Gene cdk-5 (Nematode worm)

cdk-5

Species: Nematode worm
Alias: aSWK162, cdk-5, CE21213, T27E9.3
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 13461343-13459749, WormBase Genetic Map location: III:22.34,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
cdk-5.AA Protein Genbank 292 None Fasta, JSON
cdk-5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 287 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of cdk-5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase cdk-5.AA CDK5 4-286 73 6.7e-240 766.55 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 73% (211 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTA
|.|||||||||||||.|||||...|||||||||||..||||||.|.||||.|.||||.|.|||.||.|||.|||||||.|||||||..||.||.||....
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLF
.|.|.|||.||.|||.||||||||||||||||.||.|||||||||||||.||||.|.|||||||||||||.|.|.|.|||||||.||||||..|||||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYK----PYPIYHPTLTWSQIVPNLNSRGRDLLQKLLVCNPAGRIDADAALRHAYF
||.||.||||||||..|.|.||.|||||.|||||    .||.|... .|.||||.|...|.|||||.|.|||. ||.|.|||.|.||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase cdk-5.AA CDK 4-286 47 8.70000000001e-179 576.81 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 47% (150 aa)

YDKMEKIGEGTYGTVFKARNKNSG-----EIVALKRVRLDD-----DDEGVPSSALREICILRELKHRNVVRLYDVVHSE-----------NKLTLVFEY
|.| |||||||||.|.|||.|..|     .|||||..|..      ..||.|..|.|||..|.|| | |.|.|.||.|..           |||..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDQDLKKFFDSLNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGT-----LKLADFGLARAFGV------PVRCFSAEVVTLWYRPPD
.|.||||. |           ...|.||||||..|| ....||||||||.||| ||.     ||.||||||||||.      |.|... ||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLFGAKLYN--TSIDMWSAGCIFAEISN--AGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPNLNSRGRDLLQKLL
.|.|.| |.  |.|||||.||||||. .  ...|||||    |||..||. .|.|.|||||..|.||||                        |||.|.|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML

VCNPAGRIDADAALRHAYF
...|. || |..|| | ||
CYDPKKRISAEQALQHPYF
Kinase cdk-5.AA CDC2 4-286 51 3.8e-165 511.93 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-301/301
Sequence Identity: 51% (156 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEG--VPSSALREICILRELK-HRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFD-SLNG--Y
| | ||||||||| |.|.... ...|||||..||. .|||  |||.|.|||..| ||| | |.|.| ||.|. ||| .||||.|.||||. | |.    .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFS--AEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEI
|. |. .|.| |.|.|..|||.. ..||||||||.||...|..|.||||||||||.|.|      ||||||||.| .|.|.| |.|..|||| ||||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

-SN-AGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKP-YPIYHPTLTWSQIVPN---------LNSRGRDLLQKLLVCNPAGRIDADAALRH
  .   .|||.|    ||| .||. ||.|.|..||..|||||||. .| ..|. . |.|.||         |. .|.|||...|. .|. || |..||.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDL-SKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

AYF
 ||
PYF
Kinase cdk-5.AA CMGC 4-286 26 1.8e-139 461.44 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 26% (136 aa)

YDKMEKIGEGTYGTVFKARN--------------KNSGEIVALKRVRLDDDDE----------GVPSSALREICILRELK-----------------HRN
|....||||||||.|.|.|.              ....||||.|.....  .|          |.|..||||| ||..|.                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVRLYDVVHSEN-----------------KLTLVFEYCDQDLKKFFDSLN---------GYMDAQ-----------TARSLM------LQLLRGLS--FC
.|.|||.....|                 .| |||||.|.||... .. .         .  . .           . ...|       |.||||   .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HAHH--VLHRDLKPQNLLINTN--------------------GTLKLADFGLARAFGVP---------------------VRCFSAEVVTLWYRPPDVLF
| |   ..||||||.|.||| |                    |.||..||||||.....                     .| .. .|||.|||.| .|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GAKLYN---------TSIDMWSAGCIFAEISNA-------GRPLFPGADV-----------DDQLKRIFKQLGSPS---------------EDNWPSITQ
|.| |.         |.|||||.||||||. .        |.||||| .             |||..||| ||.|.               |..||....
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPDYKPYP--------------------------IYHPTLTWSQIVPN-----------------------------------LNSRGRDLLQKLLVCNP
||.|...|                            .|  .|....|.                                   ... ..|||.|.|...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

AGRIDADAALRHAYF
. || |. ||.| ||
DKRITAEQALQHPYF
Kinase cdk-5.AA PFTAIRE 4-286 49 2.1e-132 446.2 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 49% (142 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTA
| |.|| |||.| ||.|.. .  . .|||| .|| ...||.|  | ||   |..||| |.| | |..| .  ||.|||| . ||... |. .| |. .  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRL-QQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

RSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLF
|  . |||||||.||  .|||||||||||||   | |||||||||||  || . .| ||||||||||||| |.  | |..||| .|||| |   .|.|.|
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMM-WGQPAF

PGA-DVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIY---HPTLTWSQIVPNLN--SRGRDLLQKLLVCNPAGRIDADAALRHAYF
||  |. ||| .||| ||.| || || ...|| |||. .    .      ...| .     . ||..|.| |.|  |. |..|. | ||
PGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase cdk-5.AA PCTAIRE 4-286 48 2.5e-129 435.96 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-291/291
Sequence Identity: 48% (143 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTA
| |..| ||||| ||.| | |  . .|||| .|| . .|| |  | ||.  |..||| |.| | |..| .  ||||||| |.|||.. |     |.    
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

RSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLF
. .. |||||| .||   .|||||||||||||  | |||||||||||  || . .| ||||||||||||| |   | |.||||  ||||.|.. .|||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMC-TGRPLF

PGAD------VDDQLKRIFKQLGSPSEDNWPSITQLPDYKPY--PIYHPTLTWSQIVPNLN---SRGRDLLQKLLVCNPAGRIDADAALRHAYF
||        | |||  ||. || |.|  || .. ......|  | | . .      | |    . . |||..||   .  |. |..|..| ||
PGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYRE-QPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase cdk-5.AA CDK7 4-236 44 6.7e-121 323.81 In-house 1-236 (288) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-236/288
Sequence Identity: 44% (105 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVR----LDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMD
|.|...||||...||.||. ...|.||| |...     .. . |.  .|.||| ||.|..| ||. | |.      . |||.. | ||          . 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

AQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAG
     . |...|.|| .||.. .||||||| |||.| || ||.|||||||..| | | ..  ||| ||| |  ||||. | |..|||| ||||||     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM-LR

RPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDY
 | .||    |||.|||. || |.| .|| .....||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY
Kinase cdk-5.AA CDK4 4-286 45 1.5e-108 366.94 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-290/290
Sequence Identity: 45% (134 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDE--GVPSSALREICILRELK---HRNVVRLYDVVH------SENKLTLVFEYCDQDLKKFFD
| ..  |||| ||||..||   .| .||||.||    .|  |.| | .||| ..| |.   | |.|.|.|| |      .| |.|.||| ||.||. . |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SLNG-YMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCI
 .    | ..|.. .| |||||. | |.| . ||||||||.|.. .|..||||||||| ..     .   ||||||| | ||  .  ||| .||||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FAEISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPNLNSRGRDLLQKLLVCNPAGRIDADAALRHAYF
|||. .  ||||.|    ||| .||.  | | || ||.   ||    .| .||.     ..| .   | ||||| |  |.. |. | ..| | ||
FAEMYCR-RPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP-WDHFPQRHPR-PFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase cdk-5.AA PITSLRE 4-286 40 8.20000000001e-103 347.86 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-295/295
Sequence Identity: 40% (121 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLD--DDDEGVPSSALREIC-ILRELKHRNVVRLYDVV--HSENKLTLVFEYCDQDLKKFFDSLN---
. .. .|.||||| |..|..|  .|||||||. ..   . || |  .||||  ||..|.|.|.| .  .|     .|  .|.|| . |||   .  .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEI
         .||.||||| .. | . ..|||||  |||.. .| ||..|||||| .| |.. ..  ||||||| | .| |.|.| | .|||| ||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

SNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYP--IYHPTLTWSQIVP---NLNSRGRDLLQKLLVCNPAGRIDADAALRHAYF
   ..|||.|    ||...|||..| |.|  || .| ||  |       .|  .  ...|    ..  | |||...|  ||. || |..|| | .|
I-TMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase cdk-5.AA S_TKc 4-286 30 9.3e-96 325.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQ---DLKKFFDSLNG----
|....|||.|..|.|.|.|.|..|.|||.|...          ...||| ||.. .| |.|.|||| .. ..| .|.||||.   ||... .. ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

-YMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNT-SIDMWSAGCIFAE
 ...  .||..| |....| .|| |...||||||.|.|...  ..|..|||||| .       .  ..|.||..| ||     |.. ..|.|| |||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

ISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPNLNSRGRDLLQKLLVCNPAGRIDADAALR-------HAYF
    |.|.||      |....||..|                                    . ..|...|.|. .|. |. |  ||.       | .|
MLC-GYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase cdk-5.AA Pkinase 4-286 31 6.6e-92 316.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALR--EICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSL-------
| . .|||.|..|.|.|...|..|.|||.|............ ...|  ||.|...|.| |.|||||........ .|.|||. .|.  .|         
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

NGYM--DAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTL----KLADFGLARAF-GVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWS
.| .  . ..... |.|.|||| .||.. ..||||||.|.||. ||..    |..|||||. |   . . ..  ..|.||..| |. |.. | ...||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCIFAEISNAGRPLFPGA----DVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPNLNSRGRDLLQKLLVCNPAGRIDADAALRH
.|||..|  . |||.|||.    . .||...|.. .| | . .||     ....  ..   . .  . ..|... ..|.. ..|  .|. |. |. .| |
CGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

AYF
 .|
PWF
Kinase cdk-5.AA CRK7 4-234 37 3.1e-87 296.1 In-house 1-284 (343) Show / Hide 
Range on Protein: 4-234
Range on HMM: 1-284/343
Sequence Identity: 37% (108 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDD---DEGVPSSALREICILRELKHRNVVRLYDVVHSE------NKLT----LVFEYCDQDLKKF
|.. . ||||||| | ||.||. ||.||||.||.|..    || |  | ||| |||.|.|.|.|.| ..| .       .|      .|||| | ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

FDSL-NGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPV--RCFSAEVVTLWYRPPDVLFGAKLY--------
 .|    .   |  ...| ||| |.  ||   .||||.|  |.|.| .| .|.||||||| .      | .   |.|||||||  | |.. |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------NTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLP
                              ...||||| |||..|  . ..|.|.|    .||  |.|  |||  .||| ...||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFT-KKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLP
Kinase cdk-5.AA Pkinase_Tyr 4-150 27 2.5e-19 66.11 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-150
Range on HMM: 1-160/270
Sequence Identity: 27% (44 aa)

YDKMEKIGEGTYGTVFKARNK----NSGEIVALKRVRLDDDDEGV--PSSALREICILREL-KHRNVVRLYDVVH-SENK--LTLVFEYCDQ-DLKKFFD
  ...|.||| .|.|.|.. |    | .  || | .  .. ..      . .||. |...| .| |.|||| |.   .    . .|.||.   ||...  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SL---NGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARA
.    ..  . ..  .  .|  .|... ....  ||||   | |.. |.. | .||||||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase cdk-5.AA TyrKc 4-233 21 3.7e-13 -9.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-233
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILREL--KHRNVVRLYDVVHSE-------NKLTLVFEYCDQ-DLKKFFDS
  . .|.||| .|.|.|.. |   . || | .. |          .||. |...|  .| |.|||| |. ..         | .|.||..  |||..  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVP--------VRCF----SAE-VVTLWYRPPDVLFGAKLYN
  .    ..  | ..|  .| .. | ... ||||   | |.. |.| | .||||.|. .          .       ..  .. .   .| ..   . ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TSIDMWSAGCIFAEISNAGRPLFPG-----ADVDDQLKRIFKQLGSPSEDN--------------------WPS-----------ITQL
|  | || |    ||   | .  ||      . .. .... .    |  .|                    |             . ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase cdk-5.AA CDK7 261-286 30 3.4e-09 20.17 In-house 263-288 (288) Show / Hide 
Range on Protein: 261-286
Range on HMM: 263-288/288
Sequence Identity: 30% (8 aa)

DLLQKLLVCNPAGRIDADAALRHAYF
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DLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase cdk-5.AA CRK7 261-286 42 3e-06 17.35 In-house 318-343 (343) Show / Hide 
Range on Protein: 261-286
Range on HMM: 318-343/343
Sequence Identity: 42% (11 aa)

DLLQKLLVCNPAGRIDADAALRHAYF
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DLLDKMLCLDPKKRFTAEECLQHDWF