VRK3

Species: Mouse
Alias: AI428238, VRK3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CK1
Family: VRK

Sequence

Name Sequence Type Origin Length Description Download
VRK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 295 Kinase domain by global Sugen HMM Fasta, JSON
VRK3.NA RNA Sugen 1790 None Fasta, JSON
VRK3.AA Protein Sugen 453 None Fasta, JSON

Protein domain

Protein domains of VRK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase VRK3.AA VRK 145-411 44 2.3e-171 552.49 In-house 1-284 (284) Show / Hide
Range on Protein: 145-411
Range on HMM: 1-284/284
Sequence Identity: 44% (127 aa)

WTLGALQIRDDQGILYEAEPTSAVPSESRTQKWRFSLKLDSKDGRLFNEQNFFQRVAKPLQVNKWKKQFL------------LPLLAIPTCIGFGIHQDK
| ||  . .. .|..|.| |..  |.|.  |.  .... ....|.||.|..|.||.|||.|..||.|..             ||.|.||.|.|||.|...
WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEP-PHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFN

---YRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVNP-EDLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSP
   |||.|.|..||.||....|...|..|...|||.|||.||.||||||||||||...|.|..... .. .||.||.||..|||||.|||..|||..|..
GEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRC

HDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLP--NTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYL
|.|..||.|||.||||.|||||||..|||||..||||.|||..||.  ..||....|||..|....... |..|.........|.
HNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM

Kinase VRK3.AA CK1 181-428 18 1.8e-56 193.94 In-house 40-339 (339) Show / Hide
Range on Protein: 181-428
Range on HMM: 40-339/339
Sequence Identity: 18% (56 aa)

LKLDSKDGR--LFNEQNFFQRVAKPLQVNKWKK-------QFLLPLLAIPTCIGFGIHQ---DKYRFLVFPSLGRSLQSALD--DNPKHVVSERCVLQVA
.|. .|. .  .. .. ..|...|. . .|| |       .|. .....| .. ...|.   |.|...| . ||..|.. ..   ....  | ...|..|
MKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIA

CRLLDALEYLHENEYVHGNLTAENVFVNP--------------EDLSQVTLVGYGFTY-RYCPGGKHV----------AYKEGSR----SPHDG-DLEFI
...|.||||.|.. ..| .. ..|. .                ... || .. .|.   .|.. ..|.           ...  .     .. |  ... 
IQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYC

SMDLHKGCGPSRRSDLQTLGYCMLKWLYGS--LPWTNCLPNTE-K---ITRQKQKYLDSPERLVGLCGRWNK-----ASETLREYLKVVMALNYEEKPPY
|.. |.|. ..|| || ...|... || |.  |||.|.  ... |   . ..|... | .. .. .. ..         . . ...|....|.|...|.|
SINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDY

ATL
. .
EMI

Kinase VRK3.AA CK1-D 220-428 25 7.6e-13 41.49 In-house 57-261 (261) Show / Hide
Range on Protein: 220-428
Range on HMM: 57-261/261
Sequence Identity: 25% (53 aa)

IPTCIGFGIHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVN-PEDLSQVTLVGYGFTYRYCPGG--
||.   .|   | |  .|   || ||   |    .   | . || .|  ..  .||.| ....|  .  .|  .      . | .. .| . ||      
IPEIRWCGQEGD-YNVMVMDLLGPSLE-DLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTH

KHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMA
.|..|.|       |   . |.  |.|   ||| ||  ||| .. .  |||||      | .   ..        ..  ||  . ..     .|.  .  
QHIPYRE--NKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSE---FQQYMNYCRN

LNYEEKPPYATL
| ...|| |. |
LKFDDKPDYCYL

Kinase VRK3.AA Ciliate-E6 231-293 30 9.9e-11 30.72 In-house 22-86 (154) Show / Hide
Range on Protein: 231-293
Range on HMM: 22-86/154
Sequence Identity: 30% (20 aa)

DKYRFLVFPSLGRSLQSALD--DNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFV
..| | |.......||  .   .| |   .    ....| |. |.|||| . ||..|.| .| |.
ENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFL

Kinase VRK3.AA CK1-A 220-428 25 2.6e-09 28.91 In-house 57-261 (261) Show / Hide
Range on Protein: 220-428
Range on HMM: 57-261/261
Sequence Identity: 25% (55 aa)

IPTCIGFGIHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVNPE-DLSQVTLVGYGFT--YRYCPGG
||.   .|  .| |  .|   || ||   |    |   . . || .|  ..  .||.||  ..|  .  .|  .  .    .. |. .| .  ||     
IPHMRWYGCEKD-YNVMVMDLLGPSLE-DLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTR

KHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMA
.|. |.|       |   . |.. | |   ||| |.  .||.|. .  |.|||     .| |    |         .  ||         .  |.. . .
QHIPYREDKN--LTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLC---KGFPAEFCMYMNYCRN

LNYEEKPPYATL
| .||.| |  |
LRFEEQPDYMYL

Kinase VRK3.AA Jak 258-293 30 5.7e-08 24.33 In-house 116-151 (299) Show / Hide
Range on Protein: 258-293
Range on HMM: 116-151/299
Sequence Identity: 30% (11 aa)

SERCVLQVACRLLDALEYLHENEYVHGNLTAENVFV
.| ...|.|  ......||... |.||.. | |. |
TEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILV

Kinase VRK3.AA UTK 244-294 26 2.6e-07 21.08 In-house 96-152 (296) Show / Hide
Range on Protein: 244-294
Range on HMM: 96-152/296
Sequence Identity: 26% (15 aa)

SLQSALDDNPK------HVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVN
.|.| | ....      | ..... |. |    ....|||.  .||..| | |..|.
DLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVH

Kinase VRK3.AA Ciliate-C3 263-306 31 1e-06 19.88 In-house 99-140 (140) Show / Hide
Range on Protein: 263-306
Range on HMM: 99-140/140
Sequence Identity: 31% (14 aa)

LQVACRLLDALEYLHENEYVHGNLTAENVFVNPEDLSQVTLVGY
||..  .| |..||||   ||| .  .|. .| .|  .. .. .
LQISKQILQAIDYLHEHNIVHGDIKFSNILINSKD--EIKIIDF

Kinase VRK3.AA S_TKc 150-452 8 3e-06 -85.12 SMART 1-231 (231) Show / Hide
Range on Protein: 150-452
Range on HMM: 1-231/231
Sequence Identity: 8% (30 aa)

LQIRD-----DQGILYEAEPTS--------AVPSESRTQKWRFSLKLDSKDGRLFNEQNFFQRVAKPLQVNKWKKQFLLPLLAIPTCIGFGIHQDKYRFL
 .| .       |  | .  ..         ..                   .. .| .  ..          .  ..  |. .           .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK----------HHPNIVKLYDVFQD--------DHLYM

VFPSLGR---SLQSALDDNPKHV----VSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVNPEDLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSPH
|.  ..    .| . ......|      .|  .  ... ...||||.|..  .|  |  ||....     .. .   |.  ..              .  
VMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTF

DGDLEFISMDLHKGCGPSR-RSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMALNYEEKPPYATL
 | .....  .    | .. ..|   .| ..   |.|  |.     . ... ..                                             .
CGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------------------------------SPEA

RNSLEALLQ---DMRVSPYDPLD-------LQMV
.. .. .||   . | .  . |         . .
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase VRK3.AA CK1-G 262-369 25 2.5e-05 13.93 In-house 98-208 (266) Show / Hide
Range on Protein: 262-369
Range on HMM: 98-208/266
Sequence Identity: 25% (29 aa)

VLQVACRLLDALEYLHENEYVHGNLTAENVFV---NPEDLSQVTLVGYGFT--YRYCPGGKHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLG
|..||  ... .||.|. . . .    .|  .     .|   . .. .|    |. .  ..|..| |  .    |   . |   | |   ||| |.  ||
VCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYRE--HKSLTGTARYMSINTHLGREQSRRDDMEALG

YCMLKWLYGSLPW
   .  | |||||
HMFMYFLRGSLPW

Kinase VRK3.AA Worm6 341-428 18 0.000157 12.56 In-house 193-279 (279) Show / Hide
Range on Protein: 341-428
Range on HMM: 193-279/279
Sequence Identity: 18% (16 aa)

HKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMALNYEEKPPYATL
|||.  .|. |. .  | |. .. | ||| ..    ..  ..|... .  ...  .  . .   | ... ....  ..|...| |...
HKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFG-PCPKEEFNDIMDYIDQYSYWDRPDYKFI

Kinase VRK3.AA Worm6 231-283 25 0.000922 9.77 In-house 73-127 (279) Show / Hide
Range on Protein: 231-283
Range on HMM: 73-127/279
Sequence Identity: 25% (14 aa)

DK--YRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVH
|.  ....| . .|..|.    . |.   | .. |..|.  |.|.| || . ..|
DNRGFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIH

Kinase VRK3.AA CK1-G 410-428 42 0.005317 5.91 In-house 248-266 (266) Show / Hide
Range on Protein: 410-428
Range on HMM: 248-266/266
Sequence Identity: 42% (8 aa)

YLKVVMALNYEEKPPYATL
||. |  |...|.| |  |
YLRYVRRLDFFECPDYDYL