Gene MAP3K4 (Mouse)

MAP3K4

Species: Mouse
Alias: Map3k4, MAP3K4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK4

Sequence

Name Sequence Type Origin Length Description Download
MAP3K4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
MAP3K4.NA RNA Sugen 5405 None Fasta, JSON
MAP3K4.AA Protein Sugen 1601 None Fasta, JSON

Protein domain

Protein domains of MAP3K4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP3K4.AA MEKK4 1336-1594 70 7e-229 766.66 In-house 1-271 (271) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-271/271
Sequence Identity: 70% (192 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVI
||||..|||||.||||||...||.|.|||||.|||.||||.||..|||.||||||||||||||.|||.||||||||||||..||||.|..||  .|||.|
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIADEIKIFEGIKHPNLVRYYGVEVHREEMYIFMEYCSQGTLERVCHLGGNMQEHMI

RLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE-------GHGRAADIWSLGC
|.||||...|.|.||.|||||||||.|||||......|||||||||||.|..||||||..||.||||||||||.|.....       |||||||||||||
RQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGEFQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRAADIWSLGC

VVIEMVTGKRPWH---EYEHNFQIMYKVGMGHKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFV
||.||.|||||||   .|.|||||||||||||.|.||...|||||.|..||||.|||.||||..||||.|.
VVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MAP3K4.AA STE11 1336-1594 46 2.1e-161 542.49 In-house 1-303 (303) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-303/303
Sequence Identity: 46% (141 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND------------HKTIKETADELKIFEGIKHPNLVRYFGVELH---REEMYIFMEYCDEGTL
||.|..||.|..|.||.|. ||||||||.|.|..|.|.            ||..|. ..|.|......|.|.|||.|..||   .....|||||| .|.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

EEVSRLG-----LQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGL-IKLGDFGCSVKLKNNAQT-------------MPGEVN-STLGTAA
... |..     ..|.||| |||||  ... ||.|||.|||||||||.| | |  .||.||||...|......             |.|... |..||..
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH-NFQIMYKVGMGHK--PPIPERLS------PEGKAFLSHCLESDPKIRWTASQLLDH
.||||||.. ...|.||.||||||||.||||.|||.|||.|.| ....|.|.|||||  |||||..|      .|...||.||.| ||| |.||.|||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

AFV
 |.
PFI
Kinase MAP3K4.AA STE 1336-1594 29 2.9e-103 349.35 In-house 1-359 (359) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-359/359
Sequence Identity: 29% (109 aa)

WQRGNKIGEGQYGKVYTCISVD---------------TGELMAMKEIRFQPND---------------HKTIKETADELKIFEGIK--HPNLVRYFGVEL
|..  |||.| .|.||... ..               |||.||.|........               |. ...   |.||    .  ||| |.|.| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

H-------REEMYIFMEYCDEGTLEEVSR------LGLQ----------EHVIRLYTKQITVA-INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSV
.       ..| .|.|||.| |.|... .       .|.          |..|. ...||  .  . ||.|.|.|||||.|||.|     .|| |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLKNNAQ------------TMPGEVNSTLGTAAYMAPEVITRAK---GEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN---FQIM--YKVGM------
.| ..              || .. |.  ||  .||||||.. .     |... .|||||||..|||.||| |||.. .    |.|.  |....      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GHKPPIPE-------------------RLSPEGKAFLSHCLESDPKIRWTASQLLD--HAFV
   |. ||.|.                   ..||| | |...||. ||. |.||||||   | |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K4.AA STE11-Unclassified 1336-1594 36 3.6e-94 319.17 In-house 1-308 (308) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-308/308
Sequence Identity: 36% (113 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND--HKTIKET-----ADELKIFEGIKHPNLVRYFGVE--LHREEMYIFMEYCDEGTLEEVSRL
|| |. ||.| .|.||.|. ..|||.|| |.|. . ..   ......     ..|.|. .   |.| |.| |.|   |.   .|||||. .| . .  . 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

G--LQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLK------------------NNAQTMP---GEVNSTLGTAA---
.  . | ||. |||||   .  ||.|||.||||||||| . . | .|| ||||. . .                  .. |.     .  .|  ||     
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

YMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH--NFQIMYKVG-MGHKPPIPERLS-----------PEGKAFLSHCLESDPKIRWTAS
.||||||..   .||.|..|||||||.|||| |||.||  ..     ....|..  .. |.|||.||           .|.|.||..|.. ||| |.||.
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

QLLDHAFV
||| | | 
QLLQHPFI
Kinase MAP3K4.AA S_TKc 1336-1594 31 8.6e-94 318.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDE--GTLEEVSRLG------
.. ..|||.| .|||| |. ..||...|.|.|.         . .  |..| .  .|||.|....|  . ...|..|||||   |.| .. .        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR-AADIWSL
  . | ..| |..||  |.. .|.|||.|||.| .||.|..   ||..||| . .|           ..  ||  ||||||.      |.|. ..|.||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL------GYGKCKCDWWSC

GCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLD-------HAFV
||...||..|. |..    . | |.|. .          |||.| |...||. ||. |.|| ..|        | ..
GCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K4.AA Pkinase 1336-1594 28 1e-73 256.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD--ELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEG----TLE----EVSR
...| |||.| .|.|| |. ..||.. |.|.|. . ....  .. .   |..|   ..||| ||....   . ..|. ||||. |     |       ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

LGL--QEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLI----KLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA
 ..  .|.... | .||  ... .|..||.|||.| .||.. . | |    |..|||.. ...    . ... ..  ||  |||||||   .|...|...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNSMTTFCGTPWYMAPEVIR--GGQYYGPKV

DIWSLGCVVIEMVTGKRPWHEY------EHNFQIMYKVGMGHKPPIPERLS-------------------PEGKAFLSHCLESDPKIRWTASQLLDHAFV
|.||.||...||..|. |. .       .... |  . |   . ..|.  |                   .|.| |.. ||. ||| |.|| |.| | ..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K4.AA STE20 1336-1594 34 9.4e-70 238.04 In-house 1-288 (288) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-288/288
Sequence Identity: 34% (101 aa)

WQRGNKIGEGQYGKVYTCISVDTGEL----MAMKEIRFQPNDH--KTIKETADELKIFEGIKHPNLVRYFGVELHR----EEMYIFMEYCDEGTLEEVSR
..   |||.| |||||... ..|||.     | | .   . |   . ...   |  |    |||| |.|.|  |      .| .| ||||. |.| .. .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

----LG-------LQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN--NAQTMPGEVNSTLGTAAYMAPEVITRAKG
    .|       ..|  |   ....  . . ||...|.|||||..|| ||..| .|| ||| . .| .    .|| .. |.  ||  .|||||| . .|
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-DTMQFKRNTFVGTPYWMAPEVIQCMEG

--EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI------PERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFV
   |..  .||||||   |||..|. | ... | .. |...  . .||       |.. ||| . |...||. ||. |.|||||| | |.
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K4.AA MEKK2 1336-1594 40 2.2e-68 233.47 In-house 1-262 (262) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-262/262
Sequence Identity: 40% (108 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETA---DELKIFEGIKHPNLVRYFGVELHRE--EMYIFMEYCDEGTLEEVSRL--GL
|.||  .| | .|.|| |  ||||  .| | ..|.|..  | ||      |...   ..|. .| |.|    ..   . |||||   | . .  ..   |
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

QEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVV
 | | | ||.||   .  ||.| |||||||||||   ||| .|||||| | .|.       | . |  ||  .|.||||    ||| || ||.||.|| |
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITG-MKSVTGTPYWMSPEVIN---GEGYGRKADVWSIGCTV

IEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFV
.||.| | || |||    |        .| .|. .| ... ||  |     . |  |  || | ||
VEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K4.AA ASK 1342-1594 39 6.5e-65 214.79 In-house 2-254 (254) Show / Hide 
Range on Protein: 1342-1594
Range on HMM: 2-254/254
Sequence Identity: 39% (103 aa)

IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV--SRLG-LQ--EHVIRLY
.| | || ||     .|   .|.|||  .  |..  .   .|... . ..| |.|.| |   . . . ||||    | | ..  |. | ..  |. .. |
LGKGTYGIVYAGRDMHTQVRIAIKEIPER--DSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFY

TKQITVAINVLHEHGIVHRDIKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGK
||||   .. |||. |||||||| |. . | ||..|. ||| . .|   |   |   ..  ||  ||||||| . .  |.|..|||||.|| ..|| |||
TKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRL---AGINP-CTETFTGTLQYMAPEVIDQGQ-RGYGKPADIWSFGCTMVEMATGK

RPWHEYEHNFQIMYKVGM-GHKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFV
 |.|| ..    |.||||  . |.||| || | |.|. .| | ||. | .|..||   |.
PPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K4.AA CAMK 1341-1594 19 7.5e-63 201.07 In-house 1-425 (425) Show / Hide 
Range on Protein: 1341-1594
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

KIGEGQYGKVYTCISVDTG------------ELMAMKE-------------------IRFQPNDH-------KTIKETADELKIFEG-------IKHPNL
..|.|..|||. ||   |.            .  |.|                    |... ..|       |. |.   |..|          ..|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYFGVELH-------------------REEMYIFM---EYCDEGTL--EEVSRL-------------------GLQEHVIRLYTKQITVAINVLHEHGI
.. . |                      ...||..|   |||. | |  .  ...                    ..|.  | | .||  |.. .|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKGANIFLTSS-----------------GLIKLGDFGCSVKL-----------KNNAQTMPGE----------VNSTLGTAAYMA-PEVITRAK--
||||.|  || |...                 . ||. ||| . |.           ..... |  .           .   || .||| |||. . .  
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------GEGHGRAADIWSLGCVVIEMVTGKRPWH-EYEH----------NFQIMY-KVGMGHKPPIPERLSP-----------------------EG
          ...|...|.||.|..   |..|. |.  ...           | . .. |.  |    .|. .||                       | 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KAFLSHCLESDPKIRWTASQLLDHAFV
| .....|. ||. |.|..| |.| ..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K4.AA MEKK15 1336-1594 39 1.4e-62 214.19 In-house 1-264 (264) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-264/264
Sequence Identity: 39% (105 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKET----ADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE-VSRLG-LQ
|..|| .| | || || |   .|| |.|.| .  .  | .  |.      .| ..   .|| |.| | || |.   . |||..   | .   . | | |.
WKKGNILGKGAYGTVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLD

EHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNN--AQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCV
| |   |||||   .  |||  .|||||||.|. | . |.||| ||||  .|      .|    . |  ||  .||||||  .   |.|| .||||.|| 
EMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMET---GYGRKSDIWSIGCT

VIEMVTGKRPWHEYEHNFQIMYKVGMG--HKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFV
| || |.| || . .     |. .| .    |..|.. | . . |   ||  | . | |||||| |.|.
VFEMATRKPPWADMDR-MAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K4.AA Ciliate-E2 1336-1594 22 8.5e-57 193.49 In-house 1-365 (365) Show / Hide 
Range on Protein: 1336-1594
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQP-------------------NDHKTIKETADELKIF----------------EGIKHPNLVRYFG
    .|||.|..|.|| |    .... |.| |. |                    . .. |...  |..|.                | ..|||..... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VEL--HREEMYIFMEYCDEGTLEEVSR-------------LGLQEHVIRLYTKQITV---------------AINVLHEHG-IVHRDIKGANIFLTSSGL
.     .. .|. ||||. |.|..  .             . . |  |. ..|||.                |.. ||. . |.|||||  ||..     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKLGDFGCSVKLKNN---------AQTMPGEV-------------------NSTLGTAAYMAPEVITRAK------GEGHGRAADIWSLGCVVIEMVTGK
||. ||| | |....         .. ..                      |...||. |||||.. . |      ..|.. ..||||||..  ||..||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

RPWHEYEHNFQIMYKVGMGHKPPI---------------PERLSPEGKAFLSH----CLESDPKIRWT-ASQLLDHAFV
.|.       |.  | .    |.                .. .|.|.| ...     .|. ||. | | ..|.|.| . 
PPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MAP3K4.AA TyrKc 1336-1592 23 2.8e-16 40.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 1336-1592
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI--KHPNLVRYFGVELHR-------EEMYIFMEYCDEGTLEE---V
 . | |.|||..|.|| ..     .  | | ..        ...  .|..|   .  .|||.|| .|| ..        | ..| |||.. | | .    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNN-------AQTMPGE-VNST-LGTAAYMAPEVITRAKGEG
.|  |.      .  ||    . ||.....|||.   |. ... . .| .||| | ....           .. |  ..  .     ||||.|   |   
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK---

HGRAADIWSLGCVVIEMVT-GKRPWHEY----EHNFQIMYKVGMGHKPPIPER--------LSPEGKAFLSHCLESDPKIRWTASQLLDHA
   . |.|| | .  |. | |. |. .       |.... .|  |. .|.|.          ..|     . | . ||. | | |.. .  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MAP3K4.AA Pkinase_Tyr 1336-1420 31 7.1e-08 27.29 Pfam 1-94 (270) Show / Hide 
Range on Protein: 1336-1420
Range on HMM: 1-94/270
Sequence Identity: 31% (30 aa)

WQRGNKIGEGQYGKVYTCISV----DTGELMAMKEIRFQPNDHKT--IKETADELKIFEGI-KHPNLVRYFGVEL-HREE--MYIFMEYCDEGTL
 . | |.|||..|.|| ..      .|.   | | .. .  .|.   ...   |.||   . .|||.||. || . ..|   .|| |||.  | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase MAP3K4.AA Pkinase_Tyr 1447-1476 33 0.000129 16.26 Pfam 127-156 (270) Show / Hide 
Range on Protein: 1447-1476
Range on HMM: 127-156/270
Sequence Identity: 33% (10 aa)

LHEHGIVHRDIKGANIFLTSSGLIKLGDFG
|......|||.   |. .|... .| .|||
LESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MAP3K4.AA Pkinase_Tyr 1502-1561 30 0.002076 12.17 Pfam 181-239 (270) Show / Hide 
Range on Protein: 1502-1561
Range on HMM: 181-239/270
Sequence Identity: 30% (19 aa)

MAPEVITRAKGEGHGRAADIWSLGCVVIEMVT-GKRP-WHEYEHNFQIMYKV-GMGHKPPIPE
||||.|   |      . |.|| | .  |..| |. | . .   |.... ..   |.  |.||
MAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPE