Gene TTK (Mouse)

TTK

Species: Mouse
Alias: TTK, Ttk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: TTK

Sequence

Name Sequence Type Origin Length Description Download
TTK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
TTK.NA RNA Sugen 2904 None Fasta, JSON
TTK.AA Protein Sugen 830 None Fasta, JSON

Protein domain

Protein domains of TTK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TTK.AA TTK 498-764 54 1e-215 720.74 In-house 1-344 (344) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-344/344
Sequence Identity: 54% (188 aa)

YSILKQIGSGGSSKVFQVLNE-KKQINAIKYVNLEDADSQTIESYRNEIAFLNKLQQHSDKIIRLYDYEIT--EQYIYMVMECGNIDLNSWLKKKK---S
|||.||||.||||||||||.| .|.|.|.|||.|..||.|||..|.|||..||||||..|.||.|||||.|  |||||||||||..|||.||.|.|   .
YSIIKQIGCGGSSKVFQVLSEDSKKIYALKYVCLDFADPQTIQGYMNEIEMLNKLQQQKDCIIQLYDYEMTMEEQYIYMVMECGDCDLNKWLQKYKTPMN

INPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGIANQMQP-DTTSIVKDSQVGTVNYMAPEAIRDMSSSRENSKI----------
.|||....||..||..||.|||||||||||||||||.|.||||||||||||..|. |||.|||.||.||.|||.||||.|||...||...          
LNPWFMWCYWQQMLQCVHVIHQHGIVHSDLKPANFVMVQGMLKLIDFGIANAIQNDDTTNIVKESQIGTFNYMSPEAIQDMSYGNENMCMHHKKPRLKIN

------------------RT------------------------------------KVSPRSDVWSLGCILYYMTYGRTPFQHIINQVSKLHAIINPAHE
                  ||                                    |.|..|||||.|||||||.||.||||||.||.||.|||.||.|.
CKSDVWSLGCILYSMVYGRTKFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVWKISCKSDVWSCGCILYYMIYGKTPFQHIQNQYSKMHAICNPHHK

IEFPEIS------EKDLRDVLKCCLVRNPKERISIPELLTHPYV
|||||..      .|.|..|.||||.||||.|.||||||.||..
IEFPEHPPYYEKINKMLIHVMKCCLYRNPKKRWSIPELLNHPFH
Kinase TTK.AA Pkinase 498-764 27 3e-84 290.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-293/293
Sequence Identity: 27% (86 aa)

YSILKQIGSGGSSKVFQVLNEKKQI-NAIKYVNLEDADSQTIESYRN--EIAFLNKLQQHSDKIIRLYDYEITEQYIYMVMECGNI-----DLNSWLK--
| |...||||....|..  . . ..  |.| .......|.  .. |.  ||. ...|.  .. |.||||.  ....||||||. .      || ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KKKSI--NPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIV-DGML----KLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENSKI
.....   .|| |.|.. .|...  .|..||.| ||||.|. |. .| .    |..|||.| |..    .   .. .|| .||||| ||           
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----------G

RTKVSPRSDVWSLGCILYYMTYGRTPFQHI-----INQVSKLHAIINPAHEIEFPEISE-------------------KDLRDVLKCCLVRNPKERISIP
... .|..|.||.|||||.|  ||.||..      ..|  ..  |  |  . ..|. ..                   ....|..|.|| ..||.|....
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELLTHPYV
..| ||..
QILQHPWF
Kinase TTK.AA S_TKc 498-764 28 6.9e-80 272.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-231/231
Sequence Identity: 28% (81 aa)

YSILKQIGSGGSSKVFQVLNEK-KQINAIKYVNLEDADSQTIESYRNEIAFLNKLQQHSDKIIRLYDYEITEQYIYMVMECGNI---DLNSWLKKKKS--
| ||..||.|. .||... . | ..| ||| ..         |. |.||. | |   | . |..|||.  . ...|||||. .    || . .||...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----INPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSSRENSKIRTKVSP-
    ... . ..| . ...|.  .|.|||.| ||||.|  . .  .|..|||.| |.         ....|| .||||| .              . .. 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------------GYGKC

RSDVWSLGCILYYMTYGRTPFQHIINQVSKLHAIINPAHEIEFPEISEKDLRDVLKCCLVRNPKERISIPELLT-------HPYV
..|.||.||||| | .|..||.    |. ..  .|             ....| .. ||...|..|... |.|.       ||..
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TTK.AA CAMK 503-764 18 3.1e-57 182.66 In-house 1-425 (425) Show / Hide 
Range on Protein: 503-764
Range on HMM: 1-425/425
Sequence Identity: 18% (80 aa)

QIGSGGSSKVFQVLNEKKQ--IN-----------AIKYVNLEDAD--------------------------SQTIESYRNEIAFLNKLQQ-----HSDKI
..|.|. .||. . . . .  ..           ||| .. . ..                           .. .. |.||. ..|||.     .   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYDYEIT-------------------EQYIYMVM------ECGNI--DLNSWLKKKKS---------------INPWERKSYWKNMLEAVHIIHQHGI
|.||..  .                   ....||||      . |    || ........               .. .| . | . ...||| .|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHSDLKPANFVIVD------------------GMLKLIDFGIANQMQPDTTSI---------------------VKDSQVGTVNYMA-PEAIRD--MSSS
|| |||| |  ..|                  . .|.|||| ||...|.  .                          ..||  ||| || ..   ....
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

RENSKI----RTKVSPRSDVWSLGCILYYMTYGRTPFQHI------------INQVSKLHAIINPAHEIEFPE---------------ISEK-------D
   . .    .. ..| .|.||.|.||| |  |. ||..              |.   .. |..   . . |.               ||.        .
Q--N-ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

LRDVLKCCLVRNPKERISIPELLTHPYV
 .| ....|...|..|..| . | || .
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TTK.AA ULK 498-764 24 3.4e-49 169.76 In-house 1-329 (329) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-329/329
Sequence Identity: 24% (83 aa)

YSILKQIGSGGSSKVFQVLNEKK-----QINAIKYVNLEDADSQT--------IESYRNEIAFLNKLQQH--SDK----IIRLYDYEITE--QYIYMVME
|.. ...|.|   ||..  |.|.     .. |.| . ..  . .         ... .|||  . || .   .      |..|||.  |    .||..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

CGNI-DLNSWLKKKKS----------INPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDG-------------MLKLIDFGIANQMQPD-TTSI
  |  || . .||.|           ..  | ... |  |..   .|.|.|.| |.||.|  | .|              ||. ||| | ... |     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VKDSQV------GTVNYMAPEAIRDM--SSSRENSKIRTKVSPRSDVWSLGCILYYMTYGRTPF--QHIINQV-----SKLHAIINPA-----HEIEFP-
.  ..|      ||  ||||. . ..       ..|        .|.||||||.|.| ||..||  . .  |.     . .    ...     . ..|| 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYK--------CDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPK

----EISEKDLRDVLKCCLVRNPKERISIPELLTHPYV
     .  ....| ....|....|.|||..||. || .
DGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase TTK.AA ULK 498-764 24 2.4e-48 166.91 In-house 1-324 (324) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-324/324
Sequence Identity: 24% (83 aa)

YSILKQIGSGGSS-KVFQVLNEKK----QINAIKYVN---LEDADSQ-----TIESYRNEIAFLNKL----QQHSDKIIRLYDYEITE--QYIYMVMECG
|.. ...|.|    ||..  |.|.    |. |.| ..   . .  ..      ... .|||  . ||     ..   |..|||.  |    .||..||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

NI-DLNSWLKKKKS---------INPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDG-------------MLKLIDFGIANQMQPD-TTSIVKD
|  || . .||.|          ..  | ... |  ...   .|.|.|.| |.||.|  | .|              ||. ||| | . . .     .  
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SQV------GTVNYMAPEAIRDM--SSSRENSKIRTKVSPRSDVWSLGCILYYMTYGRTPF--QHIINQV----SKLH-----AIINPAHEIEFP---EI
..|      ||  ||||. . ..       ..|        .|.||||||.|.| ||..||  . . .|.    . ..      |.     |.||   ..
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYK--------CDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

SE--KDLRDVLKCCLVRNPKERISIPELLTHPYV
    ....| ....|....|.|||..|.. || .
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase TTK.AA Ciliate-E2 498-764 20 4.8e-48 163.02 In-house 1-365 (365) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-365/365
Sequence Identity: 20% (79 aa)

YSILKQIGSGGSSKVFQV--LNEKKQI-----------------NAIKYVNLEDADSQTIESYRNEIAFLNKLQ--QHSDK---------------IIRL
| ..|.||.|. ..|...   ...||.                 ..||.....    . ||.  .||  .....  .   |               ||..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFY---KKINEKNILEQLNHPNIIKM

YDYEI--TEQYIYMVME-CGNIDLNSWLKKK-----------KSINPWERKSYWKNMLE---------------AVHIIHQHG-IVHSDLKPANFVIVDG
|.. .  ....||.||| |   || ...|..           |...  |.| . |  |.               |.. .|. . |.| |.|| | ..   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

MLKLIDFGIANQMQPD---------------------TTSIVKDSQ----------VGTVNYMAPEAIRDMSSSRENSKIRTKVSPRSDVWSLGCILYYM
 .|.||||.. . ..|                     |... .  |          .|| .||||| ..  . . .  . ..  .  .|.||||.|||.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMD--QIIQQNMFNTICGTPGYMAPEILNGKKYDNQ--QKQKGYDYKCDIWSLGVILYEM

TYGRTPFQHIINQVSKLHAIINPAHEIEFP------------------EISEKDLRDVLKC----CLVRNPKERIS-IPELLTHPYV
 .|..||            ...   .|.||                  .  ...  | .|     .|...|..||. . ..| ||. 
LFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TTK.AA STE 498-764 18 3.7e-47 162.97 In-house 1-359 (359) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-359/359
Sequence Identity: 18% (68 aa)

YSILKQIGSGGSSKVFQVLNEK----------------KQINAIKYVNLEDADS---------------QTIESYRNEIAFLNKLQ-QHSDKIIRLYDYE
. ....||.|.. .|.. .| |                ..| ||| .|||. ..               . .... .|| ...|..   .. |.. |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

ITE-------QYIYMVMECGN-IDLNSWLKKKKSINP--------------WERKSYWKNMLEA-VHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGIAN
. |       ......||  .   | . .|.|....                . . . .  |..  . .|.|.|.| |.||||  .     ||.|||.. 
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

QMQPD--------------TTSIVKDSQVGTVNYMAPEAIRDMSSSRENSKIRTKVSPRSDVWSLGCILYYMTYGRTPFQH-IINQVSKLHAIINPAHE-
|....              |..   .. |||  .|||| |. ....      . . . ..|.||||| .  |  |. |.      ..  . .. . ... 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

--------IEFPEISE----------------------KDLRDVLKCCLVRNPKERISIPELLT--HPYV
         . | . .                      ....| .. ||...|..| .  .||   || .
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TTK.AA CAMKL 498-764 25 5.7e-45 141.36 In-house 1-297 (297) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-297/297
Sequence Identity: 25% (80 aa)

YSILKQIGSGGSSKVFQVLN-EK-KQINAIKYVN--LEDADSQTIESYRN-----------EIAFLNKLQ----QHSDKIIRLYDYEITEQY------IY
| |.|..| |. .||   ..    ..  ||| ..      | ..    ..           ||. . .|.    ..   ||.||.   |...      ||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPN---IIKLYEVIETPEHDIETKKIY

MVMECGN---IDLNSWLKKK----KSINPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIV-DG--MLKLIDFGIANQMQP--DTTSIVKDSQVGTV
.|||      .||  ...|.    ... ..| . | . ...||. .|.||||| |.|| |  .  .|   .|.|||| .|...|  ...    . . |. 
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

NYMAPEAIRDMSSSRENSKIRTKVSPRSDVWSLGCILYYMTYGRTPFQ--HII-----NQVSKLHAIINPAHEI-EFPEISEKDLRDVLKCCLVRNPKER
.||||| . .          .    |  |.||.| ||| | .|. ||   ..      |.  ... |.   ...  ....|  |.|| ..  |..||..|
PYMAPEIFQGN--------NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS--DCRDLIRKMLQVNPEKR

ISIPELLTHPYV
..| ... || .
PTIHQIMNHPWM
Kinase TTK.AA Ciliate-E2-Unclassified 498-764 21 1.2e-44 152.85 In-house 1-352 (352) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-352/352
Sequence Identity: 21% (78 aa)

YSILKQIGSGGSSKVFQVLNEKKQ--------INAIKYVNLEDADSQTIESYRNEIAFLNK---------------LQQHSDKIIRLYDYEITEQYIYMV
| |.||||.|| .||... ..|..        . ...|  .    .. ...   .. . .|               |.  .  |....... ..|.||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

ME-CGNIDLNSWLKKKKS-----------------INPWERK-----SYWKNMLEAV-HIIHQHGIVHSDLKPANFVIVDGM----LKLIDFGIANQMQP
|| | . ||  ..||.|.                 .   . |      | .  |..  ...|...|.| |.|| | .. ...    .|.|||||. . | 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

DTTSIVKD--------------SQVGTVNYM----APEAIRDMSSSRENSKIRTKVSPRSDVWSLGCILYYMTYGRTPFQ---HIINQVSK---------
.  .  ..              ...|| |||    ||| ..    . . .         .|.||||.|||.| .|. ||.    ...|...         
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYR

--LHAIIN------PAHEI-EFPEISEKDLRDVLK----CCLVRNPKERISIPELLTHPYV
  |. .|.      | ..  ..| .. .   | ..    ..|. ||..||.....| ||. 
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase TTK.AA CMGC 498-764 15 1.3e-40 130.53 In-house 1-513 (513) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-513/513
Sequence Identity: 15% (78 aa)

YSILKQIGSGGSSKVFQVLN---------------EKKQINAIKYVNLEDADSQTIE-----------SYRNEIAFLNKLQ---------------QHSD
| |.|.||.|  ..|..  .               | ..| ||| . ..  .  .             ..| || .| .|.               .|  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALR-EIKILKHLNKNHDPNWQRRDDPDNKHHN

KIIRLYDYEITEQ-----------------YIYMVMECGNIDLNSWLKKKK---------SINPWE------------RKSYW------KNMLEAVH--I
 |..|||.  ...                 ..|.|.|.   ||   .|...           .. .             |..       . .|....   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHQHG--IVHSDLKPANFVIVD---------------------GMLKLIDFGIANQMQPDTTSI-------------------VKDSQVGTVNYMAPEAI
.|.|.  |.| ||||.|  | .                     | ||..||| | .  |    .                      ..| |  | ||| .
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

RDMSSSRENSKIRTKVSPRSDVWSLGCILYYMTYG--------RTPFQ----------------HIINQVSKLHAIIN---------------PA-----
  ..   ..  . .. ..  |.||.|||.. |  |        .. |.                . ...  |.   ..               .      
LGWKHYTNH-NYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

---------------------HEIE----------FPEISEKDLR----------------------------------------------DVLKCCLVR
                     . .           ||..  |...                                              | || .|. 
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

NPKERISIPELLTHPYV
.|..||.. . | ||| 
DPDKRITAEQALQHPYF
Kinase TTK.AA CAMK-Unique 498-764 21 3.3e-35 113.51 In-house 1-363 (363) Show / Hide 
Range on Protein: 498-764
Range on HMM: 1-363/363
Sequence Identity: 21% (80 aa)

YSILKQIGSGGSSKVFQVLN-EKKQINAIKYVNLEDAD-SQTIE-----------------SYRNEIAFLNKLQQHSDKIIRLYDY----EITEQ-----
|  .. ||.|. ..|. ... | . . |.| |.....  .  ..                 ....|.. . |.. |   ||.|||.      ...     
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIW-KMVDH-PNIIKLYDWNNPIFCDRKYPLCD

----------YIYMVME-CGNIDLNSWLKK--------------------KKSINP--WERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDG-----
          |.|.||| |   ||..|. |                    . . .   |.  ..    |.||   |. .||| |||. | ..        
LIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

------------MLKLIDFGIANQMQPDTTSIVKD---SQVGTVNYMAP--------------EAIRDMSSSRENSKIRTKVSPRSDVWSLGCILYYMTY
            ..||.|||.. . .   ....     . .||  ||||              | |       .....  ..|| || |||| |.|||  
HHRDFPYDWSNWHIKLCDFGLCCHYN---HNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI-------NMQCYDQQCSPASDIWSLGVIMYYMLC

GRTPFQHIINQ-------VSKLHAIINPAHEI-EFPEISEKD-------LRDVLKCCLVRNPKERISIPELLTHPYV
|..|| .  .        .. . .|   .... .|..  . .       . |..|||... |. |.|. ||| |...
GCPPFDCECEDRDYENHDKEIFECIC--KGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase TTK.AA TyrKc 498-766 18 1.3e-12 -18.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 498-766
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

YSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIESYRNEIAFLNKL-QQHSDKIIRLYDYEITE-------QYIYMVME-CGNIDLNSWLKK
 . .|..|.|   .|..      .  |.| .. .      .|  ..|.  . ||  .| . |.||| . ...       . ...||| . . ||.. |.|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHH-PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KKS-INPWERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDGM-LKLIDFGIANQMQPD------TTSIVK----DSQ-VGTVNYMAPEAIRDMSSSR
..  ... .  |.     .    .|.....| ||   |  . ..   |  ||| .     |      .  ..|    ..  .  .  ||||.|       
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------

ENSKIRTKVSPRSDVWSLGCILY-YMTYGRTPFQHII---NQVSKLHAIINPAHEIEFPEI--------SEKDLRDVLKCCLVRNPKERISIPELLTHPY
       | .. ||||| |  ..  .||| .|   .|      . ... .   .  . |.           ... .. |.|  ..|..| .  |.    .
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----H

VQI
 ..
ECF
Kinase TTK.AA Pkinase_Tyr 637-713 26 0.000598 14.0 Pfam 154-222 (270) Show / Hide 
Range on Protein: 637-713
Range on HMM: 154-222/270
Sequence Identity: 26% (21 aa)

DFGIANQMQPDTTS-IVKDSQVGTVNYMAPEAIRDMSSSRENSKIRTKVSPRSDVWSLGCILY-YMTYGRTP-FQHIINQ
||| |  ...| .   ....    .  ||||.|...             .  ||||| |  ..  .|||..| .. . |.
DFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-----------FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE