Gene IME2 (Bakers Yeast)

IME2

Species: Bakers Yeast
Alias: IME2
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
IME2.AA Protein Refseq_NP 645 `Positive regulator of meiosis, dispensable for mitosis, stimulates early, middle and late gene expression and negatively regulates IME1; Ime2p [Saccharomyces cerevisiae]` Fasta, JSON
IME2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 349 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of IME2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IME2.AA MAK 38-386 58 8e-283 911.17 In-house 1-352 (352) Show / Hide 
Range on Protein: 38-386
Range on HMM: 1-352/352
Sequence Identity: 58% (207 aa)

YQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDS
||.|..||.|..|||.|||.||||||||||||||||||||||||||||||..|...||||.|..|..........||.|......|........||..||
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENYQLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVEN
||..|..|.|.|..|||||||.|.||.|..|....|..|||.||...|.|.|||||.|||||.....|||||||||||||||||..||.|||||||....
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

KNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNLVHKLNL
|.|||.||||||||.||.||||.|||.|.|.||.||...|...||.||||..|||||.||..|||||.|..|||||||||||||||||.|...|.|..|.
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

KLPYVEG---SSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFF
..|....   ..|.||......||..|..|..|.||||.|.|||..|..|.|
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase IME2.AA RCK 38-386 40 2.7e-193 619.02 In-house 1-298 (298) Show / Hide 
Range on Protein: 38-386
Range on HMM: 1-298/298
Sequence Identity: 40% (143 aa)

YQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDS
||.|..||.|..|||..|..                              ..|...||||.|..|..........||||.. ........|...||..|.
YQIIKQLGDGTYGCVMKAQN------------------------------KETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDN

ENYQLHIVMECMEQNLYQMMKH---RRRRVFSIP-SLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLAR
..|||..|.|.|..|||||||.   ||....... |.|.|..|||.||.|.|.|.|||||||||||..|.|.||||.        ||...||.|||||.|
DTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFED--------QDQDHIKIADFGLCR

HVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNLVH
....|.|||.||||||||.||.|||..||..|.||||.||...|....|.||||..|||||.||..|.|||.|.                .|.|...|..
EIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKK----------------DWPDGYKLAS

KLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFF
..|...|...|..|..|... . .|..|...|.|.|||..|.|||.....|.|
QMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase IME2.AA CMGC 38-386 20 1.5e-104 344.54 In-house 1-513 (513) Show / Hide 
Range on Protein: 38-386
Range on HMM: 1-513/513
Sequence Identity: 20% (109 aa)

YQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYI-----TKTQGVVAIKTMM-TKLHTLQDY----------TRVREIKFILAI
|. |.|.| |..| |  .. .    ...                     .     ..|. .|||| ..  . .. |            .  ||||.   .
YEIIKKIGEGTYGVVYKCRDKRTNQKKD---------------------NGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHL

P---------------ANDH-LIQIFEVFIDSE---------------NYQLHIVMECMEQNLYQMMKHRR--------------------------RRV
                 ... .......| ...               ...|..|.|.|...|||..|. .                           . 
NKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKY

FSIPSLKSILSQILAGLK--HIHEHN--FFHRDLKPENILITPSTQYFEKEYM------NQIGYQDNYVIKLADFGLARHVENK----------------
|.|   . .  ||| |||  ..| |.  ..|||||||||||.. ....... |      |    |.|...|..||||||....                 
FMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-MWKSEDWNPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVN

------NPYTAYVSTRWYRSPEILLRSGYYS---------KPLDIWAFGCVAVEVTV--------FRALFPGANE-----------IDQIWKILEVLGTP
       ||| ||.|||||.|||||....|.         .| |.|..||.  |            . |||| .|           |||. || .|||||
KDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTP

I---------------KRSDFVNTNHITAPPPGG---------FWDDASNLVHKLNLKLPYVEGSSLDHLLSSSQL------------------------
                .. ..  ..  . ...           .|..   .  . |...| . . ..  |   ..                         
TWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKF

----------SDLSEVVKKCLRWDPNERATAQELCEMPFF
          ... . .||.|..||..| ||.. ...|.|
NHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase IME2.AA S_TKc 38-386 21 3.3e-75 257.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-386
Range on HMM: 1-231/231
Sequence Identity: 21% (78 aa)

YQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDS
|....|.| |.||.| ...                                 |. .|||| .          .  |||.        ........|| | 
YEILRKIGKGAFGKVYKCRHKK------------------------------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-

ENYQLHIVMECMEQ---NLYQMMKHRRR----RVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFG
    |..|||....   .|....|.|.|    ..|.    .... ||. .|...|.|.. ||||||||||..                    .||..|||
--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------HIKICDFG

LARHVENKNPYTAYVSTRWYRSPEILLRSGYYSK-PLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDDAS
|||..      | .. |.||..||.|     |.| . |.|..||.  |  . . .||   ......|..                               
LARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------------------------

NLVHKLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCE-------MPFF
                           ... . ..|||..||..| || |. .       .|.|
--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IME2.AA Pkinase 38-386 24 2.5e-66 231.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-386
Range on HMM: 1-293/293
Sequence Identity: 24% (90 aa)

YQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTL-QDYTRVR--EIKFILAIPANDHLIQIFEVF
|....|.|.||||||   |..   ...                            .||.|..  .     .|.|..|  ||.  . .   .. ......|
YHIGRKIGSGSFGCV--YKCHHKGTGK----------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWF

IDSENYQLHIVMECMEQNLYQMMKHR------RRRVF--SIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKL
 |  .  ...|||..|  ||  |         |...|  |   .|... ||| ||...|.... |||||||||||  .. . .              .|.
ED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA------------CVKI

ADFGLARH--VENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGA----NEIDQIWKILEVLGTPIKRS--------DFVN
.|||||..    |.  .| .. |.||..||... . ||... |.|..||.  |.   | .|||.    | .||...| ...|.|....        .|  
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-

TNHITAPPPGGFWDDASNLVHKLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFF
..| . .                              ..   . ... ...|.||..||..| ||..... |.|
FRH-W-H--------------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IME2.AA CDC2 127-304 34 5.1e-54 164.13 In-house 63-228 (301) Show / Hide 
Range on Protein: 127-304
Range on HMM: 63-228/301
Sequence Identity: 34% (65 aa)

LIQIFEVFIDSENYQLHIVMECMEQNLYQMMK--HRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVI
......|..    . | .| |.....| . |.     . ...   .||.. ||| |. . | .  .|||||| ||||  . .                 |
IVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-----------------I

KLADFGLARHV-ENKNPYT--AYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEV---TVFRALFPGANEIDQIWKILEVLGTP
|.||||||| .  ....||    | |.|||.|||||.. .|| | |.|..||.  |      ...||.|  ||||. || ..||||
KIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTP
Kinase IME2.AA MOK 95-304 38 1e-51 160.06 In-house 28-218 (283) Show / Hide 
Range on Protein: 95-304
Range on HMM: 28-218/283
Sequence Identity: 38% (80 aa)

AIKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDL
| | |  .. ....   .|||. .  .     .... ||  |    .| .. | |. |.| ...  ||   .   ..  . |..  | |.|    |||| 
ACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRG-RRHYLPQKKIMHYMYQLCKSLDHMHRNGIFHRDV

KPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQI
|||||||                 ||  ..||||||  | |  | ||| |.|||||| || ||  |||.  .|.|. |||  |.   . ||||.||.|||
KPENILIK----------------QD--HLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLFPGVNEVDQI

WKILEVLGTP
 || .|.|||
SKIHDVMGTP
Kinase IME2.AA CDKL 170-303 42 2.7e-44 149.35 In-house 100-218 (286) Show / Hide 
Range on Protein: 170-303
Range on HMM: 100-218/286
Sequence Identity: 42% (58 aa)

LKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKN-PYTAYVSTRWYRSPEILLRSGYYSKPLDI
..... ||| .... | ||  ||| |||||||||                 |...|| |||.||  ....  || || |||||.|| |.    |.|| ||
VRKYMWQILKAINFCHKHNCIHRDIKPENILITP----------------KNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDI

WAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGT
|| |||  | .   .|.|| ..|||  .|  .||.
WAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGP
Kinase IME2.AA GSK 38-304 27 1.3e-41 124.46 In-house 1-238 (328) Show / Hide 
Range on Protein: 38-304
Range on HMM: 1-238/328
Sequence Identity: 27% (78 aa)

YQLIEKLGAGSFGCVTLAKAQ---FPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGV----VAIKTMMTKLHTLQDYTRVREIKFILAI---PAND--
|. ... | |||| |. |...   .                              |. .    ||||    . ..     . || ...  .     ..  
YEEMKVIGHGSFGVVYQAYMNSPSN-----------------------------ETKEIWLGPVAIKKVWQDKRYK----CNRELQIMKMLGKLDHPNIV

HLIQIFEVFIDS--EN--YQLHIVMECMEQNLYQMMKH--RRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQ
.|.. |. . ..  ||  |.. .|||.|.|.|||. .|  . .....|  .| .  |.. ||...|.|.  |||.||.|||. |.|              
RLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDT--------------

DNYVIKLADFGLARHVEN--KNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTP
   | |..||| |. .|   . | ..|  .| || || .. . .|.   |.| .|||  |    . |||| ...||.  | ..||||
--GVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTP
Kinase IME2.AA p38 141-304 37 4.7e-39 130.97 In-house 82-223 (289) Show / Hide 
Range on Protein: 141-304
Range on HMM: 82-223/289
Sequence Identity: 37% (62 aa)

QLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNP
.  .|.. |.  |...||. |   .|    . .. ||| ||| ||  .  |||||| || ..                      .  ||||||| ...  
DVYMVTHFMGADLNNIMKCQR---LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCEL-----------------RILDFGLARHCDDE--

YTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTP
 | || |||||.|||.|  . | .  |||  ||.. |    |.|||| . |||. .|..|.|||
MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTP
Kinase IME2.AA DYRK 144-304 34 4.5e-36 126.17 In-house 78-223 (320) Show / Hide 
Range on Protein: 144-304
Range on HMM: 78-223/320
Sequence Identity: 34% (57 aa)

IVMECMEQNLYQMMKHRRRRVF-SIPSLKSILSQILAGLKHIHEH-NFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNPY
|| |....|||. .| .. ..| |.   .... ||| .||..|.. |  | |||||||.            ..|   .... ||..|||.. ...     
IVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM------------LKQP--RNKSTIKVIDFGSSCFEHQ--RI

TAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGANEIDQIWKILEVLGTP
. |.  | ||.||..|. . |... |.| .||. .|      ||||.|| ||. .| |||| |
YTYIQSRFYRAPEVILG-CPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMP
Kinase IME2.AA Ciliate-E2 38-274 21 7.7e-36 120.49 In-house 1-285 (365) Show / Hide 
Range on Protein: 38-274
Range on HMM: 1-285/365
Sequence Identity: 21% (68 aa)

YQLIEKLGAGSFG-----CVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQ----DYTRVREIKFILAIPANDHLI
| .|.|.| |.||     .| . . || .  |  .   .|.  | |.|.  . |  |..    |. .. ..| ..    .| .  . | || .  ....|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQ-M-QEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNII

QIFEVFIDSENYQLHIVMECMEQ-NLYQMMKHRRRR---------VFSIPSLKSILSQILA---------------GLKHIHEHN-FFHRDLKPENILIT
...|.|..  .  . .|||  .. .|.. .|...            |..   | |  |||                .|...|. |  .|||.||||||. 
KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

PSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNPYTAY--------------------------------VSTRWYRSPEILLRSGY--------Y
                     ||..||||.. . ..| .. .                                . |  | .|||| . .|        |
---------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGY

SKPLDIWAFGCV
..  |||..|..
DYKCDIWSLGVI
Kinase IME2.AA CDK 223-304 43 2.2e-35 110.53 In-house 151-244 (284) Show / Hide 
Range on Protein: 223-304
Range on HMM: 151-244/284
Sequence Identity: 43% (41 aa)

VIKLADFGLARHVE-------NKNPYTAYVSTRWYRSPEILLRSGYYS--KPLDIWAFGCVAVEVTV---FRALFPGANEIDQIWKILEVLGTP
..|.|||||||          . ..||  | |.|||.||.|| |  ||   | |.|..||. .|       ..|||| .||||. || ...|||
RLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTP
Kinase IME2.AA CDK 112-202 26 1.6e-21 65.44 In-house 56-142 (284) Show / Hide 
Range on Protein: 112-202
Range on HMM: 56-142/284
Sequence Identity: 26% (26 aa)

VREIKFILAIPANDHLIQIFEVFIDSE---------NYQLHIVMECMEQNLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILIT
.|||.    .  ... .....|.....         .  | .|.| |.. |.. |.            |... |.| || ..|.... |||||| ||||.
IREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILIN
Kinase IME2.AA TyrKc 38-384 16 6.1e-14 2.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-384
Range on HMM: 1-280/280
Sequence Identity: 16% (62 aa)

YQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVAIKTMMTKLHTLQDYTRVREIKFILAI-PANDHLIQIFEVFID
 .|..||| | || | ....                                    ||.|..      ..|    ||..    . . ........ | ..
ITLGKKLGEGAFGEVYKGTWK---------------------------------IQVAVKMLKEDA--REDF--MREARIMCKLGGHHPNIVRLYGVCTQ

S-EN----YQLHIVMECMEQ-NLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFG
. .|     .| |||| |.  .| .  . .|.. .. . | |.  || .|  ..|..|. ||||   |.|..                    ..| .|||
QGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------TVKISDFG

LARHVENK-------NPYT------AY--VSTRWYRSPEILLRSGYYSKPLDIWAFGCVAVEVTVFRALFPGA-----NEIDQIWKILEVLGTPIKRSD-
|.| ....         |.      .   .  ||. .|| . . | ..   |.|.|| .  |.  . .  .        . ... . ..  . . .  . 
LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPND

---FVNTNHITAPPPGGFWDDASNLVHKLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMP
                                             .    ... .. |.| . ||..| | .|..|  
YPMS-----------------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IME2.AA GSK 358-386 41 3.6e-09 23.54 In-house 300-328 (328) Show / Hide 
Range on Protein: 358-386
Range on HMM: 300-328/328
Sequence Identity: 41% (12 aa)

DLSEVVKKCLRWDPNERATAQELCEMPFF
|. . ..|||. ||..| .. |.| .|||
DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase IME2.AA CDKL 363-386 50 9.5e-08 22.57 In-house 263-286 (286) Show / Hide 
Range on Protein: 363-386
Range on HMM: 263-286/286
Sequence Identity: 50% (12 aa)

VKKCLRWDPNERATAQELCEMPFF
.||||  || || |...| ..|.|
MKKCLHMDPDERMTCEQLMHHPYF
Kinase IME2.AA DYRK 345-386 28 4.4e-07 22.8 In-house 280-320 (320) Show / Hide 
Range on Protein: 345-386
Range on HMM: 280-320/320
Sequence Identity: 28% (12 aa)

SSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFF
...|...   . ...   .|||| |||..| |...  . |.|
RNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase IME2.AA Pkinase_Tyr 144-274 26 1e-06 23.18 Pfam 84-203 (270) Show / Hide 
Range on Protein: 144-274
Range on HMM: 84-203/270
Sequence Identity: 26% (37 aa)

IVMECMEQ-NLYQMMKHR--RRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQIGYQDNYVIKLADFGLARHVENKNP
|||| |.  .|.   . .   .. .... | ..  || .|. . ...|. ||||   |.|.|                 .| |.| .|||||| ..|.  
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-----------------ENNVVKICDFGLARDIYNDDY

YTAYVST------RWYRSPEILLRSGYYSKPLDIWAFGCV
|  ....      .|. .|| .  . . .|  |.|.|| .
Y-YRKRGGGKLPIKWM-APECINYGKFTTKS-DVWSFGVL
Kinase IME2.AA Ciliate-E2 364-386 32 8e-06 16.01 In-house 338-365 (365) Show / Hide 
Range on Protein: 364-386
Range on HMM: 338-365/365
Sequence Identity: 32% (9 aa)

KK----CLRWDPNERAT-AQELCEMPFF
||    .|  ||..| | .... . |.|
KKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase IME2.AA CDK 338-386 22 1.3e-05 13.75 In-house 254-284 (284) Show / Hide 
Range on Protein: 338-386
Range on HMM: 254-284/284
Sequence Identity: 22% (11 aa)

KLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFF
|||.                   .   |.|  ||. | .|..  ..|.|
KLPDY------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase IME2.AA CDK 38-56 42 3.4e-05 12.39 In-house 1-19 (284) Show / Hide 
Range on Protein: 38-56
Range on HMM: 1-19/284
Sequence Identity: 42% (8 aa)

YQLIEKLGAGSFGCVTLAK
|. .||.| |..| |  |.
YEKLEKIGEGTYGVVYKAR
Kinase IME2.AA CDC2 38-56 52 5.8e-05 10.62 In-house 1-19 (301) Show / Hide 
Range on Protein: 38-56
Range on HMM: 1-19/301
Sequence Identity: 52% (10 aa)

YQLIEKLGAGSFGCVTLAK
|| |||.| |..| |. .|
YQKIEKIGEGTYGVVYKCK
Kinase IME2.AA MOK 335-386 30 5.8e-05 10.94 In-house 233-283 (283) Show / Hide 
Range on Protein: 335-386
Range on HMM: 233-283/283
Sequence Identity: 30% (16 aa)

LNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFF
.|   |.  || .. |..      | |...|   .|| || ||.     |.|
MNYDFPFKKGSGIEKLTPNLTKQCL-EIMHKMCTYDPDERITAHQVIQHPYF
Kinase IME2.AA DYRK 38-52 53 0.008537 6.61 In-house 1-15 (320) Show / Hide 
Range on Protein: 38-52
Range on HMM: 1-15/320
Sequence Identity: 53% (8 aa)

YQLIEKLGAGSFGCV
|. .| .| |||| |
YEILEYIGKGSFGQV
Kinase IME2.AA p38 38-58 33 0.015076 4.2 In-house 1-21 (289) Show / Hide 
Range on Protein: 38-58
Range on HMM: 1-21/289
Sequence Identity: 33% (7 aa)

YQLIEKLGAGSFGCVTLAKAQ
|| .. .| |..| |  | ..
YQNLQPVGSGAYGQVCKAEDR
Kinase IME2.AA Pkinase_Tyr 38-57 35 0.037583 7.91 Pfam 1-20 (270) Show / Hide 
Range on Protein: 38-57
Range on HMM: 1-20/270
Sequence Identity: 35% (7 aa)

YQLIEKLGAGSFGCVTLAKA
 ....|||.|.|| | ....
ITFGKKLGEGAFGEVYKGTW
Kinase IME2.AA CDC2 367-386 40 0.053419 1.34 In-house 282-301 (301) Show / Hide 
Range on Protein: 367-386
Range on HMM: 282-301/301
Sequence Identity: 40% (8 aa)

LRWDPNERATAQELCEMPFF
|. ||. | .|.|  . |.|
LQYDPQKRISAKEALQHPYF