Gene mpk-1 (Nematode worm)

mpk-1

Species: Nematode worm
Alias: mpk-1, F43C1.2, F43C1.2A, F43C1.2a, sur-1, aSWK192, CE01583
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 4215152-4215153, WormBase Genetic Map location: III:-3.9478,

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
mpk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 289 Kinase domain by global Sugen HMM Fasta, JSON
mpk-1.AA Protein Genbank 444 None Fasta, JSON

Protein domain

Protein domains of mpk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase mpk-1.AA ERK1 96-384 84 1.6e-242 811.96 In-house 1-289 (289) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-289/289
Sequence Identity: 84% (244 aa)

YVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSND
|.||.||||||||||.||.||....||||||||||||||.|||||||||||.|||||||||||.|||..|.....|.||||||||||||||||||.||||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSN
|.||||||||||||||||||||||||||||||||||||||||||||||..||..||||||||||||||||||||||||||||||||.|||||||||||||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN

RPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYL
||.|||||||||||.||.|.||||..||.||||.|||.||.|||||||.|||||.|.||..||||||||||||||.||..|.|||||||
RPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase mpk-1.AA MAPK 96-384 53 3.4e-199 668.06 In-house 1-328 (328) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-328/328
Sequence Identity: 53% (177 aa)

YVNLSYIGEGAYGMVASALDTITRDR------VAIKKIS-PFEHQTFCQRTLREIKILNRF-KHENIINIQEIIRS------ETVDSLKDIYIVQCLMET
|..|..||.||||.|.|| |. |...      ||||||| ||...|.|.||.||||.|..| .|||||....|..       .. ....|||||. ||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLKTQK-LSNDHVCYFLYQILRG--LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDP-QTDHTG----------FLTEYVATRWYRAP
||....|.|. ||.||..||.||||||  |||||||||.||||||||.|.|. ||||||||||||..|| ...|..          ..||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--SKGYTKSIDVWSVGCILAEMLS-NRPLFPGKHYLDQLNLILAVVGSPSNADLQCII-NDKARSYLISL---PHKPKQPWARLYPG----ADPR
|||||  ...|||..|.||||||.||||. ..||||||.|.||.|||..|.|.||  ..|||  ...||.|. ||   |..||.||. ..|.    |.| 
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLDKMLTFNPHNRIDIEQALAHPYL
|.|||.|||.|.|. ||..|.||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase mpk-1.AA ERK 96-384 54 1.5e-174 586.22 In-house 1-307 (307) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-307/307
Sequence Identity: 54% (166 aa)

YVNLSYIGEGAYGMVASALDTI-----TRDRVAIKKI-SPFEHQTFCQRTLREIKILNRFK-HENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLK
|  .. ||.|||| |.|| |.      |...||||||  .|.|  .| |||||||.|. || |||||... |....  ....|||.|. |||||| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

TQ-KLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDP--QTDHTG---FLTEYVATRWYRAPEIMLNSKGYTKSIDV
.|  || ||. ||.||||.||||||||||.||||||||.|.|  ||||||||||||. |.  |  |..   |.||||||||||||||||. . |||..|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSP-SNADLQCIINDKARSYLISLPH--KPKQPWARLYPGAD--PRALDLLDKMLTFNPHNRIDIEQ
||.|||.||||  .|||||| |..|.|.|... |.| |  |||.| ...|. |...||.  .|..||  ..| |.  | |.|||.|||.|.|  || .|.
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYL
.|.|||.
CLEHPYF
Kinase mpk-1.AA CMGC 96-384 28 6.2e-145 479.73 In-house 1-513 (513) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-513/513
Sequence Identity: 28% (145 aa)

YVNLSYIGEGAYGMVASALDTITRDR--------------VAIKKIS-PFEHQTFCQ----------RTLREIKILNRFK-----------------HEN
| ....||||.||.| .. |. |  .              ||||||. || ... ..          |.||||||| ...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IINIQEIIRSET-------------VDSLKDIYIVQCLMETDLYKLLKTQK----------LSNDH------------VCYFL------YQILRGLK--Y
|.....|....              . .....|.|  .|..|||...| ..          ||  |            ..||.      ||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAN--VLHRDLKPSNLLLNTTCDL--------------------KICDFGLARVTDPQTDH------------------TGFLTEYVATRWYRAPEIM
.||..  ..||||||.|.|.| .|.|                    ||||||||| ..|  ||                  . ..|.||.|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNS---------KGYTKSIDVWSVGCILAEMLSN--------RPLFP-----------GKHYLDQLNLILAVVGSP----------------SNADLQCI
|..         ..||..||.||||||.|||. .        .||||           ||...|||..|  | |.|                .. . ..|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

I--------------------NDKARSYLIS---LPHKPKQPWARLYPG-----------------------------------ADPRALDLLDKMLTFN
                     ...|| |. |   .| .|..|| .|.|.                                   .|| |.|||.|||...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PHNRIDIEQALAHPYL
|..|| .||||.|||.
PDKRITAEQALQHPYF
Kinase mpk-1.AA p38 96-384 46 2.3e-140 472.64 In-house 1-289 (289) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-289/289
Sequence Identity: 46% (137 aa)

YVNLSYIGEGAYGMVASALDTITRDR---VAIKKIS-PFEHQTFCQRTLREIKILNRFKHENIINIQEIIRS--ETVDSLKDIYIVQCLMETDLYKLLKT
|.||...|.|||| |..| |. |...   |||||.. ||.   .  || ||.. |   .|||.| . ..     . .....|.|.|  .|..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QKLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCIL
|.|| ||. . .|||||||||||||.. ||||||||. .|  |.|.| ||||||    ..|    .|.|||||||||||||||   ||. .|.||||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----HCDDE--MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYL
||... |.||||. ..|||. |..|.|.|.   .| | ...||.|. |.|  |..  .....||.| |.|||.|||   |  ||  |.|..|||.
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase mpk-1.AA ERK5 96-384 50 1.3e-128 433.53 In-house 1-295 (295) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-295/295
Sequence Identity: 50% (148 aa)

YVNLSYIGEGAYGMVASALDTITRDRVAIKKI-SPFEHQTFCQRTLREIKILNRFKHENIINIQEIIR-SETVDSLKDIYIVQCLMETDLYKLLK-TQKL
|  .  ||.||||.|.||    . ..||||||   |.  |  .||.||.|||  |.|.||| |..|..  .    .||.|.|  ||| || ...   | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--VTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILA
. .|. ||||||||||||.|||.|.|||||||||| |  |.||| |||.||   |    .|  |.|||||||||||||.|. |. ||. |||||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLIS-LPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYL
||.. | .|||| |..||.||. |.| |. . .| .  |. . |. . .| .  ..| ..||.||. ||||| .|| | | .|| . .|| ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase mpk-1.AA ERK7 96-384 44 3.9e-119 402.1 In-house 1-292 (292) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-292/292
Sequence Identity: 44% (132 aa)

YVNLSYIGEGAYGMVASALDTITRDRVAIKKI-SPFEHQTFCQRTLREIKILNRFK-HENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLK-TQKL
|  .. .| ||||.|  |.|  |.. ||.|||   |  ||  ||| ||| .|  |. |.||| . ..|| .     .|||.|   |||||    .  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADND---RDIYLVFEFMETDLHAVIRKGNIL

SNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VTDPQ--TDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCIL
 . |. | .||.|| .||.||.||.||||||||.||.. | .|.||||||| ... .   .... |||||||||||||||.| |. ||| .| ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYL
.||| ..|.|||   ..|...|| ... |...|.. |  . | . | .........   ..|.. . |.||| ..| |||..|...||||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase mpk-1.AA ERK3 96-384 43 4.1e-111 358.84 In-house 1-300 (300) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-300/300
Sequence Identity: 43% (130 aa)

YVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKD-----------IYIVQCLMETDLY
.. |   | |  |.| || |     .||||||.    .  |   ||||||. |  |.||. . |..  .  |   |           ..||| .||||| 
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKS-CKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLA

KLLKTQKLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVW
 ..  |.||..|.  | || ||||||||||||||||||| |.. ||    ||| |||.||. ||   | |.|.| . |.||| |. .|    ||| || |
CVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMW

SVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPY
. ||||||||  ..||.| | | |. |||  .    . |.. .      .|.      |..|  .| .. |  |||.| .||||.| .|.  | || |||
AAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPY

L
.
M
Kinase mpk-1.AA CDK 96-384 34 7.89999999999e-101 323.34 In-house 1-284 (284) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-284/284
Sequence Identity: 34% (110 aa)

YVNLSYIGEGAYGMVASALDTITR-----DRVAIKKIS-PF-----EHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSL------KDIYIVQCL
|  |  ||||.|| |  | |..|      . ||.|||         |   | . ..|||..|    |.||... ... ... |.       . .|.|   
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLYKLLKTQKLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-----LKICDFGLARVTDP----QTDHTGFLTEYVATRWYRAPEI
|..||.|...        .  ...|.|||| |.|| ...||||||.|.|.| .       ||| ||||||        . . .  .|  | |.||||||.
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPEL

MLNSKGYT--KSIDVWSVGCILAEMLS---NRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKM
 | || |.   .||.||||||.|||.    ..|||||.  .||| .|  . |.|.  .   .                                |||.||
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNKM

LTFNPHNRIDIEQALAHPYL
|...|..||  |||| |||.
LCYDPKKRISAEQALQHPYF
Kinase mpk-1.AA S_TKc 96-384 28 9.4e-97 328.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMET---DLYKLLKTQK-
|  |  ||.||.| |  . .. |  .||||.|.        ....|||.|| . .|.||... .....      ...|.|  ....   ||....| .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTK-SIDVWS
      ..  |.....|||...|.|.|| ...||||||.|.||..   .|||||||||.           | .. |.||.|||..    ||.| ..|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALA----
.||||.|||. .|.||      |..... ..|                                     .| |.|...|.|...| .|. . .||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase mpk-1.AA Pkinase 96-384 29 2.4e-88 304.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLR---EIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMET-----DLYKLL
|. .. ||.|..| |  . .  |...||.|.|.  .    ...|.|   ||.|..|..|.||. . .. ..      ..||.|. ..|      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K---TQKL--SNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL----KICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTK
.     ..  | .... ..|||||||.|.|| ...||||||.|.|.. ....    ||||||||.. |  . . . .| .. |.||.|||. . ...|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SIDVWSVGCILAEMLSNRPLFPGK----HYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRID
..|.||.||||.|||. ||.|||.    . .||. .|  . | |   | .  ..   .. .   . .  .   .. . ... ..|.....|...|. |. 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

IEQALAHPYL
.||.| ||..
AEQILQHPWF
Kinase mpk-1.AA MAPK-Unclassified 96-248 47 1.3e-67 230.98 In-house 1-163 (575) Show / Hide 
Range on Protein: 96-248
Range on HMM: 1-163/575
Sequence Identity: 47% (77 aa)

YVNLSYIGEGAYGMVASALDTIT-RDRVAIKKIS-PFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDS--LKDIYIVQCLMET---DLYKLLK
|    .|| |||| |. | |. .    |||||.   |. .| | |.|||| ||    |.|||.||.|.. .       .|||||  .|.|   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

TQK--LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VTDPQ
     ..  |. ||.|||||||||.|||...||||||||||.|  | ..|||||..| . | |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDNQ
Kinase mpk-1.AA MAPK-Unclassified 251-384 34 1.4e-54 187.6 In-house 401-575 (575) Show / Hide 
Range on Protein: 251-384
Range on HMM: 401-575/575
Sequence Identity: 34% (61 aa)

HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSN-----------RPLFPGKH--------------------YLDQLNLILAVVGSPS
| . .|.||.||||||||||| .. |.. .| ||.|||.|||...           ||||||.                     . ||...|. . |.| 
HCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP

NADLQCIINDKARSYLISLPHKPKQPWARLYPGADP----------RALDLLDKMLTFNPHNRIDIEQALAHPYL
  |.. | .|.|| |. |.  |.  ..  |.. . |           ..|...||| |||  || ..||| ||| 
EEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase mpk-1.AA TyrKc 96-384 20 5.2e-15 19.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRF--KHENIINIQEIIRSETVDSL---KDIYIVQCLMET-DLYKLLKT
 . .  .||||.| |  .  .     ||.|.. .       .  .||..|. ..  .|.||...  .....        . ..||  .|.  || . |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

QK--LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQ--------TDHTGF--LTEY-VATRWYRAPEIMLNSKGY
 .  |.... ..| .|| .|  |.|| |. ||||   | |..     ||.||||.|  .          . ..     . . .  ||. ||| .  .|  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT

TKSIDVWSVGCILAEMLSN-RPLFPG-----------KHYLDQLNLILAVVG----SPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDL
||| |||| |  . |....  .  ||            .|..| .           |                                .... .   ..
TKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------FVCCPDEMYQI

LDKMLTFNPHNRIDIEQALAHPYL
  .   ..|..|   ..   | ..
MKQCWHEDPEDRPTFSEI--HECF
Kinase mpk-1.AA Pkinase_Tyr 96-294 28 3.3e-08 28.43 Pfam 1-209 (270) Show / Hide 
Range on Protein: 96-294
Range on HMM: 1-209/270
Sequence Identity: 28% (62 aa)

YVNLSYIGEGAYGMVASALDT----ITRDRVAIKKISPFEHQT--FCQRTLREIKILNRF-KHENIINIQEIIRSETVDSLKDIYIVQCLMET-DLYKLL
 . .  .||||.|.|  .  .     |.  ||.|.. .  ..   . .  .||.||.  . .|.||..   .. ..   .   ||||  .|.  ||.. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL

KTQ-----KLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVT--DPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI
...     .|.  . . . .|| .|. | .| |  ||||   | |.. .   |||||||||    | .  ..      .  .|. ||| . ..|  ||| 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGKFTTKS-

DVWSVGCILAEMLS
|||| |  . |...
DVWSFGVLMWEIFT