Gene PCTAIRE1 (Mouse)

PCTAIRE1

Species: Mouse
Alias: Pctk1, PCTAIRE1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PCTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PCTAIRE1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 282 Kinase domain by global Sugen HMM Fasta, JSON
PCTAIRE1.AA Protein Sugen 578 None Fasta, JSON
PCTAIRE1.NA RNA Sugen 2968 None Fasta, JSON

Protein domain

Protein domains of PCTAIRE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PCTAIRE1.AA PCTAIRE 247-528 82 4.5e-246 823.77 In-house 1-291 (291) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-291/291
Sequence Identity: 82% (239 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNVK
|||||||||||||||||..|||||||||||||||||||||||||||||||||||||||||||||||||...|||||||.|.|||||.|||||..||||||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG
|||||||||||||||.|.||||||||||||||||||||||||||||||.||||||.|||||||||||.|.|||||||||||||||||||||.||||||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

ST------VEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPRLD---SDGADLLTKLLQFEGRNRISAEDARKHPFF
||      |..|||.||||||||.|.||||. |||||||||.|.||...|..||||||   ....||||.|||.|..||.|||.|.|||.|
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PCTAIRE1.AA PFTAIRE 247-528 61 2.8e-195 655.05 In-house 1-287 (287) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-287/287
Sequence Identity: 61% (176 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNVK
| ||.|||||.|||||||.|...  .||||||||. |||.|.|||||.||||.|||||||.|||||||.. ||.||||...||.||.| . . ....||.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG
||||||||||.|||...||||||||||||| . |||||||||||||||.|..|||.|||||||||||.|||||.|||..||||||||| || .|.|.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

S-TVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYP--KYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDARKHPFF
  .. .||  ||..||||||.||||. .  ... .  .   |. . |    ||..   .. ||..|.|| |.|.|.||..| .||.|
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PCTAIRE1.AA CDK5 247-528 59 3.4e-180 574.56 In-house 1-287 (287) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-287/287
Sequence Identity: 59% (172 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNV
| |..|.|||||.||||.. | |  .||||..||. | || |.|||||..||| ||| ||| |||.||.|| ||||||..|.||| |.|.|.  ..|| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMA-TGRPLF
| |..|||.|||.|| ..|||||||||||||| .|||||||||||||  || ..|| |||||||||||.|.||  ||| |||| .|||| ||| .|||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFR--TYNYPKYRAEA-LLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKHPFF
||. ||.||  ||.|.|||.|..||.|    ...    .||.| |.  . .. |.||. | ||| |.||..   ||||..| .||.|
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PCTAIRE1.AA CDK 247-528 47 8.70000000001e-179 576.8 In-house 1-284 (284) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-284/284
Sequence Identity: 47% (153 aa)

YIKLDKLGEGTYATVYKGKSKLTD-----NLVALKEIRLEH-----E-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTE-----------KSLTLVFEY
| ||.|.|||||..|||...|.|.     ..||||.||.|.     | || |.|||||.||||.| |.|||.|||..||.           ..|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE-----LKLADFGLARAKSI------PTKTYSNEVVTLWYRPPD
.| |||.|.|          .| ...||||||.|||.....||||||||.|||..||     ||.||||||||..|      |..||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ILLGSTDYS--TQIDMWGVGCIFYEMAT---GRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKL
.||||..||  |.||||.|||||.||.|   ..|||||..  .||. ||||.|||||..|||. .  ..                         ||| |.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LQFEGRNRISAEDARKHPFF
|...  .|||||.| .||.|
LCYDPKKRISAEQALQHPYF
Kinase PCTAIRE1.AA CDC2 247-528 49 1.1e-156 485.45 In-house 1-301 (301) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-301/301
Sequence Identity: 49% (149 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA---PCTAIREVSLLKDLK-HANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLD-DCG--NV
| |. |.|||||  |||.| . |. .|||| ||||.|.     | ||||| |.||.|| | |||.|||.||  ..| .|||||| |||.|.|   .   .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

INMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYS--NEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEM
.  ..|| ...|.|.|...||.....||||||||.||.. |..|.|||||||| .|| .||    ||||||||.| ||||. .||| .||| .||||.||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPR---------LDSDGADLLTKLLQFEGRNRISAEDARKH
   .| .|||.|    .||  ||||||||.|.||||. .. .. .  .|....  | .. |.         || .| ||| ..|| .  .||||..| .|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PFF
|.|
PYF
Kinase PCTAIRE1.AA CMGC 247-528 26 5.70000000001e-140 463.11 In-house 1-513 (513) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-513/513
Sequence Identity: 26% (138 aa)

YIKLDKLGEGTYATVYKGKSKLTD--------------NLVALKEIRLE----------HEEGAPCTAIREVSLLKDLK-----------------HANI
| ...|.|||||..|||.. |.|.              ..||.| |...          ...| |..|.||...|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLHDIIHTEK-----------------SLTLVFEYLDKDLKQYLDDCG------NVINM-------------HNVKLFL------FQLLRGLA--YCHR
|.|.||.....                 .| |||||.|.||.||....       . ...             ||.| |.      .|.||||.  |||.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

QK--VLHRDLKPQNLLINERGEL--------------------KLADFGLARAKSIP---------------------TKTYSNEVVTLWYRPPDILLGS
..  ..||||||.|.|||...||                    |..||||||. ...                     ...|...|||.|||.| ||||.
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

TDYS---------TQIDMWGVGCIFYEMATG--------RPLFPGSTV-----------EEQLHFIFRILGTPT---------------EETWPGILS--
..|.         |.||||.|||||.|| ||        .|||||..             .||. ||..|||||               ||.||....  
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLP

------------------NEEFRTYN-----YPKYRAEALLSHAPR-----------------------------------LDSDGADLLTKLLQFEGRN
                  .|  |.|      .|...   . .  |.                                   .|... ||| |.||..  .
WYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RISAEDARKHPFF
||.||.| .||.|
RITAEQALQHPYF
Kinase PCTAIRE1.AA CDK7 247-528 39 4.8e-115 307.88 In-house 1-288 (288) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-288/288
Sequence Identity: 39% (115 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIR-----LEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVIN
| |....|||..|||||.  . |.  || |.|.      | . |   |||||. .|. ..| |.. | ||.    .. |||...| ||     |   .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

MHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGR
  ..| .  ..|.|| ||||  .||||||| |||.|| |.||.|||||||.   | . |.  ||| ||| |  | |   | | .||| ||||| |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAE---ALLSHAPRLDSDGA-DLLTKLLQFEGRNRISAEDARKHPFF
| .||     ||  ||..|||||||.||..    .. .|.  |   .     | |     || . ||. ... ..  .|... .. |.|.|
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMC---CMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PCTAIRE1.AA S_TKc 247-528 28 5.4e-100 339.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDK---DLKQYLDDCGNV----
| .|.|.|.|....|||.. | |. .||.|.|.        ....||...||  .| |||.|.|.... ..| .|.||.|    ||..|....|      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-INMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYST-QIDMWGVGCIFYEM
 ..   .. .. |....|.|||.....||||||.|.|..|  ..|..||||||         .  ..|.||..| .|     |..  .|.| .|||.|||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARK-------HPFF
..|.|.||      |.. .|...|                                    .... |.. |.||.. ..|..| .| .       ||.|
LCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PCTAIRE1.AA PITSLRE 247-528 41 1.1e-99 337.52 In-house 1-295 (295) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-295/295
Sequence Identity: 41% (121 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE---HEEGAPCTAIREVS-LLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCG---
. .|.. .||||  ||..| |.||  |||| . .|     || | |..||.. .|. |.| |||..  |.   .  .  .|.||.. |||  ..      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

NVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEM
       .| .. ||||| .. |  ...|||||  |||..  | ||..||||||    | | |.  ||||||| | .|||.  ||| .||| ||||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYN-YPKYRAEALLSHAP---RLDSDGADLLTKLLQFEGRNRISAEDARKHPFF
 |..|||.|.   .|.. ||  .|||||  |||. .   ..  |  |.|    | .. |   ..   | ||| ..| .   |||.|.|| |||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PCTAIRE1.AA Pkinase 247-528 31 2e-95 328.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEG-APCTAIR--EVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC-------
| .. |.|.|....|||.. | |  .||.|.|...||.   . |..|  |....| |.| |||.|.|. ...... .|.||....|.  .| .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GNVI--NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL----KLADFGLARAK-SIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWG
....   .. .| .. |.||||.|||.....||||||.|.||...|..    |..|||||. .   .   ..  ..|.||..| ...|...|.. .|||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGCIFYEMATGRPLFPGS----TVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKH
.|||.|||..|||.|||.    .  .|.. |.||.|.|... ||   |.  |   .. . . . .    ....... |.....|..    |..||.. .|
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFF
|.|
PWF
Kinase PCTAIRE1.AA CRK7 247-469 37 1.3e-91 310.61 In-house 1-278 (343) Show / Hide 
Range on Protein: 247-469
Range on HMM: 1-278/343
Sequence Identity: 37% (106 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE----EGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK-----------SLTLVFEYLDKDLKQ
| ...  |||||  ||| | | |  .|||| .|...|    || | |||||. .|. |.|.|||.|..|. |.|           |  .|||| | ||  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIV-TDKQDASEFKKHKGSFYMVFEYMDHDLMG

YLDDCGNV-INMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPT--KTYSNEVVTLWYRPPDILLGSTDY-------
 |.    . ..  ..| |. ||| |..|||....||||.|  |.|.| .||.|.|||||||        . | | |.|||||||  ||| . |       
LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK

-------------------------------STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP
                                ..||||..|||. | .|..|.|.|.   .||  |..| |.|. . ||
ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWP
Kinase PCTAIRE1.AA CDK4 247-528 41 2.1e-87 296.66 In-house 1-290 (290) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-290/290
Sequence Identity: 41% (123 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEE--GAPCTAIREVSLLKDLK---HANIVTLHDIIHT------EKSLTLVFEYLDKDLKQYLD
| ..  .||| | |||.  .  | . |||| .|    ||  | |   |||.|... |.   |.||| | |. |.      |  .|.|||  | ||..|||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

DCGN-VINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCI
 |    .    .|   .|||||. . |   . ||||||||.|..  |..|||||||||  |  ..  .  ||||||| | .|| |. | | .||| ||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLLQSY-YNTPVDMWSVGCI

FYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP--GILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKHPFF
| ||   ||||.|.   .||| || . |.|.|. ||    |  . |     | ...  ...  | ..  |.||| | | ..   |.||. . .||.|
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHF-----PQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PCTAIRE1.AA Pkinase_Tyr 247-392 31 1.4e-19 66.98 Pfam 1-160 (270) Show / Hide 
Range on Protein: 247-392
Range on HMM: 1-160/270
Sequence Identity: 31% (51 aa)

YIKLDKLGEGTYATVYKGKSK----LTDNLVALKEIRLEHEEGAPCTA------IREVSLLKDL-KHANIVTLHDIIH-TEKS--LTLVFEYLDK-DLKQ
 ... ||||| . .||||. |     |.  || | ..    |||   .      .||....| | .| ||| |. ..   ...  . .|.||  . ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLDDC---GNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA
|| .    .. ..|.    . .|  .|..| ....  ||||   | |..| .  | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PCTAIRE1.AA TyrKc 247-528 20 2.1e-13 -5.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 247-528
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI-REVSLLKDL--KHANIVTLHDIIHTE-------KSLTLVFEYLDK-DLKQYLDD
  ...||||| . .||||. |     || | .. ..       .. || .... |  .| ||| |. .. ..       . | .|.|| .. |||.|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIP------TKTYS-----NEV--VTLWYRPPDILLGSTD-Y
... ..|     | .|  .| .| |.... ||||   | |..|..  | .||||.|.          ...|.     ..   . .   .|  .   .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

STQIDMWGVGCIFYEMAT-GRPLFPG-----STVEEQLHFIFRILGTPTEET----WPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQF
.|. | |  |   .|. | | .  ||      . .| .... .    |  .                             .  ..  ..  .. ..  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F--VCCPDEMYQIMKQCWHE

EGRNRISAEDARKHPFF
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DPEDRPTFSEI--HECF
Kinase PCTAIRE1.AA CRK7 503-528 38 7.1e-05 12.53 In-house 318-343 (343) Show / Hide 
Range on Protein: 503-528
Range on HMM: 318-343/343
Sequence Identity: 38% (10 aa)

DLLTKLLQFEGRNRISAEDARKHPFF
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DLLDKMLCLDPKKRFTAEECLQHDWF