|.|.||| |||||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase rl.AA ERK 38-326 55 1.1e-178 599.92 In-house 1-307 (307) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-307/307
Sequence Identity: 55% (171 aa)

YIKLAYIGEGAYGMVVSADDTL-----TNQRVAIKKI-SPFEHQTYCQRTLREITILTRFK-HENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLK
|  .  ||.|||| |.|| |..     |.|.||||||  .|.|  || |||||| .|  || ||||| ..||....|..|. |.|.|. |||||| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

TQ-RLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHT-----GFLTEYVATRWYRAPEIMLNSKGYTKSIDI
.| .|| ||. ||.||||.||||||||||.||||||||.|.|. ||||||||||||. |....       .|.||||||||||||||||. . |||..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSP-SRDDLECIINEKARNYLESLPF--KPNVPWAKLFPNAD--ALALDLLGKMLTFNPHKRIPVEE
||.|||.||||  .|.|||| |..|.|.|. ..|.| | .||..| .|.|..|. .||.  .| .|| ..||||.   .|.||| |||.|.| ||| |||
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYL
.|.|||.
CLEHPYF
Kinase rl.AA CMGC 38-326 29 1.1e-148 492.26 In-house 1-513 (513) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-513/513
Sequence Identity: 29% (150 aa)

YIKLAYIGEGAYGMVVSADDTLTNQR--------------VAIKKIS-PFEHQTYCQ----------RTLREITILTRFK-----------------HEN
| .. .||||.||.|... |..|||.              ||||||. || ... ..          |.|||| || ...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIDIRDILRVDS-------------IDQMRDVYIVQCLMETDLYKLLKTQR----------LSNDH------------ICYFL------YQILRGLK--Y
|. ..||.. .              .  ....|.|  .|..|||...| ..          ||  |            |.||.      ||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAN--VLHRDLKPSNLLLNKTCDL--------------------KICDFGLARIADPEHDH------------------TGFLTEYVATRWYRAPEIM
.||..  ..||||||.|.|.|..|.|                    |||||||||. .|..||                  . ..|.||.|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNS---------KGYTKSIDIWSVGCILAEMLSN--------RPIFP-----------GKHYLDQLNHILGVLGSP----------------SRDDLECI
|..         ..||..||.||||||.|||. .        .|.||           ||...|||..|  |||.|                .... ..|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

I--------------------NEKARNYLES---LPFKPNVPWAKLFPN-----------------------------------ADALALDLLGKMLTFN
                     .|.||||..|   .| .|  || .|||.                                   .| .|.||| |||...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PHKRIPVEEALAHPYL
|.||| .|.||.|||.
PDKRITAEQALQHPYF
Kinase rl.AA p38 38-326 49 5.4e-140 471.38 In-house 1-289 (289) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-289/289
Sequence Identity: 49% (145 aa)

YIKLAYIGEGAYGMVVSADDTLTNQR---VAIKKIS-PFEHQTYCQRTLREITILTRFKHENIIDIRDILRV--DSIDQMRDVYIVQCLMETDLYKLLKT
| .| ..|.|||| | .| |. |.|.   |||||.. ||.   .  || ||.  |   .|||.|.. |.     .|.....|||.|  .|..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
|||| ||| . .|||||||||||||.. ||||||||. .|  |.|.| |||||| .| |      .|.|||||||||||||||   ||. .||||||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE------MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYL
||... |. |||. ..|||. |. |.|.|..  .. | .|.||||..|.|  |    ...|..|. .|.||| |||   | ||| .|||..|||.
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase rl.AA ERK5 38-326 51 1.2e-126 426.99 In-house 1-295 (295) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-295/295
Sequence Identity: 51% (151 aa)

YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKI-SPFEHQTYCQRTLREITILTRFKHENIIDIRDILR-VDSIDQMRDVYIVQCLMETDLYKLLK-TQRL
|  .  ||.||||.| ||   .. |.||||||   |.  |  .||.||. ||  |.|.||| |||||.    .  |.|||.|  ||| || ...   | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADP--EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA
. .|| ||||||||||||.|||.|.|||||||||| |  |.||| |||.||        .|  |.|||||||||||||.|. |. ||. ||.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLES-LPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYL
||.. | .|||| |..||. |. ||| |.   .. .  .. .||. . .| .  ..| |..| ||  |||||..|| | | .|| | .|| ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase rl.AA ERK7 38-326 47 1.8e-115 389.89 In-house 1-292 (292) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-292/292
Sequence Identity: 47% (139 aa)

YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKI-SPFEHQTYCQRTLREITILTRFK-HENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLK-TQRL
|  .  .| ||||.|  | |  | | ||.|||   |  ||  ||| |||..|  |. |.||| . ...|    |  ||.|.|   |||||    .  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRA---DNDRDIYLVFEFMETDLHAVIRKGNIL

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLAR-IADPE--HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
 . |  | .||.|| .||.||.||.||||||||.||.  | .|.||||||| ||. |  ..... |||||||||||||||.| |. ||| .| ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYL
.||| ..|.|||   ..|.. || ... |.. |.| |  . | | ||... ..  .  ...|..   |.||| ..| |||.||. .|.||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase rl.AA ERK3 38-326 43 2.6e-106 343.13 In-house 1-300 (300) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-300/300
Sequence Identity: 43% (132 aa)

YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRD-----------VYIVQCLMETDLY
.. |   | |  |.| || |    ..||||||.    .  |   |||| |. |  |.||. . ..|     |   |           |.||| .||||| 
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKS-CKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLA

KLLKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDI
 ..  ||||..|.  | || ||||||||||||||||||| |.. | | |  ||| |||.||| ||.  | |.|.| . |.||| |. .|    ||| ||.
CVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFIN-TEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDM

WSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHP
|. ||||||||  .. |.| | | |.  ||         |.. .       |.      |  |  .| .| |  |||.| .||||.|  |.  |.|| ||
WAAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHP

YL
|.
YM
Kinase rl.AA CDK 38-326 35 2.4e-102 328.27 In-house 1-284 (284) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-284/284
Sequence Identity: 35% (114 aa)

YIKLAYIGEGAYGMVVSADDTLTN-----QRVAIKKIS-PFE----HQTYCQR-TLREITILTRFKHENIIDIRDILRVDSIDQM------RDVYIVQCL
| ||. ||||.|| |  | |..|.     | ||.|||    |    . .     ..|||..|    |.||. ..|.   .. |        . .|.|   
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCD-----LKICDFGLARIADPEHD---HTGFLTEYVATRWYRAPEIM
|..||.|...        |  ...|.|||| |.|| ...||||||.|.|.|..       ||| ||||||.   .|.    .  .|  | |.||||||. 
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LNSKGYT--KSIDIWSVGCILAEMLS---NRPIFPGKHYLDQLNHILGVLGSPSRDDLE-CIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKM
| || |.   .||.||||||.|||.    ..|.|||.  .||| .|  ..|.|. |.   .                                 ||| ||
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNKM

LTFNPHKRIPVEEALAHPYL
|...|.|||  |.|| |||.
LCYDPKKRISAEQALQHPYF
Kinase rl.AA S_TKc 38-326 29 2.4e-95 323.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-231/231
Sequence Identity: 29% (91 aa)

YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMET---DLYKLLKTQR-
| .|  ||.||.| |  . .. |...||||.|.        ....||| || . .|.||. . |. .        ..|.|  ....   ||....| .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK-SIDIWS
      ..  |.....|||...|.|.|| ...||||||.|.||..   .|||||||||.           | .. |.||.|||..    ||.| ..|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALA----
.||||.|||. .| ||      |.. .. ..|                                     .  |.|.. |.|...| ||. . |||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase rl.AA Pkinase 38-326 30 1.1e-84 292.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLR---EITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMET-----DLYKLL
| ..  ||.|..| |  . .  |...||.|.|.  .    ...|.|   || |. |..|.||. ..|. .       ...|.|. ..|      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K---TQRL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDL----KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK
.     ..  | .... ..|||||||.|.|| ...||||||.|.|.......    ||||||||. .|  . . . .| .. |.||.|||. . ...|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDIWSVGCILAEMLSNRPIFPGK----HYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIP
..|.||.||||.|||. ||.|||.    . .||.  |  ..| | . | .  ...  .. .   . .   . ...|.|..  ..|.. ..|...|.||. 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTFHNWSEECKDFIKWCLCKDPKKRPT

VEEALAHPYL
 |..| ||..
AEQILQHPWF
Kinase rl.AA MAPK-Unclassified 38-188 49 1.3e-66 227.56 In-house 1-161 (575) Show / Hide 
Range on Protein: 38-188
Range on HMM: 1-161/575
Sequence Identity: 49% (79 aa)

YIKLAYIGEGAYGMVVSADDTLT-NQRVAIKKIS-PFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQ--MRDVYIVQCLMET---DLYKLLK
|    .|| |||| |. | |. . || |||||.   |. .| | |.|||| ||    |.||| |.||.. ..       |.|||  .|.|   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

TQR--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLAR-IAD
     ..  || ||.|||||||||.|||...||||||||||.|  | ..|||||..| | |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase rl.AA MAPK-Unclassified 193-326 35 3.9e-55 189.5 In-house 401-575 (575) Show / Hide 
Range on Protein: 193-326
Range on HMM: 401-575/575
Sequence Identity: 35% (62 aa)

HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-----------RPIFPGKH--------------------YLDQLNHILGVLGSPS
| . .|.||.||||||||||| .. |.. .||||.|||.|||...           ||.|||.                     . ||.. |. .||.| 
HCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP

RDDLECIINEKARNYLESLPFKPNVPWA-KLFPNAD---------ALALDLLGKMLTFNPHKRIPVEEALAHPYL
  |.  | . .|| |..|.  |. |..    |..|           ...|.. ||| ||| |||  ..|| ||| 
EEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase rl.AA TyrKc 38-326 20 2.9e-14 7.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-326
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRF--KHENIIDIRDILRVDSIDQM---RDVYIVQCLMET-DLYKLLKT
  ..  .||||.| |. .  .   . ||.|.. .       .  .||. |....  .|.||. .  . . ..         ..||  .|.  || . |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

QR--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPE------HDHTGF----LTEY-VATRWYRAPEIMLNSKGY
 |  |.... ..| .|| .|  |.|| |. ||||   | |...    ||.||||.|  . .      .|         . . .  ||. ||| .  .|  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT

TKSIDIWSVGCILAEMLSNRPIFPGK-----HYLDQLNHILGVLGSPSRDDL--ECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNP
||| |.|| |  . |....    .          ... . .   . . . .   . .                       |. . .   ..  .   ..|
TKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------FVCCPDEMYQIMKQCWHEDP

HKRIPVEEALAHPYL
..|   .|   | ..
EDRPTFSEI--HECF
Kinase rl.AA Pkinase_Tyr 38-185 28 5.1e-11 37.95 Pfam 1-159 (270) Show / Hide 
Range on Protein: 38-185
Range on HMM: 1-159/270
Sequence Identity: 28% (47 aa)

YIKLAYIGEGAYGMVVSADDT----LTNQRVAIKKISPFEHQTY--CQRTLREITILTRF-KHENIIDIRDILRVDSIDQMRD--VYIVQCLMET-DLYK
 ...  .||||.|.|. .  .     |.. ||.|.. .  ..     .  .||. |.. . .|.||.    .      || .   .|||  .|.  ||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLLD

LLKTQ-----RLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLAR
 |...     .|.  ... . .|| .|. | .| |  ||||   | |....   |||||||||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR