Gene SgK110 (Mouse)

SgK110

Species: Mouse
Alias: SgK110
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: Other
Family: NKF1

Sequence

Name Sequence Type Origin Length Description Download
SgK110.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
SgK110.AA Protein Sugen 361 None Fasta, JSON
SgK110.NA RNA Sugen 1083 None Fasta, JSON

Protein domain

Protein domains of SgK110.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK110.AA NKF1 43-304 45 3.7e-158 531.71 In-house 1-269 (269) Show / Hide 
Range on Protein: 43-304
Range on HMM: 1-269/269
Sequence Identity: 45% (124 aa)

YRLIRKLGSGSYGRVLLAQPRQGGQTVALKLLRRDSVLRTTFLREFCVGRCVSSHPGLLQTLGRPLQTPR--YFAFAQEFAPCGDLSGMLQ---EKGLPE
|..||.||.|.||..||...||.|...|||...........|.||||.|.|.|.|.....|.....||..  |..||||.||||||..|.|   ..||||
YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE

LMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLVFDP-DCNRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLP-PNTLPLRPAVDSWALGVLLFCA
...||.|||||.||||.|.|.|||.|.||.||||||| ||.||.|.|.|.|||.|....... ..|...||.|. || . ..|..|..|.|..|||.||.
NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC

ATACFPWDVALAP-DPEFEAFAGWMTTKPQPPRPPAPWDQFAPPALTLLQGLLDLDPETRSPPLAVFDVL
 |.||||. |... ||..|.|. | ..| ||| .| ||..|.|.|......||...||.|.|. .... .
LTGCFPWQKADWMCDPCYEWFMWWQRRK-QPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM
Kinase SgK110.AA S_TKc 43-304 18 9.7e-42 145.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-304
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

YRLIRKLGSGSYGRVLLAQPRQGGQTVALKLLRRDSVLRTTFLREFCVGRCVSSHPGLLQTLGRPLQTPRYFAFAQEFAPC--GDLSGMLQEKG------
|...||.|.|..|.| ... .  |. ||.| ..       ...||  . .    || . . ..       .. .  |...   |||  .....|      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLVFDPDCNRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLPPNTLPLRP-AVDSWALGVLL
 .|| .......|.. ||...| .| .| |.||.|.|. .    .. ..| || |          . .   .||..        .  . ..| |..|..|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

FCAATACFPWDVALAPDPEFEAFAGWMTTKPQPPRPPAPWDQFAPPALTLLQGLLDLDPETRSPPLAVFD---------VL
.  .. . |..       ... |   .                 |.|. .....|. ||| |     ..           .
YEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SgK110.AA Pkinase 43-294 18 1.1e-31 113.11 Pfam 1-281 (293) Show / Hide 
Range on Protein: 43-294
Range on HMM: 1-281/293
Sequence Identity: 18% (53 aa)

YRLIRKLGSGSYGRVLLAQPRQGGQTVALKLLRRDSVLRTT---FLR--EFCVGRCVSSHPGLLQTLGRPLQTPRYFAFAQEFAPCG----DLSGMLQ--
|...||.||||.|.| ... .  |..||.| .....         .|  | .. . . .||  .....     ...  . .|....|    ||. ...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW

-EKGL--PELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLVFDPDCNR---VALGDLGLT----RPEGSPTPAPPVPLPTAPPELCLLLPPNTLPLRP
 ....  .|  .|... |.. .|...| .| .| |.||.|.|.   ...    | ..| ||        .| .  . . .. ..||...       .  |
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGP

AVDSWALGVLLFCAATACFPWDVAL----APDPEFEAFAGWMTTKPQPPRPPAPWDQFA-----------------PPALTLLQGLLDLDPETR
.|| |..|..|.. ..  .|..         . . . ..  .. .|.....   |.                    .... .. ..|..||. |
KVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMIC--RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR
Kinase SgK110.AA CAMK 48-186 15 3.6e-22 67.6 In-house 1-242 (425) Show / Hide 
Range on Protein: 48-186
Range on HMM: 1-242/425
Sequence Identity: 15% (39 aa)

KLGSGSYGRVLLAQPRQGG------------QTVALKLLRRD-----------------------------SVLRTTFLREFCVGRCVS------SHPGL
.||.||.| | |.. .. .            | || | . ..                              . |  ..|| .. . ..      .|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQTLG-----------RPLQ-TPRY--------FAFAQ---EFAPCG----DLSGMLQEKG----------------LPELMVKRIVAQLAGALDFLHGR
.. .            ..   | ..        . .     |... |    ||  ...|.|                ..|  ..|.. |.. |....| .
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GLVHADVKPDNVLVFDP---DC------------NRVALGDLGL
. || | ||.|.|. |    ..            | . . | |.
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGF
Kinase SgK110.AA CAMKL 43-171 24 1.3e-19 59.17 In-house 1-160 (297) Show / Hide 
Range on Protein: 43-171
Range on HMM: 1-160/297
Sequence Identity: 24% (39 aa)

YRLIRKLGSGSYGRVLLAQP-RQGGQTVALKLLRRDSVLRTTFLR----------------EFCVGRCVS--SHP---GLLQTLGRPLQ---TPRYFAFA
||... || ||.| | ||.  |  |. || | . ..     .. .                | .  . ..   ||    |....  |     |  ..   
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

QEFAPCGD--LSGMLQEKG-----LPELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLV
 | .. |.  |  .....|     .||   .|.  |.  |....| .| || | ||.|.|.
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL
Kinase SgK110.AA CMGC 43-193 13 2.7e-18 55.84 In-house 1-257 (513) Show / Hide 
Range on Protein: 43-193
Range on HMM: 1-257/513
Sequence Identity: 13% (36 aa)

YRLIRKLGSGSYGRVLLAQP--------------RQGGQTVALKLLRRDSVLRT-------------TFLREFCVGRCVS----------------SHP-
|  |.|.|.|.|| |  ..               ..... ||.| ....    .             . |||    ....                 |. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

--GLLQTLGRPLQTPR-------------YFAFAQEFAPCGDLSGMLQEKG----------LPELM------------VKRIV------AQLAGALD--F
  .|.  . ..  ..              .. .  |. .. || ......           |.|              .| ..       |.  .|.  .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHGRG--LVHADVKPDNVLVFDPDCN------------------RVALGDLGLTRPEGSP
.| ..   .| | || |.|. .   .                  |. ..| || | ....
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase SgK110.AA TK 43-188 12 1.2e-15 48.14 In-house 1-299 (486) Show / Hide 
Range on Protein: 43-188
Range on HMM: 1-299/486
Sequence Identity: 12% (38 aa)

YRLIRKLGSGSYG---RVLLAQPRQGG-------------------------QTVALKLLRRD-SVLRTT--------------FLREFCVGRCVSS---
 .|..|||.| .|   .| ... |...                         ..|| | |. . .   .               ||.|  .    ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPGLLQTLG--RPLQTP---------RYFAFAQEFAPCGD----LSGMLQEKGLPELMVKR--------------------------------------
 || ... .|     ..          . .    |..|.||    |   |...  ..                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------IVAQLAGALDFLHGR------GLVHADVKPDNVLVFDPDCNR---------VALGDLGLTR
                                      . .|.| .. .|| .      ..|| |.   |.||.. . ..         . ..| ||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
Kinase SgK110.AA AGC 109-170 20 4.5e-15 33.94 In-house 101-187 (395) Show / Hide 
Range on Protein: 109-170
Range on HMM: 101-187/395
Sequence Identity: 20% (18 aa)

QTPRY--FAFAQEFAP--------CGD-LSGMLQEK-----GLPELMVKRIVAQ-------LAGALDFLHG-RGLVHAD-VKPDNVL
|....    |  |..|        .|.  . . . .      ..| ... . |.       .. ||..||  .| .| | .||.|.|
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL
Kinase SgK110.AA TKL 49-188 17 1.7e-14 48.66 In-house 1-202 (364) Show / Hide 
Range on Protein: 49-188
Range on HMM: 1-202/364
Sequence Identity: 17% (36 aa)

LGSGSYGRVLLAQPRQGG--------QTVALKLLRRDS-------------------------VLRTTFLREFCVGRCVSS--HPGLLQTLG--------
.|||..| |  .. |. |        ..|| | .....                          ..  . .|  . .. |.  || ..| .|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

----RPLQTPRYFAFAQEFAPCGD-LSGMLQEKGLPELMVKRIVAQLAGALDFLHG--------RGLVHADVKPDNVLVFDPDCNR------------VA
    .|.... ....  |..|.|. |. ..           |.. . | ....||         ....| | |..|.||..   |             . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LGDLGLTR
..|.|| |
ICDFGLSR
Kinase SgK110.AA NuaK 43-79 35 5.4e-13 29.96 In-house 1-37 (252) Show / Hide 
Range on Protein: 43-79
Range on HMM: 1-37/252
Sequence Identity: 35% (13 aa)

YRLIRKLGSGSYGRVLLAQPRQGGQTVALKLLRRDSV
|.....||.| ||.| ||  .. |. || |. ... .
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKI
Kinase SgK110.AA AGC 43-75 25 2.9e-10 21.21 In-house 1-39 (395) Show / Hide 
Range on Protein: 43-75
Range on HMM: 1-39/395
Sequence Identity: 25% (10 aa)

YRLIRKLGSGSYGRVLLAQPR------QGGQTVALKLLR
..... .| ||.|.| |.. .      . |.  |.| |.
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLK
Kinase SgK110.AA TyrKc 43-304 20 2.9e-10 -56.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-304
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YRLIRKLGSGSYGRVLLAQPRQGGQTVALKLLRRDSVLRTTFLREFCVGRCV-SSHPGLLQTLGRPLQTP------RYFAFAQEFAPCGDLSGMLQEKG-
 .|..|||.| .|.| ... .   ..|| | |. |.  |  |.||  . . .  .|| ... .|  .|               |..| |||   |.... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LPELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLVFDPDCNRVALGDLGLTRPEGSP----------TP----APP--VPLPTAPPELCLLLPPNTL
 |.      .  | |   ..|| ....| |    |.|| ..   .|  .| ||.|  ..           ..         .|.   .|| |.    |. 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE-CI----NYG

PLRPAVDSWALGVLLF--CAATACFPWDVAL--APDPEFEAFAGWMTTKPQPPRPPAPWDQF----APPAL-TLLQGLLDLDPETRSPPLAVFDVL
   .. | |. ||...  .   .  ......   .. |  ..       |||| .           .|... .. .   . ||| |    .. . .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SgK110.AA CDC2 43-78 41 3.4e-09 23.85 In-house 1-36 (301) Show / Hide 
Range on Protein: 43-78
Range on HMM: 1-36/301
Sequence Identity: 41% (15 aa)

YRLIRKLGSGSYGRVLLAQPRQGGQTVALKLLRRDS
|  |.|.| |.|| |  .. .| .| ||||  | ..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQ
Kinase SgK110.AA CDC2 131-188 34 5.1e-09 23.31 In-house 96-151 (301) Show / Hide 
Range on Protein: 131-188
Range on HMM: 96-151/301
Sequence Identity: 34% (20 aa)

QEKGLPELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLVFDPDCNRVALGDLGLTR
..| .|.  || .  |.  ...|.| |. .| | ||.| |. | . | . ..| || |
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI-DKKGN-IKIADFGLAR
Kinase SgK110.AA MARK 43-74 37 1e-06 17.68 In-house 1-32 (262) Show / Hide 
Range on Protein: 43-74
Range on HMM: 1-32/262
Sequence Identity: 37% (12 aa)

YRLIRKLGSGSYGRVLLAQPRQGGQTVALKLL
|.... .| |||. | ||. .  |. ||.| .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIY
Kinase SgK110.AA NuaK 119-177 33 1e-06 12.88 In-house 79-137 (252) Show / Hide 
Range on Protein: 119-177
Range on HMM: 79-137/252
Sequence Identity: 33% (20 aa)

EFAPCGDLSGMLQE-KGLPELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLVFDPDCN
|.|  |.|   . | | |||  ....  | . |. . |  . .| | |  |.|  | .||
EYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILL-DQNCN
Kinase SgK110.AA MARK 221-243 47 5e-06 15.75 In-house 185-207 (262) Show / Hide 
Range on Protein: 221-243
Range on HMM: 185-207/262
Sequence Identity: 47% (11 aa)

PAVDSWALGVLLFCAATACFPWD
|.|| |.|||.|.   . .||.|
PKVDIWSLGVVLYFMVCGYFPFD
Kinase SgK110.AA MARK 119-171 32 2.2e-05 13.75 In-house 82-137 (262) Show / Hide 
Range on Protein: 119-171
Range on HMM: 82-137/262
Sequence Identity: 32% (18 aa)

EFAPCGDLSGMLQEK---GLPELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLV
| |. |.| . ....    |.|   .||  |.  |. ..| .. || | ||.|.|.
EYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI
Kinase SgK110.AA Pkinase_Tyr 43-87 24 4.9e-05 17.69 Pfam 1-53 (270) Show / Hide 
Range on Protein: 43-87
Range on HMM: 1-53/270
Sequence Identity: 24% (13 aa)

YRLIRKLGSGSYGRVLLAQPR----QGGQTVALKLLRRDSVLR----TTFLRE
 ....|||.|..|.| ..  .    .....|| | |. ..  .      |.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMRE
Kinase SgK110.AA NuaK 221-233 69 0.000215 6.87 In-house 178-190 (252) Show / Hide 
Range on Protein: 221-233
Range on HMM: 178-190/252
Sequence Identity: 69% (9 aa)

PAVDSWALGVLLF
| ||.|.|||||.
PEVDCWSLGVLLY
Kinase SgK110.AA CAMKL 221-245 36 0.000319 9.21 In-house 215-239 (297) Show / Hide 
Range on Protein: 221-245
Range on HMM: 215-239/297
Sequence Identity: 36% (9 aa)

PAVDSWALGVLLFCAATACFPWDVA
|.|| |..||.|.   .  .|.| .
PKVDIWSCGVILYAMVCGYLPFDDD
Kinase SgK110.AA CAMK 221-294 22 0.001325 6.69 In-house 313-413 (425) Show / Hide 
Range on Protein: 221-294
Range on HMM: 313-413/425
Sequence Identity: 22% (23 aa)

PAVDSWALGVLLFCAATACFPWDVA-LAPDPE--------FEAFAGWMTTKPQ-PPRPPAP---------WD--------QFAPPALTLLQGLLDLDPET
|..| |..||.|.   . ..|..      ..|         | |   |. | . || .  |         ||        .. . .  |....|  ||| 
PKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEK

R
|
R
Kinase SgK110.AA Pkinase_Tyr 119-161 22 0.26629 5.03 Pfam 87-134 (270) Show / Hide 
Range on Protein: 119-161
Range on HMM: 87-134/270
Sequence Identity: 22% (11 aa)

EFAPCGDLSGMLQEK-----GLPELMVKRIVAQLAGALDFLHGRGLVH
|..|.|||   |...      |.  .   . .| | ....|. ....|
EYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH