Gene ERK1 (Mouse)

ERK1

Species: Mouse
Alias: ERK1, Mapk3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
Erk1.AA Protein Sugen 380 None Fasta, JSON
Erk1.NA RNA Sugen 1766 None Fasta, JSON
Erk1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 289 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Erk1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk1.AA ERK1 43-331 89 1.6e-246 825.3 In-house 1-289 (289) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-289/289
Sequence Identity: 89% (260 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSND
||.||||||||||||.||||.|.|.|||||||||||||||||||||||.||.||.|||.|.|.||.||.|.|.||||||||.|||||||||||.|.||||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN
||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN

RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
||||||||||||||||||.||||||.|||||||.||||||||||.|.||.||.||||.|||||||||.||||||.||||||||||||||
RPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk1.AA MAPK 43-331 55 1.2e-203 682.81 In-house 1-328 (328) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-328/328
Sequence Identity: 55% (181 aa)

YTQLQYIGEGAYGMVSSAYDHV------RKTRVAIKKIS-PFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRA------PTLEAMRDVYIVQDLMET
|. |..||.||||.| ||.|         ...||||||| ||...|.|.||.||| .| .| .|||.|...||...      ..|| ..|.|||..||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLKSQQ-LSNDHICYFLYQILRG--LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHDHTG----------FLTEYVATRWYRAP
||....|||| ||.|||.||.||||||  |||||||||.||||||||.|.|. ||||||||||||..|| .|.|..          ..||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCII-NMKARNYLQSL---PSKTKVAWAKLFPK----SDSK
|||||  ...|||..|.||||||.||||. ..|.||||.|.||.|.|. .||.||.|...||  . .||||.|||   | ..|. |.|.||.     ...
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLDRMLTFNPNKRITVEEALAHPYL
|.|||..||.|.|.|||||||||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk1.AA ERK 43-331 53 8.8e-178 596.91 In-house 1-307 (307) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-307/307
Sequence Identity: 53% (165 aa)

YTQLQYIGEGAYGMVSSAYDHV-----RKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLK
|  .. ||.|||| | || |         ..||||||  .|.|  || |||||| .|  |. |||.|...||..    | . |.|.|..|||||| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHT-----GFLTEYVATRWYRAPEIMLNSKGYTKSIDI
||| || ||. ||.||||.||||||||||.||||||||.|.|  ||||||||||||. |....       .|.||||||||||||||||. . |||..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP-SQEDLNCIINMKARNYLQSLPS--KTKVAWAKLFPKSD--SKALDLLDRMLTFNPNKRITVEE
||.|||.||||  .|.|||| |..|.|.|. |.|.| |.|||..| . .|..|. .||   .... | ..||. .  ..|.|||..||.|.|.|||||||
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYL
.|.|||.
CLEHPYF
Kinase Erk1.AA CMGC 43-331 28 3.2e-148 490.75 In-house 1-513 (513) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-513/513
Sequence Identity: 28% (148 aa)

YTQLQYIGEGAYGMVSSAYD--------------HVRKTRVAIKKIS-PFEHQTYCQ----------RTLREIQILLRFR-----------------HEN
|. ...||||.||.| ...|              |  . .||||||. || ... ..          |.||||.|| ...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGIRDILRAPT-------------LEAMRDVYIVQDLMETDLYKLLKSQQ----------LSNDH------------ICYFL------YQILRGLK--Y
.....||.. .              .  ....|.| ..|..|||...|..|          ||  |            |.||.      ||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAN--VLHRDLKPSNLLINTTCDL--------------------KICDFGLARIADPEHDH------------------TGFLTEYVATRWYRAPEIM
.||..  ..||||||.|.||| .|.|                    |||||||||. .|..||                  . ..|.||.|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNS---------KGYTKSIDIWSVGCILAEMLSN--------RPIFP-----------GKHYLDQLNHILGILGSP----------------SQEDLNCI
|..         ..||..||.||||||.|||. .        .|.||           ||...|||..|  .||.|                ..|. |.|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

I--------------------NMKARNYLQS---LPSKTKVAWAKLFPK-----------------------------------SDSKALDLLDRMLTFN
                     . .||||.||   .| . .  | .|||.                                    |..|.|||..||...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PNKRITVEEALAHPYL
|.||||.|.||.|||.
PDKRITAEQALQHPYF
Kinase Erk1.AA p38 43-331 48 1.8e-141 476.31 In-house 1-289 (289) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-289/289
Sequence Identity: 48% (142 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRA--PTLEAMRDVYIVQDLMETDLYKLLKS
| .||..|.|||| |..|.|  ....   |||||.. ||.   .  || ||.  |   ||||||.. |.       .. ..|||.|  .|..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
|.|| ||| . .|||||||||||||.. ||||||||. .|  |.|.| |||||| .| |      .|.|||||||||||||||   ||. .||||||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE------MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
||... |. |||. ..|||. |. ..|.|..| .. | . .||||.||.|  ..   ...|.. . .|.|||..||   | ||||.|||..|||.
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk1.AA ERK5 43-331 52 1.7e-130 439.82 In-house 1-295 (295) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-295/295
Sequence Identity: 52% (154 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPT-LEAMRDVYIVQDLMETDLYKLLKSQQ-L
|  .  ||.||||.|.||  .    .||||||   |.  |  .||.||..||  |||.|.| |||||.    .  |.|||.| |||| || ... |.| .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP--EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA
. .|| ||||||||||||.|||.|.||||||||||.|  |.||| |||.||        .|  |.|||||||||||||.|. |. ||. ||.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS-LPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
||.. | .|||| |..||. |. .|| |.   .  .   . .||.|. .| .. . | |..|| | .||||| ||| | | .|||| .|| ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Erk1.AA ERK7 43-331 47 2.6e-119 402.7 In-house 1-292 (292) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-292/292
Sequence Identity: 47% (139 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLK-SQQL
|  .. .| ||||.|  |||   |  ||.|||   |  ||  ||| ||| .|  |. |.|.| . ...||   .  ||.|.| . |||||    .  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRA---DNDRDIYLVFEFMETDLHAVIRKGNIL

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPE--HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
 . |  | .||.|| .||.||.||.||||||||.|... | .|.||||||| ||. |  ..... |||||||||||||||.| |. ||| .| ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL
.||| ..|.|||   ..|.. || ... |.|||.. |    | | |...... .    ...|..   |.||| |.| |||.||.|.|.||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Erk1.AA ERK3 43-331 42 2.3e-107 346.6 In-house 1-300 (300) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-300/300
Sequence Identity: 42% (129 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRD-----------VYIVQDLMETDLY
.  |.  | |  |.| || |     .||||||.    .  |   ||||.|. |  |.|.. . ..|     .   |           |.||| .||||| 
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKS-CKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLA

KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW
 ..  |.||..|.  | || ||||||||||||||||||| |..|||    ||| |||.||| ||.  | |.|.| . |.||| |. .|    ||| ||.|
CVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMW

SVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY
. ||||||||  .. |.| | | |.  ||        ||.| .       |..      .    .| .  |. |||.| .||||.|  |.| |.|| |||
AAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPY

L
.
M
Kinase Erk1.AA CDK 43-331 34 1e-104 335.98 In-house 1-284 (284) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-284/284
Sequence Identity: 34% (109 aa)

YTQLQYIGEGAYGMVSSAYDHVRK-----TRVAIKKIS-PFE----HQTYCQR-TLREIQILLRFRHENVIGIRDILRAPTLEAM------RDVYIVQDL
| .|. ||||.|| |  | |. ..       ||.|||    |    . .     ..||| .|    |.|.. ..|.    ...        . .|.| . 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHD---HTGFLTEYVATRWYRAPEIM
|..||.|...        |  ...|.|||| |.|| ...||||||.|.||| .       ||| ||||||.   .|.    .  .|  | |.||||||. 
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LNSKGYT--KSIDIWSVGCILAEMLS---NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML
| || |.   .||.||||||.|||.    ..|.|||.  .||| .|  |.|.|. ..   .  .                             |||..||
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNKML

TFNPNKRITVEEALAHPYL
...|.|||. |.|| |||.
CYDPKKRISAEQALQHPYF
Kinase Erk1.AA S_TKc 43-331 28 2e-99 337.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMET---DLYKLLKSQQ-
|. |. ||.||.| |  ....  . .||||.|.        ....|||||| . .|.|.. . |. .        ..|.| .....   ||....|... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK-SIDIWS
      ..  |.....|||...|.|.|| ...||||||.|.|...   .|||||||||.           | .. |.||.|||..    ||.| ..|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA----
.||||.|||. .| ||      |.. .. ..|                                     .. |.|.....|...|.||.|. |||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase Erk1.AA Pkinase 43-331 30 3.1e-91 314.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR---EIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMET-----DLYKLL
|. .. ||.|..| |  ....    .||.|.|.  .    ...|.|   ||||..|..|.|.. ..|. .       ...|.|....|      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K---SQQL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL----KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK
.   .  .  | .... ..|||||||.|.|| ...||||||.|.||. ....    ||||||||. .|  . . . .| .. |.||.|||. . ...|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDIWSVGCILAEMLSNRPIFPGK----HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT
..|.||.||||.|||. ||.|||.    . .||.  |  |.| |  .|    ...  .. ..  . .     ...|.. .. ..|.....|...|.||.|
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTFHNWSEECKDFIKWCLCKDPKKRPT

VEEALAHPYL
 |..| ||..
AEQILQHPWF
Kinase Erk1.AA MAPK-Unclassified 43-193 50 1.7e-69 237.21 In-house 1-161 (575) Show / Hide 
Range on Protein: 43-193
Range on HMM: 1-161/575
Sequence Identity: 50% (81 aa)

YTQLQYIGEGAYGMVSSAYDHVR-KTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEA--MRDVYIVQDLMET---DLYKLLK
|.  ..|| |||| |  | |    .  |||||.   |. .| | |.|||| ||    |.|.| |.||...  |.     |.||| |.|.|   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SQQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IAD
| |  ..  || ||.|||||||||.|||...||||||||||||  | ..|||||..| | |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase Erk1.AA MAPK-Unclassified 198-331 37 7.2e-59 201.89 In-house 401-575 (575) Show / Hide 
Range on Protein: 198-331
Range on HMM: 401-575/575
Sequence Identity: 37% (65 aa)

HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-----------RPIFPGKH--------------------YLDQLNHILGILGSPS
| . .|.||.||||||||||| .. |.. .||||.|||.|||...           ||.|||.                     . ||.. |.  ||.| 
HCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP

QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS----------KALDLLDRMLTFNPNKRITVEEALAHPYL
.||.| | . .|| |.||.  || | .  |..   .           ..|... || |||.|||| ..|| ||| 
EEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk1.AA TyrKc 43-331 21 9.3e-15 15.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-331
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF--RHENVIGIRDILRAPTLEAM---RDVYIVQDLMET-DLYKLLKS
 | .. .||||.| |  .      . ||.|.. .       .  .||..|. ..  .|.|.. .  . . .          ..||  .|.  || . |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

QQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE------HDHTGF----LTEY-VATRWYRAPEIMLNSKGY
 .  |.... ..| .|| .|  |.|| |. ||||   | |..     ||.||||.|  . .      .|         . . .  ||. ||| .  .|  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT

TKSIDIWSVGCILAEMLSNRPIFPGK-----HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK
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TKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------FVCCPDEMYQIMKQCWHEDPED

RITVEEALAHPYL
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RPTFSEI--HECF
Kinase Erk1.AA Pkinase_Tyr 119-190 37 2e-06 22.12 Pfam 82-159 (270) Show / Hide 
Range on Protein: 119-190
Range on HMM: 82-159/270
Sequence Identity: 37% (29 aa)

VYIVQDLMET-DLYKLLKSQ-----QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR
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IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase Erk1.AA Pkinase_Tyr 43-102 23 0.000138 16.16 Pfam 1-67 (270) Show / Hide 
Range on Protein: 43-102
Range on HMM: 1-67/270
Sequence Identity: 23% (16 aa)

YTQLQYIGEGAYGMVSSAYDH----VRKTRVAIKKISPFEHQTY--CQRTLREIQILLRF-RHENVI
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ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIV