Gene C53A5.4 (Nematode worm)

C53A5.4

Species: Nematode worm
Alias: CE08953, C53A5.4, aSWK095
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 14538970-14537043, WormBase Genetic Map location: V:6.19,

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
C53A5.4.AA Protein Genbank 346 None Fasta, JSON
C53A5.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of C53A5.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C53A5.4.AA TTBKL 20-284 40 5.9e-150 504.48 In-house 1-288 (288) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-288/288
Sequence Identity: 40% (118 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQYAMKVEFNSNANAGNVLKMEVQILTHLV--SKNHVAKCMASGKKDRYSYVVMTLLGESLESLMKKHGPF--FN
.......|.||.|.||.|.|..||.. .|||.|.|.... ....||||..|..|   .. |..||..|||...|...||||.|..|  |.|..  .  |.
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

VSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKG--SPDERYFIVLDFGLARQYITDKEDG--------KKMRRPRE---KALFRGTSRYCSVAM
..|..||||..|...||.||.||||||.||.|...|...  ....|.....|||.||||... ...        ..|||||.   || |||| ||||..|
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HDRFEQGRVDDLWALIYMLAELRCQLAWSDLDDKVEIGEMKRHVADQNLFAK------SPIQMLEFVKIVRATQFYHRPDYEKLFNLL
||| ||||.||||...||..||.| | |....|| ||..||..  |..|| .      .| ....|.| .|. ..|.|||||......
HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C53A5.4.AA CK1 20-280 29 1.9e-105 356.6 In-house 1-339 (339) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-339/339
Sequence Identity: 29% (100 aa)

YRVIQQLGQGGCG-SVYKV-----EDIEDKT----KQYAMKVEFNSNANAGNVLKMEVQILTHLVS--------------------KNHVAKCMASGKKD
..|....|.||.|  .|||     .|....     ..|||||| ....  . .|..|.|..  |                      . |. ... .|..|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

RYS-YVVMTLLGESLESLMK--KH-GPFFNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGS-----------PDERYFIVLDFGLAR-QYI
.|  |.||||||..||.|.|  .  .  |...| ..|.|..|......||.||||||.||.|...| ..|           ...| . ..|||.|| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

TDKEDG---------KKMRRPRE---KALFRG-TSRYCSVAMHDRFEQGRVDDLWALIYMLAELR-CQ--LAWSDLDDKVE-----IGEMKRHVADQNLF
......         ...|.|||   |. ||| | ||||...|.. ||||.||||...|||.|.  ..  | |....|. .     ...||.   | ...
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

AK------------SPIQMLEFVKIVRATQFYHRPDYEKL
              .| .. ...|..|. ..|.|||||..
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase C53A5.4.AA TTBK 20-280 39 6.5e-70 238.57 In-house 1-257 (257) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-257/257
Sequence Identity: 39% (103 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQYAMKVEFNSNANAGNVLKMEVQILTHLVSKNHVAKCMASGKKDRYSYVVMTLLGESLESLMKKHGP-FFNVST
 .|..  |.|| | .|  .|.  .  | |.|||  |      |||||| .|  |  ..|| . .  |  |.. |.||.|.|..|  |  |     |..||
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVE--SAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST

QMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITDKEDGKKMRRPREKALFRGTSRYCSVAMHDRFEQGRVDDLWALI
 .|.|. .| .|..||..|| ||| || | |.|   |   . .. |||||||||.. . .    | ||| | |||| || |.  |   | || |||| | 
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYM-LDFGLARQYTNACGE---VRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLF

YMLAE-LRCQLAWSDLDDKVEIGEMKRHVADQNLFAKSPIQMLEFVKIVRATQFYHRPDYEKL
||| | .  || |  . || ..||||     . |    | ..  |.. ..  ..  ||||  .
YMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase C53A5.4.AA Worm6 20-280 32 3.3e-62 212.99 In-house 1-279 (279) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-279/279
Sequence Identity: 32% (91 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTK-QYAMKVEFNSNANAGNVLKMEVQILTHLVSKN--HVAKCMASGKKDR--YSYVVMTLLGESLESLMKKH-GPF
. | . .|.||.|.|||||| .||.| |.|||.|     .. ..||||. .|. .  ..  |. | .  ||.|.  . |.||||.|..|. |.|   .  
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGN---KGSPDERYFIVLDFGLAR--QYITDKEDGKKMRRPR-EKALFRGTSRYCSVAMHDRFE
| ..| ..|.|  | .| . | .||||||.||.| . |    | . ...    ||||..|  .|.   ..|...| || ... |||| ||...| |.. |
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYC---NKGNELRTPRWTACGFRGTVRYAPLACHKGQE

QGRVDDLWALIYMLAELRCQ-LAWSDLDDKVEIG--EMKRHVADQ----NLFAK-SPI-QMLEFVKIVRATQFYHRPDYEKL
|.| ||.    ||..|. .  | |  ..|. . .   ....   .     .| .  |  .. .  ...  .... ||||...
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase C53A5.4.AA CK1-Unclassified 20-221 33 3.4e-36 104.35 In-house 1-206 (244) Show / Hide 
Range on Protein: 20-221
Range on HMM: 1-206/244
Sequence Identity: 33% (70 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQYAMKVEFNSNANAGNVLKMEVQILTHLVSKN-------HVAKCMASGKKDR--YSYVVMTLLGESLESLMKKH
||||. .|||  | .||. ..... . .|.|.| . .      |. |..|.. |           ...|.  .|. .   | ..||.|||.|||.|... 
YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC

GPFFNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITDKEDGKKMRRPREKALFRGTSRYCSVAMHDRFEQGR
.  |.. | . |.  ..  | ..|  .|||||.|| |   |  |    . .|. ||||.  ||. ...||     ..| |  || || |. .|   ||.|
NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYII-DFGLSKRYIDMDKTGKHIPYRENKNLT-GTARYASINAHLGIEQSR

VDDLWALIYML
 ||| .| | |
RDDLESLGYVL
Kinase C53A5.4.AA CK1-Unique 20-224 24 1.3e-30 103.31 In-house 1-223 (337) Show / Hide 
Range on Protein: 20-224
Range on HMM: 1-223/337
Sequence Identity: 24% (55 aa)

YRVIQQLGQGGCGSVYKVEDIEDK-----TKQYAMKVEFNSNANAGNVLKMEVQILTHLVSKN-------HVAKCMASGKKDRYSYVVMTLLGESLESLM
. ||  .| || | |..| .  .       . |.|| |  . .     |. |  ..  .           |. .  ...  . ... |||..| |.|.. 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KKHGP-FFNVS------TQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQ-YITDKEDGKKMRRPREKALFRGTSRYCS
 . ..  |  .      .  . |   |..|   |  ||.||..||.|. ..     ... . .||.|  |   . ..     .| ||... |||. .||.
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSN--NHQIRQPRPITPFRGCKDYCP

VAMHDRFEQGRVDDLWALIYMLAEL
 . |   |.|| ||.  . |||  |
CSCHQCREHGRRDDMESWFYMLYHL
Kinase C53A5.4.AA CK1 20-221 29 9.6e-29 96.18 In-house 1-206 (271) Show / Hide 
Range on Protein: 20-221
Range on HMM: 1-206/271
Sequence Identity: 29% (65 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQ--YAMKVEFNSNANAGNVLKMEVQILTHLVS------KNHVAKCMASGKK--DRYSYVVMTLLGESLESLMKK
|||.. .|||  | .|..... ....   .|.|.| | . .    |. |..|.. |          .....  .|.     | ..||.|||.|||.| ..
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP--QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF

HGPFFNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITDKEDGKKMR-----RPREKALFRGTSRYCSVAMHD
 .  | . | . |.  ..  |  .|  .|||||.|| |   | .|    . .|. ||||| .|.       ...       ||.  . || || |. .| 
CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYII-DFGLAKRYR-------DDKTHQHIPYRENKNLTGTARYASINTHL

RFEQGRVDDLWALIYML
  ||.| ||. .| |.|
GIEQSRRDDMESLGYVL
Kinase C53A5.4.AA Dual 20-284 27 1.2e-26 86.53 In-house 1-282 (282) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-282/282
Sequence Identity: 27% (80 aa)

YRVIQQLGQGGCGSVYKVEDIED---KTKQYAMKVEFNSNANAGNVLK--MEVQILTHL---VSKNHVAKCMAS------GKKDRYSYVVMTLLGESLES
 .|.. || || . ||.| .      |.| |..|.|      .   ||  |.|.... .    .|  . ||  .       ..|.  |.|| . | ||. 
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LMKKHG-PFFNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITDKE-DGKKMRRPREKALFRGTSRYCSVAMH
 ..| .   .....   ..|  |  |.  | ||..||. |||| . |     ||     .||...| ||   .   || | .| |  . |. || . |  
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGM--DETTVYMQDFRIVRKYI---DPENKKHRTARKKVKMYGCGRYACRACM

DRFEQGRVDDLWALIYMLAEL--RCQ-LAWSDLDDKVEIGEMK---RHVADQNLFAKSPIQMLEFVKIVRATQFYHRPDYEKLFNLL
   .||| ||| . |||.  |      . |  . | ... . |       |.  ... | ..   |  |   |.   |||. . | |
MQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase C53A5.4.AA CK1-G 86-280 32 1e-25 84.04 In-house 65-266 (266) Show / Hide 
Range on Protein: 86-280
Range on HMM: 65-266/266
Sequence Identity: 32% (67 aa)

GKKDRYSYVVMTLLGESLESLMKKHGPFFNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITDKEDGKKMRRP
|    |   || ||| ||| |    .  | | | . . | ..  ....|.   | || || |   | ....|..   . |||.|.||| | | ..     
GQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYI-DPETKQHIPY-

REKALFRGTSRYCSVAMHDRFEQGRVDDLWALIYM-LAELRCQLAW-----SDLDDKVE-IGEMKRHVADQNLFAK--SPIQMLEFVKIVRATQFYHRPD
||.    || || |.  |   || | ||. ||  | .  || .| |       .  . . ||. ||... . |      |.|.  . ..||  .|   ||
REHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPD

YEKL
|. |
YDYL
Kinase C53A5.4.AA CK1-D 20-280 29 1.7e-23 79.68 In-house 1-261 (261) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-261/261
Sequence Identity: 29% (79 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQYAMKVEFNSNANAGNVLKMEVQILTHLVSKNHVAKCMASGKKDRYSYVVMTLLGESLESLMKKHGPFFNVSTQ
||.  ..| |  | .|  ..|.      |.|.|  .       |..| ..   .     . .    |.   |  .|| ||| ||| |    .  | . | 
YRIGRKIGSGSFGDIYHGTNIQ-TNEEVAIKLE--CIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTV

MRIGICLLFGIKQIHDIGFIHRDLKPAN--VALGNKGSPDERYFIVLDFGLARQYITDKEDGKKMRRPREKALFRGTSRYCSVAMHDRFEQGRVDDLWAL
. ..  ..  |. ||   |||||.|| |  . || .|.       ..|||||..|   .   ..    ||.    || || |.  |   || | ||| .|
LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGN----MVYIIDFGLAKRYRDART--HQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESL

IYMLAEL-RCQLAWSDLD-----DKVE-IGEMKRHVADQNLFAKSPIQMLEFVKIVRATQFYHRPDYEKL
 |.|    |  | |  |      .| | | | | ..  . | .  | .  ...  .|  .| ..|||  |
GYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase C53A5.4.AA Pkinase 20-199 24 6e-15 53.93 Pfam 1-179 (293) Show / Hide 
Range on Protein: 20-199
Range on HMM: 1-179/293
Sequence Identity: 24% (47 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQYAMKVEFNSNANAGN---VLK-MEVQILTHLVSKNHVAKCMASGKKDRYSYVVMTLLGE-----SLESLMK--
|......|.|. |.|||  .. .   ..|.|.   .... .     .. .|.||. .| ..| . ..  .   ... |.|| ...      .| ....  
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KHGPF-FNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITDKEDGKKMRRPREKALFRGTSRYCS
.||.| |   .  ..   .| |.. .|. |.|||||||.|. . |.| .|.  . . |||||.|.           . .    | ||..|..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMA
Kinase C53A5.4.AA S_TKc 20-289 19 1.1e-14 38.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-289
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQYAMKVEFNSNANAGNVLKMEVQILTHLVSKNHVAKCMASGKKDRYSYVVMTLLGE---SLESLMKKHGPF---
|......|.|. |.|||. ...   ...|.|.         . .. |.||| .     .. |.  .     . |.|| ...    .| ...||.|.    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITDKEDGKKMRRPREKALFRGTSRYCS--VAMHDRFEQG
  |.  .  ..   .. ... .|. |.|||||||.|. | .          . |||||||.                  | ||  |..  |        |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------------TTFCGTPWYMAPEVL-----GYG

R-VDDLWALIYMLAELRC-QLAWSDLDDKVEIGEMKRHVADQNLFAKSPIQMLEFVKIVRATQFYHRPDYEKLFN----LLNDAMK
.   | |..  .|.|. | .  ..      .. .| ...         . ....|..        .||   ....      ..   
KCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C53A5.4.AA CK1 239-278 24 4e-06 17.36 In-house 231-271 (271) Show / Hide 
Range on Protein: 239-278
Range on HMM: 231-271/271
Sequence Identity: 24% (10 aa)

IGEMKRHVADQNLFAK-SPIQMLEFVKIVRATQFYHRPDYE
|.|.|. .  . |..   | .. .. ...|  .|. .|||.
IMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase C53A5.4.AA TyrKc 20-228 14 3.3e-05 -138.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-228
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

YRVIQQLGQGGCGSVYKVEDIEDKTKQYAMKVEFNSNANAGNVLKMEVQILTHL-VSKNHVAKCMASGKKD-------RYSYVVMTLL-GESLESLMKKH
 . ...|| |  | ||| . .     | | |.  ..       .  | .|...|  .  .. .. .   ..          ..|| .  . .| .  .||
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GPFFNVSTQMRIGICLLFGIKQIHDIGFIHRDLKPANVALGNKGSPDERYFIVLDFGLARQYITD------KEDGKKMRRPREK-----------ALFRG
.| .....   . .    |   .|. ..|||||   |. .|...        . ||||.|    |      |.  .|. .  .|           ... |
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

----------------------TSRYCS--------VAMHDRFEQGRVDDLWAL------------IYML---------------AELRCQL
                       . |            .. . .||.  .  .             .|..               .|.. ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF