Gene RSK1 (Mouse)

RSK1

Species: Mouse
Alias: RSK1, Rps6ka2, RSK3, Rps6ka1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
RSK1.AA Protein Sugen 741 None Fasta, JSON
RSK1.NA RNA Sugen 3004 None Fasta, JSON
RSK1.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of RSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK1.AA AGC 68-327 34 3.6e-189 494.52 In-house 1-395 (395) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-395/395
Sequence Identity: 34% (137 aa)

FELLKVLGQGSFGKVFLVRKVTRP---DSGHLYAMKVLKKAT---LKVR-DRVRTKME------------RDILADVN----------HPFVVK-LHYAF
||.|||.|.||||||.||||....   |.|..||||||||..   .| . .  .|. |            |.||. .|          |||.|| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALGLDHLHS-LGIIYRD-LKPENILLDEEGHIKLTDFG
|.. .  ||......          || .||..|    ||  |.|| ..||.||       ..|.|..||| .|||.|| ||||||||||.|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEAIDHE--------------------------------------------------KKAYSFCG--TVEYMAPEVVNRQGHTHSADWWS--YGVLMF
|.|| .. .                                                  .....|||  | ||||||..    .....||||  .|.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGSLPFQGK----------DRKETMTLIL------KAKLGMP----------QFLSTEAQSLLRALFKRNPANRLGSGPD-----GAEEIKRHIFY
|||||  ||.|.          ...|.. .|.      . |. .|          ...| ||..|.. |....|..|||.|..     ||||||.| . 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK1.AA RSK 68-327 53 2.5e-186 625.29 In-house 1-271 (271) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-271/271
Sequence Identity: 53% (146 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
.||....|||||.||....|....|....||||..||||..|.|||....||.||....|||.|||||.||.|||.|.|.||.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE----GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLT
..||||.||.|| ...|||.||..|||||||||.|.|    ||||..|||..|...|.......||.|..||||||..||||....||||.||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GSLPFQGKDRKETMTLILKAKLGM-------PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY
| .|||.|.|...|..|...||||       ..|.| ||..|||....|.|.||||.||.|.|.||.| ..
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK1.AA RSK 71-327 55 5.70000000001e-170 570.95 In-house 1-278 (278) Show / Hide 
Range on Protein: 71-327
Range on HMM: 1-278/278
Sequence Identity: 55% (154 aa)

LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR-VRTKM-ERDILADVN-HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM---
|||||||..|||||.||.|. |.|..|||||||||....|.. .|..| ||.||.... |||.|.||||||||||||||....|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKE-AIDHEKKAYSFCGTVEYMAPEVVN----RQGHTHSADWWSYGV
|.|....||.||..| ..|||..|||.|||||||||.|.   ||||||||||..|.  .||......||.|.||||||...    . ||....|||| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGSLPFQG---KDRKETMTLILKAK--LGMP--QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY
||.||||| .||||   ..|||.|. |.|.|  |.||  |.||.||..|.|....|.|..|||.||..|||||.| . 
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK1.AA Akt 68-327 49 1.2e-144 465.35 In-house 1-264 (264) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-264/264
Sequence Identity: 49% (131 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLY-AMKVLKKATLKVRDRVR-TKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|..|||||.|||||||||.|    |.. .| |||||||  .  .. |. || || ||  .||||.|.|||.|||. |||...|.  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALGLDHLHSLGIIYRD-LKPENILLDEEGHIKLTDFGLSKEA-IDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWS-YGVLMFEML
.|.  .|| ||. |...|||| .||||| |||||||.|..|||.||||||.||  | .  |...|||| ||.|||. | .||| ..|||.  |..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGSLPFQGKDRKETMTLILKAKLGMP--QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY
.| .||  .|... . .|. ... .|   ..| |...|.. | ...| .|||.||..|.||||| ..
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK1.AA p70 68-327 47 1.9e-138 466.26 In-house 1-299 (299) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-299/299
Sequence Identity: 47% (142 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKA--TLKVRDRVRTK-------------------------MERDILADVNHPFVVKLHYAFQTE
||||||||.| .||||.|||||  |.| .||||||.||  .   .|   |.                          || ||  |.|||...|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK----------AYSFCG
|||||||..| || ||. | .. .. |. ..|||.|  . | |||..|||||||||||..|.. ||..||||||.|| |   ..           ..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAK--LGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFY
| ||||||.. | || |  |||| |.||. ||||. || |  ||.|.  |||.|  | .|  |. |.  |...| ||.|. |.|.||. |..|..| |.
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK1.AA AktR 68-327 45 7.69999999999e-122 411.08 In-house 1-268 (268) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-268/268
Sequence Identity: 45% (124 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK-ATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|...|.||.| ||||.||.|  | |.. .||||..||    . . . .| .||.|..  .|||| |||||.|||. ||..|... .||.||. |.|.  |
FHVYKCLGKGAFGKVYLVQKK-R-DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

TEEDVKFYLAELALGLDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSK-EAID-HEKKAYSFCGTVEYMAPEVVNR-QGHTHSADWWSYGVLMFEM
.||...|| |.  |.|..||.   |||||||||||||||.||.|.||||||| . ..  . ||||||||.||||||.... .||. |.|||. |.. .||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LTGSLPFQGKDRKETMTLILKAK-LGMPQF--LSTEAQSLLR-ALFKRNPANRLGSGPDGAEEIKRHIFY
.||  ||. |....   .|..   .  |.   .| ....|.   |...|| .|||..  |.||||.| . 
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK1.AA MSK 71-322 40 2.5e-107 362.86 In-house 1-277 (277) Show / Hide 
Range on Protein: 71-322
Range on HMM: 1-277/277
Sequence Identity: 40% (112 aa)

LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK--MERDILADV-NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
|||||.|. ||.|..||... |.| |||||.|.|||.  . ..      || .| .. .||..|.||||||.. ..||......|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE---GHIKLTDFGLSKEAIDH-EKKAYSFCGTVEYMAPEVVN----RQG-HTHSADWWSYGVLM
. . ....|| . .||.|..|||.|||||||||.|.|   ||.||.|||....     |....|.|.| .|||||...     .| .  . |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGSLPFQ--GKDRK-------ETMTLILKAKLGMP----QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIK
..||||  |||  ..||.       | |  |.|..   |    |  |..|. |.. |  ..|. ||| .. .|.|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK1.AA S_TKc 68-327 34 3.9e-106 359.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRG--GDLFTRLSKEVM-
.|.|...|.|.||||...|..    .|...|.|..|          ... |..||   .||..|||...||. ..||...... |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTH-SADWWSYGVLM
     |.| ...||.......|...||.|||.||||||||||||  |||..||||...        ..|||| .||||||.   |... ..|||| |...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGA--EEIKRHIFY
.|||.|  ||.      .| ...|  .      | || ...| .....|..|..     .  ..|| | . 
YEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK1.AA Pkinase 68-325 30 5.5e-96 329.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 68-325
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM--ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG----DLFTRLS-
.......|.||||.|   .| .. ..|...|.|..|| . |   ...     |  |.. .|||..|.|...|......|.......||    |||...| 
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKEA-IDHEKKAYSFCGTVEYMAPEVVN-RQGHTHSADW
 ..  |  .|...|||. ... ||...|| |||.|||||||||.|..|||    |..||||.| . . .   ...|||| .||||||.. .|......|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSYGVLMFEMLTGSLPFQGK------DRKETMTLILKAKLGMPQFLS---------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRH
||.|....|||.| .||.|.      | .. . .|....|  . . .                      |...... .....|. |..     ||.|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

--I
  .
PWF
Kinase RSK1.AA Ciliate-E2 68-327 23 4.4e-87 295.6 In-house 1-365 (365) Show / Hide 
Range on Protein: 68-327
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

FELLKVLGQGSFGKVFLVRKVTRP--------------------DSGHLYAMKVLKKATLKVRDRVRTKM-----------ERDILADVNHPFVVKLHYA
....|..|||.||.|.....   .                    . . .||||..||  ..   ..   |           |. ||  .|||...|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALGLDHLHSLG-IIYRDLKPENILLDEEGHI
||  .. ..||..... ||||| ..                   ||.  .... ..       ||.|.. |.| .||| . ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSKEAIDHEK-------------------------------KAYSFCGTVEYMAPEVVNRQG---------HTHSADWWSYGVLMFEMLTGSLP
|..||||||.. | ..                                ....||| .|||||..|...         .....|.|| ||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGKDRKETMTLILKAKLGMPQF------------------LSTEAQSLLRA----LFKRNPANRLGSGPDGAEEIKRHIFY
|        .  |.. |.  |..                  .| |.. |..     .....| .|..    |.|.|. | . 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase RSK1.AA CAMK 73-327 21 1.8e-83 268.72 In-house 1-425 (425) Show / Hide 
Range on Protein: 73-327
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

VLGQGSFGKVFLVRKV-TR---------PDSGHLYAMKVLKKATLK--------------------------VRDRVRTKMERDILAD-------VNHPF
.||.||||||.|..   |           . |. .|.|...|  ||                           .|| . . | .|.         ..|| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VVKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALGLDHLHSL
..||. ...            |  |        .|...   ..  ||    ||| .. .                  |||.....|   .. .....||.
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIIYRDLKPENILLDEE-----------------GHIKLTDFGLSKEAIDHE-----------------------KKAYSFCGTVEYMA-PEVVNR----
.|. |||||||||||.                  . ||..|||.... .. |                       .| . |||| |||| |||.|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------QGHTHSADWWSYGVLMFEMLTGSLPFQGK-------------DRKETMTLILKAKLG-MPQFLST-----------------------EA
          .... ..| || ||... ||.| .||.|.             . .|..  |.|.|    | ..|.                       |.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRALFKRNPANRLGSGPDGAEEIKRHIFY
..|.| . ...| .|.      .|....| ..
KDLIRKMLQVDPEKRM-----TIEQCLNHPWM
Kinase RSK1.AA CAMK1 68-311 29 5.2e-64 184.94 In-house 1-265 (276) Show / Hide 
Range on Protein: 68-311
Range on HMM: 1-265/276
Sequence Identity: 29% (79 aa)

FELLKVLGQGSFGKVFLVRKVTR-PDSGHLYAMKVLK-KATLKVRDR---VRTKMERDILADV---NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRL
.|. |..| |.|..|.|. .       |. ||.|... |  .|  |.    . ..| .|.  |   .||...|..  .... ..||... . ||.|| | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHIK--LTDFGLSKEAIDHEK-KAYSFCGTVEYMAPEVVNR---QGHTHSAD
 .   .||.|      ...  . ..||.||  |||||||.|.   ||.  ||  . ||||||  .||.  . .  ||| .|.||||...   ...  . |
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSK-IFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

WWSYGVLMFEMLTGSLPFQGKD-RKETMTLILKAKLGMPQF----LSTE-AQSLLRALFKRNPANRL
 || ||  . .|.|  ||....  .| . .|.|.....| .     | . |  ... . . .| .|.
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY
Kinase RSK1.AA S_TK_X 328-389 39 3.6e-25 90.88 SMART 1-79 (79) Show / Hide 
Range on Protein: 328-389
Range on HMM: 1-79/79
Sequence Identity: 39% (31 aa)

STIDWNKLYR--REIKPPFKPAVA----QPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQL-----------FRGFSFVA
. |||.|||.  .||.||||| .      | || .||.|||. ||...|  ||. ....            ||||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase RSK1.AA Pkinase_Tyr 68-289 28 9.1e-22 74.34 Pfam 1-237 (270) Show / Hide 
Range on Protein: 68-289
Range on HMM: 1-237/270
Sequence Identity: 28% (68 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLY-AMKVLKKATLKVRD--RVRTKMERDILADV-NHPFVVKLHYAFQ-TEGK--LYLILDFLRGGDLFTRLS
 ...|.||.|.||.|.. .    ||....  | |.| | .   ..  |     |  |.    .|| .|.|. .    ..   .|... .  .||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY-SFCG----TVEYMAPEVVNRQGHTHSADW
|    .  .| .|   . .. | |...|.| ..| |||   |.|..|....| .||||..    ...  |    |     .  ||||. |    |.  | 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGVLMFEMLT-GSLP-FQGKDRKETMTLILKAKLGMPQ
||.||||.|..| |  | ..| .  | . .| .    ||.
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase RSK1.AA TyrKc 68-325 23 7.8e-18 65.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 68-325
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV--NHPFVVKLHYAFQTE-------GKLYLILDFLRGGDLFTR
 .|.|.|| | ||.|.. .           | |.||. .     |     |  |.  .  .|| .|.|. .  ..       . |.... .  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH-----EKKAYSF----CGT----VEYMAPEVVNRQG
| |    .. .|   .    | | ..||| ..| |||   |.|..|....| .|||||..  |.     .|. |.     .|     .  ||||. |   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HTHSADWWSYGVLMFEMLT-GSLPFQG-----KDRKETMTLILKAKLGMPQFL---------STEAQSLLRALFKRNPANRLGSGPDGAEEIKRHI
 |.  | ||.||.|.|..| |  |  |     .. .| . .. . .  ..            ..|  .. .   ...|..|        .||.. .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEIHECF
Kinase RSK1.AA Pkinase_C 347-391 40 1.4e-13 51.01 Pfam 1-46 (46) Show / Hide 
Range on Protein: 347-391
Range on HMM: 1-46/46
Sequence Identity: 40% (19 aa)

AVAQPDDTFYFDTEFTSRTPRDSP--GIPPSAGAHQLFRGFSFVATG
 |  |.|| .||.|||. .|.|.|  .   |.|.. .||||..|.  
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase RSK1.AA RSK 424-681 56 4.6e-192 644.34 In-house 1-271 (271) Show / Hide 
Range on Protein: 424-681
Range on HMM: 1-271/271
Sequence Identity: 56% (154 aa)

YVVKETIGVGSYS---VCKRCVHKATNMEYAVKVIDKSKRDPS-----EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSE
| ..| ||.||.|   |||.|.||.||..||.|.|.|..||..     ||..|.||||.||.|..|..|..|...||.....||||.|.|..|.||.|||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

REASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLA
||..|....| ...|||||||.|||||||.||||.||||||....|||||||||||.|||.|||.|||||..|||||||||.|. ||.||.|.|.|.||.
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWI
|.|||.|.| |||..|. ||..|.|....|||...|..||||...|||.|||.||.|     .|..||||.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK1.AA RSK 426-681 43 2.1e-160 539.17 In-house 1-278 (278) Show / Hide 
Range on Protein: 426-681
Range on HMM: 1-278/278
Sequence Identity: 43% (123 aa)

VKET--IGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPS--------EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF---
.|.   .|.|....|..|.|..|...||.||..|.|....        .|..||.|..|||.|.||..........||..|..|||||.......|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQGYDEGCDIWSLG
|||.||.|.. .|...||.||.||..||||||.|||| ||| |.. ....||||.||.|.. |...||.|||....|||.||    . |.|. ||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ILLYTMLAGYTPFANGPSD-TPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLT-----AKQVLQHPWI
.|.|.||.|..||.. | | ...||..||..|||.|...||...|..||||..||||.|||.||.     |....||||.
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK1.AA CAMK1 424-681 38 1.3e-118 346.41 In-house 1-276 (276) Show / Hide 
Range on Protein: 424-681
Range on HMM: 1-276/276
Sequence Identity: 38% (107 aa)

YVVKETIGVGSYSVCKRCVHKAT---NMEYAVKVIDKSKRDPSE-----------EIEILLRYG--QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKI
|.....|| |. |. ..|.|| |   . .||.|.||| |.  ..           ||||. . .  .||||| ....|.. .|.|||.||. ||||.|.|
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK-KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

LRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLR-ICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR---QGYDEGCDI
.  ....|..|. . . | . |||.||.|.||||||| |.||.|.. . .  | |.||| .|..  ...|. |.| |  .||||||..   ..||  ||.
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSLGILLYTMLAGYTPFANGPSDT-PEEILTRIGSGKFTLSGGNWNTVSET-AKDLVSKMLHVDPHQRLTAKQVLQHPWI
|| |. .|..| || ||    ...  .|..  | .....     |. .|.  |||....|| ||| .|.|..|.|.||||
WSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase RSK1.AA Pkinase 424-681 35 2.3e-114 391.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 424-681
Range on HMM: 1-293/293
Sequence Identity: 35% (104 aa)

YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGG----ELLDKIL--R
|.....|| ||......|.|| |. ..|||.|.|.......        ||.|..|  .||||..|.|.. |..|.|.|.|...||    .| | |   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QKFF--SEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL-RAENGLLMTPCYTANFVAPEVLK-RQGYDEGCDIWS
.. |  ||.|. |..  | . .||.||.|..||||||.|||....  ...|..|||||.|||.    |. ..|.| | ...||||.. .|.|.  .|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILLYTMLAGYTPFANG----PSDTPEEILTRIGSGKFTLSGGNWNTVS-----------------ETAKDLVSKMLHVDPHQRLTAKQVLQHPWI
.|..|| || |..|| .     . ... ... ||.....  .  .|...|                 |..||.....|..||..|.||.|.|||||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RSK1.AA AGC 424-681 23 1.6e-109 283.79 In-house 1-395 (395) Show / Hide 
Range on Protein: 424-681
Range on HMM: 1-395/395
Sequence Identity: 23% (94 aa)

YVVKETIGVGSYSVCKRCVHK------ATNMEYAVKVIDKSK---------RDPS-------------EEIEILLRYGQ---------HPNIIT-LKDVY
. .. .|| ||.. .  . .|      .|.  ||.||..|..          .               || .|| .. .         ||.|.  |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGKH--VYLVTELMR---------GG-ELLDKIL---RQKFFSEREASFVLHT-------ISKTVEYLHS-QGVVHRD-LKPSNILYVDESGNPECLRI
 | .|  .|.| |.|          || ||.  .    ... |.| .| | .         |   .||||| .|..||| ||| |||  ..      ...
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKL

CDFGFAKQLRAE-----------------------------------------------------NGLLMTPCYTANFVAPEVLKRQGYDEGCDIWS--L
.|||..|... .                                                     .  .  || |....|||.|    |.  ||.||  |
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGL

GILLYTMLAGYTPFANGPSD-------TPEEILTRIGSGKFTLSGGNWNT------------VSETAKDLVSKMLHVDPHQRLT----------AKQVLQ
|.|.| ||.||.|| . . .       .|.|.  .| .|..... .                .|. ||||..|.|..|| .||.          |... .
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPWI
||| 
HPWF
Kinase RSK1.AA S_TKc 424-681 36 6.30000000001e-107 362.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 424-681
Range on HMM: 1-231/231
Sequence Identity: 36% (100 aa)

YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRG--GELLDKILRQKF------FSE
| . ..|| |.......|.|| |. ..|.|.|.   ..   ||.|| .  .||||..|.||..| .|.|.|.|.. |  |.|.| | ...       |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

REASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDE-GCDIWSLGILLYTML
 .| |... | . .||.||.|..||||||.|||  .      .. |||||.|.||       .| | | ...|||||   ||.   ||.||.|..|| ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQ-------HPWI
.||.||      ...... .||              |. |||...|.|..|| .|.|| ..||       |||.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK1.AA CAMK 429-681 25 5e-106 342.71 In-house 1-425 (425) Show / Hide 
Range on Protein: 429-681
Range on HMM: 1-425/425
Sequence Identity: 25% (108 aa)

TIGVGSYSVCKRCVHKATN------------MEYAVKVIDKS--------------------------------KRDPSEEIEILLRYG------QHPNI
|.| ||... |.|.|| |.             ..|.|.|||.                                ..    ||||. .        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLKDVYDDGKH-------------------VYLVT---ELMRGGEL----LDKILRQKF---------------FSEREASFVLHTISKTVEYLHSQGV
| | .||.|...                   .|.|.   |.. ||||    .|.| ...                |.||||... . |   |.|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYVDESGNPE-------------CLRICDFGFAKQLRA-----------------------ENGLLMTPCYTANFVA-PEVLKR------
||||||| |||..| ... .              . |.|||||....                        |. .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDEGCDIWSLGILLYTMLAGYTPFANGPSD----------TPEEILTRIGSGKFTLSGGN------------WNTVSET--------AKD
        ..|.. ||.||.|..||.|| || ||     .          ...|.. .| .||..                 |. .|.         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVSKMLHVDPHQRLTAKQVLQHPWI
|..||| ||| .|.|..|.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase RSK1.AA MSK 426-681 36 3.8e-92 311.79 In-house 3-277 (277) Show / Hide 
Range on Protein: 426-681
Range on HMM: 3-277/277
Sequence Identity: 36% (100 aa)

VKETIGVGSYSVCKRCVHKATNMEYAVKVID-----KSKRDPSE---EIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSERE
|. |.| |....|..|||. |. .||.|..       ... ...   |. .|..  ||||| .|.... |  | ||| |. .||||. .| . . |.| |
VLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESE

ASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQG-YDEGCDIWSLGILLY
.....  .   |...|. |..|||||| |||. ||. | . ... |||||. . .. .  . .||.|  . |||.|.     .| ||| ||.||||..||
CRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGH-VKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILY

TMLAGYTPFA-NGPSDT-----PEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWI
||| |  ||. |...         ||  ||  |.| . |  |...|. ||||....| .||  ||..   ..| |.
TMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK1.AA Ciliate-E2 424-681 24 5.9e-82 278.58 In-house 1-365 (365) Show / Hide 
Range on Protein: 424-681
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

YVVKETIGVGSYSVCKRCVH-----------------------KATNMEYAVKVIDKS--KRDPSEEIEI--------------LLRYGQHPNIITLKDV
| . . || |.... ..| .                       |.....||.|.. |.  .   .|. ..              .|.  .||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YD--DGKHVYLVTELMRGGELLD--KILRQKF---------FSEREASFVLHTISK---------------TVEYLHSQG-VVHRDLKPSNILYVDESGN
.   | ...|||.|.  ||.|.|  |. ..|.         |.|.|....   | .                .|||||.. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PECLRICDFGFAKQLRAENG-------------------------------LLMTPCYTANFVAPEVLKRQG---------YDEGCDIWSLGILLYTMLA
   . |.|||..|..  .|                                .  | |.|....|||.|....         ||. |||||||..|| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYTPFANGPSDTPEEILTRIGSGKFTLSGG--------------NWNTVSETAKDLVSK----MLHVDPHQRLT-AKQVLQHPWI
|..||           .  |  .|. ..                .|. .|. .||| .|    || .|| .|.| ..|.|.|||.
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase RSK1.AA p70 474-681 29 3.6e-35 123.18 In-house 86-299 (299) Show / Hide 
Range on Protein: 474-681
Range on HMM: 86-299/299
Sequence Identity: 29% (67 aa)

QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE
.||.|. |   . ..   ||. | . ||||     |.  . |  |.| |  |.   |.||..|.. ||||| |..  .. |    .   |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCM-LNQQG---HVVLTDFGLCKESIHD

NGL----------LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGK--FTLSGGNWNTVSETAKDLVSKM
             . | | |  . |||.| | |..  .| ||||.|.| || |  ||     ... ..   |  ||   .|        .. ..||. |.
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFT---GENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKL

LHVDPHQRLT-----AKQVLQHPWI
|  .| ||..     |... .||. 
LKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK1.AA Akt 492-620 36 2.4e-29 90.92 In-house 76-203 (264) Show / Hide 
Range on Protein: 492-620
Range on HMM: 76-203/264
Sequence Identity: 36% (48 aa)

YLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRD-LKPSNILYVDESGNPECLRICDFGFAKQL-RAENGLLMTPCYTANFVAP
|.|.. . ||||   . |...||| .| |    |.   |.|||.... || ||| ||| .|. |.   ....||| .|.    ..   .| | |.   ||
YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENIL-MDKDGH---ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAP

EVLKRQGYDEGCDIWS-LGILLYTMLAGYTPF
|.|. .|..  .|.|. ||...| |. |  ||
EILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase RSK1.AA AktR 474-620 33 1.3e-25 91.38 In-house 59-205 (268) Show / Hide 
Range on Protein: 474-620
Range on HMM: 59-205/268
Sequence Identity: 33% (51 aa)

QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAK--QL
.|| |. |..   . .. ... | ..||||.. . ..|.||| .| |    |   .||||..  .. ||||| |||  || |.   ..| ||| .|    
NHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENIL-LDEDGH---VKITDFGLSKLQFM

RAENGLLMTPCYTANFVAPEVLKR-QGYDEGCDIWSLGILLYTMLAGYTPF
.... .  . | |   .|||.... .|..  .|.|..||..| |..|..||
MHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPF
Kinase RSK1.AA Pkinase_Tyr 424-611 25 1.2e-17 60.4 Pfam 1-205 (270) Show / Hide 
Range on Protein: 424-611
Range on HMM: 1-205/270
Sequence Identity: 25% (54 aa)

YVVKETIGVGSYSVCKRCVHK----ATNMEYAVKVIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYD-DGKH--VYLVTELMRGGELLDKIL
 .  ...| |.. . .... |     |... |||.. | . ....        |..|.  .|.||||. |  |   .|..  .|.|.|.| .| |||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

R----QKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL-------RAENGLLMTPCYTANFVAPEVLKRQGY
.    .. ..  .     . |.|  |||.|.. .||||   |.|  .    . . .||||| |. .       |.  |  .    .    |||...   .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF

DEGCDIWSLGILLY
 .  |.|| |.|..
TTKSDVWSFGVLMW
Kinase RSK1.AA TyrKc 424-681 19 1.9e-15 27.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 424-681
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE---EIEILLRYG-QHPNIITLKDVYDDG-------KHVYLVTELMRGGELLDKILRQK-
 . ....| | . .  ... |   .. |||.. ...    .   |..|. ..| .||||. |  |  ..       . ...|.|.| .| |.| . . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-----NGLLMTPCY--TANFV------APEVLKRQGYD
 .. ..     . |..  |||||....||||   |.|. ..     . .|.||| .. .  .     ..   ..     ....      |||...   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EGCDIWSLGILLYTMLA-GYTPFAN---GPSDTPEEILTRIGSGKFTLSGGN------WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWI
.  |.|| |.... ..  | .|  .       ...|.. .. .|.      |          .|  . . ..  | ||..| | ...  |  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase RSK1.AA Akt 648-681 35 9.6e-09 23.99 In-house 226-264 (264) Show / Hide 
Range on Protein: 648-681
Range on HMM: 226-264/264
Sequence Identity: 35% (14 aa)

NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWI
...|  .|||.|..|. ||..||     .|... .||| 
DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK1.AA AktR 650-681 31 6e-07 23.22 In-house 231-268 (268) Show / Hide 
Range on Protein: 650-681
Range on HMM: 231-268/268
Sequence Identity: 31% (12 aa)

VSETAKDLVS-KMLHVDPHQRLT-----AKQVLQHPWI
.|...|||.  | |  .| .||.     ....  ||| 
FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK1.AA AktR 424-459 27 0.043981 4.35 In-house 1-37 (268) Show / Hide 
Range on Protein: 424-459
Range on HMM: 1-37/268
Sequence Identity: 27% (10 aa)

YVVKETIGVGSYSVCKRCVHK-ATNMEYAVKVIDKSK
..| . .| | ..    . .|  ..  || |.|.|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKK