Gene ZK354.6 (Nematode worm)

ZK354.6

Species: Nematode worm
Alias: ZK354.6, CE15320, aSWK108
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:1.77, WormBase Physical Map location: IV: 5297482-5295967

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
ZK354.6.AA Protein Genbank 368 None Fasta, JSON
ZK354.6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ZK354.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZK354.6.AA TTBKL 69-329 34 3.3e-124 418.93 In-house 1-288 (288) Show / Hide 
Range on Protein: 69-329
Range on HMM: 1-288/288
Sequence Identity: 34% (100 aa)

FEVKGIIGGGGFAQIYKAWDKVRKEDCAIKVEHESQ-D--IRRMKLEITVLLALR--GSMGIPEILAQGKWQHEDNKSHYIVMQLVGRNLSDVRRALPHK
......||.|||.|.|..||...|.|||...|.  . .   .|||.|. ||..|   ||  .|.....||      . ...||.|.|.||.|.|. .|.|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGK----RKDYNFMVMTLCGPNLQDLRKMMPNK

R-ITERTLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIGAID-----CTRIYLIDYGLTRQYLDKGG-----------IVRKPRA---GVGLRGTVRYM
. ....| .| .||.|.|| ..| .||.|||.||.|||.|. |     | ..||||.|..|||..| |           ..|.||     ...|||.||.
KRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYC

SLDAHARQDLGPKNDLVAFLYTTIECGDGYLPWSHEKTHENIIKLKQAHIGDKLCTKQP-------VMTKAAEYIESLNYHSIPDYEKLLALM
|...|.|...|...||....|..||. .| |||.... ...|...|.......|. ..|        ..| .....||.|.. ||||......
SPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase ZK354.6.AA CK1 69-325 27 8.7e-97 327.85 In-house 1-339 (339) Show / Hide 
Range on Protein: 69-325
Range on HMM: 1-339/339
Sequence Identity: 27% (94 aa)

FEVKGIIGGGGFA-QIYKA-----WDKVRK-----EDCAIKVEHESQD--IRRMKLEITVLLALRG-----------------SMGIPEILAQGKWQHED
..|.  ||.|||  ||||.     .|. ..     |..|.|||....    .... |. ....|.|                 . |.| . . .  ..||
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NKSHYIVMQLVGRNLSDVRR--ALPHKRITERTLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIGA--------------IDCTRIYLIDYGLTR-QYL
.. .|.||.|.|.||.|.|.  ... .... .| .. .|| |.||  .| .||.|||.||.|.|.|.               .. ..|.||.|. | .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DKGGIV------------RKPRA---GVGLRG-TVRYMSLDAHARQDLGPKNDLVAFLYTTIECGDGY--LPWSHEKTHEN-----IIKLKQAHIGDKLC
||.| .            | ||     .|.|| |.||.|...| ....|.. ||.. .|. ||. .|   |||.. | ...     ..| |...| .|..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

TKQP-------------VMTKAAEYIESLNYHSIPDYEKL
  ..              . | ..||.||.|...||||..
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase ZK354.6.AA Worm6 69-325 33 1.9e-62 213.77 In-house 1-279 (279) Show / Hide 
Range on Protein: 69-325
Range on HMM: 1-279/279
Sequence Identity: 33% (94 aa)

FEVKGIIGGGGFAQIYKAWDKVRKE--DCAIKVEH--ESQDIRRMKLEITVLLAL--RGSMGIPEILAQGKWQHEDNK-SHYIVMQLVGRNLSDVRRALP
..|   || |||  .||. || .|.    |.|.|   |.  ..  |.|. ||.|.  ... . ..|  .||    ||.  .||||.|||.||.| |...|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGK---VDNRGFNYIVMTLVGKNLWDLRKNRP

HKRITERTLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIGA------IDCTRIYLIDYGLTR--QYLDKGGIVRKPR-AGVGLRGTVRYMSLDAHARQD
 .... .| ..  || |.|.  .| .||.|||.||.| |||        .  .||..|.|..|  .|..||. .|.|| . .| ||||||..| .| .|.
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE

LGPKNDLVAFLYTTIECGDGYLPWSHEKTHENIIKLKQA---HI-----GDKLCTKQP-VMTKAAEYIESLNYHSIPDYEKL
...| |.   .|  .|   | ||| | | | .  |.| .   ..      . . . ..  ...  .|| ...|.. |||...
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase ZK354.6.AA TTBK 69-325 37 2.6e-59 203.38 In-house 1-257 (257) Show / Hide 
Range on Protein: 69-325
Range on HMM: 1-257/257
Sequence Identity: 37% (98 aa)

FEVKGIIGGGGFAQIYKAWDKVRK-EDCAIKVEHESQDIRRMKLEITVLLALRGSMGIPEILAQGKWQHEDNKSHYIVMQLVGRNLSDVRRALPHKRITE
  |.  ||||||  || | | . . |  |||||   |    .|.|. ||  | |   .      |     ..|  |.|||| |.||.| ||. |    . 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGR----NDKFNYMVMQLQGKNLADLRRKQPRGCFSL

RTLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIG--AIDCTRIYLIDYGLTRQYLDKGGIVRKPRAGVGLRGTVRYMSLDAHARQDLGPKNDLVAFLYT
 |  |  .|.|...  .|  |||||| ||||  .|  .  | ..|..|.|| |||.   | || ||.  | |||||| |  ||  ...| . ||    | 
STTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYM

TIECGDGYLPWSHEKTHENIIKLKQAHIGDKLCTKQPV-MTKAAEYIESLNYHSIPDYEKL
 .|   | |||   |  . . ..|.      |    |  .    . |.||||   |||  .
LVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase ZK354.6.AA CK1-A 69-325 28 4e-25 85.62 In-house 1-261 (261) Show / Hide 
Range on Protein: 69-325
Range on HMM: 1-261/261
Sequence Identity: 28% (75 aa)

FEVKGIIGGGGFAQIYKAWDKVRKEDCAIKVEHESQDIRRMKLEITVLLALRGSMGIPEILAQGKWQHEDNKSHYIVMQLVGRNLSDVRRALPHKRITER
. .   || | |  || .      |. |||.| .      .  |  |   |.|  |||..    .|  ..     .||.|.|  | |.   . ..| | .
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHM----RWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMK

TLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIG-AIDCTRIYLIDYGLTRQYLDKGGIVRKP-RAGVGLRGTVRYMSLDAHARQDLGPKNDLVAFLYTT
|      |..  .  ||  .|.|||.|| |  .|    | ...|||.||...| |.      | |    | ||.|| |..||   .   . |. .. |  
TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM

IECGDGYLPW------SHEKTHENIIKLKQAHIGDKLCTKQPV-MTKAAEYIESLNYHSIPDYEKL
.    | |||        ..  | |   | .   ..||   |  ..   .|. .| ..  |||  |
MYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase ZK354.6.AA CK1-D 69-325 27 5.3e-22 74.3 In-house 1-261 (261) Show / Hide 
Range on Protein: 69-325
Range on HMM: 1-261/261
Sequence Identity: 27% (73 aa)

FEVKGIIGGGGFAQIYKAWDKVRKEDCAIKVEHESQDIRRMKLEITVLLALRGSMGIPEILAQGKWQHEDNKSHYIVMQLVGRNLSDVRRALPHKRITER
. .   ||.| | .||   .    |. |||.|        ...|  .   ..| .|||||    .|  ..     .||.|.|  | |.     |..   .
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEI----RWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLK

TLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIG-AIDCTRIYLIDYGLTRQYLDKGGIVRKP-RAGVGLRGTVRYMSLDAHARQDLGPKNDLVAFLYTT
|      |... .  .|.  |.|||.|| |  .|       .|.||.||...| |       | |    | || || |.  |   .   . || .  |  
TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

IECGDGYLPW------SHEKTHENIIKLKQAHIGDKLCTKQPV-MTKAAEYIESLNYHSIPDYEKL
.    | |||         .  | |.  |     |.||   |   ..  .|  .| .   |||  |
MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase ZK354.6.AA Dual 137-329 27 1e-21 69.73 In-house 82-282 (282) Show / Hide 
Range on Protein: 137-329
Range on HMM: 82-282/282
Sequence Identity: 27% (55 aa)

EDNKSHYIVMQLVGRNLSDVRRALPHKRITERTLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIG-AIDCTRIYLIDYGLTRQYLD-KGGIVRKPRAGV
|  |  |.|| ..|  | ..||    .  .  . .   || |.|.   | .|.|||. ||.|  .|   | | .|. |... | |.| . . .| .| .|
EQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKV

GLRGTVRYMSLDAHARQDLGPKNDLVAFLYTT---IECGDGYLPWSHEKTHENIIKLKQ---AHIGDKLCTKQP-VMTKAAEYIESLNYHSIPDYEKLLA
   |. || .      .| | | || .  |.    .  . | ..|  |     .|| |.   .| . .  .. |  . .   |. .. | | |||. .. 
KMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHG-MSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRN

LM
 .
CL
Kinase ZK354.6.AA CK1-Unique 143-265 23 3.7e-17 56.06 In-house 86-219 (337) Show / Hide 
Range on Protein: 143-265
Range on HMM: 86-219/337
Sequence Identity: 23% (32 aa)

YIVMQLVGRNLSDVRRALPHKRITER------TLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIGAID---CTRIYLIDYGLTRQ--YLDKGGIVRKPR
.|||...|...  .....    .|        .. .   |.| ..   | .||.||..|| | | .|        .| .|||  |    ... . .|.||
WIVMTMHGPSMEECCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPR

AGVGLRGTVRYMSLDAHARQDLGPKNDLVAFLYT
  .  ||. .| .   |  ...| . |.  ..|.
PITPFRGCKDYCPCSCHQCREHGRRDDMESWFYM
Kinase ZK354.6.AA CK1 174-248 35 5.1e-15 48.31 In-house 111-188 (271) Show / Hide 
Range on Protein: 174-248
Range on HMM: 111-188/271
Sequence Identity: 35% (28 aa)

MIQVLKALSLVHGAGFLHRDLKPSNCCIGA--IDCTRIYLIDYGLTRQYLD-KGGIVRKPRAGVGLRGTVRYMSLDAH
. | .. .  ||  .|.|||.|| | ..|    .|...|.||.||  .|.| | .     | . .| ||.||.|. .|
ADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTH
Kinase ZK354.6.AA CK1-Unclassified 69-153 25 1.3e-14 39.6 In-house 1-90 (244) Show / Hide 
Range on Protein: 69-153
Range on HMM: 1-90/244
Sequence Identity: 25% (24 aa)

FEVKGIIGGGGFAQIYKAWDKVRKEDCAIKVEHESQDIRRMKLEITVLLALRGSM-------GIPEILAQGKWQHEDNK--SHYIVMQLVGRNL
..|.  || | | .|||.... ..|  |||.| . . ..  . |. .. .|.. .       ||| .     | . ...    ..|| | |..|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKM----YWCGQEEQGDYNIMVMDLLGPSL
Kinase ZK354.6.AA S_TKc 69-337 20 1.4e-14 37.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 69-337
Range on HMM: 1-231/231
Sequence Identity: 20% (59 aa)

FEVKGIIGGGGFAQIYKAWDKVRKEDCAIKVEHESQDIRRMKLEITVLLALRGSMGIPEILAQGKWQHEDNKSHYIVMQLVGR---NLSDVRRALPHKR-
.|.  .|| |.|.. ||...|  .. .|||. .     .... || .|       . | |     . ..  .. |.|| ...    .| |. .  .... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITERTLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIGAIDCTRIYLIDYGLTRQYLDKGGIVRKPRAGVGLRGTVRYMSLDAHARQDLGP-KNDLV
   ..| .  . | |...||   |  |..||||||.|  .      .| ..| || ||.               . ||  ||.         |. | |  
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWW

AFLYTTIECGDGYLPWSHEKTHENIIKLKQAHIGDKLCTKQPVMTKAAEYIESLNYHSIPDYEKLLALMEECN-------PPDL
..  . .|.  || |..   ... ..|.                    | .. ..     | || .   |  .        | .
SCGCILYEMLCGYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ZK354.6.AA CK1-Unclassified 174-248 35 3.6e-14 38.25 In-house 110-188 (244) Show / Hide 
Range on Protein: 174-248
Range on HMM: 110-188/244
Sequence Identity: 35% (28 aa)

MIQVLKALSLVHGAGFLHRDLKPSNCCIG--AIDCTRIYLIDYGLTRQYL--DKGGIVRKPRAGVGLRGTVRYMSLDAH
. | .. . ..|  .|.|||.|| | ..|      ...|.||.||   |.  || |     | . .| || || |. ||
ADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAH
Kinase ZK354.6.AA Pkinase 69-199 22 1.2e-09 35.15 Pfam 1-139 (293) Show / Hide 
Range on Protein: 69-199
Range on HMM: 1-139/293
Sequence Identity: 22% (33 aa)

FEVKGIIGGGGFAQIYKAWDKVRKEDCAIKVEHESQDIRRMKL-------EITVLLALRGSMGIPEILAQGKWQHEDNKSHYIVMQLVGRNLSDVRRAL-
......|| |.|.. ||. .|   .  |.|.   . ...  |.       || ... |.    .  . .        ... |.|| ...  |. |     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLY-VMDLFD

-----PHKRI--TERTLYRAMIQVLKALSLVHGAGFLHRDLKPSNC
      |...  .|... . | |.|..|   |  |..||||||.|.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI
Kinase ZK354.6.AA CK1 69-153 23 2.4e-09 28.51 In-house 1-91 (271) Show / Hide 
Range on Protein: 69-153
Range on HMM: 1-91/271
Sequence Identity: 23% (23 aa)

FEVKGIIGGGGFAQIYKAWDKVRKED---CAIKVEHESQDIRRMKLEITVLLALRG------SMGIPEILAQGKWQHED--NKSHYIVMQLVGRNL
..|   || | | .||....   ..     |||.| . .     . |. ..  |.|      ..||| .    .| . .  ..  ..|| | |..|
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHM----YWCGQEEQGDYNIMVMDLLGPSL
Kinase ZK354.6.AA TyrKc 69-337 15 7.8e-07 -112.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 69-337
Range on HMM: 1-280/280
Sequence Identity: 15% (50 aa)

FEVKGIIGGGGFAQIYKAWDKVRKEDCAIKVEHESQDIRRMKLEITVLLAL--RGSMGIPEILAQGKWQHEDN------KSHYIVMQLV-GRNLSDVRRA
 . . ..| | | ..||.  |   ...|.|. .|.  .. .  |. ..  |  .     | |..      ..       . ..||| .. . .| |  |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHH----PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LPHKRITERTLYRAMIQVLKALSLVHGAGFLHRDLKPSNCCIGAIDCTRIYLIDYGLTRQYLDK---GGIVRKPRAGV----GLR--GTVRYMSLDAHAR
  .| .. ..|   ..|. .  .  |  .. ||||   || .|.  . .|   | ||.|   |.   |  ..|    .    | .    .| |.. .   
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKI--SDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECI--

QDLGPKNDLVAFLYTTI---------------ECGDGYLP-----WSHEKTHENIIKLKQAHIGDKLCTKQPVMTKAAEYIESLNYHSIPDYEKLLALME
             .||                 ..  |        | .  .|.. . .   . .  .   | |             .    ...  .|.
---------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MS------------FVCCPDEMYQIMK

ECNPP-------------DL
.|                ..
QCWHEDPEDRPTFSEIHECF
Kinase ZK354.6.AA CK1 309-323 33 0.350639 0.06 In-house 257-271 (271) Show / Hide 
Range on Protein: 309-323
Range on HMM: 257-271/271
Sequence Identity: 33% (5 aa)

EYIESLNYHSIPDYE
.|. .|..   |||.
NYCRQLHFEEKPDYM