R10D12.10

Species: Nematode worm
Alias: CE12690, R10D12.10, aSWK100
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 13960920-13959126, WormBase Genetic Map location: V:5.65,

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
R10D12.10.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
R10D12.10.AA Protein Genbank 425 None Fasta, JSON

Protein domain

Protein domains of R10D12.10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase R10D12.10.AA TTBKL 27-287 38 5.5e-128 431.48 In-house 1-288 (288) Show / Hide
Range on Protein: 27-287
Range on HMM: 1-288/288
Sequence Identity: 38% (112 aa)

WFSIGEIAKGDLSTVSRVIDSEG-KIEAAMKVEKLSKD--SKKRSIEKDVLEALR--DSPHSAHIIEQLLIGDYRFTVMTLSGPTLGIIKHIMDNK--FS
|  ...|..|   .| .|.|... | .||||.|| ...  ...  .| .|| .|   .||| ......  ..||.| |||| || |. ... | ||  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

DSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKS----SRNILLLDFGEARQFARNDNG--------KWMLRKPRD---KAPFRGSDQYCSPRM
|.|..|.....|.|.|..|..||||||. | |...  ...    .|...|.||| |||.|..|..        |||.|.||.   ||||||. .||||.|
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HNHEEQGRVDDLWSWLYVFVELRAFLPWTDSTSRFKYGPLKRELLDDLLASDP-----FITTFCPIVTLLREGKYADRPDYGKIYEIL
|.. ||||.||||||.|...||.. ||||..... ... .|....|..|..|.     .   ||.... ||. .|.|||||..|||..
HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF

Kinase R10D12.10.AA CK1 27-283 25 1.3e-83 284.06 In-house 1-339 (339) Show / Hide
Range on Protein: 27-283
Range on HMM: 1-339/339
Sequence Identity: 25% (88 aa)

WFSIGEIAKGDLS-TVSRV-----IDSEGK-----IEAAMKVEKLSKD--SKKRSIEKDVLEALRDS----------------PHSAHIIEQLLIGD---
|  .  |..|    .. .|     .|....      |.|||||. .    . .. .|  ....|..                 ..  ... .. ..    
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--YRFTVMTLSGPTLGIIKH---IMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPY-------------KSSRNILLLDFGEAR-QFA
  |.. |||| ||.|. ..     ...|||..|.|.. ...|.|....|..||||||. | |.... .             . .|.. ..||| || ...
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

RNDNG---------KWMLRKPRD---KAPFRG-SDQYCSPRMHNHEEQGRVDDLWSWLYVFVELR-AF--LPWTDSTSRFK-----YGPLKRELLDDLLA
..|..         .|..| ||.   |..|||    |||...|.. ||||.||||||.|...|.      |||.. ..  |      .  |.|  |. . 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SDP-----------FITTFCPIVTLLREGKYADRPDYGKI
|.|           .   | .|.. .|. || ||||| .|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI

Kinase R10D12.10.AA Worm6 28-283 30 2.6e-39 136.9 In-house 1-279 (279) Show / Hide
Range on Protein: 28-283
Range on HMM: 1-279/279
Sequence Identity: 30% (85 aa)

FSIGE-IAKGDLSTVSRVIDSEGKI--EAAMKVEK--LSKDSKKRSIEKDVLEAL--RDSPHSAHIIEQLLIGD--YRFTVMTLSGPTLG-IIKHIMDNK
..... |..|. ..|  | |...|   . |||.||   .  ...  .|  || |.  . ..|   |...  ..   ... |||| |. |. ..|. .|.|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPY-----KSSRNILLLDFGEAR-QFARNDNGKWMLRKPR-DKAPFRGSDQYCSPRMHNHEEQ
|| .| |...  .| || ||| .||||||. | | .   |     . ...| .|||| .|  ...|....  ||.|| ....|||  .|..   |.. ||
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNE--LRTPRWTACGFRGTVRYAPLACHKGQEQ

GRVDDLWSWLYVFVELRAF-LPWTDSTSRFKYGPLKRELLDDL------LASDPFIT-TFCPIVTLLREGKYADRPDYGKI
.| ||. ||.|. ||.  . |||  .. ..  ...|..  ...      .   |. .  |  | . . ...| ||||| .|
CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI

Kinase R10D12.10.AA TTBK 94-232 39 3.4e-24 82.41 In-house 69-207 (257) Show / Hide
Range on Protein: 94-232
Range on HMM: 69-207/257
Sequence Identity: 39% (56 aa)

DYRFTVMTLSGPTLG-IIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEP--FNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDK
.. . ||.| |  |     .  . .|| || ||| .  | .|.  |. || |||  |  | . . |..  |.. .|||| |||.    |..   | ||  
KFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST-CRKCYMLDFGLARQYT---NACGEVRPPREV

APFRGSDQYCSPRMHNHEEQGRVDDLWSWLYVFVE-LRAFLPW
| |||   | |   |   | || |||||  |. || .   |||
AGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW

Kinase R10D12.10.AA CK1-Unique 27-226 26 1e-22 75.59 In-house 1-223 (337) Show / Hide
Range on Protein: 27-226
Range on HMM: 1-223/337
Sequence Identity: 26% (61 aa)

WFSIGEIAKGDLSTVSRVIDS-EG-----KIEAAMK--VEKLSKDSKKRSIEKDVLEALR-------DSPHSAHIIEQLLIGDYRFTVMTLSGPTLGIIK
|  | .| .|.  .| |||.. .|     . . .||  .   .| .   .||. |. ..        .. |   ..   . .|. . |||. || .  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

HIMDN-KFSDS------TILRLSMRTLMAIKDLHEHGFIHRDLEPFNIAL-SPY-KSSRNILLLDFGEARQ--FARNDNGKWMLRKPRDKAPFRGSDQYC
  | | .|  .      ......  .| .|   |.|||.||.. | |. . .|     . .  ||.|. |   |  | .    .|.|| ..||||   ||
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNH---QIRQPRPITPFRGCKDYC

SPRMHNHEEQGRVDDLWSWLYVFVEL
.   |  .|.|| ||. ||.| .. |
PCSCHQCREHGRRDDMESWFYMLYHL

Kinase R10D12.10.AA CK1-A 94-283 29 2.5e-13 43.27 In-house 68-261 (261) Show / Hide
Range on Protein: 94-283
Range on HMM: 68-261/261
Sequence Identity: 29% (57 aa)

DYRFTVMTLSGPTLGIIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPF
||   || | || |  .  . . .|.  |.| |    .| |  .||..|||||. | |  .   .    . |.||| |... |  . .  .    ||   
DYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY-RDSRTRQHIPYREDKN-L

RGSDQYCSPRMHNHEEQGRVDDLWSWLYVFVEL-RAFLPW---TDSTSRFKYGPLKRELLDDLLAS--DPFITTFCPIVTLLREGKYADRPDYGKI
 |   | |   |   || | ||. |  ||..   |. |||   .  | . ||  .    .   ..     | . || ...  |. .. . |||  .
TGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL

Kinase R10D12.10.AA CK1-D 93-283 29 8.1e-13 41.4 In-house 67-261 (261) Show / Hide
Range on Protein: 93-283
Range on HMM: 67-261/261
Sequence Identity: 29% (58 aa)

GDYRFTVMTLSGPTLGIIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAP
|||   || | || |  .    . |||  |.| |.   .  |. .| . |||||. | |  .   |    . ..||| |...      . .    |..  
GDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPY--RENKN

FRGSDQYCSPRMHNHEEQGRVDDLWSWLYVFVEL-RAFLPWT---DSTSRFKYGPLKRELLDDLLAS--DPFITTFCPIVTLLREGKYADRPDYGKI
  |   | |   |   || | ||| |  ||..   |  |||      | | ||  .    ..  .    . .   |   .   |. |. |.|||  .
LTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL

Kinase R10D12.10.AA S_TKc 27-292 17 6.4e-11 -16.73 SMART 1-231 (231) Show / Hide
Range on Protein: 27-292
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

WFSIGEIAKGDLSTVSRVIDSEGKIEAAMKVEKLSKDSKKRSIEKDVLEALRDSPHSAHIIEQLLIGDYRFTVMTLSGPTLGIIKHIMDNK--------F
.  . .| ||  ..| .... . . . |.|. |     ..   | ..|.   . |.  ....     |. . || . .  ||  .......        |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRGSDQYCSPRMHNHEEQGR-VDDLW
.  .. ..   .. |.. .|.||.||||| | || |.      .| . ||| |||.                  | |.  |..| .      |.   | |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCKCDWW

SW---LYVFVELRAFLPWTDSTSRFKYGPLKRELLDDLLASDPFITTFCPIVTLLREGKYADRPDYGKIYE----ILAAKMT
|    || ..  .   |               .... ..        .. ..  . .   ..||   .. .    | .    
SCGCILYEMLCGYPPFP------------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase R10D12.10.AA MSK 132-218 28 2.8e-09 27.49 In-house 112-195 (277) Show / Hide
Range on Protein: 132-218
Range on HMM: 112-195/277
Sequence Identity: 28% (26 aa)

MAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRGSDQYCSPRMHNH--EEQG---RVDDLWS
||.. .|. |.||||| | || .   .... . | ||| || | .. . .           .... .| .| | .   ...|    . |.||
MAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS--------PCFTLHYMAPEMLRRGYAQDGGYDEACDWWS

Kinase R10D12.10.AA Dual 97-221 28 3.3e-09 26.97 In-house 88-211 (282) Show / Hide
Range on Protein: 97-221
Range on HMM: 88-211/282
Sequence Identity: 28% (36 aa)

FTVMTLSGPTLG-IIKHIMDNKFSDSTILRLSMRTLMAIKDLHEHGFIHRDLEPFNIALSPYKSSRNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRG
. || . ||.|  | .  . . .| ..     . .| ||.|||  |..||.  | | .         . ..||. .| .    |.|   | .| |  . |
YWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKK--HRTARKKVKMYG

SDQYCSPRMHNHEEQGRVDDLWSWLY
   | .    .  .||| ||| .| |
CGRYACRACMMQKDQGRKDDLECWIY

Kinase R10D12.10.AA RSK 132-202 34 1.1e-08 28.18 In-house 115-177 (278) Show / Hide
Range on Protein: 132-202
Range on HMM: 115-177/278
Sequence Identity: 34% (25 aa)

MAIKDLHEHGFIHRDLEPFNIALSPYKSS-RNILLLDFGEARQFARNDNGKWMLRKPRDKAPFRGSDQYCSP
.|.. ||..|.||||| | || .   . . . | | ||| ..|| |.|...|.         |... .|. |
LAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-RCDHNQWTMT-------FCYTIEYMAP

Kinase R10D12.10.AA TTBK 273-283 63 0.078663 2.29 In-house 247-257 (257) Show / Hide
Range on Protein: 273-283
Range on HMM: 247-257/257
Sequence Identity: 63% (7 aa)

KYADRPDYGKI
.|.|||||  |
NYEDRPDYQLI