Gene GSK3A (Mouse)

GSK3A

Species: Mouse
Alias: GSK3A
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
GSK3A.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 286 Kinase domain by global Sugen HMM Fasta, JSON
GSK3A.AA Protein Sugen 490 None Fasta, JSON
GSK3A.NA RNA Sugen 2259 None Fasta, JSON

Protein domain

Protein domains of GSK3A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GSK3A.AA GSK 119-404 62 4.3e-232 717.11 In-house 1-328 (328) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-328/328
Sequence Identity: 62% (205 aa)

YTDIKVIGNGSFGVVYQARLA----ETREL----VAIKKVLQDKRFK-NRELQIMRKL---DHCNIVRLRYFFYSSGEKKDE--LYLN-LVLEYVPETVY
|...||||.||||||||| .     || |     ||||||.||||.| |||||||..|   ||.|||||.||||...|||||  .|.| ||.||.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVR--GEPNVSYICSRYYRAPELIFGATDYTSSI
.|.||. |.|   |||.||.||||.||.|||.|| |.|||||||||.||||||.|||.|||||||||..  .|||.||||||||||||||||.|.||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP-----QIKAHPWTK-------------------VFKSSKTPPE-
||||.|||.||.|.|||.|||||.|||||||||.|||||.|||..|||.|.|||||     |||.|||.|                   .||. .|... 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

AIALCSSLLEYTPSSRLSPLEACAHSFF
.| |.|..|.|.|..|||||||||| ||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GSK3A.AA CMGC 119-404 22 1.1e-127 422.03 In-house 1-513 (513) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-513/513
Sequence Identity: 22% (118 aa)

YTDIKVIGNGSFGVVYQARL--------------AETRELVAIKKVLQDKRFKN----------------RELQIMRKL-----------------DHCN
|. ||.|| |..||||..|                || |.|||||. ... ...                ||..|...|                 .| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLRYFFYSSGEKKDEL-----------YLNLVLEYVPETVYRVARHFTK-------AKL---------------ITPII-YIKVYMYQLFRSLA--YI
||.|...||.......|            .|.|| ||.. . |.. ..  .        .|               |  .. .|. ||||..|.|.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIR-YMYQILRGLKLKYC

HSQG--VCHRDIKPQNLLVDPDTAV-------------------LKLCDFGSAKQLVRG----------------------EPNVSYICSRYYRAPELIF
||..  ..|||.||.|.|..... .                   ||.||||.|...                         .|. .|...|.|||||...
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GA---------TDYTSSIDVWSAGCVLAELLLG--------QPIFPGDSG-----------VDQLVEIIKVLGTPT---------------REQIREMNP
|.         ..||..||.||.||..||...|        .|.|||.|.           .||| .|.|||||||                |.. .|..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

NYTEFK---------------------------FPQIKAHPWTKVFKSSK---------------------------------TPPEAIALCSSLLEYTP
... .|                           ||... .||...|. ..                                  .|.|| | . .|.| |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SSRLSPLEACAHSFF
. |... .|..| .|
DKRITAEQALQHPYF
Kinase GSK3A.AA Pkinase 119-404 31 2.9e-103 354.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR--------ELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHF-
|. ...|| ||||.||...   |...||.|..  ... ..         |.|||..|.|.|||||...|..    ||..|  .|.||.. ..| |.  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIY--MVMEYCEGGLY-VMDLFD

---TKAKLIT--PIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAV---LKLCDFGSAKQ--LVRGEPNVSYICSRYYRAPELIFGATDYTS
   |...     .   .| ||||..| |.|.||.|..|||.||.|.|.| .  .   .|.||||.|||  . ... . .. ....|.|||.| |...|..
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSP
..|.||.||.|.|.|.|.|.|||.    . .||.. | ...|.|..... . ......| |.. . |. ...|   ....|.. .....|.. |..|...
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF--HNWSEECKDFIKWCLCKDPKKRPTA

LEACAHSFF
 ... | .|
EQILQHPWF
Kinase GSK3A.AA S_TKc 119-404 28 1.9e-86 294.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPE---TVYRVARHFTKAKLI
|. ...|| |.||.||..|  .| ..||||..    .   ||.||..| .| |||.| ..|..        .| .|.||..    ..... ..  . .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--TPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS-SIDVWSAGCVLAE
   |   .. ||||... |.|.||.|..|||.||.|.|.|    ..|.||||.|.||       ... ...|.|||..     |.  ..|.|| ||.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACA-------HSFF
.| |.| ||      |. ...|..|                                    .|||. . . .|.. |. |..  || .       | .|
MLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GSK3A.AA RCK 119-404 31 4.4e-77 244.07 In-house 1-298 (298) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-298/298
Sequence Identity: 31% (97 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN-------RELQIMRKLD-HCNIVRLRYFFYSSGEKKD--ELYLNLVLEYVPETVYRVARH
|. || .| |..|.|  |.  || |.|||||    ..|..       ||.. .|||  | ||. |.  ..     .|  .||  .|.||. . .|   ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLY--FVFEYMDMNLYQMMKD

--FTKAKLITPIIY-IKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPD--------TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY
    . |... .   || .|||.. .||..|..|  |||.|| |... ..        . ..|..|||...      |.  |. .|.|||||..  .| |
FKE-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYY

TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSP
.| .|.|. ||. .||   .| ||| | .||. .|.||.|||. .   .     . ..|.||| |. |  ... .   ....| |.  .| . |. | ..
NSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN--CSQDCIELMEKMLQWDPQKRITA

LEACAHSFF
 .|. | .|
QQALQHPYF
Kinase GSK3A.AA CDK 119-404 29 6.8e-77 245.51 In-house 1-284 (284) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-284/284
Sequence Identity: 29% (96 aa)

YTDIKVIGNGSFGVVYQARLAETR-----ELVAIKKVL--------QDKRFKN---RELQIMRKLDHCNIVRLRYFFYSS-----GEKKD-ELYLNLVLE
|  .. || |..|||| ||  .|      ..||.||.          .  |     ||  ....| | |||.|.  ....     . |   |  | .| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTA----VLKLCDFGSAKQLV-------RGEPNVSYICSRYY
|..   . . .             || ||.|| | |.|.||... |||.||||.|.. .      .||. ||| |.             .  . .  . |
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGATDYT--SSIDVWSAGCVLAELLL---GQPIFPGDSGVDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEA
||||| .|...|.   .||.||.||..||...   ..|.|||||  |||  |....|||| ..   . .. |.|                          
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKL-PDY--------------------------

IALCSSLLEYTPSSRLSPLEACAHSFF
  | ...| | |. |.|  .|  | .|
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GSK3A.AA CDC2 119-404 31 1.5e-72 222.1 In-house 1-301 (301) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-301/301
Sequence Identity: 31% (99 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN--------RELQIMRKLD-HCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVAR-H
|. |. || |..||||...  .| ..||.||.  .             ||. .. .|. | |||.|.  ...       ||  .| ||.     .  .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLY--MVFEYLDMDLKKYMDMS

FTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICS-----RYYRAPELIFGATDYTSSIDV
. | | ..| ...| ||||. . ... |.... |||.||||.|.| .....|. ||| |.    | |   |        . |||||. .|. .|. ..|.
IPKNKHMPP-QLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDM

WSAGCVLAEL---LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK--FPQIKAHPWTKVFKS-------SKTPPEAIALCSSLLEYTPSS
|| ||..||.       |.|.|||  |||  | ..||||. .   ..  .....|  ||. |.   .|....       | ..||.| | ...| | |. 
WSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQK

RLSPLEACAHSFF
|.|  || .| .|
RISAKEALQHPYF
Kinase GSK3A.AA CDK7 221-404 37 8.5e-64 168.6 In-house 104-288 (288) Show / Hide 
Range on Protein: 221-404
Range on HMM: 104-288/288
Sequence Identity: 37% (72 aa)

IKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ
|| || .. . | | |   . |||.|| |||....  .||. ||| |..   | ||  |   .  |.|||||| |||  |....|.|| ||..|||.|  
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNEN-GQLKIADFGLARFY--GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFK-FPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
|..|||| .|||. | . ||||| |.  .|   ..| .|| ||     |  ..|  .  . ... | . ..   |. |..  ..  . .|
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIF--TAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase GSK3A.AA CDK5 119-404 35 7.3e-61 190.85 In-house 1-287 (287) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-287/287
Sequence Identity: 35% (106 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR------FKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKA
|  .  ||.| .|.|| ||  ||.|.||.|.|  |           ||  ... | | |||||     |  |||    | || |.. .   .    ..  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHS--EKK----LTLVFEFCDQDLKKYMDSCNG-

KLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCV
..  .|  || .|||| . ||. |.. | ||| ||||||.      ||| ||| |     | |   |   .    ||.|   .|.  |. |||.||.||.
EMDMHI--IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN-KNGELKLADFGLARAF--GIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

LAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQ---IREMNPNYT--EFKFPQIKAHP-WTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHS
.||.   |.| ||| .  |||  | |..|||. ..   | .. |.|     ..|   ||. | .. ..     .   | . .|.. |  |.|  .|  | 
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKL-PDYKPNHQQYPMYPAHQSWQQIVPK--LDEKGMDLLQKMLQCNPNQRISAKAALHHP

FF
.|
YF
Kinase GSK3A.AA CDKL 221-404 36 1.8e-57 195.06 In-house 100-286 (286) Show / Hide 
Range on Protein: 221-404
Range on HMM: 100-286/286
Sequence Identity: 36% (69 aa)

IKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI
.. ||.|. ..... |.. . |||||| |.|. |   ..|||||| |..|   ||    |   | ||||||  | |.| ...|.|..|||.||.. |||.
VRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTP-PEAIALCSSLLEYTPSSRLSPLEACAHSFF
.||.| .|||  |.|.||  .|  ..|  .|| .   |||.|. |. .   . ..   ..|. .  ..|.  |. |..  ..  |..|
WPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE-HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GSK3A.AA MAPK 225-404 34 4.1e-54 185.49 In-house 121-328 (328) Show / Hide 
Range on Protein: 225-404
Range on HMM: 121-328/328
Sequence Identity: 34% (74 aa)

MYQLFRS--LAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNV-------------------SYICSRYYRAPELIFG--ATDYTSSI
|||. |   | |||| .| |||.|| |.||. .  . |.||||    | |.. .                     |.  |.|||||....  ...|| ..
MYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFG----LARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAV

DVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-P----NYTE-FK-FPQIKAHPWTKVFKSSK--TPPEAIALCSSLLEYTPSS
|.||.|| .||.|  ..|.|||.. .||.  |..|||||..| |. .  .    || . .. .|. ...||.|.|. .   . |.|| | . .|.  |. 
DMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDK

RLSPLEACAHSFF
|..  || .| .|
RITVEEALQHPYF
Kinase GSK3A.AA ERK 225-404 34 2.5e-52 180.17 In-house 114-307 (307) Show / Hide 
Range on Protein: 225-404
Range on HMM: 114-307/307
Sequence Identity: 34% (68 aa)

MYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAK-QLVRGEPNV--------SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL
|||. . | ||||..| |||.|| |.||  .  .|| |||| |  . .  ..|.         |. .|.|||||..  ...||...|.||.|| .||.| 
MYQILCGLKYIHSANVIHRDLKPSNILVNSN-CDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLG

GQPIFPGDSGVDQLVEIIKVLGTP-TREQIREM-NPNYTEF--KFPQ--IKAHPWTKVFKSSKTP--PEAIALCSSLLEYTPSSRLSPLEACAHSFF
..|.||| . |.|. .|....||| . |....  ..|. ..  ..|   ... || ..|.  ...  |.|| | ...|.  |. |..  |. .| .|
RKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFP--NANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase GSK3A.AA TyrKc 119-404 23 2.6e-13 -7.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 119-404
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN---RELQIMRKL--DHCNIVRLRYFFYSSGEKKDE---LYLNLVLEYVPETVYRVARHFT
 | .|..|.| ||.||....    . ||.|..  |.  .    ||..||.||  .| |||||     ..|..        | .|.||.|    .   . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKH

KAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRG----EPNVSYI-----CSR-----YYRAPELIFGATD
. |   .      ...|  .  .|.||... |||.   | ||. .  . | .||| .. .  .    |    |      ...        ||| |   . 
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYG

-YTSSIDVWSAGCVLAELL-LGQPIFPG---DSGVDQLVEIIKVLGTPTREQIREM----NPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEY
 .|.  |||| | .. |.. .||.  ||      .    |.|. . .  |  . .                         |     |.|   . ..  ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F--VCCPDEMYQIMKQCWHE

TPSSRLSPLEACAHSFF
 |..| .  |   |..|
DPEDRPTFSEI--HECF
Kinase GSK3A.AA CDK7 119-150 50 1.3e-12 29.46 In-house 1-32 (288) Show / Hide 
Range on Protein: 119-150
Range on HMM: 1-32/288
Sequence Identity: 50% (16 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKV
|. || || | |..|| |.  .| . |||||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase GSK3A.AA Pkinase_Tyr 119-199 31 3.6e-12 41.83 Pfam 1-90 (270) Show / Hide 
Range on Protein: 119-199
Range on HMM: 1-90/270
Sequence Identity: 31% (29 aa)

YTDIKVIGNGSFGVVYQARLA----ETRELVAIKKVLQDKRFKN-------RELQIMRKL-DHCNIVRLRYFFYSSGEKKDELYLNLVLEYVP
 | .|..| |.||.||....     .|.  ||.|.. ..   ..       ||..||..| .| |||||    .. || .   .. .|.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMP
Kinase GSK3A.AA MAPK 119-176 32 1.4e-10 32.53 In-house 1-71 (328) Show / Hide 
Range on Protein: 119-176
Range on HMM: 1-71/328
Sequence Identity: 32% (23 aa)

YTDIKVIGNGSFGVVYQARLAETREL------VAIKKV---LQDKRFKN---RELQIMRKL-DHCNIVRLR
|...| || |..|||  |.  .|..       |||||.    |.. .     ||. ..| . .| ||..|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLL
Kinase GSK3A.AA ERK 119-176 34 1.1e-08 28.66 In-house 1-70 (307) Show / Hide 
Range on Protein: 119-176
Range on HMM: 1-70/307
Sequence Identity: 34% (24 aa)

YTDIKVIGNGSFGVVYQARLAE-----TRELVAIKKV---LQDKRFKN---RELQIMRKLD-HCNIVRLR
| .|| || |..|||  |.  |     |.. |||||.     .... .   ||. ..| .. | ||. |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF
Kinase GSK3A.AA CDKL 119-202 37 5.3e-08 23.44 In-house 1-84 (286) Show / Hide 
Range on Protein: 119-202
Range on HMM: 1-84/286
Sequence Identity: 37% (34 aa)

YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQ---DKRFK---NRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETV
|  . ..| || |||.  |  || ..||||| .    |.  |    ||. . . | | ||| |.  |     .| .|.  || ||.  ||
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVF----RRKRKLH--LVFEYCDHTV