Gene SRPK1 (Mouse)

SRPK1

Species: Mouse
Alias: Srpk1, SRPK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 567 Kinase domain by global Sugen HMM Fasta, JSON
SRPK1.NA RNA Sugen 2484 None Fasta, JSON
SRPK1.AA Protein Sugen 648 None Fasta, JSON

Protein domain

Protein domains of SRPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK1.AA SRPK 80-646 52 0.0 1166.25 In-house 1-554 (554) Show / Hide 
Range on Protein: 80-646
Range on HMM: 1-554/554
Sequence Identity: 52% (316 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPN---------------------DPNGEMVVQLLDDFKISGVNG
|||||||||||||||||.||.|....||||.||||.||||||.|||.||..||..|||                     ||| ..||||||.||..|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

THICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQ--
.|.|||||||||.|||||...||||.|..|||.|..|||.||||||.||.||||||||||.||.||..||.|.|||.||||..|...||.|.|.||||  
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

-PKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVDRPLTENPPNKMTQEKLEESNSIGQDQTLTERGGEGGAPEIN
 .....|||||||||.|||||.|.|..||..|....||......  ..|.||......|.....|..|.|..|..|..| ..|........ .....|..
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDN--EDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQE

CNGVIGVVNYPENSNNETLRHKEDLHNANDCDVHTLKQEPSFLNSSNGDSSPSQDTDSCTPT---ASETMVCQSS--AEQSLTRQDITQLEESIRADTPS
|..|....|.                             |.|. |.| ||...|.|.||...   ...||.||.|   .... .|.... ..|......|
CQNVQKQNND-----------------------------PNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECES

GDEQEPNGALDSKGKFSAGNFLINPLEPKNAE---KLQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPH
 |.||.           ||.|| ....|.||.   |...||||||||||||.|||||||||||||.||.||.||||||||||||||||||||||||||||
EDMQEQ-----------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPH

SGEDYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWL
|||||.||.||||.||||.||.|......||||.|||.|||.|.||.|||||.|..||.|||||..|||. |.|||.|||...|||||||.|||.||||
SGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SRPK1.AA CMGC 80-646 14 5e-125 413.11 In-house 1-513 (513) Show / Hide 
Range on Protein: 80-646
Range on HMM: 1-513/513
Sequence Identity: 14% (113 aa)

YHVIRKLGWGHFSTVWLSWD--------------IQGKKFVAMKVVKSAEHYTE-------------TALDEIRLLKSVR----------NSDPNDPNGE
|..|.|.|.|....|.  .|              ......||.| .|... |.|             .||.||..|| ..          . ||.... .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

MVVQLLDDFKISGVNGT-------------HICMVFEVLGHHLLKWIIKSN--YQG------------------------LPLPCVKKIIQQVLQGLD--
 .|.|.| |. .. .|.             |...||| ..| |.. | . .  |||                        ... ... ...|.|.||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHTKC-RIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
|.| .. .|||.|.||||||.. | ..|.|. .    | .|     .                                                     
YCHSHWGNIIHRDLKPENILINHNCELITRM-M----W-KS-----E-----------------------------------------------------

KRPNKQEESESPVDRPLTENPPNKMTQEKLEESNSIGQDQTLTERGGEGGAPEINCNGVIGVVNYPENSNNETLRHKEDLHNANDCDVHTLKQEPSFLNS
                                                                                                    
----------------------------------------------------------------------------------------------------

SNGDSSPSQDTDSCTPTASETMVCQSSAEQSLTRQDITQLEESIRADTPSGDEQEPNGALDSKGKFSAGNFLINPLEPKNAEKLQVKIADLGNACWVHKH
                                                                     . . ||.    ... ..||.| |.|.|.|.|
---------------------------------------------------------------------D-W-NPC----QKNGRLKICDFGLARWYHPH

------------------------FTEDIQTRQYRSLEVLIGSG----------YNTPADIWSTACMAFELATG--------DYLFEPHSGE-----DYT
                        .|....|| ||. |.|.|..          |.|| |.|| .|. .|. ||        ..|| .||..     ...
SDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGK

RDEDHIALIIELLGKVPRKLIVAGK-------YSKEFFTKKGDLKHITKLK-------------------------PWGLLEVLVEKYEWPQE-------
.. |....|...||. . ..| .||       ...|...... . .....|                         ||     . ... | ..       
SHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKK

-------------------------EAAGFTDFLLPMLELMPEKRATAAECLRHPWL
                         .   . |.|  ||.. |.|| ||...|.||..
AMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SRPK1.AA CLK 80-646 16 2.6e-62 185.34 In-house 1-350 (350) Show / Hide 
Range on Protein: 80-646
Range on HMM: 1-350/350
Sequence Identity: 16% (95 aa)

YHVIRKLGWGHFSTVWLSWDIQG-KKFVAMKVVKSAEHYTETALDEIR-LLKSVRNS-DPNDPNGEMVVQLLDDFKISGVN-GTHICMVFEVLGHHLLKW
| .. .|| | |..|   || .  ||.|| |.....| |.| |  ||.  .|.. .  |||  . | .....| |.    . . |||.||| .|  .   
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFD----YGHGHICIVFELYGLSIYDF

IIKSN------YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNE--QYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNK
. . |      |...|.  ....  | .. .  || . ...||| |||||.. |..  ....      ..   .                          
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICF-VDSRFTHFDCTFKYNHKKKIN--------------------------

KKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVDRPLTENPPNKMTQEKLEESNSIGQDQTLTERGGEGGAPEINCNGVIGVVNYPE
                                                                                                    
----------------------------------------------------------------------------------------------------

NSNNETLRHKEDLHNANDCDVHTLKQEPSFLNSSNGDSSPSQDTDSCTPTASETMVCQSSAEQSLTRQDITQLEESIRADTPSGDEQEPNGALDSKGKFS
                                                                                                    
----------------------------------------------------------------------------------------------------

AGNFLINPLEPKNAEKLQVKIADLGNAC---WVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIE
.     .  . .  . . ... | |.|      | | .. ..||.||  ||  | |...| |.|| .|  ||| ||. ||  |.        .| |.. .
KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMER

LLG-KVPRKLIVAG---KYSKEFF---TKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWL
..|  .|   | .    | ....|      .| .  .  .     . | .  .  ..|.  . | .  |||  | || |... | ||. 
IMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase SRPK1.AA S_TKc 80-646 13 3.7e-49 170.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 80-646
Range on HMM: 1-231/231
Sequence Identity: 13% (78 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGH---HLLKWI
|...||.| | |..|.. ...  .. ||.|..|      |... ||..||.      . ||   .|.|.| |       .|..||.| ...    |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPN---IVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IKSNYQG----LPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRR-------LAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSK
 | ...|    .|   ......|....|.|.| . .||| |.|||||||.       .       ||..                               
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE------HIKICDFGLARQL------------------------------

NKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVDRPLTENPPNKMTQEKLEESNSIGQDQTLTERGGEGGAPEINCNGVIGVVNY
                                                                                                    
----------------------------------------------------------------------------------------------------

PENSNNETLRHKEDLHNANDCDVHTLKQEPSFLNSSNGDSSPSQDTDSCTPTASETMVCQSSAEQSLTRQDITQLEESIRADTPSGDEQEPNGALDSKGK
                                                                                                    
----------------------------------------------------------------------------------------------------

FSAGNFLINPLEPKNAEKLQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNT-PADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIE
                                    |  . |. |.. |||   ||.. ..|.||  |. .|...|  .|.            .......
------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFK

LLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLR-------HPWL
..|                                                   . ||.  .|.  |||| || |.|.       |||.
KIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRPK1.AA DYRK 479-646 28 5e-32 112.73 In-house 138-320 (320) Show / Hide 
Range on Protein: 479-646
Range on HMM: 138-320/320
Sequence Identity: 28% (55 aa)

KNA-EKLQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAG
|..  | ..|..| | .| .|....  || | ||. ||..|  |... |.||  |   || ||  ||   .||..    | .|.|.|.||. |...| .|
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKG

--KYSKEFFTK---------KGDLK----------HITKLKPWGLLEVLVE-KYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWL
  .. ..||..         ..  |          |.||    ...      ...    .   |.||.. .|...|.|| |... |.|||.
RCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK1.AA DYRK 80-221 32 5.9e-31 109.17 In-house 1-137 (320) Show / Hide 
Range on Protein: 80-221
Range on HMM: 1-137/320
Sequence Identity: 32% (47 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEM-VVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIK
| ..  .| | |. |   || .... ||.|.... . .  .|..||..|.  ..    ||. .. .|...| |.  .    | |.||| |   |   . .
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ---DPDDKYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFLKN

SNYQGL-PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL
 . ||. .|  |.|..||.|..|..||.. .||| |.|||||.|
NHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML
Kinase SRPK1.AA DYRK2 80-221 35 2.9e-27 85.42 In-house 1-135 (318) Show / Hide 
Range on Protein: 80-221
Range on HMM: 1-135/318
Sequence Identity: 35% (51 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS
| .   .| | |  |    |   |..|| |..     . ..|. ||| |.  |  |..  |   .| .|| |   .    |.|..|| |.  | . | | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD--NTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL
..||. |  | . ....||.|. || | .||| | |||||||
HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENILL
Kinase SRPK1.AA Pkinase 80-222 28 4.1e-23 82.81 Pfam 1-142 (293) Show / Hide 
Range on Protein: 80-222
Range on HMM: 1-142/293
Sequence Identity: 28% (45 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALD------EIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGH---
||..||.| | |..|..  ..   | ||.|..|   |  .  .       ||...|...         . .|.|.| |      ..||.||.| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLY

--HLLKWIIKSNYQGL--PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLS
   |  .|  ... ..  .   .|... |.|.||.|.|  ..||| |.||||||..
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID
Kinase SRPK1.AA CAMKL 80-222 21 2.8e-22 67.76 In-house 1-161 (297) Show / Hide 
Range on Protein: 80-222
Range on HMM: 1-161/297
Sequence Identity: 21% (37 aa)

YHVIRKLGWGHFSTVWLSWD-IQGKKFVAMKVVKSAEHYTETALD----------------EIRLLKSVRNS-DPNDPNGEMVVQLLDDFKISGV---NG
| ... || |.|..| | .. .  .. ||.|...      ..  .                ||...|.....  ||      ...|.. .  .     . 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPN------IIKLYEVIETPEHDIET-

THICMVFEVLGHH---LLKWIIKSNYQG--LPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLS
..|..| |  .     |. .|.|  . .  .| .  ... .|.. ...|.| .. |.| |||||||||.
KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLD
Kinase SRPK1.AA CDC2 80-222 31 5.7e-22 63.84 In-house 1-137 (301) Show / Hide 
Range on Protein: 80-222
Range on HMM: 1-137/301
Sequence Identity: 31% (47 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTE-----TALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGHHLLK
|  |.|.| | .  |    | | .. ||.| ..      .     ||. || .||  .    ..||   .|.| | ...       . |||| | ..| |
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK----DHPN---IVKLHDVIHQ-----NKLYMVFEYLDMDLKK

WIIKSNY--QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLS
   .|.   . .|.  ||... | |||....|.. ||.| |.|| |||..
YMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQR-RIMHRDLKPQNILID
Kinase SRPK1.AA DYRK1 80-221 32 1.1e-21 72.48 In-house 1-137 (321) Show / Hide 
Range on Protein: 80-221
Range on HMM: 1-137/321
Sequence Identity: 32% (46 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS
| ..  .| | |  |   .| | ...||.|..|    . . |. |||||  . . |..  .   .|.|   |.       |.|.|||.|   |   .   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKE--MKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT

NYQGLPLPCVKKIIQQVLQGLDYLHT-KCRIIHTDIKPENILL
...|  |  ..|. ||... | .. |    ||| |.|||||||
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL
Kinase SRPK1.AA DYRK2 479-588 31 1.7e-19 59.8 In-house 136-245 (318) Show / Hide 
Range on Protein: 479-588
Range on HMM: 136-245/318
Sequence Identity: 31% (37 aa)

KNAEKLQVKIADLGNACWVHK-HFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAG
| . .  .|..| |  | .|  ..  .||.| ||. || .|  |... |.||  | . || ||  ||    ||..    | .|...|.||. |.|..   
KQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLGMPPKKFFDTW

-----KYSKEFFTKKG
     .. | ||....
FYIHCFRRKYFFNSHC
Kinase SRPK1.AA DyrkP 479-587 36 1.7e-17 53.57 In-house 140-242 (323) Show / Hide 
Range on Protein: 479-587
Range on HMM: 140-242/323
Sequence Identity: 36% (40 aa)

KNAEKLQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAGK
|   | |||| | | .|..| |    .| | ||  ||.||  |    |.||  |.  || ||  ||      |       .| .| ..| .|  ..  |.
KSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQ----NDNIQ--GLLARVIGIIGPFPEWMMQEGR

YSKEFFTKK
  . |||.|
LVQNFFTRK
Kinase SRPK1.AA Pkinase 482-646 20 6.6e-17 60.85 Pfam 143-293 (293) Show / Hide 
Range on Protein: 482-646
Range on HMM: 143-293/293
Sequence Identity: 20% (37 aa)

EKLQV----KIADLGNAC---WVHKHFTEDIQ-TRQYRSLEVLI-GSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLG---KV
.. ..    ||.| | |.   . ... . ..  |. |.. ||.  |..| ...|.||  |. .|...|  .|  ... .  .  |....| . .|   . 
NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHF

PRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWL
..     . |.. |.. .               . . ....|..|    . ||.  .|.. |.|| ||...| |||.
DWPWWCSISYFF-FRH-W-H-------------F-HWTFHNWSEE----CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK1.AA DYRK1 480-595 33 3e-16 53.12 In-house 139-248 (321) Show / Hide 
Range on Protein: 480-595
Range on HMM: 139-248/321
Sequence Identity: 33% (39 aa)

NAEKLQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAGKY
|. . ..|| | | .| . .   . || | ||| |||.|  |..  |.||  |.  |. ||. ||   || .   . | .  |.| ||  |...|  .  
NPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPK

SKEFFTKKGDLKHITK
.. .|.|. |  .  |
AHKYFEKDPDNTWYCK
Kinase SRPK1.AA CDK4 80-226 27 1.3e-15 49.81 In-house 1-148 (290) Show / Hide 
Range on Protein: 80-226
Range on HMM: 1-148/290
Sequence Identity: 27% (43 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYT-----ETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNG--THICMVFEVLGHHL
|  .  .| | . ||.   |..  .||| | |.              . || ...    .  . ||   .|.|.| .. . . .  . | ||||     |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQF--EHPN---IVKLMDVCHVMDTDRAEMKITMVFEHCDWDL

LKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQ
  .. |    |.| . .|..  | | |.|.||. . ||| | ||.|||.. . .
HTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILVTSDGH
Kinase SRPK1.AA DyrkP 189-221 57 6.8e-09 24.71 In-house 108-139 (323) Show / Hide 
Range on Protein: 189-221
Range on HMM: 108-139/323
Sequence Identity: 57% (19 aa)

VKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL
..|| ||.| .|||.|   |.|| |.||||||.
LQKITQQILIALDYIHS-LRLIHCDLKPENILM
Kinase SRPK1.AA DYRK2 619-646 39 2.3e-08 22.97 In-house 291-318 (318) Show / Hide 
Range on Protein: 619-646
Range on HMM: 291-318/318
Sequence Identity: 39% (11 aa)

FTDFLLPMLELMPEKRATAAECLRHPWL
|.||..  .| .|..| |... |.|||.
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK1.AA CDK4 510-537 53 2.9e-08 24.21 In-house 175-202 (290) Show / Hide 
Range on Protein: 510-537
Range on HMM: 175-202/290
Sequence Identity: 53% (15 aa)

YRSLEVLIGSGYNTPADIWSTACMAFEL
||. |||  | |||| |.|| .|  .|.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM
Kinase SRPK1.AA CAMKL 626-646 47 1.4e-07 20.08 In-house 277-297 (297) Show / Hide 
Range on Protein: 626-646
Range on HMM: 277-297/297
Sequence Identity: 47% (10 aa)

MLELMPEKRATAAECLRHPWL
||.  ||||.|. . ..|||.
MLQVNPEKRPTIHQIMNHPWM
Kinase SRPK1.AA CDC2 621-646 46 2.8e-07 17.88 In-house 276-301 (301) Show / Hide 
Range on Protein: 621-646
Range on HMM: 276-301/301
Sequence Identity: 46% (12 aa)

DFLLPMLELMPEKRATAAECLRHPWL
| |  || . |.|| .| | |.||..
DLLMQMLQYDPQKRISAKEALQHPYF
Kinase SRPK1.AA TyrKc 80-444 11 8.1e-07 -112.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 80-444
Range on HMM: 1-280/280
Sequence Identity: 11% (50 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSV--RNSDPNDPNGEMVVQLLDDFKISGVNG---THICMVFEVLGHHLLK
 . ..||| |.| .|..   .     || |..|.     |  ..|.|.....  ..        . .|.|.     .| |      ...|.|   |  ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

WIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNE-----------------------QYI-------RR-------LAAEATE
  ....   |...   ..  |. .| .||| | ..|| |.   |.|.. |                        .|.       ..       .| |.  
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

WQRS---------------------GAPPPSG------SAVSTAPQPKPADKMSKNKK----KKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQ
 . .                     |..|..|      |.     . |  . | . .                                           
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------

EESESPVDRPLTENPPNKMTQEKLEESNSIGQDQTLTERGGEGGAPEINCNGVIGVVNYPENSNNETLRHKEDLHNANDCDVHTLKQEPSFLNSSNGDSS
                                                                                                    
----------------------------------------------------------------------------------------------------

PSQDTDSCTPTASETMVCQSSAEQSLTRQDITQLEESI
 .     | |..  ..  |  .|.   |   ... | .
-F----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SRPK1.AA CDK4 621-646 42 3e-06 17.26 In-house 265-290 (290) Show / Hide 
Range on Protein: 621-646
Range on HMM: 265-290/290
Sequence Identity: 42% (11 aa)

DFLLPMLELMPEKRATAAECLRHPWL
|.|. ||   ..|| .| .|| ||..
DLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase SRPK1.AA CDC2 498-544 33 4e-06 14.38 In-house 157-209 (301) Show / Hide 
Range on Protein: 498-544
Range on HMM: 157-209/301
Sequence Identity: 33% (18 aa)

HKHFT--EDIQTRQYRSLEVLIGSG-YNTPADIWSTACMAFEL---ATGDYLF
..  |   .. |. ||. |.| |.  |.|| |.||  |   |.   .|  .||
IRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLF
Kinase SRPK1.AA DyrkP 80-129 30 5e-06 15.0 In-house 1-50 (323) Show / Hide 
Range on Protein: 80-129
Range on HMM: 1-50/323
Sequence Identity: 30% (15 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLK
| ..  ||   ||      | |  . . ||..     | . ..|||.||.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR
Kinase SRPK1.AA DyrkP 619-646 42 2.5e-05 12.73 In-house 296-323 (323) Show / Hide 
Range on Protein: 619-646
Range on HMM: 296-323/323
Sequence Identity: 42% (12 aa)

FTDFLLPMLELMPEKRATAAECLRHPWL
| ||   .| .   .| || | |.|||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase SRPK1.AA DYRK1 619-646 32 0.000641 9.09 In-house 294-321 (321) Show / Hide 
Range on Protein: 619-646
Range on HMM: 294-321/321
Sequence Identity: 32% (9 aa)

FTDFLLPMLELMPEKRATAAECLRHPWL
| | .. ||.  |..| |  . |.|...
FKDLIKRMLQYDPKQRITPYYALQHSFF