Gene Haspin (Mouse)

Haspin

Species: Mouse
Alias: Gsg2, Haspin
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: Haspin

Sequence

Name Sequence Type Origin Length Description Download
Haspin.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 314 Kinase domain by global Sugen HMM Fasta, JSON
Haspin.AA Protein Sugen 754 None Fasta, JSON
Haspin.NA RNA Sugen 2811 None Fasta, JSON

Protein domain

Protein domains of Haspin.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Haspin.AA Haspin 442-698 40 2.5e-125 422.65 In-house 1-264 (264) Show / Hide 
Range on Protein: 442-698
Range on HMM: 1-264/264
Sequence Identity: 40% (106 aa)

RCEKIGEGVFGEVFQIINDQAPVALKIIAIEGLDL-----VNGSHQKTFEEILPEIIISKELSLLSS-EAYNRTEGFIGLNSVHCVQGLYPPLLLKAWDH
.|.|||||..||||...... .|..||| |.. .      ..|.||.|..|.|.|||| |... ||  .. .....|.|...|..|.| ....|.|.|||
NCKKIGEGCYGEVFSVTWNGKEVVMKIIPIHWSCCKYYGEYCGEHQQTNDEALNEIIIMKKMGKLSHRNMCPNFPNFCGMCVVTQVPGKCCKKLNKMWDH

YNTTKRSANDRPDFFQEDQLFIILEFEFGGVDLERMKTKLSSVATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLK-KTNLKELRYTLNGKTSTIPT
|..|..|.|||||||...||.|....|.|| .|. ...|...  . .||..|.. |...|.....|.|.||||||||.| ||..|.| ||..||| .|..
YCYTHHSENDRPDFFKKNQLHIHWIMEYGGRPLDNFRWKFNTCNQCISIMCQLVMSMYIAKDEMQFWHNDLHWGNVLIKRKTKKKWLHYTMDGKTIKIKS

HGLQVNIIDYTLSRLERDGIVVFCDISAEEDLFTGEGDYQFEIYRLMRKENKNCWGEYHPYNNV
||..|.|||...||...|......|..  |..|.. .||||..|| |||.....|...|..|..
HGVMVTIIDFCKSRCGKDNKKIYWDWKNDETMFEQFWDYQFDVYRDMRKNCQHFWFVHHAKNWK
Kinase Haspin.AA DUF3635 664-754 42 1.2e-55 193.45 Pfam 1-121 (121) Show / Hide 
Range on Protein: 664-754
Range on HMM: 1-121/121
Sequence Identity: 42% (52 aa)

EDLFTGEG---------DYQFEIYRLMRKENKN--CWGEYHPYNNVLWLHYLTDKILNKMKFKTKC--QSAAMKQIRKNL-----------QHFHRTVLS
.|.|.|.|         ||||.|||.|||..||  ||...||..||||||||..|.|.|||||..|  ..|||....|..           .|||....|
HDFFQGKGKSKINEYQYDYQFDIYRMMRKMLKNPICWSQFHPMTNVLWLHYLIHKLLHKMKFKSICTENTAAMRMYMKKIINHHLMDPARHKHFHQIFMS

FSSATDLLCQHSLF------R
|.||....|||.||      .
FESASIRHCQHYLFNWVRQMK
Kinase Haspin.AA Ciliate-A9 440-470 37 6.9e-07 11.5 In-house 1-35 (392) Show / Hide 
Range on Protein: 440-470
Range on HMM: 1-35/392
Sequence Identity: 37% (13 aa)

LERCEKIGEGVFGEVFQIINDQ----APVALKIIA
.|  ..|||| || |.| .  |      .| |.|.
FEPIKIIGEGAFGCVIQCRDIQQEDKQEYAVKVIQ
Kinase Haspin.AA CMGC 440-469 26 7.3e-07 17.6 In-house 1-46 (513) Show / Hide 
Range on Protein: 440-469
Range on HMM: 1-46/513
Sequence Identity: 26% (12 aa)

LERCEKIGEGVFGEVFQIIN----------------DQAPVALKII
 |  .||||| .|.|.. ..                ..  ||.|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKI
Kinase Haspin.AA Src 440-469 38 8.6e-07 19.06 In-house 1-31 (255) Show / Hide 
Range on Protein: 440-469
Range on HMM: 1-31/255
Sequence Identity: 38% (12 aa)

LERCEKIGEGVFGEVFQ-IINDQAPVALKII
. .|.|.|.| ||||.. . |.. .|| | .
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTL
Kinase Haspin.AA STE 440-499 22 3e-06 18.13 In-house 1-86 (359) Show / Hide 
Range on Protein: 440-499
Range on HMM: 1-86/359
Sequence Identity: 22% (19 aa)

LERCEKIGEGVFGEVFQIINDQAP-----------------VALKIIAIEGLDL---------VNGSHQKTFEEILPEIIISKELS
.|. ||||.| ||.|.. .|   .                 .| |.. .|  .          .. .... ...|| || | |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCN
Kinase Haspin.AA S_TKc 440-753 14 2.2e-05 -98.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 440-753
Range on HMM: 1-231/231
Sequence Identity: 14% (51 aa)

LERCEKIGEGVFGEVFQIINDQ--APVALKIIAIEGLDLVNGSHQKTFEEILPEIIISKELSLLSSEAYNRTEGFIGLNSVHCVQGLYPPLLLKAWDHYN
 |  .|||.| ||.|.. ..      ||.|||                                      | |  |  .          | . |  |.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------------------EHIRREIQILKK--------HHPNIVKLYDVFQ

TTKRSANDRPDFFQEDQLFIILEFEFG--GVDLERMKTKLS-------SVATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTNLKELRYTLNGK
.              | |....|.  |  |  ....| . .       .  .|.....||   |.      .. ||||   |.|| .             
D--------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-------------

TSTIPTHGLQVNIIDYTLSRLERDGIVVFCDISAEEDLFTGEGDYQF---------EIYRLMRKENKNCWGEYHP----------------YNNVLWLHY
         .. |.|  |.|.                       . |         |.              | .                .   ..   
---------HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL------------GYGKCKCDWWSCGCILYEMLCGYPPFP--

LTDKILNKMKFKTKCQSAAMKQIRKNLQHFHRTVLSFS-----SATDLLC------QHSLF
  .....|..              . . .| |  | .      .| ..|       .|  |
QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Haspin.AA YSK 441-472 47 2.7e-05 11.53 In-house 2-35 (257) Show / Hide 
Range on Protein: 441-472
Range on HMM: 2-35/257
Sequence Identity: 47% (16 aa)

ERCEKIGEGVFGEVFQIIND--QAPVALKIIAIE
 . |.|| | ||||.  |.   |  || |||  |
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLE
Kinase Haspin.AA SRM 443-469 50 3e-05 13.34 In-house 4-31 (253) Show / Hide 
Range on Protein: 443-469
Range on HMM: 4-31/253
Sequence Identity: 50% (14 aa)

CEKIGEGVFGEVFQII-NDQAPVALKII
| | ||| ||||.     .| .|| |.|
CRKLGEGYFGEVWEGLWKGQVHVAIKVI
Kinase Haspin.AA CAMK 445-494 20 3.4e-05 11.91 In-house 1-84 (425) Show / Hide 
Range on Protein: 445-494
Range on HMM: 1-84/425
Sequence Identity: 20% (17 aa)

KIGEGVFGEVFQIINDQAP--------------VALKIIAIEG--------------LDLVNGSH------QKTFEEILPEIII
..|.| ||.|.  |. . .              || |||  .               .|  ...|      .|. .... || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEI
Kinase Haspin.AA CLK 440-470 38 4.1e-05 10.48 In-house 1-34 (350) Show / Hide 
Range on Protein: 440-470
Range on HMM: 1-34/350
Sequence Identity: 38% (13 aa)

LERCEKIGEGVFGEVFQIINDQA-P--VALKIIA
.|   . |||.|| |.. .  .  .  ||||||.
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIR
Kinase Haspin.AA MOS 440-469 36 5.1e-05 12.34 In-house 1-30 (299) Show / Hide 
Range on Protein: 440-469
Range on HMM: 1-30/299
Sequence Identity: 36% (11 aa)

LERCEKIGEGVFGEVFQIINDQAPVALKII
  .|. || | ||.|.  .    ||| |..
VCLCQMIGRGGFGSVWKAQYCGRPVAVKQV
Kinase Haspin.AA Pkinase 440-475 31 0.000268 16.28 Pfam 1-38 (293) Show / Hide 
Range on Protein: 440-475
Range on HMM: 1-38/293
Sequence Identity: 31% (12 aa)

LERCEKIGEGVFGEVFQIINDQAP--VALKIIAIEGLD
... .|||.| ||.|.. ..   .  ||.|||  .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEK