Gene C03C10.2 (Nematode worm)
C03C10.2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| C03C10.2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 267 | Kinase domain by global Sugen HMM | Fasta, JSON |
| C03C10.2.AA | Protein | Genbank | 363 | None | Fasta, JSON |
Protein domains of C03C10.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | C03C10.2.AA | TTBKL | 72-338 | 36 | 9.3e-136 | 457.31 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 72-338 Range on HMM: 1-288/288 Sequence Identity: 36% (105 aa) WSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITKRMIMEQQVLMKMQ--GKTHIPTMYASGFNDQFNFIIMQLLSMNVGDFRKRSPLGR-LS | |...|| ||.||...|.|.| ...|...|.| | | ...||.||..||||.| |..|.|....|| ....||..|.|...|..| ||..| .. .| WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS KETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQN---RHILYLLDFGLVRRFKTESGVC-----------IPWRI---NAGFKGTERYVSVRV ..|..||..|.| |||..||.|..||||||.|.|.|.|... ....||.|||..|......| . ..| |.| || ||.|... DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HEKLEQTPWDDAFSVLYTAYELVVGELPWRYLEDIHEIHGVKKLMNEVTKNGEMF--KDIASILVDFHKMILECDPVVELPYEKLLECL |. .||...|| .|..|...||..| |||...|| .||. .|| |.. . ...|. .|. | . .|.|.. .... . .||...||. HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
|||||||||
| Kinase | C03C10.2.AA | CK1 | 72-334 | 26 | 9.5e-93 | 314.44 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 72-334 Range on HMM: 1-339/339 Sequence Identity: 26% (90 aa) WSIEGVIGNGGYG-QIFMV-----MDVKKN-----DERAMKIEPKLRAEVITKRMIMEQQVLM-------------------KMQGKTHIPTMYASGFND | .. || ||.| ||..| .|.| | .| |||.||| . ..|...| ... |..|. |..... .|..| WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED Q-FNFIIMQLLSMNVGDFRK--RSPLGRLSKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVH------------AQNRHILYLLDFGLVR-RFK . .|...|.|| .| .|.|| | . ...|. |. .||.|.|.||...||.|..|||.||.|.|.|.. ......|..|||..| ... DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR TESGVC------------IPWRI---NAGFKG-TERYVSVRVHEKLEQTPWDDAFSVLYTAYELVVGE--LPWRYLEDIHE-----IHGVKKLMNEVTKN . .| .| | ..|| | | ||.|...|. ||...|| |..|. |...|. |||. ..| . .. |. . .|. DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM GEMF--------KDIASILVDFHKMILECDPVVELPYEKL .| .|. . . .. |.| .... . .||.. STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
|||||||||
| Kinase | C03C10.2.AA | TTBK | 72-294 | 36 | 2.1e-53 | 183.72 | In-house | 1-221 (257) | Show / Hide |
Range on Protein: 72-294 Range on HMM: 1-221/257 Sequence Identity: 36% (81 aa) WSIEGVIGNGGYGQIFMVMDVKKN-DERAMKIEPKLRAEVITKRMIMEQQVLMKMQGKTHIPTMYASGFNDQFNFIIMQLLSMNVGDFRKRSPLGRLSKE | . || ||.| |. .|. . . |.|.| |. . || || |.||. |. . | ||.||...|||. | | | | | | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVE---SAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLS TVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKTESGVCIPWRINAGFKGTERYVSVRVHEKLEQTPWDDAFSVLYTA | |. | |.... ||..|. |||.|| | | .... . |.||||| |.. . .| | | ||| || || |. | | || |. | TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML YELVVGELPWRYLEDIHEIHGVKK | |.| |||| . | .. .|. VEFVQGQLPWRKIKDKDQVGEMKE |
|||||||||
| Kinase | C03C10.2.AA | Worm6 | 72-294 | 33 | 2.6e-52 | 180.09 | In-house | 1-235 (279) | Show / Hide |
Range on Protein: 72-294 Range on HMM: 1-235/279 Sequence Identity: 33% (78 aa) WSIEGVIGNGGYGQIFMVMDVKKND--ERAMKIEPKLRAEVITKRMIMEQQVLMKMQGKT--HIPTMYASG-FNDQ-FNFIIMQLLSMNVGDFRKRSPLG |... || ||.| ...| | ... . ||| | ... . . . || ||.. . | ... | .. ||.|.|.|. .| .| || .| . WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQM-LKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDR RLSKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGV----HAQNRHILYLLDFGLVR--RFKTESGVCIPWR-INAGFKGTERYVSVRVHEKLEQT ..| | .|| |.|.|. | | .|..||||||.| |.|. ..|..|.||||. | ... . .. .. | ..||.|| || .. | . || KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQC PWDDAFSVLYTAYELVVGELPWRYLEDIHEIHGVKK . || | .| |..||.|||| ..| .. . .|| RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKK |
|||||||||
| Kinase | C03C10.2.AA | CK1-D | 72-283 | 30 | 6.6e-27 | 91.87 | In-house | 1-208 (261) | Show / Hide |
Range on Protein: 72-283 Range on HMM: 1-208/261 Sequence Identity: 30% (65 aa) WSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITKRMIMEQQVLMKMQGKTHIPTMYASGFNDQFNFIIMQLLSMNVGD---FRKRSPLGRLS . | || | .|.|.. ... |.| |.|.|. . . . .| .. ||| ||.. |.. ..| ..|.|| . | . .| . | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLEC---IKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHR----KFS KETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKTES-GVCIPWRINAGFKGTERYVSVRVHEKLEQTPWDDAFSVL || .| | . .. || ..|||.|| | |. . .. |..|||| .|.. ||.| | || || |. | .|| || |. LKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGL-GKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLG YTAYELVVGELPWRYL | | ||| | YVLMYFNRGSLPWQGL |
|||||||||
| Kinase | C03C10.2.AA | CK1-A | 72-280 | 30 | 4e-25 | 85.61 | In-house | 1-205 (261) | Show / Hide |
Range on Protein: 72-280 Range on HMM: 1-205/261 Sequence Identity: 30% (66 aa) WSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITKRMIMEQQVLMKMQGKTHIPTMYASGFNDQFNFIIMQLLSMNVGD---FRKRSPLGRLS . . || | .| |.. . ... .| |.|.| .... .| | .| .|| ||.| | . ..| ..|.|| . | | || | . YRLVRKIGSGSFGDIYLGINITNGEEVAIKME---SNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKR----RFT KETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHI--LYLLDFGLVRRFK-TESGVCIPWRINAGFKGTERYVSVRVHEKLEQTPWDDAFS || .| | . . .| ...|||.|| | |. .|| |.|.|||| .... .. ||.| || || |. | .||. || | MKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI---GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMES VLYTAYELVVGELPW . | |.||| MGYVMMYFNRGKLPW |
|||||||||
| Kinase | C03C10.2.AA | CK1 | 72-257 | 28 | 3.5e-24 | 80.26 | In-house | 1-193 (271) | Show / Hide |
Range on Protein: 72-257
Range on HMM: 1-193/271
Sequence Identity: 28% (57 aa)
WSIEGVIGNGGYGQIFMVMDVKKNDER---AMKIEPKLRAEVITKRMIMEQQVLMKMQG------KTHIPTMYASGFNDQ--FNFIIMQLLSMNVGDFRK
.. || | |.|. .... .| |. |.|.|.. | .... .|| .||.|| .|...| .|...| || . | .
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKN---KSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN
RSPLGRLSKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKT-ESGVCIPWRINAGFKGTERYVSVRVHEKLEQ
...| || || | . . .| ...|||.|| |.. |. .. |..|. |||| |.. ... || | | .. || || |. | .||
FC-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQ
|
|||||||||
| Kinase | C03C10.2.AA | CK1-Unique | 72-281 | 23 | 1.1e-21 | 71.92 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 72-281 Range on HMM: 1-233/337 Sequence Identity: 23% (55 aa) WSIEGVIGNGGYGQIFMVMDVKKN------DERAMKIEPKLRAEVITKRMIMEQQVLMKMQGKT-------HIPTMYASGFNDQFNFIIMQLLSMNVGDF | . || |||| | .|. |. .|| | .. . | |. |. . . | . ... .. .|.|... . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTE-QHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEEC RKRSPLG-RLSKE------TVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHA-QNRHILYLLDFGLVRR--FKTESGVCIPWRINAGFKGTERYVS . . . . . .... .||.||.. | |. ||. ||.|.| . | | .| ||.| || | ... . | . | |. .| . C-MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCP VRVHEKLEQTPWDDAFSVLYTAYELVVGE--LPWR |. |.. || | .|..| || .. | |. CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
|||||||||
| Kinase | C03C10.2.AA | Dual | 72-246 | 24 | 5.4e-19 | 60.38 | In-house | 1-189 (282) | Show / Hide |
Range on Protein: 72-246 Range on HMM: 1-189/282 Sequence Identity: 24% (46 aa) WSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITKRMI---MEQQVLMKMQG---------KTHIPTMYASGF--NDQFNFIIMQLLSMNVGD | . .| || . . | . .. . . |. .| |.|. |.|| ||. . . . . |. | ....| . . . WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE FRKRSPLGRLSKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKT-ESGVCIPWRINAGFKGTERY |. .| ||... .| |.| |..| | .||.||..|||| |. .. . |..||..|| . | .. . | . . |. || IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTV-YMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRY |
|||||||||
| Kinase | C03C10.2.AA | CK1-Unclassified | 72-151 | 25 | 1.5e-18 | 51.34 | In-house | 1-86 (244) | Show / Hide |
Range on Protein: 72-151 Range on HMM: 1-86/244 Sequence Identity: 25% (23 aa) WSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITKRMIMEQQVLMKMQGKT-------HIPTMYASGFNDQ--FNFIIMQLL .. ||.| |.|. ..... |.| |.|.| | . | .... .|. .|| || .| ..| .|...| || YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK---HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLL |
|||||||||
| Kinase | C03C10.2.AA | Pkinase | 72-281 | 21 | 9.8e-17 | 60.25 | Pfam | 1-213 (293) | Show / Hide |
Range on Protein: 72-281 Range on HMM: 1-213/293 Sequence Identity: 21% (48 aa) WSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITKRMI---MEQQVLMKMQGKTHIPTMYASGFNDQFNFIIMQLLSMNV---GDF----RKR . |...|| |..|. . .... ... |.|| .| ... .. .| |.. ... . | ..| . ... ..| .. . . | . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-- SPLGRL--SKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKTESGVCIPWRINAGFKGTERYVSVRVHE-KLEQT . |.. | ... ...||.| .|. .|.|| .|||.||.|| . . .. .. . |||| . |. . . . .| || .|.. |. . . WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG PWDDAFSVLYTAYELVVGELPWR | | .|. . ||.. |..|.. PKVDMWSCGCILYEMLCGRPPFP |
|||||||||
| Kinase | C03C10.2.AA | S_TKc | 72-341 | 17 | 2.6e-15 | 47.53 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 72-341 Range on HMM: 1-231/231 Sequence Identity: 17% (53 aa) WSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITKRMIMEQQVLMKMQGKTHIPTMYASGFNDQFNFIIMQLLSM---NVGDFRKRSPLGR-- . | .|| |..|. . . ..| . . |.|| . .... | |.|.| . .| ..| . . .. ...| ... .. |. |. . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LSKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKTESGVCIPWRINAGFKGTERYVSVRVHEKLEQTPWDDAF .. .. ...||...||. .|..| .|||.||.|| . . . |||| |.. | || |.. | FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------ SVLYTA------------YELVVGELPWRYLEDIHEIHGVKKLMNEVTKNGEMFKDIASILVDFHKMILECDPVVELPYEKLLE------CLKCL |. ||...|. |.. ..... . . . . || . .|. || . ..|. | . --GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | C03C10.2.AA | CK1-Unclassified | 186-257 | 39 | 1.1e-14 | 39.78 | In-house | 120-193 (244) | Show / Hide |
Range on Protein: 186-257 Range on HMM: 120-193/244 Sequence Identity: 39% (29 aa) IHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKT--ESGVCIPWRINAGFKGTERYVSVRVHEKLEQ .| ...||| || |.. | .|.|..|. |||| |... . | || | | .. || || |.. | .|| LHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQ |
|||||||||
| Kinase | C03C10.2.AA | TyrKc | 72-313 | 12 | 0.000597 | -158.76 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 72-313
Range on HMM: 1-280/280
Sequence Identity: 12% (38 aa)
WSIEGVIGNGGYGQIFM-VMDVKKNDERAMKIEPKLRAEVITKRMIMEQQVLMKM--QGKTHIPTMYASGFND-------QFNFIIMQLLSM-NVGDFRK
. . ..|.| .|... ... . | | .|... . .. | ....| . . .| .|. . . .|.| . . . |. .
ITLGKKLGEGAFGEVYKGTWK----IQVAVK---MLKEDA-REDFMREARIMCKLGGHHP-NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR
RSPLGRLSKETVGRIAYQTLNALKDIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFKTE--SGVCIPWRINAGFKGTERYVSVRV--HEK--
.. |. .. ...| . .|.....||| |. |.... . |||| | . . .| . | ... ..|
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL--VGENH--TVKISDFGLSRDIYDDDQQG------------ESKDYYRKKEHKGGKTM
----------------------------------LEQTPWDDA----FSVLYTAYELVVGELPWRYLEDIHEI------HGVKKLM----NEVTKNGEMF
. |.|. . | . |. . . .| .. . ..| .| .. |
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTF
KDIASIL
..| ...
SEIHECF
|
|||||||||