Gene CDKL4 (Mouse)

CDKL4

Species: Mouse
Alias: CDKL4, AU067824
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL4.AA Protein Sugen 342 None Fasta, JSON
CDKL4.NA RNA Sugen 2931 None Fasta, JSON
CDKL4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 283 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CDKL4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL4.AA CDKL 4-286 69 7.79999999999e-227 759.86 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-286/286
Sequence Identity: 69% (199 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVI
||||.|.||||||||.||||| .||.||||||.|||||..|.|||.|||.|||||||.|.||||||||||||.||||||||||.|.|||..|||| ..|.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KSVLWQTLQALNFCHKHNCIHRDVKPENILIT-KQGMIKICDFGFARILI-PGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLW
....||.|.|.||||||||||||.|||||||| |.|..|.|||||||.|  ||..||||||||||||||||||||.||..||.||.|||.||...|||||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSNVQ-PVALSFMKGCLKMNPDERLTCAQLLDSAYF
||.||.||||.|...||.||||||.||..|.|| |...||.|.||.||....|.. ..||.|||.||.|.||||.||.||... ||
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL4.AA CMGC 4-286 24 1.4e-134 445.13 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 24% (128 aa)

YEKLAKIGEGSYGVVFKCRN--------------KSSGQVVAIKKFVESEDDRVVRK----------IALREIRMLKQLK-----------------HPN
||.. |||||.||||.|||.              . ....|||||. . . .    |          .|||||..||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLIEVFRRKR-----------------KMHLVFEYCDHTLLNELERNPN--------GVSDGV------------IKSVL------WQTLQALN--FC
.|.|...|..|                  ...|||||.||.|.. ...|..        . |. .            ||. .      .| |..|.  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKHN--CIHRDVKPENILITKQ--------------------GMIKICDFGFARILIPGD----------------------AYTDYVATRWYRAPELLV
|.|.   |||| |||||||...                    | .||||||.||.. | .                      .||.||.||||||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------TKYGSSVDVWAVGCVFAELLTG--------QPLWPGKSD-----------VDQLYLIIRTLGKLI---------------PR-------
|.         ..|....|.|.|||.|||..||        .||.||.|.           .|||..|...||.                 ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------HQSIFRSNQFFRGISIPEPE--DMETLEEKFSN--------------------------------VQPVALSFMKGCLKMNP
                  |.|.|  |....... |..   . . |. ...|                                  | |. ..|..|...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DERLTCAQLLDSAYF
|.|.|..| |.  ||
DKRITAEQALQHPYF
Kinase CDKL4.AA Pkinase 4-286 32 3.5e-112 383.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALR--EIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDH-----TLLNELE-RNP
|... |||.||.|.|.||..|..|..||.|..  ....  ......|  ||...| |.||| | |...|..|.....|.|||..      |   .. .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NGV--SDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMI----KICDFGFARI--LIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAV
...  |. ..|....|.|..|..||....||||.||||||| ..| |    ||||||.|.   . ..  .|... |.||.|||.. |...||..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVFAELLTGQPLWPGK----SDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSNVQPVALSFMKGCLKMNPDERLTCAQLLDS
||...|.|.|.|..||.    . .||...| |..|. .... .  .|.  |  ... . .  . ....  |. . ...|.|.||...| .|.|..|.| .
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

AYF
 .|
PWF
Kinase CDKL4.AA CDK 4-218 42 6.30000000001e-107 343.16 In-house 1-242 (284) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-242/284
Sequence Identity: 42% (107 aa)

YEKLAKIGEGSYGVVFKCRNKSSG-----QVVAIKKF-VESE----DDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRK-----------RKMHLVFEY
||||.|||||.||||.|.|.| .|     |.||.||. .|.|    ..  .   |.||| .||.| ||| |.|..|.  |           .|  .||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGM-----IKICDFGFARIL-I------PGDAYTDYVATRWYRAPE
.|| |   ..          ||. .|| |..|..||... .||| || ||||...|      .|| |||.||.  |      |  .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLVGDTKYG--SSVDVWAVGCVFAELLT---GQPLWPGKSDVDQLYLIIRTLG
|| |...|.   ..|.|.|||.|||..|   ..|| ||.|. ||| .|.|..|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG
Kinase CDKL4.AA S_TKc 4-286 31 4e-104 353.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDH---TLLNELERNPNG---
||.| |||.|..|.|.|||.|..|..||||.           . ..|||..||. .|||.|.|..||.   ....|.||||.   .|.  ..... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGS-SVDVWAVGCVFAEL
   .  .......|...||..||.|. ||||.||||||...   |||||||.||.|      | .. |.||.|||.|    .||  ..|.|..||...|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

LTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSNVQPVALSFMKGCLKMNPDERLTCAQLLD-------SAYF
|.|.|..|      |...... .|                                      | |..|...||...|..|.|. ..|          .|
LCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL4.AA CDC2 4-218 46 1.2e-95 294.4 In-house 1-226 (301) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-226/301
Sequence Identity: 46% (106 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKF-VESEDDR-VVRKIALREIRMLKQLK-HPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELE-RNP--NG
|.|. |||||.||||.||... ..|.||.||. .|.||.   |   |.|||  || || |||.| | .|.   .|  .||||.|. | . ..  .|    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARIL-IPGDAYT--DYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAEL
..  ..|| ..| ||...||| .  .||| || |||| |.| ||| ||| ||   || ..||    | |.||||||.| |. .|  .||.|..||.|||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LTGQPLWPGKSDVDQLYLIIRTLG
    |  || .|.|  |||. | |.||
FMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase CDKL4.AA CDK7 4-218 43 2.8e-91 243.31 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-220/288
Sequence Identity: 43% (96 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFV----ESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVS
|||...|||| ...|.| . ...||.|||||       || .  .   |.||| .|. ..|.| ..|| .|  |    |||.. |  |    . .     
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

DGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARIL-IPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQ
   ||.   .||| | .||..   ||| || | |. . | .|| ||| ||    |  .||  | |||||||||| |   ||..||.|.|||.||||.   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLWPGKSDVDQLYLIIRTLG
|  || ||.|||  | .|||
PYLPGDSDIDQLTRIFQTLG
Kinase CDKL4.AA CDK5 4-218 44 3.3e-88 278.78 In-house 1-217 (287) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-217/287
Sequence Identity: 44% (97 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGVI
|||. ||||| ||.|.| ||| .. .||.|.    ..|  |   |.||| .|| |||.| | |. |    .|. ||||.||  |   ..    ...  .|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARIL-IPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELL-TGQPLW
|| ..| |. | |||.|.  ||| || | || |.|  |  ||| ||   ||   |.  | | |||.|  | |  .|  |.|.| .||.|||.  .|.|| 
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGKSDVDQLYLIIRTLG
|| .. ||| .| . .|
PGNDVEDQLKRIFKIMG
Kinase CDKL4.AA RCK 4-218 40 6.3e-86 272.59 In-house 1-231 (298) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-231/298
Sequence Identity: 40% (94 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLK-HPNLVNLIEVFRRKR--KMHLVFEYCDHTLLNELER---NPNG
|  ....|.|.||.|.| .|| .|..|||||    .       . ||||. |. |. |||...|.||.| .     ..||||.|  |   ..        
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

VSDGV--IKSVLWQTLQALNFCHKHNCIHRDVKPENILITK---------QGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWA
..  .  ||. . |.||.|...|||.  |||.|||||..|.         |. |||.||| .|       ||||| ||||||||.|  .|.| | .|.||
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWA

VGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG
|||...|| . .||.|| | .||.. |.  .|
VGCIMYELYMLRPLFPGSSEIDQIFKICKVMG
Kinase CDKL4.AA MAPK 4-286 30 1.9e-81 276.9 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-328/328
Sequence Identity: 30% (102 aa)

YEKLAKIGEGSYGVVFKCRNKS------SGQVVAIKKFVESEDDRVVRKIALREIRMLKQL-KHPNLVNLIEVFRRK-----RKMH------LVFEYCDH
|. | .||.|.||||.... |.      .|. |||||..   .. .  | ..|||..|. . .|.| ..|...|. .     . ..      .|.|....
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TLLNELERNPNGVSDGVIKSVLWQTLQA--LNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAY---------------TDYVATRWYRA
 | . .....   ||  |.. ..| | .  | . |  | |||| ||.|||... .  |||||| ||.. | . .               |.|||||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--TKYGSSVDVWAVGCVFAELLT-GQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRS-N----QFFRGISIPEPEDMETLEEKFSN----VQ
||.. .   ..|  .||.|.||| |||.|| ..|| |||. .||. ||. .||.  ...   . . .    .....   . . .  ..|. |.|    ..
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PVALSFMKGCLKMNPDERLTCAQLLDSAYF
| |. ...  | ..||.|.| .. |   ||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL4.AA ERK7 4-286 35 2.2e-71 243.38 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-292/292
Sequence Identity: 35% (103 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLK-HPNLVNLIEVFRRK--RKMHLVFEYCDHTLLNELERNPNGVSD
|| . ..| | ||.| |   | ..||||.||      ...      ||| .|.... |||.. ||.|.| .  | . ||||. . | |.   |  |   |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

GVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGD-------AYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAE
   .....| |.|. . |  | ||||.|| |||.  . |.|.|||| || .   .       . |.||||||||||| |.| ..|   || | .||. .|
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSNVQPVALSFMKGCLKMNPDERLTCAQLLDSAYF
.|.|.|. || | ..|. .|..|..|          |.     ..  . .  .||.. . . .. |.. .|  | .||..|||  | |   | 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL4.AA CDK-Unclassified 4-218 30 1.4e-69 228.06 In-house 1-256 (324) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-256/324
Sequence Identity: 30% (77 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKK-FVESEDD---------RVVRKIALREIRMLKQLKHPNLVNLIEVFRRKRKMH-------------LVF
|. . |.||| .| |.| .     . ||||| .|  . .          .   ...|||  |....| |.  .....    ..              .| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQG-----MIKICDFGFARILI-------------PGDAYTDYVA
|| . |. | |. | .  |   |.  . | |  ... |    .|||.||.||.|| ..     |.|| ||| |.                |.. |.  |.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG
|||||||||| |. .|.  ||.|..||..||.. | |. .|.....|.  |...||
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLG
Kinase CDKL4.AA Pkinase_Tyr 4-186 28 6e-25 85.11 Pfam 1-199 (270) Show / Hide 
Range on Protein: 4-186
Range on HMM: 1-199/270
Sequence Identity: 28% (58 aa)

YEKLAKIGEGSYGVVFKCRNK----SSGQVVAIKKFVESEDDRVV--RKIALREIRMLKQL-KHPNLVNLIEVFR-RKRK--MHLVFEYCDH-TLLNELE
 ... |.|||..|.|.|.. |    . .. ||.|.      .     |.  .||....||| .|||.|.|. |   ...   . .|.||. |  ||. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RN---PNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVAT------RWYRAPELLVGDTKYGSSVD
..   .. ..   . .  ||  ..... . .||||||.   |.|.|... .|||||| || . . | |  ....      .|. ||| .     . .  |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSD

VWA
||.
VWS
Kinase CDKL4.AA TyrKc 4-284 23 1.4e-20 75.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQL--KHPNLVNLIEVFRRK-------RKMHLVFEYCDH-TLLNELER
 ... |.||| .|.|.|.. |   . ||.|.  |.      |.  .||.|....|  .|||.|.|. | . .         . .|.||..|  |.. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPG-------DAYT------DY--VATRWYRAPELLVGDTKY
. . ..     |  ||  .  .. |..||||||    |.|..... .||.||| .| .  .       | |.          .  ||. ||| .  . |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GSSVDVWAVGCVFAELLT-GQPLWPG----KSDVDQLYLIIRTLGKLIPRHQ----SIFRSNQFFRGISIPEPEDMETLEEKFSNVQPVALSFMKGCLKM
 .  |||. | .  |..| ||. .||    . . ....  ... . . . .     |                         |    .   . || | . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCWHE

NPDERLTCAQLLDSA
.|..| | ... .  
DPEDRPTFSEIHECF
Kinase CDKL4.AA CDK7 259-286 46 5.4e-11 25.07 In-house 261-288 (288) Show / Hide 
Range on Protein: 259-286
Range on HMM: 261-288/288
Sequence Identity: 46% (13 aa)

ALSFMKGCLKMNPDERLTCAQLLDSAYF
.| .|.| . ||| .|.||.| | . ||
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL4.AA CDK 262-286 28 6e-07 18.09 In-house 260-284 (284) Show / Hide 
Range on Protein: 262-286
Range on HMM: 260-284/284
Sequence Identity: 28% (7 aa)

FMKGCLKMNPDERLTCAQLLDSAYF
.. ..| ..|. |... | |.. ||
LLNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL4.AA RCK 259-286 32 0.000148 10.05 In-house 271-298 (298) Show / Hide 
Range on Protein: 259-286
Range on HMM: 271-298/298
Sequence Identity: 32% (9 aa)

ALSFMKGCLKMNPDERLTCAQLLDSAYF
... |. .|. .|..| | .|.|   ||
CIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDKL4.AA CDK-Unclassified 270-286 29 0.000291 9.77 In-house 308-324 (324) Show / Hide 
Range on Protein: 270-286
Range on HMM: 308-324/324
Sequence Identity: 29% (5 aa)

NPDERLTCAQLLDSAYF
.|..|..| ..| . .|
QPYNRWKCMEILQHPWF
Kinase CDKL4.AA CDK5 260-286 25 0.000321 8.7 In-house 261-287 (287) Show / Hide 
Range on Protein: 260-286
Range on HMM: 261-287/287
Sequence Identity: 25% (7 aa)

LSFMKGCLKMNPDERLTCAQLLDSAYF
. .... |..||..|.. .. |  .||
MDLLQKMLQCNPNQRISAKAALHHPYF