Gene T19D12.5 (Nematode worm)

T19D12.5

Species: Nematode worm
Alias: T19D12.5, aSWK106, CE04980
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: II:-0.07, WormBase Physical Map location: II: 6636237-6634879

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
T19D12.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
T19D12.5.AA Protein Genbank 361 None Fasta, JSON

Protein domain

Protein domains of T19D12.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase T19D12.5.AA TTBKL 62-328 36 5.4e-139 468.05 In-house 1-288 (288) Show / Hide 
Range on Protein: 62-328
Range on HMM: 1-288/288
Sequence Identity: 36% (106 aa)

WLIEGLIGKGGYGEIYLALDVVRGEEVAIKVEPKKRRGKLAKRMILEQHVLAKMQ--GKPHVPMIYGSGHAEKYNFIIMQILSINVGDIKKSSPNKK-LS
|.|...||.||.|..|.. |... ...|...|.|.|...  .||..|.||| |.|  |.||.|....||. ..|||..|. .. |..|..| .|||| .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

QCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHS---RHTLILLDFGLVRRYKMESGEW-----------REPRL---RAGFRGTTRYVSIRV
.....|| .|...||...|. |..||||||.|.|.|.  ||   .....|.|||..|.|....|||           |.||    .|.|||||||.|...
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HRRCEQSPYDDLVSVMYTAYELLAGELPWKHLEKSEEVVQLKEVMTENGINPELF--QGDKSVLIDFFKQVSEMDPMKEPCYEKLIECI
|.|.||.. |||.|.||...||..| |||...|. .|....|. |... .. ...  .. .| . .|.| .........|.||...||.
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase T19D12.5.AA CK1 62-324 26 7.1e-99 334.78 In-house 1-339 (339) Show / Hide 
Range on Protein: 62-324
Range on HMM: 1-339/339
Sequence Identity: 26% (90 aa)

WLIEGLIGKGGYG-EIYLA-----LDVVRG-----EEVAIKVEPKKRRGKLAKRMILEQHVLA-------------------KMQGKPHVPMIYGSGHAE
| .. .||.||.| .||..      |. ..     ||.|.|||||| .|.. ..|...| ...                   |..|.||..|.. .|. .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

K-YNFIIMQILSINVGDIKK--SSPNKKLSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPH------------SRHTLILLDFGLVR-RYK
. ||...|. |  | .|..|    .|.|.|  .. .|  | . ||...|. |..|||.||.|.|.|. ..             .... ..|||..| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

MESGEW------------REPRL---RAGFRG-TTRYVSIRVHRRCEQSPYDDLVSVMYTAYELLAGE--LPWKHLEKSEE-----VVQLKEVMTENGIN
. .|..            |.||    ..|||| |.||.||..|...||.. |||.|..|.  |.| |.  |||..... ..     |.. |. .. .  .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

PELF--------QGDKSVLIDFFKQVSEMDPMKEPCYEKL
  .|        ..  . . ...| ...... ..| ||..
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase T19D12.5.AA TTBK 62-284 38 5.3e-60 205.65 In-house 1-221 (257) Show / Hide 
Range on Protein: 62-284
Range on HMM: 1-221/257
Sequence Identity: 38% (87 aa)

WLIEGLIGKGGYGEIYLALDVVRG-EEVAIKVEPKKRRGKLAKRMILEQHVLAKMQGKPHVPMIYGSGHAEKYNFIIMQILSINVGDIKKSSPNKKLSQC
| .   || ||.|||| |.|..   |.||||||  .      |   .|  || |.||..||   .| |  .|.|...||..  |  |   . |  . |  
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLK---MEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLS

SVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYKMESGEWREPRLRAGFRGTTRYVSIRVHRRCEQSPYDDLVSVMYTA
.  |.  |.. ...  |. |. |||.|| |   | .|  .    .||||| |.|   .|| | ||  |||||| || ||  ||  |    ||| |. |  
TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML

YELLAGELPWKHLEKSEEVVQLKE
 | . | |||  .   ..| ..||
VEFVQGQLPWRKIKDKDQVGEMKE
Kinase T19D12.5.AA Worm6 62-284 32 1.6e-52 180.82 In-house 1-235 (279) Show / Hide 
Range on Protein: 62-284
Range on HMM: 1-235/279
Sequence Identity: 32% (78 aa)

WLIEGLIGKGGYGEIYLALDVVRGE--EVAIKVEP--KK-RRGKLAKRMILEQHVLAKMQGKP--HVPMIYGSGHAEK--YNFIIMQILSINVGDIKKSS
| .. .||.||.| .|...|  ...  ..|.|.|   ..  |..|     .|  || .   ..  |.. |   |  ..  .|.|.|...  | .|..| .
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLK----MECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNR

PNKKLSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIF----PHSRHTLILLDFGLVR--RYKMESGEWREPR-LRAGFRGTTRYVSIRVHRRC
|..|.|     .|  | ..|..||| .|..||||||.| |.|       . .||. .||||. |  .|. . .| | ||  ..|||||.|| ..  |...
PDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQ

EQSPYDDLVSVMYTAYELLAGELPWKHLEKSEEVVQLKE
||.. ||. | .|   |.. |.|||.|.... .| ..|.
EQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKK
Kinase T19D12.5.AA CK1-Unclassified 62-270 32 4.2e-33 95.06 In-house 1-216 (244) Show / Hide 
Range on Protein: 62-270
Range on HMM: 1-216/244
Sequence Identity: 32% (72 aa)

WLIEGLIGKGGYGEIYLALDVVRGEEVAIKVEPKKRRGKLAKRMILEQHVLAKMQGKP-------HVPMIYGSGHAEK--YNFIIMQILSINVGDIKKSS
  ..  || |  ||||.. .. ..||||||.| |. .    .    |  ..  .|.         ..|..| .|  |.  ||...|  |  .  |...  
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK---HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC

PNKKLSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYK-M-ESGEWREPRLRAGFRGTTRYVSIRVHRRCEQSPY
 |.|.|   |  |  | |  .. ||. ...||| || | . |     .|.. . ||||  ||. | . |.  . |   .. ||.|| ||. |.  |||  
-NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRR

DDLVSVMYTAYELLAGELPW
||| |..|.   .| |.|||
DDLESLGYVLIYFLKGSLPW
Kinase T19D12.5.AA CK1-A 62-274 32 9.3e-30 102.24 In-house 1-209 (261) Show / Hide 
Range on Protein: 62-274
Range on HMM: 1-209/261
Sequence Identity: 32% (69 aa)

WLIEGLIGKGGYGEIYLALDVVRGEEVAIKVEPKKRRGKLAKRMILEQHVLAKMQGKPHVPMIYGSGHAEKYNFIIMQILSINVGDIKKSSPNKKLSQCS
. .   || | .|.|||.. .  |||||||.| .| |      .| |  |   .|| . .| .   |.   || ..|..|   . |.     ... .   
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKAR---HPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKT

VGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYK-MESGEWREPRLRAGFRGTTRYVSIRVHRRCEQSPYDDLVSVMYTA
|  .  |.|. .  .|| ...|||.|| |   ||  |  . | |.|||| ..|.  .. .  . |      || || ||  |   |||  ||. |. |  
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNK-LFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM

YELLAGELPWKHLE
     |.|||. ..
MYFNRGKLPWQGMK
Kinase T19D12.5.AA CK1-D 62-273 31 1.8e-27 93.86 In-house 1-208 (261) Show / Hide 
Range on Protein: 62-273
Range on HMM: 1-208/261
Sequence Identity: 31% (68 aa)

WLIEGLIGKGGYGEIYLALDVVRGEEVAIKVEPKKRRGKLAKRMILEQHVLAKMQGKPHVPMIYGSGHAEKYNFIIMQILSINVGDIKKSSPNKKLSQCS
. |   || | .|.||.  ..  .||||||.|. | .      . .| ..   |||   .|.|   |.   || ..|..|   . |.     ..| |   
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK---HPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKT

VGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYKMESGEWREP-RLRAGFRGTTRYVSIRVHRRCEQSPYDDLVSVMYTA
|  .  |.|. .. .|   ..|||.|| |   |.  .  ..  ..|||| .||.    .   | |      || || ||  |.  |||  ||| |. |  
VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLG-KRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

YELLAGELPWKHL
     | |||. |
MYFNRGSLPWQGL
Kinase T19D12.5.AA CK1 62-270 31 2.7e-27 91.11 In-house 1-216 (271) Show / Hide 
Range on Protein: 62-270
Range on HMM: 1-216/271
Sequence Identity: 31% (69 aa)

WLIEGLIGKGGYGEIYLALDVVRGEE--VAIKVEPKKRRGKLAKRMILEQHVLAKMQG------KPHVPMIYGSGHA--EKYNFIIMQILSINVGDIKKS
  ..  || |  |.|||. ..  |||  ||||.|..| .   .     |  ..  .||       ...|..| .|    ..||...|  |  .  | .. 
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSK---HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF

SPNKKLSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYK-MESGEWREPRLRAGFRGTTRYVSIRVHRRCEQSPY
  |.|.|   |  |  | |  .. .|. ...|||.|| | . |.     |.. . ||||  ||. .....  . |   .. ||.|| ||  |   |||  
C-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRR

DDLVSVMYTAYELLAGELPW
||. |..|    .| |.|||
DDMESLGYVLMYFLRGSLPW
Kinase T19D12.5.AA CK1-Unique 62-318 17 5.8e-21 69.44 In-house 1-337 (337) Show / Hide 
Range on Protein: 62-318
Range on HMM: 1-337/337
Sequence Identity: 17% (58 aa)

WLIEGLIGKGGYGEIYLALDVVRG-----------EEVAIKVEPKKRRGKLAKRMILEQHVLA-KMQGKPHVPMIYGSGHAEKYNFIIMQIL--SINVGD
| .  .||.||||  .   .| .|            .  . . .   | .  .   ..   .  . .   |.. .  .. .  . .|.|...  |.   .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

IKKSS----PNKKLSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFP-HSRHTLILLDFGLVRR--YKMESGEWREPRLRAGFRGTTRYVSIR
..       .| |  |  ...   |.  ..   |. |. ||. ||.| | .  . .  |..  ||.|  ||      ... | ||... |||. .| .. 
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

VHRRCEQSPYDDLVSVMYTAYELLAGE--------------------------------------------------------LPWKHLEKSEEVVQLKE
 |.  |..  ||. |  |..| |. ..                                                        ..|| |.  .  .  |.
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKLDKIIPSGIDNIIVYLRGLKFEDPVDYRQIENELRTAGKKMAPSDSSDEKMCWKGLRRQNAYDKHKN

--VMTENGINPELFQGDKSVLI-DFFKQVSEMDPMKE
  . .. .  |.|| . | ... . .. .||   |. 
YQNSKQFNEKPCLFCKIKPHNDMKMYCCMSEYFYMFN
Kinase T19D12.5.AA Dual 62-284 23 1.4e-17 55.53 In-house 1-239 (282) Show / Hide 
Range on Protein: 62-284
Range on HMM: 1-239/282
Sequence Identity: 23% (56 aa)

WLIEGLIGKGGYGEIYLALDVVR----GEEVAIKVEPKKRRGKLAKRMILEQHVLAKMQG----------KPHVPMI-YGSGHAEKYNFIIMQILSINVG
| .  |.| || ...|   .  .     . ...|.|.   ..|.  |   |. |  |. .          |  . .. ||.    | ....|   .    
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEE-GEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQ

DIKKSSPNKKLSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYKM-ESGEWREPRLRAGFRGTTRYVSIRVHRRC
.| .   .. ||      .  | . |.||||  ||.||..||||   |.      |. ..||..|| |   | .. | .|    . |. || ..      
EIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGL-GMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQK

EQSPYDDLVSVMYTAYELL-AGE-LPWKHLEKSEEVVQLKE
.|   ||| .  |. . |.  .  ..|. .  . .... |.
DQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKD
Kinase T19D12.5.AA S_TKc 62-331 18 3e-16 61.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 62-331
Range on HMM: 1-231/231
Sequence Identity: 18% (55 aa)

WLIEGLIGKGGYGEIYLALDVVRGEEVAIKVEPKKRRGKLAKRMILEQHVLAKMQGKPHVPMIYGSGHAEKYNFIIMQILSINVGDIKKSSPNKK-----
. |  .||||..|. |.. ..  |..||||. .        .... |  .| |  . |..  .|.. .  .. ...|  .. ..|| ..   ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYKMESGEWREPRLRAGFRGTTRYVSIRVHRRCEQSPYDDLV
  ..   . ....|.. ||. .|. | .|||.||.|  .        .. . |||| |..               | ||  |..  |             
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------

SVMYTA------------YELLAGELPWKHLEKSEEVVQLKEVMTENGINPELFQGDKSVLIDFFKQVSEMDPMKEPCYEKLIE------CIKVL
   |.             ||.|.|. |.      .. . .| ..              . ..|| ..  ..|| | |   .. .      |   .
--GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase T19D12.5.AA Pkinase 62-272 19 7e-16 57.24 Pfam 1-214 (293) Show / Hide 
Range on Protein: 62-272
Range on HMM: 1-214/293
Sequence Identity: 19% (45 aa)

WLIEGLIGKGGYGEIYLALDVVRGEEVAIKVEPKKRRGKLAKRMIL---EQHVLAKMQGKPHVPMIYGSGHAEKYNFIIMQIL-------SIN----VGD
. |.. ||.|..|. |.. ..  |..||.|. .|... .  ..  .   | ...... . |..  .|.. . ...  ..|  .       .      .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

IKKSSPNKKL--SQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTL----ILLDFGLVRRYKMESGEWREPRLRAGFRGTTRYVSIRV
    . ....  |   . ... |.. .|. .|. | .|||.||.|    |. ... ..     . |||| . ..     .   .   .| || .|..  |
----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN----ILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEV

HR-RCEQSPYDDLVSVMYTAYELLAGELPWKH
.| . . .|  |  |.  . ||.| |..|...
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG
Kinase T19D12.5.AA TyrKc 62-286 15 0.000272 -153.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 62-286
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

WLIEGLIGKGGYGEIYLALDVVRGEEVAIKVEPKKRRGKLAKRMILEQHVLAKM-QGKPHVPMIYGSGHAE-------KYNFIIMQILSINVGD----IK
   .  .| | .||.|..      ..||.|.  .       . .. |  .. |     |..  .||    .       .  .|.|   .   ||    ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLR

KSSPNKKLSQCSVGRIIHQVIAALQDLHETGYVHRDVKPANMCFGIFPHSRHTLILLDFGLVRRYKME--SGEWREPRLRA----GFR--GTTRYVSIRV
|. |.  |.      . .|. .  . ||. ...|||    |    .  ...||    |||| |  . .  .|  ..   |.    | .     |  .. .
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN----CLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPEC

HRRC---------------------EQSPYDDL----VSVMYTAYELLAGELPWKHLE--------KSEEV------------------VQLKEVM
 . .                      |.|| .     .|       . .|. . .  .         ..|.                   ...| .
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF