Gene ERK3 (Mouse)

ERK3

Species: Mouse
Alias: ERK3, Mapk6
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK3

Sequence

Name Sequence Type Origin Length Description Download
Erk3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 297 Kinase domain by global Sugen HMM Fasta, JSON
Erk3.AA Protein Sugen 720 None Fasta, JSON
Erk3.NA RNA Sugen 4116 None Fasta, JSON

Protein domain

Protein domains of Erk3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk3.AA ERK3 20-316 80 2.2e-268 873.54 In-house 1-300 (300) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-300/300
Sequence Identity: 80% (240 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDD--VGSLTELNSVYIVQEYMETDLAN
..||.|||||.|||||||||..|.|.||||||||||..|.|||||||||||||||||||||.|.|.|.||...||  .|.|.||..|.|||||||||||.
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKSCKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLAC

VLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
|.||..|.||||||||||||||||||||||||||||||||.|||||||||||||||.|||.||||||||.|||||||||||||||||.||||||||||||
VMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMWA

AGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIP-VYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
||||.|||||||.|||||||||||.|||||||||||||..|||.|.| .||.|.|..||.||.|||..|...|||||||.|||.||||||||.||.||||
AGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase Erk3.AA MAPK 20-316 42 4.1e-154 518.28 In-house 1-328 (328) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-328/328
Sequence Identity: 42% (141 aa)

YMDLKPLGCGGNGLVFSAVDND------CDKRVAIKKIV--LTDPQSVKHALREIKIIRRL-DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEY
| .|||.| |  |.|.||.|.       |.|.||||||.   ..|.. |...||||. |.. .|.||.|...|. |..   .|| .|| |.| .|||.|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEM---QDDQNSLEEFNDIYIVMEL

METDLANVLEQGP-LLEEHARLFMYQLLRG--LKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKG-----------HLSEGLVTKW
||||| ....... | ..| . ||||.|||  |||||||||.||||||.|. .|..... ||.||||||. ||.|.|..           |..|  .| |
METDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRW

YRSPRLLLSP--NNYTKAIDMWAAGCIFAEMLT-GKTLFAGAHELEQMQLILDSIPVVHEEDRQELL-SVIP-VYIRN---DMTEPHRPLTQLLPG----
||.| ..|..  ..||||.|||..||||||||| .|.|| | . ..|..||.. ..   ||. | .  |  .  ||..   .   | .|.....|.    
YRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFN

ISREALDFLEQILTFSPMDRLTAEEALSHPYM
 ...|.|.||. |.|.|..|.|.||||.|||.
ANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk3.AA CMGC 20-316 24 1.3e-113 374.87 In-house 1-513 (513) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

YMDLKPLGCGGNGLVFSAVD--------------NDCDKRVAIKKIVLT-DPQSVK----------HALREIKIIRRL-----------------DHDNI
|  .|..|.|  | |....|              .. ...|||||| .  ..   |           ||||||| ..|                 .| ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKVFEILGPSGSQLTDDVGS----LTELNSVYIVQEYMETDLANVLEQGP----------LLEEH------------ARLFM------YQLLRGLK--YI
|| ..|. ...|. ... ..    . ..|..|.| |||..||...... .          | | |             . ||      ||.|||||  |.
VKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDLKPANLFINTEDLV-------------------LKIGDFGLARIMDPHYSHKG------------------HLSEGLVTKWYRSPRLLL
||..  ..||||||.|. || .  .                   |||.||||||. .|| .|..                  ....  || |||.| .||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SP---------NNYTKAIDMWAAGCIFAEMLTG--------KTLFA-----------GAHELEQMQLILDSIPVVH---------------EEDRQELLS
.          ..||..||||..|||||||.||        |.||            |.....|...| . .                   ||.  . ..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------VIPVYIRN-------DMTEPHRPLTQLLPG-----------------------------------ISREALDFLEQILTFSP
                   ..   ||         . | .|...| |.                                   .. .|.|.|...|.. |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

MDRLTAEEALSHPYM
 .|.|||.||.||| 
DKRITAEQALQHPYF
Kinase Erk3.AA ERK1 20-316 44 1.7e-93 316.96 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-289/289
Sequence Identity: 44% (135 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS-VKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANV
|..|. .| |  |.| ||.|.   .|||||||   . |   .  ||||||. |  |.||... .|.          . .. ..  |||||. |||||  .
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDII---------RADTIEQMRDVYIVQCLMETDLYKL

LEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAA
|   .|  .|   |.||.|||||||||||||||||||.|| .||    ||| ||||||| ||.  | | | |   |.||| | ..|    |||.||.|. 
LKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV

GCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMT----EPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHP
||| ||||  . .| | | |.|. .||    |.    ...|  .|    || .      |. |. .| |.    |||.|...||| |  |.| |||| ||
GCILAEMLSNRPIFPGKHYLDQLNHILG---VLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHP

YM
|.
YL
Kinase Erk3.AA Pkinase 20-316 29 4.8e-90 310.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKH--ALR--EIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET--
|  ....| |. | |. ... .  |.||.|.| . .  | |.  ..|  ||.| .||.|.|||. ...                  ...|.|.||.|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------------KDHIYMVMEYCEGGL

---DLANVLE---QGPL--LEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVL----KIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPR
   ||. ...   .|..   |.... .|||.||||.|.|| ...||||||.|..|. .. ..    ||.|||||. .|  | ... ..   .| ||..| 
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPE

LLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGA----HELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPGISREALDFLEQIL
.... . |....|||..|||..|||.|...| |.    . ..|||.|    .   ..|.... |. . . ... . . . .. . . .|.|..||.. .|
VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCL

TFSPMDRLTAEEALSHPYM
.. | .|.|||..| ||..
CKDPKKRPTAEQILQHPWF
Kinase Erk3.AA S_TKc 20-316 27 4.7e-89 303.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET---DLA
|  |...| |. | |. ..... ...||||.|        .|..|||.| .. .|.|||| ...                  ...|.| ||...   || 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---------------DHLYMVMEYCDGDLGDLF

NVLEQGP-------LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNY
 .... .       . | ||| .|||....|.|.|| ...||||||.|.....   ..||.||||||..          .   .| ||..| .|     |
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GY

TK-AIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAE
.| ..|.|. |||..|||.|...|   .. . ...|.                                        |.||.||....|.. | .|.|| 
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

EALS-------HPYM
|||        ||..
EALQDEWDIKCHPWF
Kinase Erk3.AA ERK 20-246 42 5.9e-89 301.83 In-house 1-231 (307) Show / Hide 
Range on Protein: 20-246
Range on HMM: 1-231/307
Sequence Identity: 42% (103 aa)

YMDLKPLGCGGNGLVFSAVDND-----CDKRVAIKKI--VLTDPQSVKHALREIKIIRRLD-HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYM
| ..|..| |. |.|.||.|.      ....||||||  .  .|. .| .|||||. | .. |.||.. | |. |.         | ...| .|.|.|.|
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPN---------SPEQYNDIYCVEELM

ETDLANVLEQG-PLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSH-----KGHLSEGLVTKWYRSPRLLLS
||||. .     .| ..|   ||||.|.||||||||||.|||||| |. .| .. .||| ||||||. |..|.      .....|  .| |||.| ..||
ETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLS

PNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILD
 ..||||.|.|..|||||||| .|.|| |.  ..|...|..
WQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQ
Kinase Erk3.AA ERK7 20-316 37 2.4e-83 283.23 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-292/292
Sequence Identity: 37% (113 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLD-HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLA
|  .| || |  |.|  |.|    . ||.|||     ..       ||| ... .. |.||... ...  .  .             .|.| |.||||| 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR------------DIYLVFEFMETDLH

NVLEQGPLLEE-HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHY---SHKGHLSEGLVTKWYRSPRLLLSPNNYTKA
.|  .| .|.. | .  |||||| .||.||.||.||||||.|. ...| .| |. |||||| .        ... | |   | |||.|  ||.  .|||.
AVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMV-KVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKG

IDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDM-TEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL
.|||  ||| .|||.|| .|.|   ..|. .||..|| . .|| . . | . . . . | ......| |..|. . .|.| | ..| | |  |||||.||
VDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQAL

SHPYM
.||| 
QHPYV
Kinase Erk3.AA p38 20-316 37 2.4e-80 273.22 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-289/289
Sequence Identity: 37% (113 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKR---VAIKKIVLTDP-QSVKHA---LREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME
| .|.|.| |  | | .|.| . ...   |||||  |  | ||. ||    ||..  . ..|.|...  ..  |          |. ... ||.| . |.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKK--LMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTP-------PAHSMNDFQDVYMVTHFMG

TDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKA
.|| |.. .  | ..| ..  ||.||||||||||.. |||||| |. .| ||  |.| ||||||      .    . .  .|.|||.|  .|.   ||..
ADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVN-EDCELRILDFGLAR------HCDDEMTGYVATRWYRAPEIMLNWMHYTQT

IDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIP-VYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL
.|.|  ||| ||..||.||| |   ..|.| |.  . .  ||  | . |     ||..  . | | ......| .. |.| || .|   |  |.|||||.
VDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAM

SHPYM
.|||.
QHPYF
Kinase Erk3.AA ERK5 20-316 37 5.8e-77 262.0 In-house 1-295 (295) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-295/295
Sequence Identity: 37% (114 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLAN
|  .  .| |  | | ||.     ..||||||          |  .||.||.|   ||||. . .|| |           . |. .||.| . || ||  
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMP--------KVPYSEMKDVYVVFDLMESDLHQ

VLE-QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP--HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAID
..  . |.  || | |.||.||||||.|||.|.||||||.|| .| |   |||||||.|| .       |.  . |   |.||| | |..| ..||.|||
IIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAID

MWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLS-VIPVYIRNDMTEPH-RPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALS
.|. |||| ||.. . .| |   ..|.|||.. . .      |   .  .  |.  .. .   ... .. |.  | ||| | ..| | | .|.|. .|| 
VWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQ

HPYM
||..
HPFL
Kinase Erk3.AA CDK 20-244 35 5e-73 232.93 In-house 1-237 (284) Show / Hide 
Range on Protein: 20-244
Range on HMM: 1-237/284
Sequence Identity: 35% (92 aa)

YMDLKPLGCGGNGLVFSAVDNDCD-----KRVAIKKIVLTD----------PQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTEL-NS
|  |. .| |  | |. | | . .     . ||.||| .            |..   |.|||.. . | |.||||....   . .  ..  ..     |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPIT---AIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDK---HENK

VYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDL----VLKIGDFGLARIMD-------PH--YSHKGHLSE
.|.| |||..||. ...         . .|.|||||| |.|| ...||||||.|. ||        .|||.||||||..        |   |.|.     
LYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHE-----

GLVTKWYRSPRLLLSPNNYT--KAIDMWAAGCIFAEMLT---GKTLFAGAHELEQMQLI
  || |||.| |||   .|.   .||||..|||||||.|   .| || |  |..|. .|
-VVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKI
Kinase Erk3.AA MAPK-Unclassified 20-176 38 7.7e-51 175.22 In-house 1-157 (575) Show / Hide 
Range on Protein: 20-176
Range on HMM: 1-157/575
Sequence Identity: 38% (63 aa)

YMDLKPLGCGGNGLVFSAVDNDC-DKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET---
|   | .| |. | |  |.|.    . |||||.    ....  | .|||| | | | | ||... .|       .... ..  |   .||| .||.|   
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDI-------FYNKELHNQEFDDIYIVMDYMQTSLF

DLANVLEQGP--LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLAR
||  .. .    . ..| . |.||.||||||.|||...||||||.|| || .|. ..| |||..|
DLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLIN-QDCSVRICDFGMSR
Kinase Erk3.AA MAPK-Unclassified 183-316 26 3.8e-28 98.56 In-house 400-575 (575) Show / Hide 
Range on Protein: 183-316
Range on HMM: 400-575/575
Sequence Identity: 26% (47 aa)

SHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTG-----------KTLFAGAH--------------------ELEQMQLILDSIPVV
.|..|...  || ||| | ..||  .|....|.|..|||||||.             . || |                         | ..|.|     
HHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMP

HEEDRQELLS-VIPVYIRNDMTEPHRPLTQLLPGISR----------EALDFLEQILTFSPMDRLTAEEALSHPYM
 ||| ..  .  .  ||.     .  . |.| .   .          |..||. . | |.|  | ||..||.|||.
PEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk3.AA ERK 276-316 39 1.2e-11 39.82 In-house 265-307 (307) Show / Hide 
Range on Protein: 276-316
Range on HMM: 265-307/307
Sequence Identity: 39% (17 aa)

RPLTQLLPG--ISREALDFLEQILTFSPMDRLTAEEALSHPYM
.|.  . |   .. .|.| ||. |.| | .|.|.||.|.||| 
KPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase Erk3.AA TyrKc 20-316 20 2.1e-11 -38.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-316
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRL--DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLA
   .| ||.|  | |. .. .     ||.|..       ..  .||..| ..|  .|.|||. . .   .| .         .   ..|| |||.  || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------FMYIEPLMIVMEYMPHGDLK

NVLEQGP--LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPH---------YSHKGH-LSEG-LVTKWYRSPRLL
. |      |  ..   |..|  .|  |.|| |. ||||   |  .. .  . ||.||||.|  . .         |..|.|  . . |  .|. .|  .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI

LSPNNYTKAIDMWAAGCI-----------FAEM----LTGKTLFAGAHELEQMQLILD----SIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPG
   . .| . | |. |               .|    .. . ...   . . |    .    |                                   ..
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------F-VC

ISREALDFLEQILTFSPMDRLTAEEALSHPYM
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CPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Erk3.AA CDK 282-316 40 7.3e-10 27.56 In-house 255-284 (284) Show / Hide 
Range on Protein: 282-316
Range on HMM: 255-284/284
Sequence Identity: 40% (14 aa)

LPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
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LPDY-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Erk3.AA Pkinase_Tyr 102-187 35 9.9e-07 23.42 Pfam 80-173 (270) Show / Hide 
Range on Protein: 102-187
Range on HMM: 80-173/270
Sequence Identity: 35% (34 aa)

NSVYIVQEYMET-DLANVLEQG-----PLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM--DPHY-SHKGH
|..||| |||.  || . | .      ||  ..   . .|  .|. | .| |  ||||   |  ..  ..| ||.|||||| .  |  |   .|.
NQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYYYRKRGG
Kinase Erk3.AA Pkinase_Tyr 20-79 26 0.023995 8.57 Pfam 1-68 (270) Show / Hide 
Range on Protein: 20-79
Range on HMM: 1-68/270
Sequence Identity: 26% (18 aa)

YMDLKPLGCGGNGLVFSAVDN----DCDKRVAIKKI-VLTDPQS--VKHALREIKIIRRL-DHDNIVK
   .| || |  | |. .. .    . .  ||.|..   ....    .  .||.|| . | .|.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVR