Gene PCTAIRE2 (Mouse)

PCTAIRE2

Species: Mouse
Alias: Pctk2, PCTAIRE2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PCTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PCTAIRE2.AA Protein Sugen 523 None Fasta, JSON
PCTAIRE2.NA RNA Sugen 1810 None Fasta, JSON
PCTAIRE2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 282 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of PCTAIRE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PCTAIRE2.AA PCTAIRE 192-473 81 1.7e-247 828.5 In-house 1-291 (291) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-291/291
Sequence Identity: 81% (236 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVK
||||.||||||||||||.|||||.|||||||||||||||||||||||||||||||||||||||||.||...|||||||.|.|||||||||||||.|||||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG
|||.|.|||||||||||.|||||||||||||||||||||||||||||||||||||.|||||||||||||.||..||||||||||||||.||..|||||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

ST------VEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLD---SEGIELITKFLQYESKKRVPAEEAMKHVYF
||      |.|.||.|||.||||...|||||.||.||..||||.|..|||||||||||   .....|.|..||||||.||.||.||||.||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PCTAIRE2.AA PFTAIRE 192-473 63 1.9e-197 662.25 In-house 1-287 (287) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-287/287
Sequence Identity: 63% (182 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVK
| ||||||||.|||||||.|.... .||||||||. |||.|.|||||.||||.|||||||.||||.||.. ||.||||...||.|||| . . | ..||.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG
|||.| ||||.|||.|.||||||||||||| . |||||||||||||||||..|||.|||||||||||||||| ||||..|||||||||.||  |.|.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

S-TVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFP--KYKPQPLINHAPRLD--SEGIELITKFLQYESKKRVPAEEAMKHVYF
  .. | | .||..||||  .|||||..  ..| . |.   |||..| .  ||..   .. .|..|.||.| ..|| |.|||.| ||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PCTAIRE2.AA CDK5 192-473 57 4.1e-181 577.52 In-house 1-287 (287) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-287/287
Sequence Identity: 57% (166 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNV
| |.||.|||||.||||.| | |. .||||..||. | || |.|||||..||| ||| ||| |||..|..| ||||||..|.||| |||.|.  |.|| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMA-SGRPLF
| |.|| |.|||.|| ..|||||||||||||| .|||||||||||||  .| ..|| |||||||||||||.||  ||| |||| .|||| ||| .|||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFK--NYNFPKYKPQP-LINHAPRLDSEGIELITKFLQYESKKRVPAEEAMKHVYF
||. |||.| .||...|||. ..||...   ..|    ..|.| ... . .. |.||..| .|  | ||.. ..|. |..|..| ||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PCTAIRE2.AA CDK 192-473 46 8.99999999999e-177 570.26 In-house 1-284 (284) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-284/284
Sequence Identity: 46% (150 aa)

YIKLEKLGEGTYATVYKGRSKLTE-----NLVALKEIRLEH-----E-EGAPCTAIREVSLLKDLKHANIVTLHDIVHTD-----------KSLTLVFEY
| ||||.|||||..|||.|.|.|      ..||||.||.|.     | || |.|||||.||||.| |.|||.|||..||.           ..|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGE-----LKLADFGLARAKSV------PTKTYSNEVVTLWYRPPD
.| |||.|||          .| ...|.||||.|||.....||||||||.|||..||     ||.||||||||...      |..||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLGSSEYS--TQIDMWGVGCIFFEMAS---GRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKF
.||||..||  |.||||.||||| ||.    ..|||||..  | |..|||..|||. ..||||..  ..                         .|. |.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LQYESKKRVPAEEAMKHVYF
|.|. |||. ||.|..| ||
LCYDPKKRISAEQALQHPYF
Kinase PCTAIRE2.AA CDC2 192-473 51 2.2e-158 490.75 In-house 1-301 (301) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-301/301
Sequence Identity: 51% (156 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGA---PCTAIREVSLLKDLK-HANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMD-DCG--NI
| |.||.|||||  |||.. . |  .|||| ||||.|.     | ||||| |.||.|| | |||.|||..|  ..| .|||||| |||.|||   .    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYS--NEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEM
|. ..|| ..||||.|...||.|...||||||||.||.. |..|.|||||||| ..| .||    ||||||||.| .|||.. ||| .||| .|||| ||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPR---------LDSEGIELITKFLQYESKKRVPAEEAMKH
   .. .|||.|    |.|  ||| ||||. .|||||... ..||  ||..||| | .. |.         || |||.|. . |||.  ||. |.||..|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

VYF
 ||
PYF
Kinase PCTAIRE2.AA CMGC 192-473 27 3e-141 467.39 In-house 1-513 (513) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

YIKLEKLGEGTYATVYKGRSKLTE--------------NLVALKEIRLE----------HEEGAPCTAIREVSLLKDLK-----------------HANI
| ...|.|||||..|||.| |.|.              ..||.| |...          ...| |..|.||...|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLHDIVHTDK-----------------SLTLVFEYLDKDLKQYMDDCG------NIMSM-------------HNVKLFL------YQILRGLA--YCHR
|.|.||.....                 .| |||||.|.||.||....       . | .             ||.| |.      |||||||.  |||.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

RK--VLHRDLKPQNLLINERGEL--------------------KLADFGLARAKSVP---------------------TKTYSNEVVTLWYRPPDVLLGS
..  ..||||||.|.|||...||                    |..||||||. ...                     ...|...|||.|||.| .|||.
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

SEYS---------TQIDMWGVGCIFFEMASG--------RPLFPGSTV-----------EDELHLIFRLLGTPS---------------QETWPGVSS--
..|.         |.||||.|||||.||  |        .|||||..             | |..||..||||.               .|.||....  
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLP

------------------NDEFKNYN-----FPKYKPQPLINHAPR-----------------------------------LDSEGIELITKFLQYESKK
                  ..  .||      ||...|.|. |  |.                                   .|...|.|. | |||. .|
WYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RVPAEEAMKHVYF
|  ||.|..| ||
RITAEQALQHPYF
Kinase PCTAIRE2.AA CDK7 192-473 38 2.1e-113 303.44 In-house 1-288 (288) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-288/288
Sequence Identity: 38% (112 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIR-----LEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMS
| |....|||..|||||.. . |.  || |.|.      | . |   |||||. .|. ..| |.. | ||     .. |||...| ||     |   |. 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

MHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGR
  ..| .  ..|.|| ||||  .||||||| |||.|| |.||.|||||||.   | . |.  ||| ||| |  | |   | | .||| ||||| |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYN-FPKYKP---QPLINHAPRLDSEGIELITKFLQYESKKRVPAEEAMKHVYF
| .||    | |  ||. ||||. |.||...   ....|. | .. .    || .       . ..|. . .  .  ||. . .. |. ||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMC---CMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PCTAIRE2.AA S_TKc 192-473 29 2.9e-99 337.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDK---DLKQYMDDCGNI----
| .|.|.|.|....|||.| | |  .||.|.|.        ....||...||  .| |||.|.|. .. ..| .|.||.|    ||..|....|      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYST-QIDMWGVGCIFFEM
 ..   .. ..|||...|.|||.....||||||.|.|..|  ..|..||||||         .  ..|.||..| ||     |..  .|.| .|||..||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVPAEEAMK-------HVYF
..|.|.||      .....|...|                                    ..|....| | ||.. .||  | ||..       | .|
LCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PCTAIRE2.AA PITSLRE 192-473 38 3.3e-99 335.88 In-house 1-295 (295) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-295/295
Sequence Identity: 38% (115 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE---HEEGAPCTAIREVS-LLKDLKHANIVTLHDIV--HTDKSLTLVFEYLDKDLKQYMDDCG---
. .| . .||||  ||... |.|.  |||| . .|     || | |..||.. .|. |.| |||..  ||   .  .  .|.||.. |||  |.      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

NIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEM
   .   .| .. | ||| .. |  ...|||||  |||..  | ||..||||||    | | |.  ||||||| | .|||. .||| .||| ||||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYN-FPKYKPQPLINHAP---RLDSEGIELITKFLQYESKKRVPAEEAMKHVYF
 ...|||.|.   |... || ..|||.   |||... . .|. | ||.|..  | .. |   ..   | .|  ..| |  |.|  |..|.|| .|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PCTAIRE2.AA Pkinase 192-473 33 2.3e-95 327.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEG-APCTAIR--EVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC-------
| ...|.|.|....|||.. | |. .||.|.|...||.   . |..|  |....| |.| |||.|.|........ .|.||....|.  || .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GNIM--SMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGEL----KLADFGLARAK-SVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWG
.. .  |.. .| ..|||||||.|||.....||||||.|.||...|..    |..|||||. .   .   ..  ..|.||..| |..|...|.. .|||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGCIFFEMASGRPLFPGS----TVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVPAEEAMKH
.|||..||..|||.|||.    .  |....|.| .|.|  . ||  .|.  |.  .. . . . .    .....|....|.. |..  |||  ||....|
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

VYF
 .|
PWF
Kinase PCTAIRE2.AA CRK7 192-416 37 1.1e-89 304.31 In-house 1-280 (343) Show / Hide 
Range on Protein: 192-416
Range on HMM: 1-280/343
Sequence Identity: 37% (104 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE----EGAPCTAIREVSLLKDLKHANIVTLHDIVHTDK-----------SLTLVFEYLDKDLKQ
| ...  |||||  ||| . | |. .|||| .|...|    || | |||||. .|. |.|.|||.|..|| |||           |  .|||| | ||  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIV-TDKQDASEFKKHKGSFYMVFEYMDHDLMG

YMDDC-GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPT--KTYSNEVVTLWYRPPDVLLGSSEY-------
 ..       |  ..| |. |.| |..|||....||||.|  |.|.| .||.|.|||||||        . | | |.|||||||  |||  .|       
LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK

-------------------------------STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGV
                                ..||||..|||. | ....|.|.|.   . | .|... |.|  . || |
ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEV
Kinase PCTAIRE2.AA CDK4 192-473 42 1.8e-88 300.21 In-house 1-290 (290) Show / Hide 
Range on Protein: 192-473
Range on HMM: 1-290/290
Sequence Identity: 42% (126 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE-HEE--GAPCTAIREVSLLKDLK---HANIVTLHDIVH---TDK---SLTLVFEYLDKDLKQYMD
| ..  .||| | |||. |.  | . |||| .|    ||  | |   |||.|... |.   |.||| | |. |   ||     .|.|||  | ||..|.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

DCGN-IMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCI
 |    |.   .|    |.|||. . |   . ||||||||.|..  |..|||||||||  |  ..  .  ||||||| | ||| |. | | .||| ||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLLQSY-YNTPVDMWSVGCI

FFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWP-GVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVPAEEAMKHVYF
|.||   ||||.|.   | || || . |.|  . ||  ||         || ..|.|.    | ..  |..|. | | |. .||. |... .| ||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVS----LPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PCTAIRE2.AA Pkinase_Tyr 192-337 31 1.1e-20 70.65 Pfam 1-160 (270) Show / Hide 
Range on Protein: 192-337
Range on HMM: 1-160/270
Sequence Identity: 31% (51 aa)

YIKLEKLGEGTYATVYKGRSK----LTENLVALKEIRLEHEEGAPCTA------IREVSLLKDL-KHANIVTLHDIVH-TDKS--LTLVFEYLDK-DLKQ
 ....||||| . .||||. |     |.  || | ..    |||   .      .||....| | .| ||| |. ..   ...  . .|.||  . ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YMDDC---GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARA
|  .    ..  .|.    . .|| .|..| ....  ||||   | |..| .  | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PCTAIRE2.AA TyrKc 192-471 21 7.1e-15 17.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 192-471
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAI-REVSLLKDL--KHANIVTLHDIVHTD-------KSLTLVFEYLDK-DLKQYMDD
  ...||||| . .||||. |     || | .. ..       .. || .... |  .| ||| |. .. ..       . | .|.|| .. |||.|  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVP------TKTYS-----NEV--VTLWYRPPDVLLGSSEYS
...  .|     | .|| .| .| |.... ||||   | |..|..  | .||||.|.          ...|.     ..   . .   .| ..   ....
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TQIDMWGVGCIFFEMAS-GRPLFPG--------STVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYES
|. | |  |   .|. . | .  ||        . |   .   .|.   |. .  | .|                      ..  .|  .....  ... 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS---------------------FVCCPDEMYQIMKQCWHEDP

KKRVPAEEAMKHV
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EDRPTFSEIHECF
Kinase PCTAIRE2.AA CRK7 442-473 37 4.5e-05 13.22 In-house 312-343 (343) Show / Hide 
Range on Protein: 442-473
Range on HMM: 312-343/343
Sequence Identity: 37% (12 aa)

LDSEGIELITKFLQYESKKRVPAEEAMKHVYF
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MPKECLDLLDKMLCLDPKKRFTAEECLQHDWF