Gene F52B5.2 (Nematode worm)

F52B5.2

Species: Nematode worm
Alias: aSWK204, CE24993, F52B5.2
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 8326307-8324019, WormBase Genetic Map location: I:2.66,

Classification

Group: CMGC
Family: CMGC-Unique

Sequence

Name Sequence Type Origin Length Description Download
F52B5.2.AA Protein Genbank 301 None Fasta, JSON
F52B5.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 297 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of F52B5.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F52B5.2.AA CMGC-Unique 18-140 66 5.8e-88 298.54 In-house 1-122 (352) Show / Hide 
Range on Protein: 18-140
Range on HMM: 1-122/352
Sequence Identity: 66% (82 aa)

CTLRRQLNDSGEAMVFLAESGNEEKKEVIIKFFKCGYGEDEIKYLDVLTNHEQRRNIVEMLKSFETPEIRLGMVFKRYETDLFGILGDRQRLQPSTIQKY
|||||||||||||||||||||||||||..||.|||.|..|.||.|.....|||.|||.||.|.|.|..|||.||......|.|||.|||| ||.|.||..
CTLRRQLNDSGEAMVFLAESGNEEKKEFRIKMFKCKYNHDNIKKLYQICQHEQSRNIYEMMKPFTTKDIRLIMVMNQHQFDGFGIIGDRQ-LQFSMIQYI

MKGLMEGLQFIHRMDYIHRDIKP
||.||..|.|.|||||.|||.||
MKQLMQCLHFLHRMDYVHRDLKP
Kinase F52B5.2.AA CMGC-Unique 141-292 28 5.6e-82 278.65 In-house 145-352 (352) Show / Hide 
Range on Protein: 141-292
Range on HMM: 145-352/352
Sequence Identity: 28% (60 aa)

ENLLIDGETICIADFGETVLSTSDKVVKPGTLPYLTIEHILGYKENTKSMDIWAAACVLGAMFQGSHLFS----------------------QNSNLQTI
......|..||...||........|...|.........|.|.|....|.||.|.|.|....|.||..||.                      .|.|...|
QQFQQQGNKICQPHFGNMRSYQYMKPEQPCEIYMQYNHHKLSYRIYWKKMDMWSAGCIFHEMIQGKQLFNNPNLDNNNNNNNNNNNNNNNFHGNNNKNVI

HAIRLLLGNHTK-----------ETWPEMDKLPLMQSIELPPVGEKTFSKIENITKEAAD-----------------------LMEQMMKYDPTKRLMAS
|.|....|||.|           ..||||....|||.|..|...||.|.|..|....|..                       ||.||||..|.||.||.
HNIVKFNGNHFKWDNNQNIDNNFNNWPEMMMQQLMQFINFPVPWEKSFNKQRNHYFKANHNIIIKSKVERDFNGANLPTDAYNLMCQMMKCNPHKRIMAN

QVLNHEYF
|.|.|..|
QALQHKFF
Kinase F52B5.2.AA CMGC 18-292 16 2.5e-64 209.94 In-house 1-513 (513) Show / Hide 
Range on Protein: 18-292
Range on HMM: 1-513/513
Sequence Identity: 16% (87 aa)

CTLRRQLNDSGEAMVFLAESGN-------------EEKKEVIIKFFKCG-YGE----------------DEIKYLDVL-------------TNHEQRRNI
 .  ...     ..|. .   .             | ...| || .|   | |                .|||.|  |             ...... ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VEMLKSFETPE----------------IRLGMVFKRYETDLFGILGDRQ---------RLQPST------------IQKYM------KGLMEGLQ--FIH
| .. .| ...                  | .||   ..||.... . |          | .              |...|      . . .||   ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RMD--YIHRDIKPENLLIDGET---------------------ICIADFGETVLSTSD------------------------KVVKPGTLPYLTIEHILG
...   ||||.||||.||. ..                     . |.|||      .                               |. |   | .||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

YKENT---------KSMDIWAAACVLGAMFQG--------SHLFSQNSN-----------LQTIHAIRLLLGNHT---------------KETWPEMDKL
.|. |         ...|.|...|... |..|          ||  .|.           .  .. |  .||. |               .|.||.| ||
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PLM---------------QSIE----------LPPVGEKTFSKIEN------------------------------------ITKEAADLMEQMMKYDPT
|                 .|.           .|..  |......                                     ....| ||...|..|||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRLMASQVLNHEYF
||. |.| |.|.||
KRITAEQALQHPYF
Kinase F52B5.2.AA Pkinase 58-292 26 1.7e-35 126.59 Pfam 50-293 (293) Show / Hide 
Range on Protein: 58-292
Range on HMM: 50-293/293
Sequence Identity: 26% (68 aa)

EIKYLDVLTNHEQRRNIVEMLKSFETPEIRLGMVFKRYET-----DLFGILG--DRQRL--QPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLID--
||...  | ||.   |||... .||..     ||.   |      ||| ..   .. ..  .. ....||. . .||...|.|  ||||.||||.|||  
EIQIMKRL-NHP---NIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN

GET---ICIADFGET----VLSTSDKVVKPGTLPYLTIEHILGYKENTKSMDIWAAACVLGAMFQGSHLFSQN----SNLQTIHAIRLLLGNHTKETWPE
|..   ..|.|||        . |   .  ||..|.  | |.|... ... |.|.. |.|  |. |  .|..     . .  .. |.. .|  ... ||.
GHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPW

MDKLPLMQSIELPPVGEKTFSKIENITKEAADLMEQMMKYDPTKRLMASQVLNHEYF
 .  ..   .   .  . .  .  |...|. |... . ..||.||. | |.|.|..|
WCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc F52B5.2.AA S_TKc 9-292 21 2.2e-35 124.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-292
Range on HMM: 1-231/231
Sequence Identity: 21% (65 aa)

YEPGVILG----GCTLRRQLNDSGEAMVFLAESGNEEKKEVIIKFFKCGYGEDEIKYLDVLTNHEQRRNIVEMLKSFETPEIRLGMVFKRYET---DLFG
|| . ..|    |.  . . ..               ...| ||  |    |. .. ...| .  .  ||| .. .|..   .| ||.   ..   ||| 
YEILRKIGKGAFGKVYKCRHKK--------------TGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFD

ILGDRQR------LQPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDGETICIADFGETVLSTSDKVVKPGTLPYLTIEHILGYKENTK-SMDIWA
.. .|.|      . . ....||. . ..|...|..  ||||.||||.|.|  .| |.|||   .         ||. |.  | .      .| . |.|.
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWS

AACVLGAMFQGSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKLPLMQSIELPPVGEKTFSKIENITKEAADLMEQMMKYDPTKRLMASQVLN------
  |.|  |. |  .|.     |    .....                                    ..|| |........||.||. | ..|.      
CGCILYEMLCGYPPFP-----QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HEYF
 |..|
CHPWF
Kinase F52B5.2.AA Ciliate-E2 114-292 19 6e-28 93.01 In-house 147-365 (365) Show / Hide 
Range on Protein: 114-292
Range on HMM: 147-365/365
Sequence Identity: 19% (50 aa)

IQKYMKGLME---------------GLQFIHRMD-YIHRDIKPENLLIDGETICIADFG-------------------ETVLSTSDKVVKPG--------
|...|| . .               .|...|     |||||||||.|.    |.|.|||                   .     .|. . ||        
IKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQ

--------TLPYLTIEHILGYKE---------NTKSMDIWAAACVLGAMFQGSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKLPLMQSIELPPVGEK
        |..|.    ||..|.          ... |||.. ..|  |  | . |                                .| |.  ..   
NMFNTICGTPGYM-APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------QQQIKQCKIDFP

TFS-------------KIENITKEAADLMEQ----MMKYDPTKRLM-ASQVLNHEYF
 .              . .....|. ||. .    |...|| ||.  ..|.|||..|
CPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase F52B5.2.AA CDK5 109-292 28 1.3e-26 80.74 In-house 95-287 (287) Show / Hide 
Range on Protein: 109-292
Range on HMM: 95-287/287
Sequence Identity: 28% (56 aa)

LQPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDGE-TICIADFGET------VLSTSDKVVKPGTLPYLTIEHILGYKENTKSMDIWAAACVLGA
... .|. .|  |. ||.| |     ||| || ||||  . .   ||||        |   |  ||   || |      .| |  . | |.| . |..  
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVV---TLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

MF-QGSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKLPLMQ--SIELPPVGEKT--FSKIENITKEAADLMEQMMKYDPTKRLMASQVLNHEYF
|   |  ||  |.       |  ..|  . ..|| . |||  .    ..|.   ..   . . .  ..  ||...|....| .|. | . |.| ||
MANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase F52B5.2.AA CDK 191-292 28 2.3e-22 68.21 In-house 204-284 (284) Show / Hide 
Range on Protein: 191-292
Range on HMM: 204-284/284
Sequence Identity: 28% (30 aa)

DIWAAACVLGAMFQ---GSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKLPLMQSIELPPVGEKTFSKIENITKEAADLMEQMMKYDPTKRLMASQVL
|.|.. |... ||.   .  ||  .| .  .. |  ..|  | ..||.. |||.                         ||...|. |||.||. |.| |
DMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKMLCYDPKKRISAEQAL

NHEYF
.|.||
QHPYF
Kinase F52B5.2.AA CDK-Unclassified 178-292 24 1.6e-19 60.74 In-house 208-324 (324) Show / Hide 
Range on Protein: 178-292
Range on HMM: 208-324/324
Sequence Identity: 24% (29 aa)

EHILGYKENTKSMDIWAAACVLGAMFQGSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKLPLMQSIELPPVGEKT----FSKIENITKEAADLMEQMM
|  .| |. .   |||...|..  .|||  .|. .. .  .| |  .||. . . ||.. ..|.  .|  ..   .     | |   ..    ..  || 
ELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE--NNCEFQMV

KYDPTKRLMASQVLNHEYF
 |.| .|. ....| |..|
MYQPYNRWKCMEILQHPWF
Kinase F52B5.2.AA CDC2 87-156 36 1.5e-18 53.12 In-house 74-148 (301) Show / Hide 
Range on Protein: 87-156
Range on HMM: 74-148/301
Sequence Identity: 36% (27 aa)

RLGMVFKRYETDLFGILG----DRQRLQPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDGE-TICIADFG
.| |||.... ||   .      .. ..|.....||. . .|. | |..  .|||.|| |.||| . .| |||||
KLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG
Kinase F52B5.2.AA CDK 58-156 32 1.4e-16 49.4 In-house 58-158 (284) Show / Hide 
Range on Protein: 58-156
Range on HMM: 58-158/284
Sequence Identity: 32% (37 aa)

EIKYLDVLTNHEQRRNIVEMLKSFETP----------EIRLGMVFKRYETDLFGILGDRQRLQPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDG
||..|  |  |.   |||  .  . |           | .| |||   ..|| ...          |. ||. |..|| ..|.   .|||.|| |.||. 
EISLLKEL--HP---NIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINN

ETI--C----IADFG
  .  |    |||||
NGEVKCGRLKIADFG
Kinase F52B5.2.AA CDKL 178-292 27 1.8e-16 52.8 In-house 169-286 (286) Show / Hide 
Range on Protein: 178-292
Range on HMM: 169-286/286
Sequence Identity: 27% (32 aa)

EHILGYKENTKSMDIWAAACVLGAMFQGSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKLPLMQSIELPPVG--EKTFSKIENIT-KEAADLMEQMMK
|  .|. .  |. ||||..||.. |..|  |.   | .   . |.  ||. . .      | |.   . .| .   |   ..  |.  |.|.|.|.....
ELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLH

YDPTKRLMASQVLNHEYF
 ||..|. ..| ..|.||
MDPDERMTCEQLMHHPYF
Kinase F52B5.2.AA CRK7 183-292 25 6.6e-16 51.16 In-house 227-343 (343) Show / Hide 
Range on Protein: 183-292
Range on HMM: 227-343/343
Sequence Identity: 25% (30 aa)

YKENTKSMDIWAAACVLGAMFQGSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKLPLMQSIELPP-VGEKTFSKIE------NITKEAADLMEQMMKY
.|  ... |.|   | ||  | .  .|  |  .. .  |  . |  . . ||| .|||. . .        .     .      ...||. ||. .|. .
FKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCL

DPTKRLMASQVLNHEYF
||.||  |.. |.|..|
DPKKRFTAEECLQHDWF
Kinase F52B5.2.AA RCK 96-156 29 1.8e-15 45.3 In-house 83-159 (298) Show / Hide 
Range on Protein: 96-156
Range on HMM: 83-159/298
Sequence Identity: 29% (23 aa)

ETDLFGILGD---RQR-LQPST--IQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDG----------ETICIADFG
...|.  . |   |.. |. ..  | ..|. .  || ..|.  . |||.||||... |          ..| |||||
DMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFG
Kinase F52B5.2.AA RCK 260-292 45 7.7e-14 40.0 In-house 266-298 (298) Show / Hide 
Range on Protein: 260-292
Range on HMM: 266-298/298
Sequence Identity: 45% (15 aa)

NITKEAADLMEQMMKYDPTKRLMASQVLNHEYF
|..... .||| |...|| ||  |.|.|.| ||
NCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase F52B5.2.AA CDC2 253-292 32 6.6e-13 35.48 In-house 253-301 (301) Show / Hide 
Range on Protein: 253-292
Range on HMM: 253-301/301
Sequence Identity: 32% (16 aa)

KTFSKIEN---------ITKEAADLMEQMMKYDPTKRLMASQVLNHEYF
.. . ..|         ...|. || .||  ||| ||. | . |.| ||
DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase F52B5.2.AA CDK-Unclassified 114-156 36 3.7e-12 36.16 In-house 123-171 (324) Show / Hide 
Range on Protein: 114-156
Range on HMM: 123-171/324
Sequence Identity: 36% (18 aa)

IQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDGET------ICIADFG
|...|. . ||. ..|    .||||||.|..|.  .      . |||||
IRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFG
Kinase F52B5.2.AA CDKL 109-156 38 1.7e-11 35.55 In-house 95-144 (286) Show / Hide 
Range on Protein: 109-156
Range on HMM: 95-144/286
Sequence Identity: 38% (19 aa)

LQPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLID--GETICIADFG
. .. ..|||  ......| | .. |||||||||.||     .. . |||
VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFG
Kinase F52B5.2.AA CRK7 90-156 35 2.1e-11 35.38 In-house 88-157 (343) Show / Hide 
Range on Protein: 90-156
Range on HMM: 88-157/343
Sequence Identity: 35% (25 aa)

MVFKRYETDLFGILGDR--QRLQPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDGE-TICIADFG
|||     || | |     .   .. .  .|| |.||.. .|.   .|||||  |.|..    . |||||
MVFEYMDHDLMGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFG
Kinase F52B5.2.AA TyrKc 18-292 18 3e-06 -120.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-292
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

CTLRRQLNDSGE-AMVFLAESGNEEKKEVIIKFFKCGYGEDEIKY-LDVLTNH-EQRRNIVEMLKSFET--------PEIRLGMVFKRYETDLFGILGDR
 || ..|  .|.   |....       .| .|  | .  . ..   . ....   .  ||| ..    .        . . . | .  .  ||   | ..
ITLGKKL-GEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

QR-LQPSTIQKYMKGLMEGLQFIHRMDYIHRDIKPENLLIDGET-ICIADFGETVLSTSD-------KVVKP-----GT--LPY--LTIEHILGYKENTK
.. |....  ...    .| ...|.. .||||.   | |.. .  . |.||| .   ..|       .. ..     |   ||.  . .| |  .| .||
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SMDIWAAACVLGAMF-QGSHLFSQ-----NSNLQTIHAIRLLLGNHTKET-WPEMDKLPLMQSIELPPVGEKTFSKIENITKEAADLMEQMMKYDPTKRL
| |.|.   ..  .|  |    .       || . |. ..        .   | |                  |      ..|  ..|.|  ..|| .| 
S-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-----------------F---VCCPDEMYQIMKQCWHEDPEDRP

MASQVLNHEYF
  |..  ||.|
TFSEI--HECF