Gene PFTAIRE2 (Mouse)

PFTAIRE2

Species: Mouse
Alias: PFTAIRE2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PFTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PFTAIRE2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
PFTAIRE2.NA RNA Sugen 1721 None Fasta, JSON
PFTAIRE2.AA Protein Sugen 433 None Fasta, JSON

Protein domain

Protein domains of PFTAIRE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PFTAIRE2.AA PFTAIRE 101-385 72 3.3e-232 777.69 In-house 1-287 (287) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-287/287
Sequence Identity: 72% (209 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIVHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVR
|..||||||||||.||||||.||.|.||||.|....|||.||||||||||||.|||||||.||||.||||||||||||.||||.|||..||||.||.|||
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPG
||.|||||||.|.|..|||||||||||||.||.|||||||||||||||.||.|||.|||||||||||.|||.||||..||.||.||||.||..|||.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

VSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFP--PPKPQSLQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
...|..|||||..|||.|||||||||..||||.|.||.   .||..|. .|.|.. .|.||||...||...||||||||||..|.||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PFTAIRE2.AA CDK 101-385 45 8e-163 524.91 In-house 1-284 (284) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-284/284
Sequence Identity: 45% (146 aa)

YLNLEKLGEGSYAKVYKGISRING-----QLVALKVISMNA-----E-EGVPFTAIREASLLKGLKHANIVLLHDIVHTK-----------ETLTFVFEY
|  |||.|||.|..|||......|     |.|||| | |       | ||.|.||||| |||| | |.||| |||..|||            .|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGE-----LKLADFGLARAKSI------PSQTYSSEVVTLWYRPPD
|..||..||.          .. .|.||||||.|.|.....||||||||.|... ||     ||.||||||||..|      |..||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ALLGATEYS--SELDIWGAGCIFIEMFQ---GQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDRLGGVPEAEDLA
 |||...||   . |.|..||||.|||.   ..||||| |  ..||.|| ...| ||||.||||.|||.|                           || 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE-IDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLL

SQMLKGFPRDRVSAQEALVHDYF
..||   |  |.||..|| |.||
NKMLCYDPKKRISAEQALQHPYF
Kinase PFTAIRE2.AA PCTAIRE 101-385 55 2.3e-156 525.74 In-house 1-291 (291) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-291/291
Sequence Identity: 55% (162 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIVHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVR
|  |.|||||.|| |||. |.  . ||||| | .  ||| |.|||||.||||.||||||| ||||.||   ||.|||||  || ||| .   ..  |||.
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPG
||.||||||||| |....|||||||||||.   |||||||||||||||.|..||| |||||||||||.|.| |.|| ..|.|| |||| ||  |.|||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

VS-----NILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDRLG-GVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
        . .||. |  .|| |.| |||||. .... .. ||  ..|.|  .  ||   . .  || ...|.  .. |||| .|. | ||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PFTAIRE2.AA CDK5 101-385 49 4.6e-143 455.15 In-house 1-287 (287) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-287/287
Sequence Identity: 49% (144 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLLHDIVHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNV
|  .||.||| |. |||.  .  . .|||| . .. | |||| ||||| .||| ||| ||| |||..|.   || |||..  ||  || .  |.. .| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMF-QGQPLF
. ||.|||.|||. |...|||||||||||| .  |||||||||||||  || ..||.||||||||||| |.|.  ||   |.| .|||| ||   |.|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYN--PEWFPPPKPQS-LQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
|| ..  .|| .| ...| |.||.||...|||.|.   . .|.  ..  .| .  .| .  .  || ..||.  |  |.||..|| | ||
PG-NDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDE--KGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PFTAIRE2.AA CDC2 101-385 48 6.1e-131 404.87 In-house 1-301 (301) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-301/301
Sequence Identity: 48% (146 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMN-AEEG--VPFTAIREASLLKGLK-HANIVLLHDIVHTKETLTFVFEYMHTDLAQYMS-QHPG--G
|  .||.|||.| .|||.. .  .|.|||| |     .||  || ||||| |.|| || | ||| |||..|    |  ||||.. || .||  . |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYS--SEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEM
. |..|. .|.|.|.|... |..|..||||||||.|..  |..|.|||||||| .||. ||    ||||||||.|  |||.  || . |.|  ||||.||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDR-------LGGVPEAEDLASQMLKGFPRDRVSAQEALV
    .  |||.| | | .|| || ..|| |.|.|||||..|| |..  ||  ||| |...  .       .   ||. || .|||   | .|.||.||| 
FMDVTKKPLFHGDSEI-DQLFKIFRILGTPNEQTWPGVTQLPDYKNT-FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HDYF
| ||
HPYF
Kinase PFTAIRE2.AA CMGC 101-385 25 7.1e-129 425.98 In-house 1-513 (513) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YLNLEKLGEGSYAKVYKGISRING--------------QLVALKVIS---MN-------AEEGVPFTAIREASLLKGLK-----------------HANI
| ...|.|||.|..|||.. . ..              ..||.| |.   .        ...|.|..|.|| ..|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VLLHDIVHTKE-----------------TLTFVFEYMHTDLAQYMSQHP------GGLHP-------------HNVRLFM------FQLLRGLA--YIHH
| |.||...|.                  | .||||| .||.||. ...      ....              ||.. ||      .|.||||.  |.| 
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

QR--VLHRDLKPQNLLLSHLGEL--------------------KLADFGLARAKSIP---------------------SQTYSSEVVTLWYRPPDALLGA
..  ..||||||.|.|..| .||                    |..||||||. ...                     ...|...|||.|||.|  |||.
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

TEYS---------SELDIWGAGCIFIEMFQG--------QPLFPGVSNI----------LEQLEKIWEVLGVPT---------------EDTWPGVSKLP
..|.         .. |.|..|||| ||..|        .||||| |.           ..||.|| .||| ||               |..||...|||
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLP

NYNP------------EW-------------FPPPKPQSLQIVWDRLG---------------------------------GVPEAEDLASQMLKGFPRD
.||.            .|             ||...|.... .  ..                                    |.| || ..||.  | .
WYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RVSAQEALVHDYF
| .|..|| |.||
RITAEQALQHPYF
Kinase PFTAIRE2.AA CDK7 101-385 37 5.5e-108 288.71 In-house 1-288 (288) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-288/288
Sequence Identity: 37% (108 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVIS-----MNAEEGVPFTAIREASLLKGLKHANIVLLHDIVHTKETLTFVFEYMHTDLAQYMSQHPGGLH
|  ....||| .| |||.     || || | |        |. |. .|||||  .|. ..| |.. | ||   |  .  ||..| .||          | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQ
| ..  .| ..|.|| | |   .||||||| |||..  |.||.|||||||.   | . |.. ||| ||| |  | ||  | .  |.|  |||| |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP-EWFPPPKPQSLQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
| .|| | |  ||..| . || ||| .||.......|.    ||..    |. .     .  .. || . |.   |  |... ..| ..||
PYLPGDSDI-DQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIF--TAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PFTAIRE2.AA S_TKc 101-385 28 4.9e-88 299.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIVHTKETLTFVFEYMHT---DLAQYMSQHPGG----
|  |.|.|.|...||||.. .  |..||.|.|.         ...|| ..||  .| ||| |.|. .. . | .|.||. .   || .|. .....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS-ELDIWGAGCIFIEM
 ...  .| .| |....|.|.| ....||||||.|.||..  ..|..||||||         .. ..|.||..|  |     |.  . |.|  |||..||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALV-------HDY
. |.|.||       |........|                                       ||| |. ...|.  |..| .| |||        | .
LCGYPPFP-------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase PFTAIRE2.AA CDK4 101-385 39 2.7e-83 283.01 In-house 1-290 (290) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-290/290
Sequence Identity: 39% (118 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISM-NAEE--GVPFTAIREASLLKGLK---HANIVLLHDIVHTKET------LTFVFEYMHTDLAQYMS
|  .  .||| | .||.  . ..|. |||| .   . ||  |.|   ||| |... |.   |.||| | |. |. .|      .| |||    ||..|. 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

QHPG-GLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCI
. |  |. |  ..  |.|||||. . |  |. ||||||||.|..  |..|||||||||  |       . ||||||| |  || .  | .  |.| .|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSF-QMALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
| ||.  .|||.| |   .||.|| .| | |.|| ||  . ||    . ||. .|.... .   .     . ||  .||   .  |.|| ..| |.||
FAEMYCRRPLFCGQSEK-DQLHKIFDVMGLPPEDDWPRDVSLPW---DHFPQRHPRPFKDFCPHM--CKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PFTAIRE2.AA PITSLRE 101-385 37 3.8e-78 265.93 In-house 1-295 (295) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-295/295
Sequence Identity: 37% (112 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMN---AEEGVPFTAIREAS-LLKGLKHANIVLLHDIV--HTKETLTFVFEYMHTDLAQYMSQHP---
.  | . .|| |  ||..  .  .  |||| . |      || | |..|| . .|..|.| ||| .  ||   ..     |.||.  ||.  |  .    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GGLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEM
    |  .  .| ||||| .. |   ..|||||  |||.|| | ||..||||||    |   |.. ||||||| |  |||. .||  .|.|  |||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEW-FPPPKPQSLQIVWD---RLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
 ...|||.| | | .|...|   .| |||  |||...||. .    ||. ..  |        ..  .  . ||  |||  .|  | .| .|| |..|
ITMKPLFQGKSEI-DQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDT--GFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PFTAIRE2.AA Pkinase 101-385 29 1.5e-77 268.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISM-NAEEGVPFTAIR--EASLLKGLKHANIVLLHDIVHTKETLTFVFEYMHT-----DLAQYMS-QHP
|  ..|.|.||...|||.. . .|..||.|.|.  ....... |..|  |....| |.| ||| |.|....|  . .|.||.       ||. |.| .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGL--HPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGEL----KLADFGLARAK-SIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGA
|..   .. .. .| |.||||.|.| ....||||||.|.|... |..    |..|||||. .   ... ... ..|.||..|  ..|...|... |.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFIEMFQGQPLFPGV---SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALV
|||..||. |.|.|||     | ..|...| ...| |..  ||  .  ....   . . . . .. . ...   .|. |. . .|.  | .| .|...| 
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNW--SEECKDFIKWCLCKDPKKRPTAEQILQ

HDYF
|..|
HPWF
Kinase PFTAIRE2.AA CRK7 101-333 36 2e-74 253.58 In-house 1-287 (343) Show / Hide 
Range on Protein: 101-333
Range on HMM: 1-287/343
Sequence Identity: 36% (104 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMNAE----EGVPFTAIREASLLKGLKHANIVLLHDIVHTK----------ETLTFVFEYMHTDLAQY
|. ..  ||| | .|||     .|..|||| . |  |    || | |||||  .|. |.|.||| |..||  |           .   |||||  ||.  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MSQH-PGGLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIPS--QTYSSEVVTLWYRPPDALLGATEY--------
.         . ... || ||| |..|.| . .||||.|  |.|.   ||.|.|||||||     .  . |   |.|||||||  |||...|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------SSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYN
                                | |.|. |||..| | ..|.|.| .| ..||||| .. | |. . || | ||| .|
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQG-NNEMAQLEKIYKICGSPNPNNWPEVMKLPWWN
Kinase PFTAIRE2.AA Pkinase_Tyr 101-246 30 4.2e-17 58.56 Pfam 1-160 (270) Show / Hide 
Range on Protein: 101-246
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

YLNLEKLGEGSYAKVYKGISR----INGQLVALKVISMNAEEG----VPFTAIREASLLKGL-KHANIVLLHDIVH-TKET--LTFVFEYMHT-DLAQYM
   ..|||||.. .||||. .     ... || |..  .| .       |  .|||...| | .| ||| |. ..   .|   .  |.|||   ||  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF--MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

SQH---PGGLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARA
 .|   .. | ..    . .|  .|..| . ..  ||||   | |... .  | .||||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PFTAIRE2.AA TyrKc 101-385 23 8.5e-14 0.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 101-385
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YLNLEKLGEGSYAKVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL--KHANIVLLHDIVHTK-------ETLTFVFEYM-HTDLAQYMSQH
   ..||||| . .||||. .   . || |..  .|        .|||.... |  .| ||| |. .. ..       | |  |.||| | || .|   |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PGGLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSHLGELKLADFGLARAKSIP------SQTYS-----SEV--VTLWYRPPDALLGATEYSS
 . | .     |..|  .| .|.|.... ||||   | |... .  | .||||.|.          ...|.     ..   . .   .| ..    ....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT

ELDIWGAGCIFIEMF-QGQPLFPG-------VSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPPPKPQSLQIVWDRLGGVPEAEDLASQMLKGF
. |.|  |    |.|  ||.  ||        . ..|....  . .  | .|  | .|                         .  .|  .. .|  .  
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDY-P-MS---------------------F--VCCPDEMYQIMKQCWHED

PRDRVSAQEALVHDYF
| || . .|   |..|
PEDRPTFSEI--HECF
Kinase PFTAIRE2.AA CRK7 356-385 43 2e-05 14.47 In-house 314-343 (343) Show / Hide 
Range on Protein: 356-385
Range on HMM: 314-343/343
Sequence Identity: 43% (13 aa)

PEAEDLASQMLKGFPRDRVSAQEALVHDYF
.|. ||. .||   |  |..|.|.| ||.|
KECLDLLDKMLCLDPKKRFTAEECLQHDWF