Gene DYRK3 (Mouse)

DYRK3

Species: Mouse
Alias: DYRK3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 314 Kinase domain by global Sugen HMM Fasta, JSON
DYRK3.NA RNA Sugen 2072 None Fasta, JSON
DYRK3.AA Protein Sugen 586 None Fasta, JSON

Protein domain

Protein domains of DYRK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK3.AA DYRK2 208-521 63 8.8e-236 774.82 In-house 1-318 (318) Show / Hide 
Range on Protein: 208-521
Range on HMM: 1-318/318
Sequence Identity: 63% (203 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFS
||.|..|||||||||...||||..|.||.||.||.||||.||.||||||.|...|||...||..|||..|.||||.|..|||||..|||.||||.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQ-KLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQP
.||||.||.||||.|..||||.||||||||||||||...||  |||||||||||.| ..|||||||||||||.|||..|...||.||||||.|||.||.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGEDEGDQLACMIELLGMPPQKLLEQS-----KRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRC
|||||.|.||.|||.|.|||||.|.....     .|.|||.||.. ..||  ...||..... .....|..||.|||||.|...||||.|..||.|.|||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LQWDPSARLTPAQALRHPWI
..|||| |.||.|||.||||
FEWDPSERMTPSQALKHPWI
Kinase DYRK3.AA DYRK 208-521 54 7.4e-202 676.89 In-house 1-320 (320) Show / Hide 
Range on Protein: 208-521
Range on HMM: 1-320/320
Sequence Identity: 54% (177 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF-
||.|..|||||||||....|||  ..||.|..||.||||||| .||.|||.|..||.. .....||...|..|||.|. |||||..|||..|.|.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SVQLVRKFAQSILQSLDALHKN-KIIHCDLKPENILLKHH-GRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTG
|..|||||||.||..|. |||| .|||||||||||.||.. ..|. ||||||||||| |..|||||||||||||.||||.|...||.||.|||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

QPLFPGEDEGDQLACMIELLGMPPQKLLEQS--KRAKYFINSKGLPRYCSVSTQTDGRV------VLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIE
 ||||||.| |||||..|.|||||.......  .|...|...   ..|| . ..|....      .. . ...| ..|.|||...|  ... | | .|. 
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

FLKRCLQWDPSARLTPAQALRHPWI
|.|.||||||. |.||.|||.|||.
FIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK3.AA CMGC 208-521 22 7.79999999999e-129 425.85 In-house 1-513 (513) Show / Hide 
Range on Protein: 208-521
Range on HMM: 1-513/513
Sequence Identity: 22% (118 aa)

YEVLKIIGKGSFGQVARVYD--------------HKLRQYVALKMVRNEKRFHRQAA-------------EEIRILEHLK-KQDKTG-----------SM
||..| ||.|..|.| . .|              |.  ..||.| ..|.. ...||               ||.||.||. ..|. .             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NVIHMLESFTFRN-----------------HVCMAFELLSIDLYELIKKNK--------------------------FQGFSVQLVRKFAQSILQSLD--
|.......|...|                 |... ||..  |||..||.|.                           . |.. ..| ... ||..|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

ALHKNK--IIHCDLKPENILLKHHGRSAT------------------KVIDFGSSCFEYQK------------------------LYTYIQSRFYRAPEI
 .|...  |||.||||||||. | ... |                  |..|||..... .                         ...|...|.||||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGCR----------YSTPIDIWSFGCILAELLTG--------QPLFPGEDE-----------GDQLACMIELLGMPPQKLLEQSK-------RAKYFIN
.||..          |.||||.||.|||.||..||        .|||||..|            |||......||.|. ......|       . . ..|
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKGLPRYCS---------VSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKG-------------------------------CGDYLFIEFLKRCLQ
 ..||.|           .... .  . .   . .| ... |.  |..   ..                                | | ..|..||..||
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPSARLTPAQALRHPWI
.||. |.|..|||.||..
YDPDKRITAEQALQHPYF
Kinase DYRK3.AA DYRK1 208-521 45 2.4e-108 366.23 In-house 1-321 (321) Show / Hide 
Range on Protein: 208-521
Range on HMM: 1-321/321
Sequence Identity: 45% (147 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFS
||.   |||||||||.. |||. ..|||.|...| | |  ||  |||.|| . |.||    ...|. . | ||||.|. |||||  ||.|..  .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

VQLVRKFAQSILQSLDALHKN--KIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQ
. |.||||| ....|  .     .|||||||||||||    ||| |.|||||||   |..| ||||||||.||..|| .|.. ||.|| |||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGEDEGDQLACMIELLGMPPQKLLEQSKRA-KYFINSKGLPRYCSVSTQTDGRVVLLGGRSRR---GKKRGPPGSKDWATALKGCGDYL-FIEFLKR
||| | .| ||.  ..| |||||.....|. .| |||   .    ||  . .   . .  . |  .   | . | ||..    .     ||| | . .||
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

CLQWDPSARLTPAQALRHPWI
 ||.|| .|.|| .||.|...
MLQYDPKQRITPYYALQHSFF
Kinase DYRK3.AA YAK 208-441 44 6.3e-96 324.99 In-house 1-239 (347) Show / Hide 
Range on Protein: 208-441
Range on HMM: 1-239/347
Sequence Identity: 44% (106 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL-KKQDKTGSM---NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF
| || . |.| ||||.          .| | . |   .  ||  ||.||. | .. | ..      .. |. .| ..|| |. ||.||. |||..| |||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLT
 |||.||.| .  .|| ..  |   .|||||||||||.|.   . . |.||||||| | . .|||||.|.||.||||..  |.| || || |||.|||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GQPLFPGEDEGDQLACMIELLGMPPQKLLEQSK-RAKYF
| |.|||  | .|.   |. || ||  ...| . . |||
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase DYRK3.AA S_TKc 208-521 25 1.5e-93 317.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 208-521
Range on HMM: 1-231/231
Sequence Identity: 25% (85 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI---DLYELIKKNKFQ
||.|..||||.||.| .....|  ..||.|...      ...  ||.||..       .  |.......|   .|..| .|...    ||...|||.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYST-PIDIWSFGCILA
|    |.   .|.... |.. |. .|...|||.||||||||| .      |..|||....     .|.. ...|.|||..    |.. ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLK
|.|.|.|.||      |.. |....|                                                                 .  ...|..
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------SPEAKDFIR

RCLQWDPSARLTPAQALR-------HPWI
.|||.||. |.|  .||.       |||.
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK3.AA CDK 208-521 25 1.3e-68 218.64 In-house 1-284 (284) Show / Hide 
Range on Protein: 208-521
Range on HMM: 1-284/284
Sequence Identity: 25% (91 aa)

YEVLKIIGKGSFGQVARVYDHK-----LRQYVALKMVRNEK--------RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR-----------NHV
|| |. || |..|.| .  |..       |.||||..| |.         |   |  || .| .|         |..  .. ..             | .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG---RSATKVIDFGSSCFEY--------QKLYT-YIQS
 | || .  ||.....           .. . . .|. |. .|.|.|.| |||| |||. . |   .   |. ||| ..           .. ||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEIILGCR-YS--TPIDIWSFGCILAELLT---GQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLG
. |||||. ||.. ||  ||||.||.|||.||..|   ..|||||. | ||| . ....| |  .     .   ..                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

GRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWI
                              ..| ..|. ||. |..  ||| ||. 
------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK3.AA HIPK 208-441 39 2.2e-66 207.91 In-house 1-236 (329) Show / Hide 
Range on Protein: 208-441
Range on HMM: 1-236/329
Sequence Identity: 39% (93 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFS
|||| ..|.| ||||..   .     ||.|. .|.  . ||   |..||. |....    .... ..| |  .||.|. ||.|   ||.  |.|||    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQEN-ADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSA--TKVIDFGS-SCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTG
.. .|   | .|  |  | .  .|| |||||||.|    |     ||||||| | .      ||.|||.||||||||| ..   .|.|| ||..|||  |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

QPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYF
 ||.|| || ||   ...  . | . ||..  ... |
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRF
Kinase DYRK3.AA Pkinase 208-444 26 3.1e-66 231.16 Pfam 1-272 (293) Show / Hide 
Range on Protein: 208-444
Range on HMM: 1-272/293
Sequence Identity: 26% (75 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-----EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-----DLYEL
|.....||.||||.| . .... .. ||.| .. ... . .  .     ||.|. .|.      . |.. ....|. ..|..| .|..       ||...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSAT----KVIDFGSSCF---EYQKLYTYIQSRFYRAPEIIL-GCRYS
|.   ...|  || . .....  ||. |. .|...|||.||||||||....|   .    |..|||....    .. ..|.  ...|.|||.|. |  |.
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH--IDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

TPIDIWSFGCILAELLTGQPLFPGE----DEGDQLACMIELLGMPPQKLLEQS---------------------KRAKYFINS
...|.||.||||.|.|.|.|.|||.    .  ||.... . .| |.    ...                     . .| ||..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW
Kinase DYRK3.AA DyrkP 208-408 40 1e-56 184.99 In-house 1-205 (323) Show / Hide 
Range on Protein: 208-408
Range on HMM: 1-205/323
Sequence Identity: 40% (83 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK----F
| ..  .|   | .     | .  | . .|.. | | .  |. .||..|  .         ||... . |  . |. .  |||   |||  | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLT
. | |  . |  | || .|| .|  ..|||||||||||.| . .   |.||||||||    |  |.||| |||||.|.||.|   ||.|| ||||||| |
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GQPLF
|  ||
GNVLF
Kinase DYRK3.AA PRP4 208-436 36 7.6e-52 178.55 In-house 1-233 (320) Show / Hide 
Range on Protein: 208-436
Range on HMM: 1-233/320
Sequence Identity: 36% (86 aa)

YEVLKIIGKGSFGQVARVYDHKLRQ-YVALKMVRNEKRFHRQAAEEIRILEHLKKQ--DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKN-KF
|.|   .|.| |. | |  |    .  || | .||    |.    |. ||  |  .  ||     .. | ..| .|.| |. || .|  | |..||  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGS-SCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELL
 |...  || .|| ..  |  | |..|.| |.|| |||     ..  | .|||| |  . . .  | .||||||||||.| .|   ||.|| || |.|| 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSK
||  .|||    . |  . .. |  |.|..  ..
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQ
Kinase DYRK3.AA CLK 208-342 30 1.4e-51 152.56 In-house 1-147 (350) Show / Hide 
Range on Protein: 208-342
Range on HMM: 1-147/350
Sequence Identity: 30% (45 aa)

YEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIR-ILEHLKKQ-DKTGSMN--VIHMLESFTF-RNHVCMAFELLSIDLYELIKKN
||...  | | || | .. |||   .||||| .|| ...  .|  ||. |......  |. .     ...|...| .  .|.|. |||.   .|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILL
.      ....  . .|..|  .....  ||..|..| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK3.AA CLK 351-445 42 5.3e-35 101.86 In-house 187-289 (350) Show / Hide 
Range on Protein: 351-445
Range on HMM: 187-289/350
Sequence Identity: 42% (44 aa)

KVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKR-----AKYFI
.||||||     |.. . .| ...| |||||.|||. .|.| |.||.|||| || ||  ||.. |. . || | ...||| ..   |. |      |||.
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFY

NSK
. .
HNR
Kinase DYRK3.AA TyrKc 208-521 18 2.1e-12 -22.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 208-521
Range on HMM: 1-280/280
Sequence Identity: 18% (64 aa)

YEVLKIIGKGSFGQV--ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL--KKQDKTGSMNVIHMLESFTFR-------NHVCMAFELLS-IDLY
 . .|..| | ||.|  .. .     . || ||.....  ..   .|.||. .|  .        |.. ..   |           ... .|. .  || 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGH------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

ELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQK-------LYTYI----QSR-----FYRAPEI
. ..|.. . ....   .|.  | .  . ||....|| ||   |.|... .    |. ||| | . | .        |       ...        ||| 
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

ILGCRYSTPIDIWSFGCILAELLT-GQPLFPGE----DEGDQLACMIELLGMPPQKLL----EQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRR
|  ....|  |.||||  . |..| ||.  ||.     . ...   ..  ...||                                             
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------

GKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWI
                 .| | ..    |.| . ||. | | ..   |  .
--------------F-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase DYRK3.AA Pkinase 494-521 46 1e-09 35.46 Pfam 266-293 (293) Show / Hide 
Range on Protein: 494-521
Range on HMM: 266-293/293
Sequence Identity: 46% (13 aa)

FIEFLKRCLQWDPSARLTPAQALRHPWI
...|.|.||..||. |.|..|.| |||.
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK3.AA DyrkP 491-521 48 4.1e-09 25.43 In-house 293-323 (323) Show / Hide 
Range on Protein: 491-521
Range on HMM: 293-323/323
Sequence Identity: 48% (15 aa)

DYLFIEFLKRCLQWDPSARLTPAQALRHPWI
|..||.| ..||| |   | |   ||.|||.
DHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK3.AA HIPK 494-521 42 3.4e-08 21.39 In-house 302-329 (329) Show / Hide 
Range on Protein: 494-521
Range on HMM: 302-329/329
Sequence Identity: 42% (12 aa)

FIEFLKRCLQWDPSARLTPAQALRHPWI
|.. ||. . ||.  |.||..||.||..
FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK3.AA CLK 494-521 35 4.1e-08 19.67 In-house 323-350 (350) Show / Hide 
Range on Protein: 494-521
Range on HMM: 323-350/350
Sequence Identity: 35% (10 aa)

FIEFLKRCLQWDPSARLTPAQALRHPWI
... ....|  |||.|.| ..|| ||. 
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK3.AA PRP4 497-521 48 5.7e-08 25.36 In-house 296-320 (320) Show / Hide 
Range on Protein: 497-521
Range on HMM: 296-320/320
Sequence Identity: 48% (12 aa)

FLKRCLQWDPSARLTPAQALRHPWI
.| .||. ||. | |. .||.|| |
LLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK3.AA YAK 493-521 44 4.8e-07 19.56 In-house 319-347 (347) Show / Hide 
Range on Protein: 493-521
Range on HMM: 319-347/347
Sequence Identity: 44% (13 aa)

LFIEFLKRCLQWDPSARLTPAQALRHPWI
.|| |.   || .|  | .| ||  || |
CFIDFINQLLQLNPRERWKPMQAMQHPFI