Gene Y73B6A.2 (Nematode worm)

Y73B6A.2

Species: Nematode worm
Alias: Y73B6A.2, aSWK090, CE24636
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:3.2, WormBase Physical Map location: IV: 6735416-6732970

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
Y73B6A.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 241 Kinase domain by global Sugen HMM Fasta, JSON
Y73B6A.2.AA Protein Genbank 330 None Fasta, JSON

Protein domain

Protein domains of Y73B6A.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y73B6A.2.AA TTBKL 23-178 40 2.4e-72 243.55 In-house 1-160 (288) Show / Hide 
Range on Protein: 23-178
Range on HMM: 1-160/288
Sequence Identity: 40% (65 aa)

YTITGRVGQGSFGPIF--SVSKNHKD-YALKIQPRKINGKPSTVQKEASLLLKLNPHGDKYFPTFKMAGENVKCAFIVMNLLGRSLKDLRLMSPNPDSLT
..|.. .|.| || ..  ...|..|| .|.|.......|..|. ..|. .|.||.|.| ..||.....|.. .. |.|| |.|..|.||| |.||.....
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

PGTWSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTD-CLKSRIFYLIDFAIAQKFI
.||||||||||||.|||.||   .| ||||.|...|. .. |...|..||||| .|....
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYA
Kinase Y73B6A.2.AA CK1 23-178 25 1.8e-47 163.66 In-house 1-200 (339) Show / Hide 
Range on Protein: 23-178
Range on HMM: 1-200/339
Sequence Identity: 25% (50 aa)

YTITGRVGQGSFG-PIF-------SVSKNH-----KDYALKIQPRKINGKPSTVQKEASLLLKLN------------------PHGDKYFPTFKMAGENV
....   |.|.||  |.       . .||.     ..||.|. |.| .|.... ..|. ...||.                  ..| ......  .||. 
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

KCA-FIVMNLLGRSLKDLRLMSPNPD-SLTPGTWSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTD----------CLKSRIFYLIDFAIAQ-KFI
.   ..|| |||..| ||| .. ...  .. .|| .|.||.|..|...||   .| |.||.|...|  ..          . ..|..|.||| .|  |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR
Kinase Y73B6A.2.AA TTBKL 179-251 37 8.3e-32 104.71 In-house 207-288 (288) Show / Hide 
Range on Protein: 179-251
Range on HMM: 207-288/288
Sequence Identity: 37% (31 aa)

GRVDDLYSLLYMTAELKKPLPWTYLEGNE-LILKKKNAKLTELFDN--------DEFLKVQTMIESFSYRDFPNYGLLFETF
||.|||.|..||..||...||||..|  . .. .||| |.. || .        .||.|......| .|.|.|.|. ..| |
GRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase Y73B6A.2.AA CK1 179-247 27 1.5e-18 61.4 In-house 249-339 (339) Show / Hide 
Range on Protein: 179-247
Range on HMM: 249-339/339
Sequence Identity: 27% (25 aa)

GRVDDLYSLLYMTAELKKP---LPWTYLEGNEL-----ILKKKNAKLTELFDND---------------EFLKVQTMIESFSYRDFPNYGLL
||.|||.|..|| .|. |.   |||. .. ..      . |.| .. .|   ..               || |. ..|.| .| |.|.|  .
GRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase Y73B6A.2.AA Worm6 23-178 27 1.1e-14 49.36 In-house 1-165 (279) Show / Hide 
Range on Protein: 23-178
Range on HMM: 1-165/279
Sequence Identity: 27% (45 aa)

YTITGRVGQGSFGPIFSVSKNHKD----YALKIQPRKINGKPSTVQKEASLLLKLNPHGDKYFPTFKMAG-ENVK-CAFIVMNLLGRSLKDLRLMSPNPD
...|  .|.|.|| ...|..  .     .|.|   .  | | .  . |.. |.... |. ..|...  .|  . .   .||| |.|..| |||  .|   
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP-DR

SLTPGTWSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNP--TDCLKSRIFYLIDFAIAQ--KFI
 .. ||  .|.||||  . .||    .| |||| |.  | .   .  .... |..|| ..   |..
KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYC
Kinase Y73B6A.2.AA TTBK 23-178 27 2.7e-14 46.95 In-house 1-152 (257) Show / Hide 
Range on Protein: 23-178
Range on HMM: 1-152/257
Sequence Identity: 27% (43 aa)

YTITGRVGQGSFGPIFS---VSKNHKDYALKIQPRKINGKPSTVQKEASLLLKLNPHGDKYFPTFKMAGENVKCAFIVMNLLGRSLKDLRLMSPNPDSLT
 ... ..|.| || |..   .  .|   |.|.   . . .    . |   | ||   | ..   |   | | |  ..||.|.|..| |||   |     .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVE--SAQQPKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPR-GCFS

PGTWSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTDCLKSRIFYLIDFAIAQKFI
 .|  |.|.| |  ... |.    | |.|| |. .|      . |. |..||  | ...
LSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR--NPSTCRKCYMLDFGLARQYT
Kinase Y73B6A.2.AA CK1-Unclassified 23-108 27 3.1e-14 38.44 In-house 1-93 (244) Show / Hide 
Range on Protein: 23-108
Range on HMM: 1-93/244
Sequence Identity: 27% (26 aa)

YTITGRVGQGSFGPIFSV--SKNHKDYALKIQPRKINGKPSTVQKEASLLLKLNPHG--D---KYFPTFKMAGEN--VKCAFIVMNLLGRSLKDL
| .. ..|||||| |. .  ..... .|.|.  ..     .. ..|| ..  |. .   |   |..|     | .    . ..||.|||.|| ||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL
Kinase Y73B6A.2.AA CK1 23-108 28 4.6e-11 34.52 In-house 1-94 (271) Show / Hide 
Range on Protein: 23-108
Range on HMM: 1-94/271
Sequence Identity: 28% (27 aa)

YTITGRVGQGSFGPIFSVSKNHKD----YALKIQPRKINGKPSTVQKEASLLLKLNPH----GDKYFPTFKMAGEN--VKCAFIVMNLLGRSLKDL
| .. ..|||||| |. .   ..     .| |. ..|    |   ..|| ..  |. |     ....|. .  | .   .. ..||.|||.|| ||
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSK-HP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL
Kinase Y73B6A.2.AA CMGC 23-151 13 5.2e-10 28.14 In-house 1-214 (513) Show / Hide 
Range on Protein: 23-151
Range on HMM: 1-214/513
Sequence Identity: 13% (30 aa)

YTITGRVGQGSFGPIFSV----------------SKNHKDYALKIQPRK-----------INGKPSTVQKEASLLLKLN---------------PHGD--
|.| ...|.|..|  ..                  .. . .|.|.  ..            .|.|.. . | ..| .||               .|    
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

----KYFPTFKMAGENVK----------CAFIVMNLLGRSLKDLRLMSP------NPDSLTPGT------------WSRIG------IQCLYVLK--QLH
     .| . ...|.. .          . ..|. ... .|...  . .      .|  |..                 .        | |  ||   .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DGA--VVHGDVKPTN
     ..| | || |
SHWGNIIHRDLKPEN
Kinase Y73B6A.2.AA CK1-A 23-177 25 1.1e-09 30.21 In-house 1-148 (261) Show / Hide 
Range on Protein: 23-177
Range on HMM: 1-148/261
Sequence Identity: 25% (40 aa)

YTITGRVGQGSFGPIFSVSKNHKDYALKIQPRKINGKPSTVQKEASLLLKLNPHGDKYFPTFKMAGENVKCAFIVMNLLGRSLKDLRLMSPNPDSLTPGT
| .  ..| |||| |.   . ..   . |.  . . .   .  || .   |  .|   .|. .  |..     .||.||| || ||  .     ..   |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRIL--QGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMK--T

WSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTDCLKSRIFYLIDFAIAQKF
   .  | .  .  .|  . .| |.|| |...|    | |    .|||| .|.|.
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNK---LFLIDFGLAKKY
Kinase Y73B6A.2.AA S_TKc 23-263 14 2.5e-08 -54.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-263
Range on HMM: 1-231/231
Sequence Identity: 14% (40 aa)

YTITGRVGQGSFGPIFSVSKNH--KDYALKIQPRKINGKPSTVQKEASLLLKLNPHGDKYFPTFKMAGENVKCAFIVMNLLGR---SLKDLRLMSPNPDS
|.|   .|.|.||  . . ...  . .|.|| .        ....| ..| |    . ..  ... . .. .. ..|| ...    .|.|.    . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTPGTWSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTDCLKSRIFYLIDFAIAQKFIGRVDDLYSLLYMTAELKKPLPWTY------------
   ... .  ..  | .  |. .|.  ..| |.|| |  | .           ..|| .| ..        .. ||  |.    ....            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

---LEGNELILKKKNAKLTELFDNDEFLKVQTMIESFSYRDFPNYGLLFETF----LEVFLKSG-----STWM
   | |  .        . ..|..           | . .|| .  | ..          |...       |.
YEMLCGYPPFP-----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y73B6A.2.AA CK1-D 23-177 25 1.3e-07 22.73 In-house 1-148 (261) Show / Hide 
Range on Protein: 23-177
Range on HMM: 1-148/261
Sequence Identity: 25% (40 aa)

YTITGRVGQGSFGPIFSVSKNHKDYALKIQPRKINGKPSTVQKEASLLLKLNPHGDKYFPTFKMAGENVKCAFIVMNLLGRSLKDLRLMSPNPDSLTPGT
| |  ..| |||| |.   . . .    |.   |  |   .. |. .   .  .|    |. .  |..     .||.||| || ||        ||   |
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMM--QGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLK--T

WSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTDCLKSRIFYLIDFAIAQKF
   .. | .  .. .|    .| |.|| |...|      .  . |.||| .|...
VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGL---GKRGNMVYIIDFGLAKRY
Kinase Y73B6A.2.AA CK1-Unique 95-173 25 2e-06 18.42 In-house 86-168 (337) Show / Hide 
Range on Protein: 95-173
Range on HMM: 86-168/337
Sequence Identity: 25% (22 aa)

FIVMNLLGRSLKDLRLMSPNPDSLTPG------TWSRIGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTDCLKSRIFYLIDFAI
.||| ..|.|.  .. | . . . |..      .  . | ||| |.   |   . | . || ||... |    . . .| .|. |
WIVMTMHGPSMEECCMM-MKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQ-QHQHCYYMLDYGI
Kinase Y73B6A.2.AA TTBK 179-247 32 0.000607 9.86 In-house 185-257 (257) Show / Hide 
Range on Protein: 179-247
Range on HMM: 185-257/257
Sequence Identity: 32% (24 aa)

GRVDDLYSLLYMTAE-LKKPLPWTYLEGNELI-LKKKNAKLTELFDN--DEFLKVQTMIESFSYRDFPNYGLL
|| ||| || ||  | ..  |||  .   . .   |. . .  | ..   ||      |.|  | | |.| |.
GRHDDLWSLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase Y73B6A.2.AA CK1 126-178 26 0.002076 7.83 In-house 110-160 (271) Show / Hide 
Range on Protein: 126-178
Range on HMM: 110-160/271
Sequence Identity: 26% (14 aa)

IGIQCLYVLKQLHDGAVVHGDVKPTNYVLGNPTDCLKSRIFYLIDFAIAQKFI
|. | .  .  .|    .| |.|| |.. |      .. . |.||| .| ...
IADQMIQRIEYVHNKNFIHRDIKPDNFLMGR--YGKHCHQVYIIDFGLAKRYR
Kinase Y73B6A.2.AA Worm6 179-247 25 0.00316 7.83 In-house 199-279 (279) Show / Hide 
Range on Protein: 179-247
Range on HMM: 199-279/279
Sequence Identity: 25% (21 aa)

GRVDDLYSLLYMTAELKKP-LPWTYLEGNELILKKKNAK---L-----TELFD---NDEFLKVQTMIESFSYRDFPNYGLL
.| ||. | .|| .|. .. |||  ...     | | ..   .     ...|     .|| .. ..| . || | |.|  .
CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase Y73B6A.2.AA CK1-Unclassified 126-178 27 0.040847 2.06 In-house 109-159 (244) Show / Hide 
Range on Protein: 126-178
Range on HMM: 109-159/244
Sequence Identity: 27% (15 aa)

IGIQCLYVLKQLHDGAVVHGDVKPTNYVLG-NPTDCLKSRIFYLIDFAIAQKFI
|. | .  . .||    .| | || |.. |       .. . |.||| .. ..|
IADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGK---NHHQVYIIDFGLSKRYI