Gene ZC123.4 (Nematode worm)

ZC123.4

Species: Nematode worm
Alias: aSWK170, ZC123.4, CE31394
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:-21.5, WormBase Physical Map location: I: 847613-841756

Classification

Group: CMGC
Family: CDK
Subfamily: PCTAIRE

Sequence

Name Sequence Type Origin Length Description Download
ZC123.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 291 Kinase domain by global Sugen HMM Fasta, JSON
ZC123.4.AA Protein Genbank 551 None Fasta, JSON

Protein domain

Protein domains of ZC123.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZC123.4.AA PCTAIRE 233-523 68 7.2e-236 789.87 In-house 1-291 (291) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-291/291
Sequence Identity: 68% (198 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEGLPFTAIREASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKMDLSKYLEQNVYGLDSIDIK
|...||||||.|||||||.|||....||||||.|...||.|.|||||.|||..|.|||||.||||...|||||.|||||.|||..|.............|
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEICTGAALFPG
|.||||||||..|||.|||||||||||||..|.|.|||||||||||||||..|||||||||||||||||||||||||..|||||||||.|.|||..||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

SKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPYF
|.||||||.||||.|||.|.||||||.||.||.........||||||...|...|...||||..|.||.||||.....||||..||.||||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase ZC123.4.AA PFTAIRE 233-523 58 3.1e-166 558.55 In-house 1-287 (287) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-287/287
Sequence Identity: 58% (170 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEGLPFTAIREASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKMDLSKYLEQNVYGLDSIDIK
|....||||||||||||  |.. . .||||||.||  || |||||||||||.||.||||| ||||      |||||||.  ||..|...   |..   ..
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEICTGAALFPG
| |||||||| .||....|||||||||||. . | ||||||||||||||||.|||||||||||||||||.|||.|||.|||||||||| |  .| ..|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

SKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFP--RYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPYF
 ||     . |||. || . ||| | .|| |  ||.| |. |.   |.  .   . |   .| . . .|.  .||. |. ||||. || ||||
MKD-----ITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPH-AEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase ZC123.4.AA CDK 233-523 42 3.6e-166 535.77 In-house 1-284 (284) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-284/284
Sequence Identity: 42% (140 aa)

YKRIDKLGEGSYATVYKCESKLDG-----SIVALKEIKLQFQ------EGLPFTAIREASLLRNLRHANIVSLHDIFYQH-----------HQLTFVFEY
|....|.|||.|..|||. .|..|      |||||.|... .      ||.|.||||| |||..| |.|||.|||.....           . |..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MKMDLSKYLEQNVYGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGV-----LKLADFGLARAKSV------PSRTYSHEVVTLWYRPPD
| .||.||..          || ...||||||..||...|.||||||||.|....|.     ||.||||||||...      |.|||.|||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLMGSTDYS--TSLDMWGVGCIFAEICT---GAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILK
.|.||..||  |. |||.|||||||. |   . .||||. .       |||..|| | |||.|. ||.|. ||.|                         
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE------IDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------

TGQELLGMLLQLRPESRVSAASAMLHPYF
   .||  .|.. |. |.||  |. ||||
---DLLNKMLCYDPKKRISAEQALQHPYF
Kinase ZC123.4.AA CDC2 233-523 46 3.6e-145 449.4 In-house 1-301 (301) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-301/301
Sequence Identity: 46% (143 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQ-FQEG--LPFTAIREASLLRNLR-HANIVSLHDIFYQHHQLTFVFEYMKMDLSKYLE-QNV--YG
|..| |.|||.|  ||||. . .. ||||| |.|  ..||   | ||||| |.| .|. | |||.|||...| . |  ||||. ||| ||.. ...  . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYS--HEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEI
.... .| ...|.|.|..|||...|.||||||||.|.|..|..|.|||||||| ..|.|||   |||||||||.| .|.|. .|||. ||| .||||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---CTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPM------FTKILKTGQELLGMLLQLRPESRVSA
   .|  .||.|  ||      |||  || |.|||.|..||.|. || | .  |||...  .  . |.      .. . ..| .||  .||. |. |.||
FMDVTKKPLFHG--DSEI----DQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISA

ASAMLHPYF
 .|. ||||
KEALQHPYF
Kinase ZC123.4.AA CDK5 233-523 50 2e-143 456.35 In-house 1-287 (287) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-287/287
Sequence Identity: 50% (149 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQ-EGLPFTAIREASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKMDLSKYLEQNVYGLDSIDI
|....|.||| |.||||   |  . |||||...|    || | ||||| .||. |.| ||| |||.      || |||..  || ||...   ..|   |
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEIC-TGAALF
| ...|||.|| ||| ...|||||||||||    | |||||||||||  .| |.|||||||||||||||||||  |||| ||| .||||||.  .|  ||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPYF
||.      ...|||  || | ||| | ||| .  || | |.  ..       .  ..  |  ..| .||. .||..|. |.||. |. ||||
PGN------DVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase ZC123.4.AA CMGC 233-523 25 1.3e-131 435.14 In-house 1-513 (513) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-513/513
Sequence Identity: 25% (132 aa)

YKRIDKLGEGSYATVYKCESKLDG--------------SIVALKEIKLQF----------QEGLPFTAIREASLLRNLR-----------------HANI
|. |.|.|||.|..||||  |. .               |||.| ||..|           .|.|..|.|| ..|..|.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VSLHDIFYQHH-----------------QLTFVFEYMKMDLSKYLEQNVY--------GLDSID------------IKLLL------FQLLRGLD--FCH
|.|.|||| ..                 .| .||||| .|| .|...|          .|.               || ..      .|.||||.  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RKK--ILHRDLKPQNLLLDED--------------------GVLKLADFGLARAKSVP---------------------SRTYSHEVVTLWYRPPDVLMG
...  |.||||||.|.|....                    |.||..||||||. ...                     .|.|.|.|||.|||.| .|.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

STDYS---------TSLDMWGVGCIFAEICTG--------AALFPGSKDS-----HYPGTKDQLDMIFSIRGTPD---------------EKKWPEVKTL
...|.         |. |||.|||||||. ||          ||||. .      ..  . |||..|| . |||.               |..||... |
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PGYTPEL-------------------------FPRYRELSFIAVNPMFTK--------------------------------ILKTGQELLGMLLQLRPE
|.| . .                         ||...  ..  . | . .                                . . . .||  .||. |.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

SRVSAASAMLHPYF
 | .|. |. ||||
KRITAEQALQHPYF
Kinase ZC123.4.AA CDK7 233-523 39 4.8e-117 313.32 In-house 1-288 (288) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-288/288
Sequence Identity: 39% (116 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIK-----LQFQEGLPFTAIREASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKMDLSKYLEQNVYGLD
|. |...||| .|||||   .  | ||| |.||      ... |. .|||||  .|. ..| |.. | ||| .   .  ||..|  ||    . .   | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

SIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEICTGA
  .||    ..|.|| .|||  |||||||| |||..|.|.||.|||||||.   | | |.| ||| ||| |  | |   | |. ||| |||||||     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

ALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPYF
  .||  |       |||  ||.. ||| |..||..  .. |    |  . . | .. . .||       .|.  .. . |  |.... .  .|||
PYLPGDSDI------DQLTRIFQTLGTPTEEEWPNMCCMMDYI--KFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase ZC123.4.AA S_TKc 233-523 28 3.3e-88 300.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEGLPFTAIREASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKM---DLSKYLEQNVYG----
|. ..|.|.|....||||  | .| |||.|.||         ...|| ..|.. .| ||| |.|.|.  . | .|.||.     || .|.... ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYST-SLDMWGVGCIFAEI
 ..  ... .. |....|..||...|.||||||.|.||||  ..|..||||||         .. ..|.||..| ||     |.. . |.| .|||..| 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

CTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAML----
..|  .||            |..|.| . |                                        . . ...  .||  || | .|  |.     
LCGYPPFP------------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYF
   ||.|
IKCHPWF
Kinase ZC123.4.AA Pkinase 233-523 30 2.1e-84 291.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEG-LPFTAIR--EASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKM-----DLSKYLE----
|... |.|.||...||||  | .| |||.|.||.. ..   . |..|  |......|.| ||| |.|.|. .  . .|.||. .     ||. |..    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QNVYGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVL----KLADFGLARAK-SVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWG
 ..| ..  ..|  . |.||||..||...|.||||||.|.|.|..|..    |..|||||. .   ... ... ..|.||..| |..|...|... |||.
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGCIFAEICTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAA
.|||..| ..|  .|| ...   ..  ||. ||. |.|.| .  ||.  . . ..   . . .    .   .  ... .......  .|.. |..| .|.
CGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

SAMLHPYF
 .. ||.|
QILQHPWF
Kinase ZC123.4.AA PITSLRE 233-523 39 1.6e-80 273.82 In-house 1-295 (295) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-295/295
Sequence Identity: 39% (118 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQ---EGLPFTAIREAS-LLRNLRHANIVSLHDIF--YQHHQLTFVFEYMKMDLSKYLEQNV---
.. ... .|| |  ||.   |. . ||||| .|.  |   || | |..|| . .|. |.| |||..  |           |.||.  ||   .|      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

YGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEI
       || |. ||||| .. | ..|.|||||  |||.   |.||..||||||    | . |.  ||||||| | .| |.  ||| .||| |||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

CTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPEL-FPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPY
 |.  ||.|. .       ||.. ||   ||| || || .. ||.      || | .       |  ..|  || .||  .| . |. | .|  |. ||.
ITMKPLFQGKSEI------DQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPW

F
|
F
Kinase ZC123.4.AA CDK4 233-523 40 1.8e-80 273.65 In-house 1-290 (290) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-290/290
Sequence Identity: 40% (124 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEG---LPFTAIREASLLRNLR---HANIVSLHDIFYQ------HHQLTFVFEYMKMDLSKYLE
|. .  .||| | |||.  .  .| .|||| .. . .|    .|   ||| |..| |    |.|||.| |.. .         .| |||    ||. ||.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

QNVY-GLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHE------VVTLWYRPPDVLMGSTDYSTSLDM
.    |.    || . .|||||.|| |   | ||||||||.|.  || .||||||||       |.|| .      ||||||| | ||  |. | |  ||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLA-------RIYSFQMALTPVVVTLWYRAPEVLLQSY-YNTPVDM

WGVGCIFAEICTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVS
| |||||||.    .||.|. .      ||||. || . |.| |. ||    ||    . || ..  .|  . |    . | |..||   |   .. |.|
WSVGCIFAEMYCRRPLFCGQSE------KDQLHKIFDVMGLPPEDDWPRDVSLPW---DHFPQRHPRPFKDFCP---HMCKQGDDLLQKMLCYNHHKRMS

AASAMLHPYF
| ..  ||||
AYQCLQHPYF
Kinase ZC123.4.AA CRK7 233-523 32 2.5e-75 256.59 In-house 1-343 (343) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-343/343
Sequence Identity: 32% (115 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQ----EGLPFTAIREASLLRNLRHANIVSLHDIFYQ--------HHQLTF--VFEYMKMDLSKY
|..|.  ||| |  ||| . |  | .|||| ....      || | |||||  .|| | |.||| |..|            |  .|  |||||  ||.  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LEQN-VYGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVPS--RTYSHEVVTLWYRPPDVLMGSTDY--------
||   .       .| .. ||| |.| ||.|..||||.|  |.|..  | .|.|||||||     .  | |   |.|||||||  | | . |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STSLDMWGVGCIFAEICTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPR-
                               .. |||..|||..|  |. ..|.|.         .||. |. | |.|    ||||  ||..      | 
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEM------AQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQ

YRELSFIAVNPMFT--KILKTGQELLGMLLQLRPESRVSAASAMLHPYF
|. ..   .   .    . |    ||  .| | |. |..|  .  |..|
YNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase ZC123.4.AA Pkinase_Tyr 233-378 32 3.9e-21 72.21 Pfam 1-160 (270) Show / Hide 
Range on Protein: 233-378
Range on HMM: 1-160/270
Sequence Identity: 32% (53 aa)

YKRIDKLGEGSYATVYKCESK----LDGSIVALKEIKLQFQEGLPFTA------IREASLLRNL-RHANIVSLHDIFY-QHHQ--LTFVFEYMKM-DLSK
 . . |||||.. .|||.. |     ..  || | .|    ||    .      .|||.....| .| |||.|. . . |  .  .  |.|||.  || .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLEQN---VYGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARA
|| ..      |.  |.    .|  .|... ..|.. ||||   | |..|..| | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase ZC123.4.AA TyrKc 233-523 20 3.5e-12 -25.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 233-523
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEGLPFTAIREASLLRNL--RHANIVSLHDIFYQH-------HQLTFVFEYMKM-DLSKYLEQN
 . ..||||| . .|||.. |     || | .|           .|||.....|  .| ||| |. .  |.       ..|  |.|||.  || .||  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

VYGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVP------SRTYS-----HEV--VTLWYRPPDVLMGSTDYST
   |   |     .|  .| .. |.|.. ||||   | |..|... | .||||.|.          . .|.     ..   . .   .| ... .. ..|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTT

SLDMWGVGCIFAEICTGAALFPGS-----KDS----HYPGTKDQLDMIFS---IRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQ
  | |  |    ||.|  .  .       ..     .|  . . ..   .   .                                     |    .   
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------FVCCPDEMY

ELLGMLLQLRPESRVSAASAMLHPYF
..  .  .  ||.| . .    | .|
QIMKQCWHEDPEDRPTFSEI--HECF