Gene Mekk1 (Fruit Fly)

Mekk1

Species: Fruit Fly
Alias: CG7717, dMEKK, MEKK, Mekk1, SFO157, MEKK4, mekk1a, mekk1b, DmMEKK1
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 91C5,

Classification

Group: STE
Family: STE11
Subfamily: MEKK4

Sequence

Name Sequence Type Origin Length Description Download
Mekk1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
Mekk1.AA Protein Various 1571 None Fasta, JSON

Protein domain

Protein domains of Mekk1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Mekk1.AA MEKK4 1282-1542 61 3.4e-218 731.14 In-house 1-271 (271) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-271/271
Sequence Identity: 61% (168 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALT
|.||..||.|.||||||..|..|.|.|||||...|.....|.||.|.|.||.|||||.|||||||.||||||..||||.||.||||....|.||..|...
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIADEIKIFEGIKHPNLVRYYGVEVHREEMYIFMEYCSQGTLERVCHLGGNMQEHMI

RRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHT-TVPGELQGYVGTQAYMAPEVFTKTNSD-------GHGRAADIWSVG
|..|.|||..|..||.|||||||||.|||||.. ...|||||||..||.|.|. |.|||.|...||.|||||||.|.|..|       ||||||||||.|
RQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDK-CTVLKLGDFGCSVKLQNHSQTMPGEFQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRAADIWSLG

CVVVEMASGKRPWA---QFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFC
||||||..|||||.   |.|.|||||.|||||..|..|...|.||.||.||||.||||.|.||.|||.|.||
CVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase Mekk1.AA STE11 1282-1542 40 6.30000000001e-151 507.7 In-house 1-303 (303) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-303/303
Sequence Identity: 40% (124 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGE------------TRALKNVAEELKILEGIKHKNLVRYYGIEVH---REELLIFMELCSEGTL
|..| .||.| ||.||...| .||||||.|.|.||. .            ....|. .||.|......|||.|||||...|   .... |||| |..|.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

ESLVELT-GN--LPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHT--------------TVPGELQ-GYVGTQA
.|. ..  |   ..|...|..| |.|.|.. ||.|||.||||| |||.|   .|..||.|||.|.......              ...|... ...||..
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDS-NFQIMFKVGMGEKPQAP--ESLS------QEGHDFIDHCLQHDPKRRLTAVELLEH
.||||| ... .||.||.|||||.||.|.|||.||.||. .|. ....|||.|||.||. |  |..|      .|..||..||..|||| | || .||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

NFC
.|.
PFI
Kinase Mekk1.AA STE 1282-1542 28 1.5e-94 320.4 In-house 1-359 (359) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-359/359
Sequence Identity: 28% (103 aa)

WHRGIKIGQGRFGKVYTAVNNN---------------TGELMAMKEIAIQPGET---------------RALKNVAEELKILEGIK--HKNLVRYYGIEV
| .  |||.| ||.||.|.|..               |||.||.|.. ... ..                 .... .|.||.   .  |.| |.||| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

H-------REELLIFMELCSEGTLESLVE---LTGN-----------LPEALTRRFTAQLLSG-VSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSA
.       ..|| |.||... |.|.....    .|.           .|| . .... |.| |  . ||.|.|.||||| |||.|       || ||| .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

VKIQAHT-------------TVPGELQGYVGTQAYMAPEVFTKTNSD---GHGRAADIWSVGCVVVEMASGKRPWAQFDSN---FQIMFKVGMG------
 ... .              |  .. .  |||. .||||| .. ...   |... .||||.||...||| || ||. .      |.|.|. .|.      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----EKPQAPE-------------------SLSQEGHDFIDHCLQHDPKRRLTAVELLE--HNFC
     . |. |.                   ..|.| .|||..||| ||. | || .||.  | | 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Mekk1.AA S_TKc 1282-1542 31 2.1e-91 310.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSE--GTLESLVELTGN----
.. . |||.| ||||| .....||...|.|.|          ...  |..||.  .|.|.|..|.. .. ..| ..||.|.   |.| .. .  |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGR-AADIWSV
  .||  .|....|.....  .|.|||.|||.| .||.| .    .|..|||.| ..            ..||  ||||||.      |.|. ..|.||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL------GYGKCKCDWWSC

GCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLE-------HNFC
||.. ||..|. |.     . | |||. .          |.|. |||..||| ||..|.|| |.|.       | . 
GCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Mekk1.AA STE11-Unclassified 1282-1542 36 3.6e-89 302.54 In-house 1-308 (308) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-308/308
Sequence Identity: 36% (114 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGE--TRALKNV-----AEELKILEGIKHKNLVRYYGIE--VHREELLIFMELCSEGTLESLVEL
|  |  ||.| ||.||...| ||||.|| |.| |.       .....     ..|.|.|.   ||| |.|||.|  .|.  . |||| ...| . |. . 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

TGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAV---------------------KIQAHT-TVPGELQGYVGTQA--
 | . |.... .| |.|.|.. ||.|||.||||| ||| |.|.    || |||.|                      ||. |.    . ..   ||    
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANI-LIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-YMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDS--NFQIMFKVG-MGEKPQAPESLS-----------QEGHDFIDHCLQHDPKRRLTA
 .||||| .   ..||.|..||||.||.|.|||.||.||. ..     ....|..  .. || || ||           ||. ||...|.| ||| |.||
FWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

VELLEHNFC
 .|| | | 
NQLLQHPFI
Kinase Mekk1.AA Pkinase 1282-1542 26 1.3e-72 252.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAE--ELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEG----TLESLVE--LT
.|.| |||.| ||.|| ... .||.. |.|.|  .  .   ... .   |..|.  ..|.| ||.|..   . .. . ||.|  |     | ....    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GNL--PEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLV-DGSN--SLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTN-SDGHGRAA
|..  .|   ...  |.|.|.  .|..||.|||.| .||... .| .  ..|..|||.| ...  .   . .....||  ||||||    . . ..|...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEV---IRGGQYYGPKV

DIWSVGCVVVEMASGKRPWAQF-----DSNFQIMFKVGMGEKPQAPESLS--------------------QEGHDFIDHCLQHDPKRRLTAVELLEHNFC
|.||.||.. ||..|. |. .      ..  |......... .   . ..                    .|. |||. ||. |||.|.|| ..|.| . 
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Mekk1.AA MEKK2 1282-1542 38 8.5e-65 221.58 In-house 1-262 (262) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-262/262
Sequence Identity: 38% (103 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVA---EELKILEGIKHKNLVRYYGIEVHRE--ELLIFMELCSEGTLESLVELTGNL
|.||  .||| ||.||      ||  .| | . ..| .. . | |     |...|  ..|. .| |||    ..   | ||||  . | .   . . | |
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

PEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVV
 |. ||..| |.| |.. || | ||||||| ||| | | |  .|||||| . ..|        ..   ||  .|.|||    | .| || ||.||.|| |
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANI-LRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVI---NGEGYGRKADVWSIGCTV

VEMASGKRPWAQFDSNFQIMFKVGMGE-KPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFC
|||   | |||...     .||.   . .|| |...||.. ||.  | ..  . |  | ||| |.| 
VEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase Mekk1.AA CAMK 1287-1542 20 6.9e-64 204.47 In-house 1-425 (425) Show / Hide 
Range on Protein: 1287-1542
Range on HMM: 1-425/425
Sequence Identity: 20% (88 aa)

KIGQGRFGKVYTAVNNNTG------------ELMAMKEIA-----------------IQPGETR---------ALKNVAEELKILEG-------IKHKNL
..|.|.||||. ... ||.            .  |.| |                  |.  ...          .|||  |..|.         ..|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYG-IE----------------VHRE---ELLIFM---ELCSEG----TLESLVELTGN---------------LPEALTRRFTAQLLSGVSELHKHG
.. |  .|                |  .   .. ..|   |.|| |     | . .   |.               ..|. .||.  |..|.|  .|.|.
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKTANIFLVDGS----------------NSLKLGDFGSAVKIQA-------------------HTTVPGE-LQGYVGTQAYMA-PEVFTK-----
|||||.|  || |.| .                | .|. ||| | |..                     |. .|. .. ..|| .||| |||. .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

------TNSDGHGRAADIWSVGCVVVEMASGKRPWAQFD------------SNFQIMFKVGMGEKPQAPES-----------------------LSQEGH
       . ...|...|.||.|..   | .|. |.   .            .  ... |.  |.    |.                        .|||  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFIDHCLQHDPKRRLTAVELLEHNFC
|.| ..|| ||..|.|. . |.| . 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Mekk1.AA MEKK15 1282-1542 36 9.8e-60 204.77 In-house 1-264 (264) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-264/264
Sequence Identity: 36% (99 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKN----VAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLP
| .|  .|.| .| ||  .  ||| |.|.| ....  .  . |     . || ..|  .||||.| | |. ..   . |||.    | . |..   | |.
WKKGNILGKGAYGTVYCGL-TNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLD

EALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAH---TTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGC
|    ..| |.| ||  ||   .|||||| .|. |.     .|| ||| | ..       |    |.   ||  .|||||   |   |.|| .||||.||
EMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMET---GYGRKSDIWSIGC

VVVEMASGKRPWAQFDSNFQIMFKVGMG--EKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFC
 | ||| .| |||. |     || .| .    || |.  | .  .|.  ||  | . | ||..|| | | 
TVFEMATRKPPWADMD-RMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase Mekk1.AA ASK 1288-1542 35 2.3e-59 196.07 In-house 2-254 (254) Show / Hide 
Range on Protein: 1288-1542
Range on HMM: 2-254/254
Sequence Identity: 35% (92 aa)

IGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELT-GNLP--EALTRRF
.|.| .| || . . .|   .|.|||  .  . |  . . ||... . ..|.|.|.| |   . . ..||||    | | .|..   | .   |   . .
LGKGTYGIVYAGRDMHTQVRIAIKEIPER--DSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFY

TAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKR
| |.| |.. || . |||||||  |. .   |  .|. ||| . ..   . .    . . ||  ||||||  .    |.|..|||||.|| .|||| || 
TKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPC---TETFTGTLQYMAPEVIDQGQR-GYGKPADIWSFGCTMVEMATGKP

PWAQFDSNFQIMFKVGM-GEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFC
|.  ...    ||||||  . |. ||.||.| ..|| .| . ||..| .| .||. .| 
PFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase Mekk1.AA CAMKL 1280-1542 28 4e-55 174.29 In-house 1-297 (297) Show / Hide 
Range on Protein: 1280-1542
Range on HMM: 1-297/297
Sequence Identity: 28% (87 aa)

FRWHRGIKIGQGRFGKVYTAVN-NNTGELMAMKEIA--IQPGETRALKN-----------VAEELKILEGIK---HKNLVRYYGIEVHREE------LLI
.|  .   .|.| ||||  |..  .|||  |.| |       .. ..||           .  | .|.. ..   |.| .. | .   .|       . .
YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

FMELCSEGT--LESLVELTGN----LPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLV-DGSNSLKLGDFGSAVKIQAHTTVPGE-LQGYVGTQA
.||.|| |   |   ..  |.    .||  .||.  |..|.|. .|.|||||||||  || |  .|.| .|. ||| . ... .   ||. |    |. .
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFD------SNFQIMFKVGMG-EKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF
|||||.| ..| . .|...|||| | .   |  |. |. . .      .|.  ...  |. ..|  . ..| . .|.| . ||..|..| |. ....| .
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

C
.
M
Kinase Mekk1.AA STE20 1282-1542 31 4.3e-52 179.38 In-house 1-288 (288) Show / Hide 
Range on Protein: 1282-1542
Range on HMM: 1-288/288
Sequence Identity: 31% (93 aa)

WHRGIKIGQGRFGKVYTAVNNNTGEL----MAMKEIAIQPGET--RALKNVAEELKILEGIKHKNLVRYYGIEVHR----EELLIFMELCSEGTLESLVE
.    ||||| .||||.| .. |||.     | | . . . .     ....  |  |.   ||.| |.|||  .      .|| | ||.|. |.|  ...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---LTGN------LPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQA--HTTVP--GELQGYVGTQAYMAPEVFTKT
    .|.      . |.     . ..| | . ||...|.||||| .|| |.. . . || ||| . ...   . .    .. .  |||  .|||||  . 
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNI-LLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQCM

NS--DGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMG--EKP--QA--PESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFC
 .   |..  .||||.|    ||| |. | . .   .. ||..  .  ..|  .   |.. |.| |||.|.||| ||. | || .||.| | 
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHP-MRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Mekk1.AA TyrKc 1282-1541 23 3e-17 56.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 1282-1541
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGI--KHKNLVRYYGIEVHR-------EELLIFMELCSEGTLESLVEL
 . | |.| | ||.|| .. .   .  | | .         ..   .|..|.  .  .|.|.|| ||. ..        | |.| ||... | | .    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TGN-LPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAH--------TTVPGE--LQGYVGTQAYMAPEVFTKTNSD
... |. .    |  |  .| . ||.....|||. . |. ||.  .  | .||| . .|  .        . .. |     ..     ||||..     .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC-LVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

G-HGRAADIWSVGCVVVEMAS-GKRPWAQ----FDSNFQIMFKVGMGEKPQAPES--------LSQEGHDFIDHCLQHDPKRRLTAVELLEHNF
|    . |.|| | .  |. . |. |.      . ||.... .|  |. .  |..         ..| .. .  | ..||. | |  |.  . |
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase Mekk1.AA Pkinase_Tyr 1282-1425 25 3.6e-15 52.02 Pfam 1-156 (270) Show / Hide 
Range on Protein: 1282-1425
Range on HMM: 1-156/270
Sequence Identity: 25% (41 aa)

WHRGIKIGQGRFGKVYTAVNN----NTGELMAMKEIAIQPGETRA---LKNVAEELKILEGI-KHKNLVRYYGIEV-HREE--LLIFMELCSEGTLESLV
 . | |.|.| ||.|| .. .    ||.   | | .   .| .     ..   .|.||.  . .|.|.||.||. . ..|   ..| ||..  | | .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

EL----TGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFG
       ..|.      . .|  .| . |. ....|||. . |. . . .|  | .|||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFG
Kinase Mekk1.AA Pkinase_Tyr 1466-1539 27 0.000863 13.46 Pfam 194-269 (270) Show / Hide 
Range on Protein: 1466-1539
Range on HMM: 194-269/270
Sequence Identity: 27% (21 aa)

AADIWSVGCVVVEMAS-GKRP-WAQFDSNFQIMFKV-GMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEH
. |.|| | .  |. . |. | ..   ||.... ..   |.   .||  ..| .| . .| ..||..| |  |..|.
KSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ