Gene CDK4 (Mouse)

CDK4

Species: Mouse
Alias: Cdk4, CDK4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK4

Sequence

Name Sequence Type Origin Length Description Download
CDK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 290 Kinase domain by global Sugen HMM Fasta, JSON
CDK4.AA Protein Sugen 303 None Fasta, JSON
CDK4.NA RNA Sugen 1447 None Fasta, JSON

Protein domain

Protein domains of CDK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK4.AA CDK4 6-295 68 1.7e-231 775.35 In-house 1-290 (290) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-290/290
Sequence Identity: 68% (198 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDR-DIKVTLVFEHIDQDLRTYL
|..|||||.|||||||.|||.|.|||||||.||.|.|.. |||.|.||.||....|.|..|||||.|.|||||....||| ..|.|.||||.|.||.|||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEE-GGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

DKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIF
||.||||.| .|||..|.|.|.|.||||...|.||||||.||||||.|.|||||||||||||.||||||||||||||||||||||.|.||||||||||||
DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIF

AEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
|||..|.|||||.||.|||.||||..||||||||||.||||...|..|.|||.....|.|...|..||..||..|.|||.||...|||.|.
AEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK4.AA CDK 6-295 44 4.3e-153 493.28 In-house 1-284 (284) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-284/284
Sequence Identity: 44% (142 aa)

YEPVAEIGVGAYGTVYKARDPHSG-----HFVALKSVRVPNG--GAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRD------IKVTLV
|| ...|| |.||.|||||| ..|     ..|||| .|. |     .. |.| ...||..||. |    |||.|.|.||| |. .||.       |...|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL----HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

FEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGT-----VKLADFGLARIYSY-------QMALTPVVVTLWY
||..|.|| .|.|           || .|.| |.||...| | |.|||||| |||...||.     .|.|||||||...        ....|..||||||
FEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPEVLL-QSTYA--TPVDMWSVGCIFAEMFR---RKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPEMEESGAQLLLE
||||.|| ...|   ||.|||||||||||||.   ||||| |.|| ||| |||...| | ||.||  ..||                        .||  
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------DLLNK

MLTFNPHKRISAFRALQHSYL
||...|.|||||  |||| |.
MLCYDPKKRISAEQALQHPYF
Kinase CDK4.AA CMGC 6-295 25 6.30000000001e-123 406.08 In-house 1-513 (513) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YEPVAEIGVGAYGTVYKARDPHSG--------------HFVALKSVR---VPNGGA---AGGGLPVSTVREVALLRRLEA--------------FEHPNV
|| .  || |.||.|||.|| ...               .||.| ..    ....    .. |.| .. ||. .|..|                  |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VRLMDVCATSRTDRD------------IKVTLVFEHIDQDLRTYLDKAP---------PPGLPV----------ETIKDLM------RQFLSGLD--FLH
|.| |.. .. .|..             .. ||||..|.||  |... .         |    .          ..|| .|      .| | ||.  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ANC--IVHRDLKPENILVTSN--------------------GTVKLADFGLARIYSY----------------------QMALTPVVVTLWYRAPEVLLQ
 ..  |.||||||||||...|                    |..|..||||||.|.                       ....|. |||.||||||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

ST----------YATPVDMWSVGCIFAEMFRR--------KPLFCGNSE-----------ADQLGKIFDLIGLPP---------------EDDWPREVSL
..          | ||.||||||||||||...        |||| |.||            ||| |||...| |.               |..||  ..|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PRG----------------------------AFAPRGPRPVQSVVPE-----------------------------------MEESGAQLLLEMLTFNPH
|.                              | .. |.| ....|                                    . . .  ||  ||...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISAFRALQHSYL
|||.|  |||| |.
KRITAEQALQHPYF
Kinase CDK4.AA CDC2 6-295 42 3.7e-116 358.61 In-house 1-301 (301) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-301/301
Sequence Identity: 42% (132 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLD
|. .  || | || |||..|  ..  |||| .|. .  .   | | ...||  .|  |   .|||.|.| ||          |. .||| .|.||. |.|
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGD-GVPSTAIREISCLKELK--DHPNIVKLHDVIHQ------NKLYMVFEYLDMDLKKYMD

-KAPP-PGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQM-ALTPV--VVTLWYRAPEVLL-QSTYATPVDMWS
 . |.   .|....|..| | |.|..|.|.. |.|||||| |||. ..|..|.|||||||  .. . ..|.   ||||||||||.|| ...| |||||||
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

VGCIFAEM---FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLP--RGAFAPRGPRPVQSVVPE---------MEESGAQLLLEMLTFNPHKRIS
.|||||||     .|||| | || ||| |||  .| | |..||   .||     |    |   ....|          ... | .|| .||  .| ||||
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AFRALQHSYL
| .|||| |.
AKEALQHPYF
Kinase CDK4.AA CDK5 6-295 44 1.6e-108 344.07 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-287/287
Sequence Identity: 44% (134 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLD
|| .  || | ||||||||.  .. .|||| ||  .      | | . .||..||. |    |.|.||| ||  . .     | |||||..||||. |.|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDS---EDEGVPSTAIREICLLKEL---KHKNIVRLHDVIHSEK-----KLTLVFEFCDQDLKKYMD

KAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCI
.    ..  ..|| .| | | || | |.. . |||||| | |.  ||. ||||||||| .       .  |||||||.| ||. | .| |..||||.|||
SCNG-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

FAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRG-----AFAPRGPRP-VQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
||||    .||| ||.. ||| .||...| | || ||    ||       .. .. ...  |..||...| |  || .|| .||..||||  ||.| | 
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK4.AA S_TKc 6-295 29 5.5e-98 332.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQ---DLRT
|| . .|| ||.|.|||.|. ..|. ||.| ..             .. ||...|..     |||.|.| ||. .       .. .|.|..|.   ||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK----HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFD

YLDKAPPPG----LPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYAT-PVDM
|..| ...|    .|  ... .|.| ...|...| . |.||||||||||...  ..|..||||||..      | ...|.||.|||||    | . ..|.
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ------
||.|||..||. ..|.|.      |. ..|..||                                  ... ...  .|...| ||..|  |||      
WSCGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HSYL
 | ..
CHPWF
Kinase CDK4.AA Pkinase 6-295 29 2.8e-80 277.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVR--EVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQ-----
|. .  || |..|.|||...  .|. ||.| ....    .  . ... .|  |.....||    |||.||| |.. .     . .. .|.|. .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVM

DLRTYLDKAPPPGL--PVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTV----KLADFGLAR---IYSYQMALTPVVVTLWYRAPEVLL-Q
|| .|.      ..  . ...|. |.| |.||...|.. |.||||||||||. .||..    |..|||||.   . ...  .| ...|.||.||||.. .
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGG

STYATPVDMWSVGCIFAEMFRRKPLFCGN----SEADQLGKIFDLIGLPPEDDWPREVSLP------RGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTF
. | ..|||||.|||..||. ..|.|.|     . .||. .|.   | |.. ||| . | .      . .      .  . . ....|.. ...  .|..
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H------F-HWTF-HNWSEECKDFIKWCLCK

NPHKRISAFRALQHSYL
.|.||..|  .||| ..
DPKKRPTAEQILQHPWF
Kinase CDK4.AA PITSLRE 6-295 39 6.9e-80 271.71 In-house 1-295 (295) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-295/295
Sequence Identity: 39% (121 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGG--AAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTY
.. .  |. |.|| ||.|.|   .  |||| . .   .      | |.  .||.  .  | |  |||.| .  .   |  |   |. .|.| .. ||.  
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKM---ERQKEKEGFPITSLREINMI--LMALQHPNIVNVKEIVMGSNMD---KIYMVMEYVEHDLKSL

LDKAP---PPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQ-MALTPVVVTLWYRAPEVLL-QSTYATPVDMW
...      | .| | || || | |.| ...| | | |||||  |.| . .|  |..|||||| | .  ...||.||||||||||.|| . .| ||||||
MENMKRRNQPFKPGE-IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMW

SVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLP---RGA-FAPRGPRPVQSVVP---EMEESGAQLLLEMLTFNPHKRISAFRALQ
||||||||.   |||| |.|| ||. .|| . | | |  ||   .||   .   |..  .    . .|      . |  ||  |||.|| .||.|  ||.
SVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALK

HSYL
| . 
HPWF
Kinase CDK4.AA PFTAIRE 6-295 40 9.8e-79 267.89 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-287/287
Sequence Identity: 40% (120 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLD
|| .   | | | ||||..    . ||||| .|      .  | |   .||. ||. |    | |.| | |.  | .|      |.||| .. || .|.|
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRL----QQEEGTPFTAIREASLLKNL---KHANIVCLHDIIHTKET-----LTFVFEYVHTDLCQYMD

KAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCI
|  | |.  . ..  . | | || . |   . |||||| | |..  |  |||||||||  |         ||||||| | ||| || | | .||| ||||
KH-PGGMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCI

FAEMFRRKPLFCGN-SEADQLGKIFDLIGLPPEDDWPREVSLP---RGAFA--PRGPRPVQSVVPEME--ESGAQLLLEMLTFNPHKRISAFRALQHSYL
| ||.  .|.| |     |||.||| . | | || ||   .||     .|.     |.. . ..| ..    . .|. .||  .| .|.||  |.|| |.
FVEMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK4.AA CDK10 6-295 41 2.6e-72 246.52 In-house 1-285 (285) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-285/285
Sequence Identity: 41% (121 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLD
.| .  .| |.|| ||.||| .|   |||| ||.        |||.| .||. || ..    |.|.|.| .|      |    . || .. .|||   ||
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRM---DKEKDGLPISGLREIMLLIQC---RHENIVELHEVVVGQHLD---SIFLVMQYCEQDLASLLD

KAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCI
  | |      .| .| | | || .|| | ..|||||  |.|.| .| .|.||||||| |.  .  .|| .|||||||||.|| . |  | .||| ||||
NMPQP-FTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCI

FAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRP---VQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
 .|.   |||. ||||  |.  | ||.| | |  ||    ||          |   ..   . . .|| .||  .. .|| ||  |  .|. || 
LGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK4.AA CRK7 6-245 35 3.4e-68 232.89 In-house 1-284 (343) Show / Hide 
Range on Protein: 6-245
Range on HMM: 1-284/343
Sequence Identity: 35% (101 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCAT---SRTDRDIK--VTLVFEHIDQDL
|| ...|| | || ||||.. | |  |||| ||  |      | |.  .||. .|| |   .|.|.|.|...          .. |  . .||| .| ||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL---NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL

RTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSY---QMALTPVVVTLWYRAPEVLL-QSTY-----
   |.         . .| .|.| | |.| .| . . |||.|  |||.  .| ||.||||||| |     .  .|  |.|||||.|| ||    |     
MGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLP
                                  . .||||.|||..| | .||.| || | .|| ||. . | |  . ||    ||
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLP
Kinase CDK4.AA MAPK 53-295 33 4.4e-67 229.17 In-house 51-328 (328) Show / Hide 
Range on Protein: 53-295
Range on HMM: 51-328/328
Sequence Identity: 33% (94 aa)

TVREVALLRRLEAFEHPNVVRLMDVCATSR----TDRD--IKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSG--LDFLHANCIVHRDLKPE
| ||. |||..   .|.|...| |.   .      ...    . .|.|  . ||.  .   .   |  . |. .| | | |  | ..|  ...||||||.
TYREIKLLRHFH--HHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPS

NILVTSNGTVKLADFGLARIYSYQ---------------MALTPVVVTLWYRAPEVLLQ---STYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGK
||||..|...|..||||||.   .               | .|. |.| ||||||..|      | . ||||||||||||| . ||||| |..  ||. .
NILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNL

IFDLIGLPPEDDWPREV-S-LP----RGA--FAPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL
|....| |.|... .   |  .    ..   . .. ..| ... |            ||  ||.|.|.|||..  |||| |.
IMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK4.AA Pkinase_Tyr 66-199 31 3.3e-15 52.14 Pfam 60-199 (270) Show / Hide 
Range on Protein: 66-199
Range on HMM: 60-199/270
Sequence Identity: 31% (46 aa)

F-EHPNVVRLMDVCATSRTDRDIK--VTLVFEHIDQ-DLRTYLDKA--PPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADF
.  |||.|||. ||     |..    . .|.|.    ||..|| |   ... |..... .  .|  .|...|... ..||||   |.|||.|..|| .||
LGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF

GLARIYSYQMALTPVVVTL-------WYRAPEVLLQSTYATPVDMWS
||||   |      ....        |. |||..  . . |  | ||
GLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGKFTTKSDVWS
Kinase CDK4.AA TyrKc 6-295 20 3.7e-13 -10.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRR----LEAF--EHPNVVRLMDVCATS--RTDRDI----KVTLVF
 .   ..| ||.|.|||..       || |...                  .. ..|    .  .  .|||.|||  || ..  .          . .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVM

EHIDQ-DLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIY----------SYQMA----LTPVVVTL
|. .  ||. || |  |  |....  . . |  .| ..|| ....||||   |.||..|.||| .||||.|            .| ..     .  .. .
EYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

WYRAPEVLLQSTYATPVDMWSVGCI------FAEMFRRKPLF--CGNSEADQLGKIFDLIGLPPE----DDWPREVSLPRGAFAPRGPRPVQSVVPEMEE
   |||..  ... |  | || |        . ..    . .  . |.|. .. |  .    ||.                           .  ... .
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F--VCCPD

SGAQLLLEMLTFNPHKRISAFRALQHSYL
   |. ..   ..|..| . |... |...
EMYQIMKQCWHEDPEDRPT-FSEI-HECF
Kinase CDK4.AA CRK7 270-295 42 3.3e-09 27.68 In-house 318-343 (343) Show / Hide 
Range on Protein: 270-295
Range on HMM: 318-343/343
Sequence Identity: 42% (11 aa)

QLLLEMLTFNPHKRISAFRALQHSYL
.|| .||. .| ||..|  .||| ..
DLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK4.AA MAPK 6-35 38 1.4e-08 25.53 In-house 1-36 (328) Show / Hide 
Range on Protein: 6-35
Range on HMM: 1-36/328
Sequence Identity: 38% (14 aa)

YEPVAEIGVGAYGTVYKARDPH------SGHFVALK
|...  || ||||.| .|.|        .| .||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK
Kinase CDK4.AA Pkinase_Tyr 6-24 36 7.19905 0.18 Pfam 1-19 (270) Show / Hide 
Range on Protein: 6-24
Range on HMM: 1-19/270
Sequence Identity: 36% (7 aa)

YEPVAEIGVGAYGTVYKAR
 .   ..| ||.|.|||..
ITFGKKLGEGAFGEVYKGT